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Prevention or improvement of wrinkles by using ADAM activation inhibitor

An ADAM-9, wrinkle technology, applied in the field of evaluation of anti-wrinkle effect, can solve the problem that fine wrinkles cannot be fully prevented and improved, and achieve the effect of improving wrinkles, especially the formation of fine wrinkles, and inhibiting hypertrophy

Inactive Publication Date: 2007-09-19
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, what biochemical changes occur at the protein level or gene level in fine wrinkled skin has not been sufficiently clarified, and the prevention and improvement of fine wrinkles must rely on the use of moisturizing agents such as glycerin, sorbitol, or plant liquid extracts or cosmetics containing collagen etc. to protect the skin from dryness
However, fine wrinkles cannot be sufficiently prevented and improved just by protecting the skin from dryness with moisturizers etc.

Method used

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  • Prevention or improvement of wrinkles by using ADAM activation inhibitor
  • Prevention or improvement of wrinkles by using ADAM activation inhibitor
  • Prevention or improvement of wrinkles by using ADAM activation inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0064] Preparation of fine wrinkle mouse model

[0065] It is believed that the skin dries out and develops fine wrinkles with several major factors such as sebum reduction and face washing weakening or disrupting the skin barrier and increased water evaporation from the skin surface. Therefore, the tape was repeatedly peeled off on the skin of hairless mice, thereby peeling off the stratum corneum and disrupting the skin barrier. In this way a fine wrinkled mouse model can be prepared. Particularly, use cellophane tape to make the transepidermal water loss (TEWL) (by utilizing the water evaporation measurement device MEECO measurement provided by U.S. Meeco Company) fall to 4mg / cm by adjusting the number of peeling tapes. 2 / h to 6mg / cm 2 The tape was peeled off the skin on the left side of the back of a hairless mouse (HR-1, male, six weeks old, provided by Hoshino Experimental Animals) within a range of / h. Typically, the stripping tape is repeated about four times in th...

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Abstract

An agent for preventing or improving wrinkles which comprises a substance inhibiting the activity of ADAM (a disintegrin and metalloprotease) contained in the skin. Wrinkles are prevented or improved by applying the substance, which inhibits the activity of ADAM contained in the skin, to the skin. An anti-wrinkle effect of a test substance is evaluated by using as an indication the enzymatic activity of ADAM or a gene expression level thereof in the skin, a tissue or a cell.

Description

technical field [0001] The present invention relates to the prevention or improvement of wrinkles with substances that inhibit ADAM activity. The present invention also relates to a method for evaluating anti-wrinkle effects by using inhibition of ADAM activity as an index. Background technique [0002] Wrinkles, a phenomenon of skin aging, increase with age. Recently, people, especially women, have remarkably increased interest in preventing and improving wrinkles from the viewpoint of beauty and the like. Wrinkles can be roughly classified into large wrinkles, fine wrinkles, and crease wrinkles according to the wrinkle generation site, wrinkle generation mechanism, and the like. Large wrinkles are deep wrinkles that occur on the back of the neck, etc., mainly due to photoaging. Fine lines are relatively shallow wrinkles that occur around the eyes or mouth. Pucker wrinkles are fold-like wrinkles that occur on non-exposed body parts such as the belly of an elderly person...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/00G01N33/50A61Q19/00
CPCA61Q19/08A61K2800/782A61K8/442A61K8/42A61P17/16A61P43/00A61K31/166
Inventor 松永由纪子天野聪小仓有纪
Owner SHISEIDO CO LTD
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