73 results about "Biomedical polymers" patented technology

The invention discloses a self-crosslinking hydrogel with a tertiary amine group and preparation and application thereof, and belongs to the field of biomedical polymer materials, the self-crosslinking hydrogel comprises aminophenylboronic acid modified oxidized glucan, tertiary amine compound modified oxidized glucan and a solvent medium; the preparation method comprises the following steps: dissolving amino phenylboronic acid modified oxidized dextran and tertiary amine compound modified oxidized dextran in a solvent medium, mixing, standing for a certain time, and carrying out self-crosslinking to obtain the self-crosslinking hydrogel with tertiary amine groups. A cross-linking point (phenylboronic acid) of the gel network is a response unit of glucose. In addition, the hydrogel can effectively avoid uncontrollable drug release caused by non-responsive factors, and the response release efficiency of the drug is improved; by loading the hypoglycemic drug insulin to be applied to the treatment research process of diabetes, the occurrence of hypoglycemia can be avoided, and meanwhile, the possibility is provided for realizing intelligent controlled release of insulin through blood glucose response.

The invention discloses a biomedical polymer-based wound infection indicating dressing material as well as a preparation method and application thereof, and the dressing material is obtained by modifying a pH responsive dye, performing graft polymerization on the modified pH responsive dye, a cross-linking agent and hydrophilic monomer free radicals to form a hydrogel coating, and then wrapping the hydrogel coating on a biomedical polymer material. The material has a pH responsive infection indication function, can amplify a wound infection condition which is not easy to detect into a color change which is intuitive and distinguishable by naked eyes, can meet the requirement of monitoring the skin wound infection condition in actual clinical application, is beneficial to early detection of wound infection, and has a wide application prospect. And the preparation method can maintain the original texture of the biomedical polymer material to the greatest extent and reduce the risk of dye exudation, and the preparation process is conventional and easy to operate and has wide engineering prospects.

The invention relates to the field of biomedical polymer materials, in particular to a sodium alginate microcapsule as well as a preparation method and application thereof. The preparation method comprises the following steps: introducing an alkyl chain and a polyether amine chain into an oxidized sodium alginate molecular chain through a Schiff base reaction so as to obtain modified sodium alginate; the modified sodium alginate shows an amphiphilic behavior in an aqueous solution, and the sodium alginate microcapsule is formed through self-assembly. The surface layer of the sodium alginate microcapsule provided by the invention is a hydrophilic chain segment, and the interior of the sodium alginate microcapsule is an oleophylic chain segment alkylamine chain and an amphiphilic chain segment polyether amine chain. Wherein a hydrophilic chain segment of the polyetheramine chain can contain amphiphilic drugs, and a hydrophobic chain segment of the polyetheramine chain can capture medium hydrophobic drugs; and the alkylamine chain obviously improves the loading capacity on high-hydrophobicity drugs. Therefore, the sodium alginate microcapsule provided by the invention can be used for simultaneously loading an amphiphilic drug, a medium-hydrophobicity drug and a high-hydrophobicity drug, and broad-spectrum drug co-loading with gradient hydrophobicity is realized.

The invention discloses composite hydrogel capable of slowly releasing polydatin and ligustrazine as well as a preparation method and application of the composite hydrogel, and belongs to the fields of hydrogel preparation technologies and biomedical polymer materials. Oxidized hyaluronic acid is synthesized through a sodium periodate method, chitosan is modified through catechol, micromolecule medicine polydatin and ligustrazine are added into an oxidized hyaluronic acid solution, the oxidized hyaluronic acid solution added with the medicine is dropwise added into the modified chitosan solution, stirring is conducted under the normal temperature condition, and the OHA / CS-pC / TMP / PD hydrogel is formed. The hydrogel has high swelling property and can slowly release polydatin and ligustrazine at the same time, the sustained release time of the polydatin is as long as 52 hours, and the sustained release time of the ligustrazine is as long as 48 hours. The hydrogel has relatively strong adhesiveness and wearable performance, is suitable for a special environment of a diabetic skin wound, has a function of promoting healing of the diabetic wound, and has a good application prospect in the field of diabetic skin wound repair.

