24 results about "Cutaneous tissue" patented technology

The application relates to the technical field of medical materials, and particularly discloses a kind of bionic medical tissue adhesive and a preparation method thereof.A kind of bionic medical tissue adhesive is made of raw materials containing the following weight parts: alpha-cyano octyl acrylate 30-35 parts;degradable polymer material 20-30 parts;gelatin 1-5 parts;polyethylene glycol 2-5 parts;sterile water 20-30 parts;sodium alginate 2-4 parts;antibacterial agent 8-10 parts;stabilizing protective agent 1-3 parts;mussel extract 1-3 parts;slug extract 1-3 parts;its preparation method is: polyethylene glycol, sterile water, sodium alginate, antibacterial agent, stabilizing protective agent, mussel extract and slug extract are mixed, and stirred uniformly;then alpha-cyano octyl acrylate, degradable polymer material and gelatin are added, heated to 40-60 DEG C and stirred for 20-40 min, and the bionic medical tissue adhesive can be obtained.The bionic medical tissue adhesive of the application can better handle the skin tissue changes occurring in the proliferation period, so that the prominence of the scar formed in the later period is smaller, the whole is relatively flat and smooth, and thus the scar is greatly improved.

The radio frequency beauty instrument detection table comprises a machine body, a placement mechanism and a radio frequency beauty mechanism, a base is arranged at the bottom end of the machine body, and universal wheels are arranged on the two sides of the bottom end of the base. According to the radio frequency beauty instrument detection table, through the arrangement of the placing mechanism, when a user uses a radio frequency beauty mechanism to beautify the face skin, the radio frequency beauty instrument detection table needs to be used together with a skin care product, and various types of skin care products can be placed in a placing disc in the placing mechanism at the front end of the machine body; according to different types of skin, different types of skin care products are selected for use, when the face skin is beautified, the radio frequency beauty instrument can directly penetrate through deep skin tissues through the radio frequency technology, then collagen is heated, natural resistance movement of subcutaneous tissues generates heat energy, collagen hyperplasia is stimulated, and the skin care effect is achieved. The skin care product is matched for use, so that the skin is cleaned and moisturized, and the beautifying effect is improved.

Integrated device for the non-invasive personalised treatment of skin blemishes includes: a handpiece for performing a percussive treatment on the body / face, causing a microtrauma on the wrinkle furrow, facilitating the natural recovery and the reduction of the wrinkle depth; a handpiece for carrying out an ablative micro-vibration treatment on the body, suitable to expand or compact the cutaneous tissue by alleviating wrinkles, stretch marks and scars with an exfoliating effect; a handpiece for performing a compressive micro-vibration treatment on the face, expanding the pores of the epidermis; a device for adjusting the rotation and vibration of the handpieces; an electric energy absorption sensor for each handpiece, communicating the detected data to a control unit which acts on the frequency adjustment devices obtaining a variation in the rotation and vibration frequency of the rotors, depending on the mechanical strength of the skin tissue; a communication interface.

A wearable device for continuous monitoring of at least one analyte is provided. The device includes a plurality of aptamer sensors for a particular analyte and means for determining at least one position measurement. The sensors are positionable at distinct locations with respect to depth within a user's skin. The position measurement has distinct measurement responses between at least two skin tissues, such as the epidermis, dermis, and subcutaneous tissue. At least one of the sensors is positionable at a distinct tissue location.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a traditional Chinese medicine composition for treating eczema and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-3 parts of radix stemonae, 0.5-1.5 parts of rhododendron delavayi and 0.04-0.06 part of cantharides, and the specific preparation method comprises the following steps: respectively crushing the radix stemonae and the rhododendron delavayi into 20-100-mesh coarse powder, adding 500ml of 75% alcohol, soaking for 7 days, filtering, and complementing the filtrate to 500ml; and additionally taking cantharides, adding the filtrate into the cantharides, soaking for 10 days, filtering, filtering out liquid medicine, and sub-packaging into 50ml small bottles with the medicine concentration of 0.765 g.kg <-1 >, thereby obtaining the traditional Chinese medicine composition for treating eczema. The traditional Chinese medicine composition has different degrees of effects in each stage of wound repair of injured skin tissues, has no irritation or weak irritation of the allergy and irritation of the whole formula, is good in application safety and safe in clinical use, meets the standard requirements, and is worthy of further clinical popularization and application.

