12 results about "Cutaneous tissue" patented technology

The application relates to the technical field of medical materials, and particularly discloses a kind of bionic medical tissue adhesive and a preparation method thereof.A kind of bionic medical tissue adhesive is made of raw materials containing the following weight parts: alpha-cyano octyl acrylate 30-35 parts;degradable polymer material 20-30 parts;gelatin 1-5 parts;polyethylene glycol 2-5 parts;sterile water 20-30 parts;sodium alginate 2-4 parts;antibacterial agent 8-10 parts;stabilizing protective agent 1-3 parts;mussel extract 1-3 parts;slug extract 1-3 parts;its preparation method is: polyethylene glycol, sterile water, sodium alginate, antibacterial agent, stabilizing protective agent, mussel extract and slug extract are mixed, and stirred uniformly;then alpha-cyano octyl acrylate, degradable polymer material and gelatin are added, heated to 40-60 DEG C and stirred for 20-40 min, and the bionic medical tissue adhesive can be obtained.The bionic medical tissue adhesive of the application can better handle the skin tissue changes occurring in the proliferation period, so that the prominence of the scar formed in the later period is smaller, the whole is relatively flat and smooth, and thus the scar is greatly improved.

A wearable device for continuous monitoring of at least one analyte is provided. The device includes a plurality of aptamer sensors for a particular analyte and means for determining at least one position measurement. The sensors are positionable at distinct locations with respect to depth within a user's skin. The position measurement has distinct measurement responses between at least two skin tissues, such as the epidermis, dermis, and subcutaneous tissue. At least one of the sensors is positionable at a distinct tissue location.

The invention belongs to the technical field of biological materials, and particularly relates to a rosa roxburghii tratt exosome microneedle patch for promoting skin wound healing and a preparation method of the rosa roxburghii tratt exosome microneedle patch. The roxburgh rose exosome microneedle patch for promoting skin wound healing comprises a patch base body and a microneedle array which are integrally formed, the microneedle array is distributed on the surface of the patch base body, and the patch base body and the microneedle array are made of degradable materials doped with roxburgh rose exosomes; after penetrating through a skin barrier, constructing a roxburgh rose exosome delivery channel and degrading, the roxburgh rose exosome can be uniformly released to a skin wound to accelerate migration of human immortalized keratinocytes, fibroblasts, human umbilical vein endothelium and other cells so as to promote repair and healing of skin tissues such as epidermis, dermis and subcutaneous tissues; according to the application, the application range of the roxburgh rose exosome is expanded, the roxburgh rose exosome is effectively utilized, and the technical problems that the efficacy of the roxburgh rose exosome is lack of research and the roxburgh rose exosome is difficult to effectively apply at present are solved.

Methods, systems and adaptors for multiphoton imaging of, and laser-tissue interactions with, non-transparent tissue, such as ocular and periocular tissue, are provided. Aspects of the present invention include methods of imaging a structure through non-transparent tissue, such as ocular or periocular tissue, comprising: deploying an excitation source to transmit light energy to a structure through non-transparent tissue, such as ocular or periocular tissue, detecting light emitted from the structure via multiphoton excitation through the non-transparent tissue, such as ocular or periocular tissue, and imaging the structure based on the detected light. Aspects of the present invention further include methods of treating tissue, such as ocular or periocular tissue or dermatologic tissue, by manipulating an imaged structure, including, for example, providing non-incisional therapy, photo-tissue interactions, multi-photon-mediated damage, such as thermal damage, photo-disruption, photo cross-linking, blood vessel coagulation or ablating tissue. Aspects of the present invention further include methods of imaging dermatologic tissues or providing dermatologic treatments. Aspects of the present invention further include methods of providing cosmetic treatments. Aspects of the present invention further include methods of guiding delivery of gene therapy or cellular therapy in ocular or periocular tissue. Also provided are systems and adaptors for performing the methods described herein.

