Cationic polyhydroxylated polymer embolization microspheres and preparation method thereof

Abstract

The invention relates to cationic polyhydroxylated polymer embolization microspheres and a preparation method thereof, and belongs to the technical field of biomedical polymer materials. The cationicpolyhydroxylated polymer embolization microspheres are formed by cross-linking and polymerizing functional macromolecules with biocompatibility through an amino compound, an alkyl acid derivative andan amino alkyl acid derivative or an ammonium salt thereof serving as a cross-linking agent; a main chain of each cationic polyhydroxylated polymer embolization microsphere is provided with a 1,2-glycol or 1,3-glycol structural functional group, and is also provided with an amino acetal or ester structure; a side chain is an amino alkyl olefine acid derivative. Compared with the existing polyvinylalcohol cationic microspheres, the microspheres greatly simplify the types of raw materials, reduce raw material purchase cost, and simplify a production process, and meanwhile, avoid environmental pollution caused by discharging a large number of dispersing agents and organic solvents.

Description

technical field [0001] The invention relates to a cationic polyhydroxy polymer embolization microsphere and a preparation method thereof, belonging to the technical field of biomedical polymer materials. Background technique [0002] Traditional tumor treatment methods include chemotherapy, radiotherapy and surgery. In recent years, minimally invasive interventional therapy has rapidly developed into an important tumor treatment method due to its advantages of small trauma, high selectivity, good patient tolerance, and targeted drug delivery. It has a remarkable effect in the treatment of hypervascular solid tumors such as fibroids. Interventional therapy, with the assistance of medical imaging equipment, the doctor selectively introduces the microcatheter into the blood supply vessel of the tumor lesion, and then perfuses the embolization agent to achieve the purpose of cutting off the blood supply to the tumor, so that the tumor cannot get enough nutrition supply. And "s...

AI Technical Summary

Problems solved by technology

[0009] Among the existing clinically marketed microsphere products, there is a lack of drug-loading functional groups or the proportion of the drug-loading part in the entire microsphere chemical structure is low, and the problems of slow drug loading, low efficiency and unstable drug loading are common. Before entering the human body, a considerable part of the drug is "burst released", resulting in a short sustained release time of the drug, which cannot maintain a high blood drug concentration at the tumor target site

More importantly, at present, most of the drug-loaded microspheres have realized the entrapment of chemical drugs. Once the high blood drug concentration cannot be maintained, the tumor will easily develop drug resistance under the action of low-concentration drugs for a long time. It will greatly increase the difficulty and cost of tumor treatment, but will not get good treatment effect

[0010] However, many cationic polymer drug-loaded materials reported in the existing literature, such as polyethyleneimine and polyacrylamide, have severe cytotoxicity.

In order to reduce its cytotoxicity, the degree of polymerization and the density of cationic groups are often reduced in material design, which reduces its drug-loading performance and limits its application development to a large extent.