The invention provides a modified nano polysaccharide composite polylactic acid biomedical material as well as a preparation method and application thereof, and belongs to the technical field of biomedical polymer composite materials. Hydrophobic modification is carried out on the surface of the nano polysaccharide by utilizing hydroxyapatite, so that the compatibility of the nano polysaccharide and a matrix can be effectively improved, a good enhancement effect on polylactic acid is achieved, and the polylactic acid has a proper degradation rate. According to the preparation method, polylactic acid is grafted to the surface of hydroxyapatite modified nano polysaccharide in a ring-opening polymerization mode, aggregation of hydroxyapatite can be avoided, the modified nano polysaccharide serving as a nucleating agent plays a positive role in the crystallization process of a polymer matrix, the crystallinity of the composite material is improved, and the performance of the composite material is improved. The mechanical property of the obtained material is further improved.

The present invention belongs to the field of biomedicine and provides radioactive silica microspheres coated with biomedical polymer materials, as well as a preparation method and application thereof. The method comprises the following steps: S1, mixing silica microspheres, water, and a radioactive nuclide to obtain a radioactive silica microsphere mixture; S2, mixing the radioactive silica microsphere mixture with an alkaline solution and reacting to obtain radioactive silica microspheres; S3, mixing the radioactive silica microspheres with a biomedical polymer solution and coating the mixture to obtain radioactive silica microspheres coated with biomedical polymer materials. The preparation method provided by the present invention is simple, and the prepared radioactive silica microspheres coated with biomedical polymer materials have a high radionuclide labeling rate, a low escape rate, good radiostability, and excellent biosafety, and can be used for the embolization treatment of all solid tumors.

The invention relates to the field of biomedical polymer materials, and discloses zinc-loaded eutectic gel as well as a preparation method and application thereof. The zinc-loaded eutectic gel comprises the following components: gelatin, polyvinyl alcohol and a deep eutectic solvent containing zinc ions. The preparation method comprises the following steps: dissolving gelatin and polyvinyl alcohol in water, and reacting to obtain gelatin-polyvinyl alcohol hydrogel; and placing the gelatin-polyvinyl alcohol hydrogel in a deep eutectic solvent containing zinc ions for replacement to obtain the zinc-loaded eutectic gel. The tensile strength and the fracture strain of the zinc-loaded eutectic gel can reach 258kPa and 632% at most, and meanwhile, the zinc-loaded eutectic gel has good low-temperature stability and still keeps a phase-change-free state in an environment of-80 DEG C. The zinc-loaded eutectic gel can effectively antagonize bacterial infection, inhibit inflammatory response, control moisture volatilization, promote angiogenesis and collagen generation and accelerate wound healing, and is suitable for the medical fields of infectious and non-infectious wound dressings, joint wound dressings and the like.

This invention belongs to the field of biomedical polymer materials technology, and relates to a method for preparing an injectable thermosensitive composite hydrogel that promotes wound healing, and its application. Polyethylene glycol monomethyl ether is used as a macromolecular initiator, and stannous octoate is used as a catalyst to initiate the bulk polymerization of six-membered cyclic carbonate monomers and their derivatives. After polymerization, coupling is performed via hexamethylene diisocyanate to obtain an amphiphilic block polymer with hydrophilic ends and an oleophilic middle. The block polymer is then dissolved in PBS at low temperature, and a certain proportion of wound-healing nanoparticles are uniformly dispersed in the polymer aqueous solution to obtain the injectable thermosensitive composite hydrogel. This composite hydrogel is a viscous liquid at room temperature and has a viscosity of 34°C. o It rapidly gels in environments above °C, meaning that after injection into the body, it can gel quickly and release nanoparticles in situ to promote wound repair. It also possesses excellent wound-healing capabilities.

