Anti-collapsible injectable magnesium phosphate-based bone cement

A magnesium phosphate-based bone, anti-collapse technology, applied in the field of medical biomaterials, can solve the problems of good anti-collapse, unfavorable bone cement repair, long setting time, etc., achieves appropriate setting time, avoids drop in injectability, and improves anti-scour. performance effect

Active Publication Date: 2018-10-12
WUHAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chen Fangping et al. (Journal Of Materials Chemistry B, 2015, 3:9173-9181.) introduced xanthan gum into calcium magnesium phosphate bone cement to prepare injectable bone cement. Although it has good collapse resistance, its strength is only 11-12MPa
If the setting time is too long, it cannot meet the clinical needs, and if the strength is low, it is not conducive to the repair of bone cement in the stressed part.

Method used

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  • Anti-collapsible injectable magnesium phosphate-based bone cement
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  • Anti-collapsible injectable magnesium phosphate-based bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Magnesium oxide is calcined at 1600°C for 2h, the heating rate is 3°C / min, and the particle size is 0.4-3μm. The particle sizes of potassium dihydrogen phosphate and calcium dihydrogen phosphate are 1-20 μm and 0.5-30 μm, respectively. Weigh 1.5g of magnesium oxide, 3g of potassium dihydrogen phosphate and 1g of calcium dihydrogen phosphate powder, then add 0.1g of citric acid and 0.02g of xanthan gum and mix well. The liquid phase is 5% volume concentration of glycerol aqueous solution, mixed at a solid-to-liquid ratio of 2.2 g / mL, and stirred for 5 minutes until viscous.

[0045] The setting time of the bone cement is 15.5min, the compressive strength is 53.2MPa, and the injectability is 98%. Its anti-collapse performance is as figure 2 As shown in a), there is almost no powder spillage with the naked eye. The phase after curing for 2 days is as follows figure 1 As shown in a), it is mainly potassium magnesium phosphate hexahydrate and unreacted magnesium oxide. ...

Embodiment 2

[0047] Magnesium oxide is calcined at 1600°C for 2h, the heating rate is 3°C / min, and the particle size is 0.4-3μm. The particle sizes of potassium dihydrogen phosphate and calcium dihydrogen phosphate are 1-20 μm and 0.5-30 μm, respectively. Weigh 1.5g magnesium oxide, 3g potassium dihydrogen phosphate and 1g calcium dihydrogen phosphate powder, add 0.05g citric acid, 0.01g xanthan gum and mix well. The liquid phase is a 5% volume concentration aqueous glycerin solution. Mix at a solid-to-liquid ratio of 2.2 g / mL, and stir for 5 minutes until viscous.

[0048] The setting time of the bone cement is 13.5min, the compressive strength is 48.1MPa, and the injectability is 96%. Its anti-collapse performance, such as figure 2 As shown in b), there is almost no powder spillage with the naked eye. The phase after curing for 2 days is as follows figure 1 As shown in b), it is mainly potassium magnesium phosphate hexahydrate and unreacted magnesium oxide.

Embodiment 3

[0050] Magnesium oxide is calcined at 1600°C for 2h, the heating rate is 3°C / min, and the particle size is 0.4-3μm. The particle sizes of potassium dihydrogen phosphate and calcium dihydrogen phosphate are 1-20 μm and 0.5-30 μm, respectively. Weigh 1.5g magnesium oxide, 3g potassium dihydrogen phosphate and 1g calcium dihydrogen phosphate powder, add 0.23g citric acid, 0.05g xanthan gum and mix well. The liquid phase is a 5% volume concentration aqueous glycerin solution. Mix at a solid-to-liquid ratio of 2.2 g / mL, and stir for 5 minutes until viscous.

[0051] The setting time of the bone cement is 19 minutes, the compressive strength is 42MPa, the injectability is 96%, the anti-collapse performance is good, and there is little powder overflowing by naked eyes.

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Abstract

The invention relates to anti-collapsible injectable magnesium phosphate-based bone cement. The anti-collapsible injectable magnesium phosphate-based bone cement is composed of a powder phase and a liquid phase, and the powder phase comprises magnesium oxide, potassium dihydrogen phosphate, calcium phosphate salt, citric acid (or sodium citrate) and polysaccharide (or a polysaccharide derivative),wherein the magnesium oxide is 26-28 parts by mass, the potassium dihydrogen phosphate is 52 to 55 parts by mass, the calcium phosphate salt is 16 to 18 parts by mass, the citric acid (or sodium citrate) is 0 to 4 parts by mass, and the polysaccharide (or polysaccharide derivative) is 0 to 1 part by mass. The liquid phase is an aqueous solution of glycerin. The powder phase and the liquid phase are uniformly mixed at a ratio of 1.8 to 2.4 g/mL, a mixture is conditioned for 4 to 6 minutes to form viscous slurry, and the mixture can be injected by a syringe. The injectable magnesium phosphate-based bone cement has good anti-collapsing performance, suitable coagulation time and high strength, is degradable, has good cell compatibility, and is suitable for injection filling of orthopedic anddental cavity defects in ordinary or minimally invasive surgery.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and relates to an anti-collapse injectable magnesium phosphate-based bone cement. Background technique [0002] The number of clinical cases of bone defects due to accidents and diseases remains high every year. At present, the main method for treating bone defects is to use autologous bone, allogeneic bone or artificial bone material for filling. Thanks to the rapid development of the material industry and the advantages of unlimited sources, various artificial bone materials have gradually been applied clinically. Among them, bone cement has attracted widespread attention from medical researchers due to its excellent self-curing and plasticity. With the advancement of medical technology, some fractures and defects only need closed reduction, and the bone defect can be repaired by percutaneous injection of bone cement. This minimally invasive treatment method greatly simplifies the operatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/12A61L27/00
CPCA61L27/00A61L27/12A61L27/50A61L2400/06A61L2430/02
Inventor 戴红莲余素春白熠黄旅姚飊
Owner WUHAN UNIV OF TECH
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