The invention relates to a preparation method and application of vitronectin, stromal cell-derived factor-1 or fusion protein hydrogel thereof, vitronectin and stromal cell-derived factor-1 are connected through a flexible joint composed of a plurality of amino acids to form a fusion protein, and the fusion protein can carry a purification label or does not carry a purification label; the fusion protein is finally designed into hydrogel in a self-assembly or biochemical or bio-physicochemical cross-linking mode. The hydrogel disclosed by the invention has good biocompatibility, has a remarkable effect on recruiting stem cells, can realize dryness maintenance of in-situ stem cells, can be applied to the fields of skin tissue wound healing, cartilage repair, osteoarthritis clinical treatment, bone defect repair and the like, and has important significance on wound healing and body injury repair and regeneration.

The invention belongs to the technical field of biological materials, and particularly relates to a rosa roxburghii tratt exosome microneedle patch for promoting skin wound healing and a preparation method of the rosa roxburghii tratt exosome microneedle patch. The roxburgh rose exosome microneedle patch for promoting skin wound healing comprises a patch base body and a microneedle array which are integrally formed, the microneedle array is distributed on the surface of the patch base body, and the patch base body and the microneedle array are made of degradable materials doped with roxburgh rose exosomes; after penetrating through a skin barrier, constructing a roxburgh rose exosome delivery channel and degrading, the roxburgh rose exosome can be uniformly released to a skin wound to accelerate migration of human immortalized keratinocytes, fibroblasts, human umbilical vein endothelium and other cells so as to promote repair and healing of skin tissues such as epidermis, dermis and subcutaneous tissues; according to the application, the application range of the roxburgh rose exosome is expanded, the roxburgh rose exosome is effectively utilized, and the technical problems that the efficacy of the roxburgh rose exosome is lack of research and the roxburgh rose exosome is difficult to effectively apply at present are solved.

Methods, systems and adaptors for multiphoton imaging of, and laser-tissue interactions with, non-transparent tissue, such as ocular and periocular tissue, are provided. Aspects of the present invention include methods of imaging a structure through non-transparent tissue, such as ocular or periocular tissue, comprising: deploying an excitation source to transmit light energy to a structure through non-transparent tissue, such as ocular or periocular tissue, detecting light emitted from the structure via multiphoton excitation through the non-transparent tissue, such as ocular or periocular tissue, and imaging the structure based on the detected light. Aspects of the present invention further include methods of treating tissue, such as ocular or periocular tissue or dermatologic tissue, by manipulating an imaged structure, including, for example, providing non-incisional therapy, photo-tissue interactions, multi-photon-mediated damage, such as thermal damage, photo-disruption, photo cross-linking, blood vessel coagulation or ablating tissue. Aspects of the present invention further include methods of imaging dermatologic tissues or providing dermatologic treatments. Aspects of the present invention further include methods of providing cosmetic treatments. Aspects of the present invention further include methods of guiding delivery of gene therapy or cellular therapy in ocular or periocular tissue. Also provided are systems and adaptors for performing the methods described herein.

Methods, systems, and adapters are provided for multiphoton imaging and laser-tissue interaction with opaque tissue, such as ocular tissue and periocular tissue. Aspects of the invention include a method of imaging a structure through an opaque tissue, such as ocular tissue or periocular tissue, the method comprising: deploying an excitation source to transmit light energy to the structure through the opaque tissue, such as ocular tissue or periocular tissue, light emitted from the structure via multi-photon excitation by non-transparent tissue, such as ocular tissue or periocular tissue, is detected, and the structure is imaged based on the detected light. Aspects of the invention further include methods of treating tissue, such as ocular tissue or periocular tissue or skin tissue, by manipulating the imaged structure, including, for example, providing non-incision therapy, light-tissue interaction, multi-photon mediated injury, such as thermal injury, photodisruption, photocrosslinking, vascular coagulation or ablation of tissue. Aspects of the invention further include methods of imaging skin tissue or providing dermatological treatment. Aspects of the invention further include methods of providing cosmetic treatments. Aspects of the invention further include methods of directing delivery of gene therapy or cell therapy in ocular tissue or periocular tissue. Systems and adapters for performing the methods described herein are also provided.