The invention discloses an antibacterial hydrogel dressing taking spunlace non-woven fabric as a carrier and a preparation method of the antibacterial hydrogel dressing, and relates to the technical field of biomedical polymers. The antibacterial hydrogel dressing is composed of a spunlace non-woven fabric carrier layer and an antibacterial hydrogel functional layer loaded on the surface and in pores of the spunlace non-woven fabric carrier layer, and the preparation method comprises the following steps: sterilizing spunlace non-woven fabric to obtain a spunlace non-woven fabric carrier; adding the antibacterial component into the aqueous solution of the hydrophilic polymer base material to form a hydrogel precursor solution; and immersing the spunlace non-woven fabric carrier into the hydrogel precursor solution, and curing to obtain the antibacterial hydrogel dressing. The antibacterial hydrogel dressing prepared by the preparation method disclosed by the invention has the flexible breathable characteristic of spunlace non-woven fabric and the high swelling and antibacterial functions of hydrogel, has an excellent bactericidal effect on escherichia coli and staphylococcus aureus, can effectively promote healing of infected wounds, is suitable for clinical nursing of burn and traumatic skin injuries, and has wide application prospects. Wide clinical application prospects are realized.

The invention relates to the field of biomedical polymers, in particular to an antibacterial, compression-resistant and degradable pure sericin nano-composite gel dressing as well as a preparation method and application thereof. Main raw materials comprise sericin, magnesium lithium silicate, an initiator, a catalyst, an antibacterial agent and deionized water. The preparation method comprises the following steps: extraction of sericin, preparation of an inorganic nano-clay magnesium lithium silicate dispersion liquid, preparation of a gel pre-polymerization liquid, assembly of a sandwich model, injection of a sericin / magnesium lithium silicate gel pre-polymerization liquid, and preparation of the sericin / magnesium lithium silicate nano-composite gel. And carrying out post-treatment and packaging on the sericin / magnesium lithium silicate nano-composite gel dressing. The pure sericin protein hydrogel is prepared through interaction of hydrogen bonds and ionic bonds, the raw materials are non-toxic, and the pure sericin protein hydrogel has biocompatibility, high mechanical property, injectability, dissolvability and no pollution of dissolved products and can be used for wound dressing, drug delivery, biological binders, implantable electronic equipment and 3D biological printing.

The invention discloses preparation and antibacterial application of a dopamine-heme copolymer nanosheet, and belongs to the field of biomedical high polymer materials. The preparation method comprises the following steps: preparing a mixed solvent of ultrapure water, absolute ethyl alcohol and stronger ammonia water, dissolving the hydroxyferriheme in the mixed solvent, and stirring to fully dissolve the hydroxyferriheme; the preparation method comprises the following steps: preparing a dopamine hydrochloride aqueous solution, rapidly dropwise adding the dopamine hydrochloride aqueous solution into a mixed solution of hydroxyferriheme, carrying out a stirring reaction under closed conditions, and carrying out centrifugal cleaning on a reaction product to obtain the dopamine-heme copolymer nanosheet. The preparation method of the dopamine-heme copolymer nanosheet is simple and convenient, the reaction solvent is green and environment-friendly, and the whole reaction process does not need additional energy supply. The dopamine-heme copolymer nanosheet prepared by the method has good dispersity in an aqueous solution, is extremely low in cytotoxicity and relatively good in biocompatibility, and has a very good sterilizing effect on staphylococcus aureus when the concentration is relatively low.

This invention relates to the field of biomedical polymer materials and surface modification engineering, specifically to a posterior scleral reinforcement material and its preparation method. It comprises a polymer matrix and a bioactive modified layer formed by the oxidative crosslinking of a heterobifunctional polymer coupling compound. This copolymer structure includes anchoring groups, hydrophilic linkers, and bioactive groups. Its core principle is to utilize the flexible extension of the hydrophilic linkers to reduce steric hindrance, fully exposing the bioactive groups to the material surface, thereby achieving efficient recognition and binding to integrin receptors. This invention effectively solves the problems of bioinertness of the synthesized polymer matrix and lack of cell recognition sites, achieving a cell proliferation rate more than twice that of the unmodified matrix, demonstrating the material's excellent bioactivity and cell compatibility.

