Preparation method of a multi-responsive self-healing self-adhesive hydrogel

A hydrogel and responsive technology, applied in the field of preparation of multiple responsive self-healing and self-adhesive hydrogels, can solve the problems of poor mechanical properties of hydrogels, lack of tissue adhesion and cell affinity, etc. , to achieve the effect of simple preparation method, wide application potential and good biocompatibility

Active Publication Date: 2022-03-25
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a method for preparing a multi-responsive self-healing self-adhesive hydrogel in order to overcome the problems of poor mechanical properties, lack of tissue adhesion and cell affinity of the existing hydrogel, the method Using polyvinyl alcohol, tannic acid, bacterial cellulose and cystamine dihydrochloride as raw materials, the hydrogel prepared has good mechanical properties, the preparation method is simple and easy, and it is environmentally friendly

Method used

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  • Preparation method of a multi-responsive self-healing self-adhesive hydrogel
  • Preparation method of a multi-responsive self-healing self-adhesive hydrogel
  • Preparation method of a multi-responsive self-healing self-adhesive hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0025] At room temperature, take 36.9 g of bacterial cellulose suspension with a mass fraction of 8.13 mg / g (about 0.3 g of bacterial cellulose), disperse it into 30 mL of tris buffer with a pH value of 8.5, and then add 0.2 g Tannic acid, stir evenly, after the prepolymerization reaction for 6 hours, add 0.2 g of cystamine dihydrochloride to continue the reaction for 1.5 hours to obtain the bacterial cellulose suspension coated with tannic acid, and successfully introduce disulfide bonds, and the suspension Centrifuge and wash for later use.

[0026] Add 5g of polyvinyl alcohol into 45mL of deionized water and heat to 95°C, stir for 2 hours until the polyvinyl alcohol is completely dissolved, add the centrifuge obtained in the previous step into the polyvinyl alcohol solution and continue to stir evenly, then add 5mL of the concentration to 0.04g / Add 1 mL of borax solution dropwise at a rate of 1 mL / min, stir for 20 min, and then naturally cool to room temperature to obtain ...

Embodiment 2

[0030] At room temperature, take 36.9 g of bacterial cellulose suspension with a mass fraction of 8.13 mg / g (about 0.3 g of bacterial cellulose), disperse it into 30 mL of tris buffer with a pH value of 8.5, and then add 0.5 g Tannic acid, stir evenly, after the prepolymerization reaction for 6 hours, add 0.2 g of cystamine dihydrochloride to continue the reaction for 1.5 hours to obtain the bacterial cellulose suspension coated with tannic acid, and successfully introduce disulfide bonds, and the suspension Centrifuge and wash for later use.

[0031] Add 5g of polyvinyl alcohol into 45mL of deionized water and heat to 95°C, stir for 2 hours until the polyvinyl alcohol is completely dissolved, add the centrifuge obtained in the previous step into the polyvinyl alcohol solution and continue to stir evenly, then add 5mL of the concentration to 0.04g / Add 1 mL of borax solution dropwise at a rate of 1 mL / min, stir for 20 min, and then naturally cool to room temperature to obtain ...

Embodiment 3

[0034] At room temperature, take 36.9 g of bacterial cellulose suspension with a mass fraction of 8.13 mg / g (approximately containing 0.3 g of bacterial cellulose), disperse it into 30 mL of tris buffer with a pH value of 8.5, and then add 0.8 g Tannic acid, stir evenly, after the prepolymerization reaction for 6 hours, add 0.2 g of cystamine dihydrochloride to continue the reaction for 1.5 hours to obtain the bacterial cellulose suspension coated with tannic acid, and successfully introduce disulfide bonds, and the suspension Centrifuge and wash for later use.

[0035] Add 5g of polyvinyl alcohol into 45mL of deionized water and heat to 95°C, stir for 2 hours until the polyvinyl alcohol is completely dissolved, add the centrifuge obtained in the previous step into the polyvinyl alcohol solution and continue to stir evenly, then add 5mL of the concentration to 0.04g / Add 1 mL of borax solution dropwise at a rate of 1 mL / min, stir for 20 min, and then naturally cool to room tem...

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Abstract

A method for preparing multi-responsive self-healing self-adhesive hydrogels. Polyvinyl alcohol / borax was used as the main structure of the hydrogel, and bacterial cellulose was added to improve the mechanical properties of the hydrogel. Tannic acid rich in catechol groups is used as a monomer to provide hydrogel adhesion, and the quinone structure obtained by oxidation of tannic acid undergoes Schiff base or Michael addition to the amino group of cystamine dihydrochloride The reaction introduces disulfide bonds, endowing the hydrogel with redox responsiveness. The hydrogel is prepared through borate bonds, hydrogen bonds, π-π stacking, etc., which overcomes the shortcomings of traditional polyvinyl alcohol hydrogels such as poor mechanical properties and lack of tissue adhesion. The hydrogel has good biocompatibility, multi-responsiveness, excellent mechanical properties and self-adhesion, etc., thereby expanding the application range of the hydrogel.

Description

technical field [0001] The invention belongs to the field of preparation of multi-responsive hydrogels, and in particular relates to a preparation method of multi-responsive self-healing and self-adhesive hydrogels. Background technique [0002] Traditional polyvinyl alcohol / borax-based hydrogels are widely used because of their sterility and non-toxicity, but such hydrogels lack sufficient adhesion and cell affinity to tissues and have poor mechanical properties, making them useful as biological dressings. And the application of medical materials is limited. Contents of the invention [0003] The purpose of the present invention is to provide a method for preparing a multi-responsive self-healing self-adhesive hydrogel in order to overcome the problems of poor mechanical properties, lack of tissue adhesion and cell affinity of the existing hydrogel. Using polyvinyl alcohol, tannic acid, bacterial cellulose and cystamine dihydrochloride as raw materials, the hydrogel prep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L29/04C08L1/08C08K3/38C08B15/00
CPCC08J3/075C08B15/00C08J2329/04C08J2401/08C08K3/38
Inventor 贺金梅衣晓彤魏新晶于琛刘兴原钱婧婷
Owner HARBIN INST OF TECH
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