Radio frequency energy treatment is provided to subcutaneous tissue. Risk factors are reduced by employing one or more features. Electrodes that are inserted through the skin may be insulated except near the distal tips and / or the distance where the energy is provided may be at least at a minimum depth set by the treatment tool. The tissue may be treated with a power level that only denatures the tissue. The site may be analyzed with ultrasound to develop a treatment plan. A template may be provided to allow marking of the site where the skin should be pierced. A separate piercing tool may be used, thereby allowing the electrodes to have non-sharp shapes. A temperature sensor may be included to monitor temperature and / or impedance monitoring may be done where either or both may contribute to the control of RF energy and / or provide an alarm.

This invention belongs to the field of biomedical technology, and particularly relates to a gel formulation containing recombinant collagen and its preparation method. The gel formulation containing recombinant collagen comprises the following raw materials in parts by weight: 5-10 parts recombinant collagen, 2-5 parts sodium hyaluronate, 10-17 parts chitosan, 0.3-0.8 parts exudate absorbent, 1-5 parts Spartina alterniflora extract, and 50-70 parts water. The gel formulation of this invention utilizes the combination of Spartina alterniflora extract, chitosan, exudate absorbent, and other components to exert antibacterial, anti-inflammatory, and exudate absorption effects, promoting skin tissue repair and improving the quality of wound healing.

A neurostimulation trial system includes an external neurostimulation therapy controller including a processor circuit, a pulse generator circuit, a ground pad configured to be coupled with an external surface of patient skin tissue, and a transceiver circuit configured to communicate with a programmer device. The system can include at least one lead with an electrode that is configured for implantation at a neural tissue site inside a patient body. In an example, the programmer device is configured to communicate therapy instructions to the external neurostimulation therapy controller and is configured to communicate power and / or therapy instructions to an implanted neurostimulation device.

The invention discloses an exosome based on a stem cell source for tissue repair, and belongs to the technical field of biological materials. Aiming at the limitation of the traditional skin tissue repair means and the problems of poor stability, low delivery efficiency and the like of stem cell-derived exosomes in application, the human umbilical cord mesenchymal stem cells are extracted through a tissue block adherence method and are cultured and subcultured, and the exosomes are extracted through multi-step centrifugation; the preparation method comprises the following steps: preparing methyl diphenyl sulfide functionalized polycysteine modified polyethylene glycol-fucoidin gel by adopting a multi-step chemical reaction, and compounding the methyl diphenyl sulfide functionalized polycysteine modified polyethylene glycol-fucoidin gel with exosome to form a gel-loaded mesenchymal stem cell exosome composite material; the composite material is applied to skin wound repair. The gel carrier protects the exosome through interaction of physical embedding and chemical, regulates and controls the release rate of the exosome, and reduces the administration frequency; the fucoidin, polyethylene glycol and other components in the gel carrier have a synergistic effect, so that the compatibility of the material and tissues is enhanced, the inflammatory reaction is relieved, and the exosome structure is protected.

The present invention relates in part to hybrid hydrogel scaffolds including a decellularized extracellular matrix (dECM) tissue, and a synthetic polymer. The dECM may include any suitable tissue including for example, lung tissue, heart tissue, heart-lung block tissue, skin tissue, liver tissue, pancreatic tissue, kidney tissue, and the like.

The application provides a preparation method of platelet exosomes and application thereof in wound healing, and belongs to the technical field of biological medicine. The application provides a complete method for preparing animal platelet exosomes PDEs by freezing and thawing, and provides application of the animal platelet exosomes PDEs in drugs for treating skin wound healing across species. Researches of the application prove that sheep-derived PDEs treated by activation can effectively promote skin wound healing of mice, and can significantly promote formation of new blood vessels in skin tissue; the application fills the research blank of heterogenous PDEs in the field of wound healing treatment, provides a new drug selection and treatment approach for skin wound treatment, and has a wide application prospect in the field of clinical skin burn treatment.

The invention relates to a preparation method of an acellular dermal matrix as well as a product and application of the acellular dermal matrix, the preparation method comprises the following steps: mixing skin tissues with an alkali solution, and removing hair, an epidermal layer and subcutaneous tissues to obtain a dermal layer; and mixing the corium layer with an alkali solution, and cleaning to obtain the corium layer. The method is easy and convenient to operate, the steps are greatly simplified, manpower and cost input is remarkably reduced, damage or residue of enzymes, surfactants and the like to the dermis structure is avoided, main components and the complete structure of the dermis layer are reserved to the maximum extent, and it is ensured that the obtained dermis matrix has good mechanical strength and biological performance.

