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Micro-needle array patch capable of generating gas to take effect quickly and preparation and application thereof

A technology of microneedle array and gas, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, sheet delivery, etc. It can solve the problem of slow transdermal release speed, shortening the time required for drug onset, Long onset time and other issues, to achieve the effect of promoting rapid onset of action, shortening the required time, and accelerating dissolution

Pending Publication Date: 2021-11-23
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microneedles of the present invention can penetrate the skin painlessly and promote the rapid release of drugs, shorten the time required for the drug to take effect, and solve the problems of slow transdermal release and long onset time of traditional drugs

Method used

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  • Micro-needle array patch capable of generating gas to take effect quickly and preparation and application thereof
  • Micro-needle array patch capable of generating gas to take effect quickly and preparation and application thereof
  • Micro-needle array patch capable of generating gas to take effect quickly and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Include the following steps:

[0029] 1. Use a laser engraving machine to etch out a 10*10 polydimethylsiloxane (PDMS) negative template with a bottom diameter of 200 μm, a height of 850 μm, and a distance between adjacent microneedles of 600 μm;

[0030] 2. Grinding the purchased magnesium metal into granules, sieving, and finally obtaining magnesium metal particles with a size less than 30 μm for later use;

[0031] 3. Prepare a 200mg / mL polyvinylpyrrolidone (PVP) solution containing 0.5wt% magnesium metal particles and an appropriate amount of Aylar with a phosphate buffer solution of pH 9 and stir evenly;

[0032]4. Take an appropriate amount of the solution in step 3 and fill it into the tip of the PDMS mold by vacuuming, scrape off the excess solution with a scraper, place it in a desiccator for 8 hours at room temperature and then take it out. Spread a layer of pure 200mg / mL PVP solution on the dried PDMS mold, remove air bubbles in a vacuum, continue drying for...

Embodiment 7

[0037] The gas-generating microneedles obtained in Example 6 and the non-gas-generating microneedles obtained under the same operating conditions were placed in water at the same time, and the dissolution rates of the microneedle tips were compared. It was found that half of the microneedles loaded with sodium percarbonate dissolved within 6 seconds, while only a small part of the non-gas-producing group dissolved, indicating that the gas-producing microneedles can promote the dissolution and release of drugs from the microneedles.

[0038] The specific preparation process of the non-gas-producing microneedle includes the following steps:

[0039] 1. Use a laser engraving machine to etch out a 10*10 polydimethylsiloxane (PDMS) negative template with a base diameter of 300 μm, a height of 650 μm, and a distance between adjacent microneedles of 600 μm;

[0040] 2. Prepare a 200 mg / mL polyvinylpyrrolidone (PVP) solution containing an appropriate amount of chlorin e6 with a phosph...

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Abstract

The invention belongs to the field of biomedical polymer materials, and discloses a micro-needle array patch capable of generating gas to take effect quickly and preparation and application thereof. The micro-needle array patch comprises a substrate and a needle tip located on the substrate, the substrate is composed of a biocompatible matrix, the needle tip is mainly composed of the biocompatible matrix and inorganic particles capable of generating gas, and the inorganic particles capable of generating gas are formed on the surface and / or in the biocompatible matrix of the needle tip; the needle tip part of the micro-needle array patch can interact with skin tissue fluid to generate gas during application, rapid dissolution of micro-needles and diffusion of drugs to a corium layer are promoted, and the drugs can be efficiently and rapidly delivered to subcutaneous parts and take effect without the help of external equipment.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and more specifically relates to a microneedle array patch capable of generating gas and acting quickly and its preparation and application. The microneedle array patch can actively generate gas to efficiently deliver drugs to the subcutaneous site and acts quickly. Background technique [0002] Microneedle is a three-dimensional array structure with a length of 25–2000 μm and a symmetrical tapered tip made of metal, silicon or polymer. As a new type of minimally invasive drug delivery tool in the field of biomedicine, microneedles can penetrate the epidermis of the skin to achieve enhanced skin drug delivery. In recent years, microneedles have shown good application prospects in the field of transdermal drug delivery due to their advantages of high efficiency, safety, and painlessness. Among them, soluble polymer microneedles have been widely studied and paid attention to because of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/192A61K31/195A61K31/704A61K38/28A61K41/00A61K47/02A61K47/12A61K47/32A61K47/36A61P17/02A61P17/06A61P23/00A61P29/00A61P35/00
CPCA61K9/0021A61K47/02A61K47/12A61K47/32A61K47/36A61K38/28A61K31/195A61K31/192A61K31/704A61K41/0071A61P23/00A61P29/00A61P17/06A61P35/00A61P17/02
Inventor 朱锦涛柳佩张连斌陶娟
Owner HUAZHONG UNIV OF SCI & TECH
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