A method for calibrating detectors of a self-contained, tissue oximetry device includes emitting light from a
light source into a
tissue phantom, detecting in a plurality of detectors the light emitted from the
light source, subsequent to reflection from the
tissue phantom, and generating a set of
detector responses by the plurality of detectors based on detecting the light emitted from the
light source. The method further includes determining a set of differences between the set of
detector responses and a reflectance curve for the
tissue phantom, and generating a set of calibration functions based on the set of differences. Each
calibration function in the set of calibration functions is associated with a unique, light source-
detector pair. The method further includes storing the set of
calibration function in a memory of the self-contained, tissue oximetry device.