Provided are an absorbable biomedical polymer material, a ligation clip, and a method for preparing same. The ingredients selected for the absorbable biomedical polymer material consist of a first polymer and a second polymer. The first polymer consists of 50 wt%-100 wt% of poly(L-lactide) and 0 wt%-50 wt% of polyglycolide, and the second polymer is poly(p-dioxanone). The absorbable biomedical polymer material has suitable rigidity and flexibility, and can be used in preparing a medical device, such as a ligation clip. In particular, when containing 2.5 wt%-40 wt% of the first polymer, the ligation clip can readily pierce the fascia, and is less likely to undergo plastic deformation at a bend. Also disclosed are some structural forms of ligation clips and a method for preparing same.

The application of poly(D-lactic acid) and poly(D-lactic acid-glycolic acid) copolymers in constructing micro / nanocarriers for antitumor drugs belongs to the field of biomedical polymer materials and nanomedicine. The antitumor drugs are small-molecule chemotherapeutic agents, small-molecule photosensitizers, small-molecule immunotherapeutic agents, and small-molecule radiosensitizers. The particle size of the poly(D-lactic acid) and poly(D-lactic acid-glycolic acid) copolymers is 10–5000 nm. The effective concentration of the poly(D-lactic acid) and poly(D-lactic acid-glycolic acid) copolymers is 1–500 mg / kg. The antitumor mechanism of the poly(D-lactic acid) and poly(D-lactic acid-glycolic acid) copolymers includes increasing the activity of effector T cells in the tumor microenvironment and increasing the concentration of cytokines such as IFN-γ at the tumor site. In the field of tumor therapy, PLA and PLGA materials composed of D-lactic acid have shown good effects in inhibiting tumor growth, prolonging the survival period of tumor-bearing mice, and activating antitumor immune responses.

This invention discloses a biomimetic hydrogel robot with magnetically controlled switchable multi-target adhesion, belonging to the field of biomedical polymer materials and intelligent robots. The hydrogel robot includes a main material system, a dissipation control unit, a biomimetic structure, a magnetic response module, and an imaging and visualization module. The main material uses thiolated gelatin and polyethylene glycol-maleimide to construct a main cross-linking network via a Michael addition reaction; the dissipation control unit introduces ionic liquids to regulate water-containing behavior and interfacial dissipation characteristics; the biomimetic structure adopts a suction cup-shaped cavity design; the magnetic response module embeds magnetic units; and the imaging module achieves visualization via ultrasound or X-rays. Experiments have demonstrated that the biomimetic hydrogel robot of this invention can solve the problems of poor adhesion stability, lack of controllable detachment ability, and limited functionality to passive delivery of existing intestinal hydrogels, making it suitable for applications such as ingestible delivery, local treatment, and in vivo localization and monitoring.

The invention provides an implantable microwave responsive microneedle electronic system and a preparation method thereof. The implantable microwave responsive microneedle electronic system comprises a controlled drug release microneedle module and a tissue biochemical index monitoring module. The controlled drug release microneedle module comprises a backing layer and a microneedle array, a microneedle comprises a needle body shell and a needle body core, the needle body core is made of a biomedical polymer material loaded with a microwave response-anticancer bifunctional material, and the needle body shell is made of a polyester biodegradable material; the tissue biochemical index monitoring module is integrated on the surface of the other side of the backing layer and is used for monitoring a biochemical index signal of the tissue and transmitting the biochemical index signal to an external device. The microneedle electronic system is implanted into tissue, biochemical indexes of a focus part are monitored in real time, when abnormity is monitored, microwave irradiation is carried out, the microwave response-anticancer bifunctional material is triggered to generate a heat effect, a needle body shell is dissolved to achieve release of the microwave response-anticancer bifunctional material, and the treatment effect is enhanced through cooperation of microwave thermal therapy and medicine.

The invention belongs to the technical field of biomedical polymer materials, and discloses an emulsifier for microspheres, PLLA microspheres containing the emulsifier and application of the emulsifier in a composite filler for medical beauty. Sodium alginate with the molecular weight of 5-8 kDa is obtained through directional hydrolysis, and Alg-MP is prepared through octadecyl glycosylation and sulfation modification; alg-MP is used as an emulsifier, porous PLLA microspheres are prepared by adopting a pore-forming technology, the PLLA microspheres are mixed with a Ca < + >-containing sodium alginate solution with high guluronic acid (G) content and high G sodium alginate (G content is larger than or equal to 70%) to form a composite system, the storage modulus of the composite system at 37 DEG C reaches 850-1200 Pa, and the injection thrust is smaller than or equal to 12 N when the mass ratio of the microspheres to an excipient is 1: 0.3-1: 0.7. Animal experiments show that the six-month volume retention rate is 92.3 + / -3.5%, the density of new collagen is increased by 2.9 times compared with that of a control group, the composite system can be used as injectable gel for facial contour shaping or skin aging resistance, and a new solution is provided for development of medical beauty filling materials.

This invention discloses a multi-stimulus-responsive upconversion luminescent nanocrystalline magnetic microsphere and its preparation method, belonging to the field of biomedical polymer materials and nanobiotechnology. The microsphere's main body is a porous copolymer matrix, encapsulating a core of magnetite (Fe3O4) magnetic nanocrystals. Rare-earth-doped fluoride upconversion luminescent nanocrystals are coupled to the surface and pores. The copolymer side chains of the microsphere incorporate azide groups, acidic stimulus-responsive groups, and photostimulation-responsive groups, constructing an independent and non-interfering triple orthogonal logic gating system on the surface. The preparation method includes preparing an oil phase containing copolymers, magnetic nanoparticles, and a volatile porogen; pre-emulsifying and homogenizing the oil phase in an acidic aqueous phase using an SPG membrane; inducing phase separation by controlled solvent evaporation to form porous microspheres; and finally coupling the upconversion nanocrystals via a click chemistry reaction. The magnetic microspheres of this invention eliminate background fluorescence interference from complex samples from a physical perspective. Their porous structure endows the microspheres with excellent quasi-levitation properties and magnetic responsiveness, effectively solving problems such as single surface function and signal crosstalk of microspheres. They are suitable for in vitro clinical diagnosis and complex analysis of multiple targets.

A hydrogel for cell-laden bioprinting, bioink, and a preparation method and an application thereof, relates to the technical field of biomedical polymer hydrogels. The hydrogel for cell-laden bioprinting is polymer gel formed by adding a cell-specific material into a matrix of alginate and gelatin and crosslinking and curing, wherein the cell-specific material is polypeptide selected according to different laden cells. The structures printed using the hydrogel may have the advantages such as adjustable mechanical properties, adjustable porosity, high biocompatibility, high printing accuracy, and high customizability, which may widely support the printing of human tissues and organs such as spinal cord, cartilage, and heart, and has good prospects for applications in tissue repair, organ transplantation and so on.

The invention discloses a preparation method of a probe for measuring oxygen content based on a fluorescence ratio technology, and belongs to biomedical polymer materials. According to the probe for determining the oxygen content based on the fluorescence ratio technology, the ruthenium metal complex with oxygen responsiveness and the reference probe dye with an oxygen-free sensing function are modified on the surface of biomedical polymer or bovine serum albumin, and the fluorescence intensity change of the selective wavelength of a double-probe system on the surface can be used as a quantitative basis; through ratio calibration, interference of single fluorescence signal change caused by probe concentration change, excitation intensity change, instrument efficiency, photobleaching and non-uniform distribution of the probe at the action part in the testing process can be eliminated, and a more accurate monitoring result can be obtained. The polymer and the protein can solve the problems of system water solubility and fluorophore dispersibility, and enhance the in-vivo circulation half-life period of the probe. The probe disclosed by the invention has a wide prospect in the application of oxygen distribution biological imaging in organisms and oxygen concentration quantitative characterization.

The invention provides a poly (epsilon-caprolactone) based copolymer toughened polylactic acid composite material as well as a preparation method and application thereof, and belongs to the technical field of biomedical polymer composite materials. The polylactic acid is used as a main body material, the semi-crystalline thermoplastic polymer polyether-ether-ketone is used as a performance enhancing and modifying material, and the poly (epsilon-caprolactone) based copolymer is used as a toughening agent of a system, so that the obtained composite material shows good mechanical strength and compatibility, is wide in application, and has good economic benefits and practical significance; the method is expected to be further popularized and used in the biomedical field. The result of the embodiment shows that the Young modulus of the poly (epsilon-caprolactone) based copolymer toughened polylactic acid composite material provided by the invention is 834.3-1180.50 MPa, the elongation at break is 3.32-26.21%, and the poly (epsilon-caprolactone) based copolymer toughened polylactic acid composite material has good mechanical properties and flexibility, and meets the application requirements of biomedical materials.

The present invention relates to supramolecular biomedical polymers comprising quadruple hydrogen bonding units and to a process for preparing such a supramolecular biomedical polymer and porous biomedical implants thereof. The supramolecular biomedical polymers are particularly suitable for the production of porous biomedical implants that need high strength, elasticity, durability, and slow biodegradation, e.g. medical implants for living tissue regeneration within a mammal, such as the treatment of cardio-vascular diseases, medical prolapses, and hernias.

The invention belongs to the technical field of biomedical polymer materials, and discloses a preparation method and application of alkyl acid modified carboxymethyl chitosan. The preparation method comprises the following steps: (1) activating alkyl acid, EDC and NHS in absolute ethyl alcohol; (2) dropwise adding the activated alkyl acid solution into the carboxymethyl chitosan aqueous solution for grafting reaction; and (3) carrying out precipitation, alkali washing, alcohol washing and drying on the reaction liquid to obtain a target product. Preferably, the alkyl acid is C8-C20 straight-chain alkyl acid, and the dosage of the EDC and the dosage of the NHS are 6-10 times and 3-5 times of the molar weight of carboxyl of the alkyl acid respectively. The invention also provides the alkyl acid modified carboxymethyl chitosan prepared by the method and application of the alkyl acid modified carboxymethyl chitosan in preparation of hemostatic materials. The material has the dual characteristics of rapid liquid absorption and gelation and efficient coagulation promotion, is especially suitable for hemostasis scenes of non-heparinized or heparinized whole blood bleeding, and is simple and convenient in synthesis process and easy for large-scale production.

The invention discloses a preparation method of low-viscosity gel capable of enabling biological ceramic to rapidly flow, and relates to the technical field of biomedical polymer materials, the preparation method comprises the following steps: S1, synthesizing biological ceramic; s2, adding a modifier into absolute ethyl alcohol, and stirring until the modifier is completely dissolved to obtain a modifier solution; s3, adding biological ceramic into the modifier solution, carrying out ultrasonic treatment for 30-60 minutes, and then centrifuging, washing and drying to obtain modified biological ceramic; s4, preparing a low molecular weight solution carrier; s5, adding the modified biological ceramic into the low-molecular-weight solution carrier, and uniformly stirring to obtain low-viscosity gel; the modifier is a silane PEG amino group; the biological ceramic is porous flower-shaped HA microspheres. The biological ceramic gel system provided by the invention is rapid in flowability, stable and free of agglomeration.

The invention discloses an injectable hydrogel for enhancing adhesion based on temperature-sensitive driving as well as a preparation method and application of the injectable hydrogel, and belongs to the field of biomedical polymer materials. Raw materials of the injectable hydrogel pre-polymerization liquid for enhancing adhesion based on temperature-sensitive driving comprise a first monomer, a second monomer containing a cross-linking group Y and an adhesion group Z, and a photo-thermal agent. The preparation method of the injectable hydrogel is simple, and a uniform and stable pre-polymerized solution can be formed only by mixing the photo-thermal agent, the temperature-sensitive first monomer, the adhesive functional second monomer and the solvent; then the pre-polymerized liquid is conveyed to a target area in an injection mode to be crosslinked into gel, the adhesion strength of the hydrogel is further enhanced in situ through near-infrared irradiation, the whole process is few in operation steps and short in time consumption, the operation difficulty of industrial production and clinical application can be remarkably reduced, and the application prospect is wide. The problem that injectability and strong adhesion of traditional injectable hydrogel are difficult to consider at the same time is solved.

The invention belongs to biomedical polymer materials, and discloses urethane acrylate and a preparation method thereof, the preparation method comprises the following preparation steps: reacting a hydroxyl monomer with an acryloyl monomer to obtain a methacrylate monomer containing side chain acrylate double bonds; a methacrylate monomer, an initiator and a catalyst are mixed and subjected to a heating reaction to obtain a polymer, then the polymer and a functional monomer are mixed and subjected to a heating reaction to obtain a block polymer, and the functional monomer is used for introducing a disulfide bond into the block polymer; and mixing the block polymer with polyurethane, carrying out heating reaction to obtain a prepolymer, and then adding a photoinitiator for photocuring to obtain the polyurethane acrylate. The polyurethane acrylate prepared by the preparation method has good toughness and light transmittance.

The present invention discloses a ROS-enhanced liposome and its preparation method and application, which relates to the technical field of biomedical polymer materials and new dosage forms of pharmaceutical preparations. The liposome is composed of egg yolk lecithin, cholesterol and DSPE-mPEG. 2K The liposome is a membrane material prepared by a thin film dispersion extrusion method to encapsulate different drugs; wherein the drug is a ROS-responsive celecoxib dimer prodrug (CTC); or a combination of a ROS-responsive celecoxib dimer prodrug (CTC) and sinomenine hydrochloride (SIN); or a combination of a ROS-responsive celecoxib dimer prodrug (CTC), sinomenine hydrochloride (SIN) and L-butionine-(S,R)-sulfoximine (L-BSO). The liposome not only has the advantages of good stability and long circulation time, but also can target and enrich RA tissues through ELVIS, release celecoxib in a high ROS environment, and then combine with sinomenine hydrochloride to achieve a combined therapeutic effect.

The present invention relates to the technical field of biomedical polymers, and specifically to a type of coated sustained-release plant polypeptide drug-loaded nanoparticles and a preparation method thereof, in which the plant polypeptide itself is used to coat the drug-loaded nanoparticles through electrostatic adsorption and cross-linking. The plant polypeptide drug-loaded nanoparticles of the present invention have redox-sensitive response capabilities, can be released at designated locations, reduce the toxicity of drugs to the human body, and improve the therapeutic effects of drugs. The coated sustained-release plant polypeptide drug-loaded nanoparticles of the present invention have a certain sustained-release ability, and the preparation of drug-loaded nanoparticles using natural polymers as materials can be used for a variety of wide applications such as controlled release of drugs, tissue engineering and gene therapy. The preparation method of the present invention is simple to operate and has stable quality. The particle size of the prepared drug-loaded nanoparticles is controllable, the dispersion is concentrated, the stability is good, and it is suitable for mass production.

This invention discloses a tough anisotropic hydrogel, its preparation method, and its applications, belonging to the field of biomedical polymer materials technology. The method involves preparing a prepolymer solution using polymer monomers, zirconium salts, and an initiator. After polymerization to obtain an initial hydrogel, the solution is pre-stretched and simultaneously dialyzed in deionized water to achieve equilibration, resulting in a tough anisotropic hydrogel. This method utilizes the synergistic effect of physical pre-stretching and metal coordination bond locking to guide the directional reconstruction of the hydrogel network, thus simply and efficiently preparing a tough anisotropic hydrogel with a stable orientation structure. This hydrogel possesses high strength, high modulus, and high toughness, and also has the ability to guide the directional growth of nerve cells, showing promising application prospects in neural tissue engineering, flexible electronics, and other fields.

This invention discloses a method for preparing UHMWPE profiles, as well as the UHMWPE profiles and their applications, belonging to the field of biomedical polymer materials technology. The preparation method of the UHMWPE profiles enables the UHMWPE profiles to achieve a balance between "high wear resistance" and "high impact resistance." Furthermore, using the UHMWPE profiles to prepare implantable artificial joint materials can ensure the wear resistance required for clinical use while significantly improving the safety margin and long-term reliability of artificial joints under complex stresses.