The present invention provides brachytherapy radiation delivery device designed to topically treat cutaneous skin lesions in patient tissue. The topical radiation delivery device includes a layer of one or more radionuclides. The topical radiation delivery device includes a high Z top shielding layer placed adjacent the side of the radionuclide layer away from the patient tissue. The top shielding layer attenuating the energy of the radionuclide from the environment external to the patient. The patch further includes a bolus layer placed between the patient tissue and the radionuclide layer which attenuates the beta radiation fluence. The one or more radionuclides of the brachytherapy radiation delivery device producing a gamma and beta radiation fluence to achieve a desired Percent Depth Dose within the cutaneous skin lesion.

1. The name of this design product: Portable tissue optical imaging diagnostic instrument. 2. Purpose of the product with this design: used for detecting the content and distribution of melanin in skin tissue and assisting in the diagnosis of vitiligo. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The invention provides a Parkinson's disease auxiliary diagnosis kit based on an RT-QuIC technology and application of the Parkinson's disease auxiliary diagnosis kit, and belongs to the technical field of detection kits. The kit provided by the invention has remarkable minimally invasive property and high patient compliance, detection can be completed only by collecting trace skin tissues, and risks and pains of lumbar puncture or brain tissue biopsy are avoided. The kit has excellent detection performance, can realize highly sensitive and specific identification of early pathology of Parkinson's disease, has a fast detection process, can complete batch sample analysis in a short time, and powerfully supports clinical rapid diagnosis and screening requirements. Meanwhile, the overall cost is remarkably lower than that of existing methods such as imaging, a convenient, reliable and economical molecular detection means is provided for early discovery, clinical auxiliary diagnosis and treatment effect observation of the Parkinson's disease, and positive significance is achieved for improving the overall diagnosis and treatment level of the neurodegenerative diseases.

The invention discloses an application of a platelet-rich plasma exosome in preparation of a medicine for treating skin burn. The exosome is separated by a gradient centrifugation method. The research finds that the exosome extracted from the activated platelet-rich plasma can promote the healing of burnt skin tissues and promote the formation of neovascularization in the skin tissues. The invention provides a new drug selection and a new treatment approach for skin burn, and has a wide application prospect in the aspect of clinically treating skin burn.

The present invention relates to a process for the preparation of lyophilized 2-[(3-aminopropyl)amino]ethanethiol comprising the following steps: a) reacting an amifostine solution with a strong acid to obtain a 2-[(3-aminopropyl)amino]ethanethiol solution, and b) lyophilizing the 2-[(3-aminopropyl)amino]ethanethiol solution, with or without the addition of excipients.

The method of marking a cutaneous tissue sample for pathological study uses a generated dermoscopy heatmap image in which different colors shown in the heatmap image represent differing degrees of likelihood of malignant or cancerous tissue (e.g., melanoma, basal cell carcinoma or squamous cell carcinoma) or atypical melanocytic nevus of uncertain malignant potential (AMNUMP) (e.g., atypical nevi, spitz nevi, and the like) in a patient's target skin lesion of concern (TSLC) and / or in the patient's pigmented skin lesion of concern (PSLC). The patient's target skin lesion of concern and / or in the patient's pigmented skin lesion of concern is marked in vivo or ex vivo with pigment (e.g., ink, dye, or the like) in areas of interest indicated by the heatmap image. A cutaneous tissue sample is then removed by physical biopsy from the patient.

The present disclosure relates to use of a compound in preparation of a medicament for prophylaxis and treatment of inflammatory tissue damage. The present disclosure provides use of a compound in preparation of a medicament for prophylaxis and treatment of tissue damage, and the compound has a structure represented by formula I. The compound having the structure represented by formula I provided by the present disclosure can inhibit transcriptional activity of interferon regulatory factor 1 (IRF1), have prophylactic and therapeutic effects on tissue damage, enhance cell proliferation ability after tissue cell injury, and repair injured tissues. The compound having the structure represented by formula I provided by the present disclosure has important significance and application value in the preparation of the medicament for prophylaxis and treatment of tissue damage, particularly in the preparation of a medicament for inflammatory injuries of skin tissues induced by radiation and / or oxidation.