Polylactic acid-based composite material surgical medical film and preparation method thereof

A composite material and polylactic acid-based technology, which is applied in the field of medical supplies, can solve problems such as patents that have not been reported, and achieve the effects of preventing wound healing, good controllable degradation behavior, and good tissue compatibility

Inactive Publication Date: 2014-09-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, by changing the composition system and related process parameters of polylactic acid-based composite electrospun fiber membranes, surgical medical membranes with excellent comprehensive performance have been obtained, and they have been widely used in wound compounding, anti-tissue adhesion and other fields, which are related to patents have not been reported

Method used

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  • Polylactic acid-based composite material surgical medical film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Preparation of polymer electrospinning solution: the polylactic acid / ibuprofen composite material was dissolved in dichloromethane, and magnetically stirred for 24 hours to obtain a uniform solution system. The concentration of polymer solution is 10% (by mass fraction);

[0029] (2) Electrospinning: The polymer solution obtained in (1) is placed in the feeding syringe of the electrospinning equipment, the feeding speed of the solution is 0.5mm / min, and the ambient temperature of spinning is set to 30°C. Turn on the high-voltage power supply and adjust the voltage to 15kV, the distance between the needle tip of the syringe and the static ground plate is 15cm, and finally the electrospun fiber film is obtained on the static ground plate;

[0030] (3) Collect the fibrous film on the static ground plate and place it in an oven to dry to remove the organic solvent. The oven temperature is set at 40° C., and the drying time is 12 hours until the organic solvent weight co...

Embodiment 2

[0033] (1) Preparation of polymer electrospinning solution: Dissolve polylactic acid / hyaluronic acid composite material in dichloromethane, and magnetically stir for 6-48 hours to obtain a uniform solution system. The concentration of the polymer solution is 5-20% (by mass fraction);

[0034](2) Electrospinning: The polymer solution obtained in (1) is placed in the feeding syringe of the electrospinning equipment, the feeding speed of the solution is 0.5mm / min, and the ambient temperature of spinning is set to 30°C. Turn on the high-voltage power supply and adjust the voltage to 15kV, the distance between the needle tip of the syringe and the static ground plate is 15cm, and finally the electrospun fiber film is obtained on the static ground plate;

[0035] (3) Collect the fibrous film on the static ground plate and place it in an oven to dry to remove the organic solvent. The oven temperature is set at 40° C., and the drying time is 12 hours until the organic solvent weight c...

Embodiment 3

[0038] (1) Preparation of polymer electrospinning solution: dissolve the polylactic acid / antibiotic composite material in dichloromethane, and stir magnetically for 6-48 hours to obtain a uniform solution system. The concentration of the polymer solution is 5-20% (by mass fraction);

[0039] (2) Electrospinning: The polymer solution obtained in (1) is placed in the feeding syringe of the electrospinning equipment, the feeding speed of the solution is 0.5mm / min, and the ambient temperature of spinning is set to 30°C. Turn on the high-voltage power supply and adjust the voltage to 15kV, the distance between the needle tip of the syringe and the static ground plate is 15cm, and finally the electrospun fiber film is obtained on the static ground plate;

[0040] (3) Collect the fibrous film on the static ground plate and place it in an oven to dry to remove the organic solvent. The oven temperature is set at 40° C., and the drying time is 12 hours until the organic solvent weight c...

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Abstract

The invention discloses a polylactic acid-based composite material surgical medical film and a preparation method thereof. By adopting electrostatic spinning equipment and exploring proper technological parameters, different types of polylactic acid-based composite material macromolecular fiber thin films are finally formed and are applied to the field of biomedicine. In addition, by regulating and controlling composition of a macromolecular composite material system and thickness of an electro-spinning thin film, the surgical medical film which has good flexibility, high tensile strength, controllable degradation rate as well as excellent waterproof, antibacterial and air permeable performances is obtained finally. The surgical medical film is applicable to the field of various biomedicines such as healing film, wound surface dressing and anti-adhesion medicine; the medical film not only can be better adhered to tissues and avoid biotoxicity, but also can effectively promote transmission functions of blood, nutrients and growth factors in a human body due to the nature of semipermeable membrane. The process of the invention is simple and environment-friendly; the preparation method is easy to operate, low in cost, applicable to large-scale production and good in controllability, and is expected to be widely applied to various medical fields.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to a polylactic acid-based composite surgical medical film and a preparation method thereof. Background technique [0002] Although modern surgical aseptic technology has been fully developed, the incidence of local infection, complications and secondary surgical treatment in surgical operations is still high, and has become a major cause of death, prolonged hospitalization and increased costs. major factor. Surgical medical film plays a vital role in surgical operations. It can not only be used as a medical healing film and wound dressing to repair minor abrasions, small area I and II degree burns and smaller wounds. The protection of incisions and the prevention and treatment of chapped and bedsores can also be used as an anti-adhesion film to effectively prevent the occurrence of postoperative adhesions. According to reports, 50-100% of abdominal and pelvic surgery wil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/28A61L15/32A61L15/44D04H1/435D04H1/728
Inventor 陈晨朱小康何本祥王孝军颜锦江姜浩亮
Owner SICHUAN UNIV
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