This invention belongs to the field of biomedical technology, and particularly relates to a gel formulation containing recombinant collagen and its preparation method. The gel formulation containing recombinant collagen comprises the following raw materials in parts by weight: 5-10 parts recombinant collagen, 2-5 parts sodium hyaluronate, 10-17 parts chitosan, 0.3-0.8 parts exudate absorbent, 1-5 parts Spartina alterniflora extract, and 50-70 parts water. The gel formulation of this invention utilizes the combination of Spartina alterniflora extract, chitosan, exudate absorbent, and other components to exert antibacterial, anti-inflammatory, and exudate absorption effects, promoting skin tissue repair and improving the quality of wound healing.

The present invention relates in part to hybrid hydrogel scaffolds including a decellularized extracellular matrix (dECM) tissue, and a synthetic polymer. The dECM may include any suitable tissue including for example, lung tissue, heart tissue, heart-lung block tissue, skin tissue, liver tissue, pancreatic tissue, kidney tissue, and the like.

The application provides a preparation method of platelet exosomes and application thereof in wound healing, and belongs to the technical field of biological medicine. The application provides a complete method for preparing animal platelet exosomes PDEs by freezing and thawing, and provides application of the animal platelet exosomes PDEs in drugs for treating skin wound healing across species. Researches of the application prove that sheep-derived PDEs treated by activation can effectively promote skin wound healing of mice, and can significantly promote formation of new blood vessels in skin tissue; the application fills the research blank of heterogenous PDEs in the field of wound healing treatment, provides a new drug selection and treatment approach for skin wound treatment, and has a wide application prospect in the field of clinical skin burn treatment.

The present invention provides brachytherapy radiation delivery device designed to topically treat cutaneous skin lesions in patient tissue. The topical radiation delivery device includes a layer of one or more radionuclides. The topical radiation delivery device includes a high Z top shielding layer placed adjacent the side of the radionuclide layer away from the patient tissue. The top shielding layer attenuating the energy of the radionuclide from the environment external to the patient. The patch further includes a bolus layer placed between the patient tissue and the radionuclide layer which attenuates the beta radiation fluence. The one or more radionuclides of the brachytherapy radiation delivery device producing a gamma and beta radiation fluence to achieve a desired Percent Depth Dose within the cutaneous skin lesion.

The invention provides a Parkinson's disease auxiliary diagnosis kit based on an RT-QuIC technology and application of the Parkinson's disease auxiliary diagnosis kit, and belongs to the technical field of detection kits. The kit provided by the invention has remarkable minimally invasive property and high patient compliance, detection can be completed only by collecting trace skin tissues, and risks and pains of lumbar puncture or brain tissue biopsy are avoided. The kit has excellent detection performance, can realize highly sensitive and specific identification of early pathology of Parkinson's disease, has a fast detection process, can complete batch sample analysis in a short time, and powerfully supports clinical rapid diagnosis and screening requirements. Meanwhile, the overall cost is remarkably lower than that of existing methods such as imaging, a convenient, reliable and economical molecular detection means is provided for early discovery, clinical auxiliary diagnosis and treatment effect observation of the Parkinson's disease, and positive significance is achieved for improving the overall diagnosis and treatment level of the neurodegenerative diseases.

The invention discloses an application of a platelet-rich plasma exosome in preparation of a medicine for treating skin burn. The exosome is separated by a gradient centrifugation method. The research finds that the exosome extracted from the activated platelet-rich plasma can promote the healing of burnt skin tissues and promote the formation of neovascularization in the skin tissues. The invention provides a new drug selection and a new treatment approach for skin burn, and has a wide application prospect in the aspect of clinically treating skin burn.

The present invention relates to a process for the preparation of lyophilized 2-[(3-aminopropyl)amino]ethanethiol comprising the following steps: a) reacting an amifostine solution with a strong acid to obtain a 2-[(3-aminopropyl)amino]ethanethiol solution, and b) lyophilizing the 2-[(3-aminopropyl)amino]ethanethiol solution, with or without the addition of excipients.