The invention relates to multifunctional natural
polysaccharide repair
adhesive hydrogel, a preparation method and application thereof in preparation of drugs for treating
skin injury, and belongs tothe technical field of material science. Natural
polysaccharide is used as a
raw material, and functional group modification is performed on the natural
polysaccharide to enhance the tissue adhesiveness of the natural polysaccharide; then
magnesium oxide nanoparticles are added into an
aldehyde-modified
glucan solution in advance, so that the gelling time can be further shortened, and the
antibacterial effect is enhanced; therefore, the repair
adhesive hydrogel which has good
biocompatibility and tissue adhesiveness and can effectively
close wounds is constructed. The whole process is simple to operate, the raw materials are easy to obtain and low in price, and the natural
polymer functional groups have good
biocompatibility after being modified and are non-toxic and harmless to cells. Thepolysaccharide is subjected to
catechol modification and
aldehyde modification, so that the water
solubility of
chitosan is enhanced, the
viscosity of a
glucan solution is reduced, the gelation timeof the two-component gel is shortened, and the gel can be endowed with relatively strong
tissue adhesion.