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Pelvic surgery may be necessary to treat instances of infertility. Laparoscopic surgery is often used for major procedures on the pelvis and abdomen. A scalpel is a small, sharp knife that is used in surgeries to make incisions. Pelvic surgery may be utilized for someone with bladder stones or other bladder conditions.
An injectable polysiloxane / hyaluronic acid double network hydrogel, its preparation method and postoperative anti-adhesion application
This invention belongs to the field of biomedical polymer materials. Specifically, it relates to an injectable dual-network hydrogel, its preparation method, and its application in long-term prevention of postoperative tissue adhesion. The hydrogel consists of two interpenetrating three-dimensional cross-linked networks: one is a polysiloxane network formed by the condensation polymerization of γ-aminopropyltrialkoxysilane; the other is a hyaluronic acid network formed by the cross-linking of thiolized hyaluronic acid through dissolved oxygen oxidation under the catalysis of amino groups in the polysiloxane network. The two networks interpenetrate to form a stable three-dimensional cross-linked structure. Compared with existing anti-adhesion materials that struggle to balance biocompatibility, wet tissue adhesion, and long-term stability, the hydrogel of this invention exhibits good biocompatibility, wet tissue adhesion performance, a slow degradation rate, and injectability. It can be used as a medical barrier material for the prevention of postoperative tissue adhesion, especially suitable for long-term anti-adhesion applications after abdominal and pelvic surgeries.
Owner:CHINA AGRI UNIV +1