Magnesium phosphate-based bone repair material, raw material composition and preparation method and application thereof

Abstract

The invention discloses a magnesium phosphate-based bone repair material, a raw material composition and a preparation method and application thereof. The raw material composition comprises the following components: mesoporous tantalum oxide and magnesium phosphate bone cement, the weight ratio of the mesoporous tantalum oxide to the magnesium phosphate bone cement powder in the magnesium phosphate bone cement is 1: 1.5 -9; and the particle size of the mesoporous tantalum oxide is 0.1-0.5 mu m and the pore diameter less than or 50 nm. The mixture of the raw material composition is solidified to obtain the magnesium phosphate-based bone repair material. The preparation method of the bone repair material is simple and feasible; the coagulation time is suitable, the biocompatibility, the osteogenesis and the degradability are good, the adhesion, the proliferation and the differentiation of osteoblasts can be promoted, the cell growth can be stimulated, and the osteoblasts can be stimulated to differentiate into osteocytes; and the magnesium phosphate-based bone repair material can be injected directly into bone defect; and the magnesium phosphate-based bone repair material loaded with stilbene glucoside has certain anti-osteoporosis performance and obvious osteogenesis effect.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a magnesium phosphate-based bone repair material, a raw material composition, a preparation method and an application thereof. Background technique [0002] With the aging of the population and the increase of trauma among middle-aged and young people, bone repair materials have become one of the biomedical materials with the greatest clinical demand. There are millions of patients with bone tissue defects every year, but the orthopedic fixation materials and bone defect repair materials widely used in clinical practice all have the problem of poor biological activity. Finding better materials for bone tissue regeneration and repair is the frontier and hotspot of biomedical materials research. [0003] Currently, bone repair materials commonly used in the market are mainly divided into three categories: metal materials, bioceramic / bioglass, and polymer materials. Metal mater...

AI Technical Summary

Problems solved by technology

But this drug-loaded slow-release carrier has poor slow-release performance (31~90% of the drug has been released in 60 days), so it can be seen that the slow-release time is too long, which reduces the drug effect

[0005] Tantalum oxide (Ta 2 o 5 ) is an inorganic material. Although a large number of biocompatibility experiments have proved that tantalum oxide is non-toxic, non-irritating, non-allergic, non-mutagenic, and non-destructive to biological tissues, it has a certain degree of brittleness and low strength, which limits Its mechanical properties

Mei Shiqi of East China University of Science and Technology disclosed a PEEK (polyether ether ketone) composite tantalum oxide biomaterial. In order to improve the biological performance of PEEK, tantalum pentoxide (Ta 2 o 5 ) was added to PEEK to prepare PEEK / Ta2O5 composite material (PTC), and the surface roughening of PTC was prepared with sand, but due to the fixed shape of the bone restoration, it is not suitable for bone defects with complex shapes, and the bone restoration Non-degradable, not conducive to the growth of the patient's own bone

Images