Bone repair material and preparation method and application thereof

A bone repair and material composition technology, applied in the field of medical biomaterials, to achieve the effects of simple and easy preparation methods, prevention of postoperative infection, and good biocompatibility

Active Publication Date: 2020-11-03
上海禾麦医学科技有限公司
View PDF7 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The invention provides a bone repair material and its preparation method and application, so as to overcome the defects of the curing time, mid-late strength and degradability of inorganic calcium-magnesium-based bone cement in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bone repair material and preparation method and application thereof
  • Bone repair material and preparation method and application thereof
  • Bone repair material and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Embodiment 1: The preparation method of bone cement bone repair material, comprises the following steps:

[0091] (1) Disperse hydroxyapatite particles into 200 μmol / L lipoic acid solution, stir for 2 hours, and then centrifuge and dry to obtain the desired drug-loaded hydroxyapatite particles;

[0092] (2) Dissolve sodium phytate in water at a concentration of 5w%.

[0093] (3) The bone cement powder is magnesium oxide, calcium hydrogen phosphate, sodium dihydrogen phosphate and hydroxyapatite, in which magnesium oxide, calcium hydrogen phosphate and sodium dihydrogen phosphate are uniformly mixed in a molar ratio of 5:6:2.

[0094] (4) Mix 0.08g of drug-loaded hydroxyapatite particles with 0.32g of magnesium phosphate bone cement powder evenly, take 180mg of desolidified liquid and mix it with the powder, and place it in the mold at 37 ℃, 100% humidity environment to cure 72h.

Embodiment 2

[0095] Embodiment 2: the preparation method of bone cement bone repair material, comprises the following steps:

[0096] (1) Disperse hydroxyapatite particles into 200 μmol / L lipoic acid solution, stir for 2 hours, and then centrifuge and dry to obtain the desired drug-loaded hydroxyapatite particles;

[0097] (2) Dissolve sodium phytate in water at a concentration of 5w%.

[0098] (3) The bone cement powder is magnesium oxide, calcium hydrogen phosphate, sodium dihydrogen phosphate and hydroxyapatite, in which magnesium oxide, calcium hydrogen phosphate and sodium dihydrogen phosphate are uniformly mixed in a molar ratio of 2:2:1 。

[0099] (4) Mix 0.08g of drug-loaded hydroxyapatite particles with 0.32g of magnesium phosphate bone cement powder evenly, take 150mg of desolidified liquid and mix it with the powder, put it into the mold and solidify (the solidification time is 6-10min) and place it in 37 ℃, 100% humidity environment to cure 72h.

Embodiment 3

[0100] Embodiment 3: the preparation method of bone cement composite bone repair material, it comprises the following steps:

[0101] (1) The bone cement powder is magnesium oxide, calcium hydrogen phosphate, sodium dihydrogen phosphate and hydroxyapatite, in which magnesium oxide, calcium hydrogen phosphate and sodium dihydrogen phosphate are uniformly mixed in a molar ratio of 5:6:2.

[0102] (2) Dissolve sodium phytate in water at a concentration of 5w%.

[0103] (3) Add 0.02g lipoic acid powder and 0.06g hydroxyapatite to the bone cement powder and mix evenly.

[0104] (4) Mix the drug-loaded bone cement powder evenly, take 180mg of solidification liquid and mix it with the powder, put it into the mold to solidify (solidification time is 6-10min), and then place it in an environment of 37°C and 100% humidity for 72h to solidify.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention discloses a bone repair material composition, a bone repair material and a preparation method and application of the bone repair material. The bone repair material composition comprisesa bone cement component and curing liquid, wherein the bone cement comprises magnesium oxide, calcium hydrophosphate, sodium dihydrogen phosphate and hydroxyapatite, and the curing liquid is a sodiumphytate aqueous solution. The bone repair material disclosed by the invention is simple to prepare and proper in coagulation time, has good biocompatibility, osteogenesis and degradability, can be directly injected into a bone defect part, has anti-osteoporosis performance and has an obvious osteogenesis effect.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a bone repair material and its preparation method and application. Background technique [0002] Osteoporosis is a systemic bone metabolic disease characterized by decreased bone density and bone quality, destroyed bone microstructure, increased bone fragility, and prone to fractures. Fracture is one of the most common complications of osteoporosis (such as vertebral compression fractures, hip and distal radius fractures, etc.), and has become a serious public health and social problem of worldwide concern, and its incidence rate has leapt to the world's common disease No. 7. The number of patients with osteoporosis in my country has reached 120 million. Every year, the cost of osteoporotic fractures in the entire American society is 12.2 billion to 17.9 billion U.S. dollars. Osteoporosis and pathological fractures also cause a heavy economic burden on our society. [0003]...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/54A61L27/58
CPCA61L27/12A61L27/025A61L27/54A61L27/58A61L2300/216A61L2300/412A61L2300/404A61L2430/02A61L2400/06
Inventor 苏佳灿胡衍魏杰黄标通
Owner 上海禾麦医学科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap