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Fluorosiloxane-POSS acrylate block copolymers, blood-compatible coating thereof and preparation method of the fluorosiloxane-POSS acrylate block copolymers

A technology of block copolymers and blood compatibility, which is applied in the preparation of fluorosilicone copolymers and the field of biomedical polymers, can solve the problems of reducing platelet aggregation and activation, and achieves easy industrialization and large-scale production, and easy access to raw materials , the effect of high practical value

Active Publication Date: 2014-01-22
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyfluoroalkylmethylsiloxane (PFMS) macromolecules, PFPMS and PDMS are similar in structure and performance, but the introduction of fluorine-containing groups makes it have better biocompatibility and biostability, which can reduce platelet Aggregation and activation (Su T., Wang G. Y., European Polymer Journal. 2010, 46: 472-483), about fluorosilicone block copolymers with PFPMS as soft segment and acrylate functional monomer and POSS copolymer as hard segment and surface blood compatibility studies have not been reported in the literature

Method used

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  • Fluorosiloxane-POSS acrylate block copolymers, blood-compatible coating thereof and preparation method of the fluorosiloxane-POSS acrylate block copolymers
  • Fluorosiloxane-POSS acrylate block copolymers, blood-compatible coating thereof and preparation method of the fluorosiloxane-POSS acrylate block copolymers
  • Fluorosiloxane-POSS acrylate block copolymers, blood-compatible coating thereof and preparation method of the fluorosiloxane-POSS acrylate block copolymers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] (1) Preparation of hydroxyl-terminated POSS acrylate copolymer

[0032] Add 10 g methyl methacrylate, 5 g butyl acrylate, 0.9 g 4-acryloyloxybutyl-heptaisobutyl POSS, 0.075 g mercaptoethanol, 0.08 azobisisobutyronitrile and 16 g acetic acid to the reaction flask Butyl ester, after stirring and mixing evenly, raise the temperature to 60~110°C to react for 5 hours, cool down to room temperature, discharge, and dry to obtain the hydroxyl-terminated POSS acrylate copolymer with a number average molecular weight of 10,000.

[0033] (2) Preparation and properties of fluorosilicone-POSS acrylate block copolymer and its blood-compatible coating:

[0034] At room temperature 25°C, add 10g of hydroxyl-terminated POSS-acrylate copolymer prepared above, 10g of single-ended hydrogen polymethyltrifluoropropylsiloxane and 0.005g of Karstedt platinum catalyst into 180g of butyl acetate, and mix well , to generate a polymer solution with a mass concentration of 10%. The prepared polym...

Embodiment 2

[0036] (1) Preparation of hydroxyl-terminated POSS acrylate copolymer

[0037]Add 10g methyl methacrylate, 13g butyl acrylate, 3g 4-methacryloxybutyl-heptaisobutyl POSS, 0.75g mercaptoethanol, 0.12g azobisisobutyronitrile in the reaction flask and 40g of butyl acetate, stir and mix evenly, raise the temperature to 60-110°C for 5 hours, cool down to room temperature, discharge, and dry to obtain a hydroxyl-terminated POSS acrylate copolymer with a number average molecular weight of 1000.

[0038] (2) Preparation and performance of fluorosilicone-POSS acrylate block copolymer hemocompatible coating:

[0039] At room temperature at 25°C, add 20g of hydroxyl-terminated POSS-acrylate copolymer prepared above, 10g of double-terminated hydrogen polymethyltrifluoropropylsiloxane and 0.01g of Karstedt platinum catalyst to 135g of ethyl acetate and mix well , to generate a polymer solution with a mass concentration of 20%. The prepared polymer solution is coated on a dry and clean pol...

Embodiment 3

[0041] (1) Preparation of hydroxyl-terminated POSS acrylate copolymer

[0042] Add 10 g methyl methacrylate, 5 g butyl acrylate, 0.9 g 4-acryloxybutyl-heptaisobutyl POSS, 0.038 g mercaptoethanol, 0.07 azobisisobutyronitrile and 16 g acetic acid to the reaction flask Butyl ester, after stirring and mixing evenly, raised the temperature to 60°C to react for 8 hours, cooled to room temperature, discharged, and dried to obtain a hydroxyl-terminated POSS acrylate copolymer with a number average molecular weight of 20,000.

[0043] (2) Preparation and performance of fluorosilicone-POSS acrylate block copolymer hemocompatible coating:

[0044] At room temperature at 25°C, add 10g of hydroxyl-terminated POSS-acrylate copolymer prepared above, 20g of double-terminated hydrogen polymethyltrifluoropropylsiloxane and 0.01g of Karstedt platinum catalyst into 150g of ethyl acetate, and mix well , to generate a polymer solution with a mass concentration of 20%. The prepared polymer solutio...

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Abstract

The invention relates to fluorosiloxane-POSS acrylate block copolymers, a blood-compatible coating thereof and a preparation method of the fluorosiloxane-POSS acrylate block copolymers, and belongs to the fields of fluorosilicone copolymer preparation and biomedical polymers. The blood-compatible coating prepared from the fluorosiloxane-POSS acrylate block copolymers has good hydrophobicity, a static contact angle with water of more than 107 degrees, and an improved anticoagulation time compared with polyvinyl chloride surfaces. Adhesive platelet adhesion and aggregation states are observed under a scanning electron microscope. Compared to a bank PVC surface, surface adhesive platelets of the surface after being coated are obviously reduced above 85%, the surface adhesive platelets are distortionless largely, and blood compatibility is good. The preparation process of the blood-compatible coating is simple with easily available raw materials, is prone to industrialization and large-scale production, and has high practical value. The fluorosiloxane-POSS acrylate block copolymers are shown as the formula 1 and the formula 2. The formula 1 and the formula 2 are shown in the description.

Description

technical field [0001] The invention relates to a fluorosiloxane-POSS acrylate block copolymer, a hemocompatible coating and a preparation method thereof, and belongs to the field of fluorosilicone copolymer preparation and biomedical polymers. Background technique [0002] Human beings have always been attacked by cardiovascular diseases, and the necessary blood-compatible biomaterials have always been a major issue in medicine that needs to be solved urgently. At present, there are many types and large quantities of artificial blood vessels or medical device materials that are in contact with human tissues and blood for a long time in clinical practice, but they still cannot meet the requirements, and the problem of blood compatibility still exists, which has become a limit for biological materials in contact with blood. One of the key problems in the application in the environment, there is an urgent need to develop a biomaterial with excellent comprehensive properties. ...

Claims

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Application Information

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IPC IPC(8): C08G81/02C08F220/14C08F220/18C08F230/08A61L33/06
Inventor 李辉袁晓燕张书香褚国红赵蕴慧张炉青
Owner UNIV OF JINAN
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