45 results about "Tissue phantom" patented technology

A photoacoustic probe for port wine stain (PWS), burn and melanin depth measurements is comprised of optical fibers for laser light delivery and a piezoelectric element for acoustic detection. The probe induced and measured photoacoustic waves in acryl amide tissue phantoms and PWS skin in vivo. Acoustic waves were denoised using spline wavelet transforms, then deconvolved with the impulse response of the probe to yield initial subsurface pressure distributions in phantoms and skin. The waves were then analyzed for epidermal melanin concentration, using a photoacoustic melanin index (PAMI) related to the amount of laser energy absorbed by melanin. Propagation time of the photoacoustic wave was used to determine the depth of blood perfusion underlying necrotic, burned tissue. Thus, the photoacoustic probe can be used for determining PWS, burn and melanin depth for most patients receiving laser therapy.

A method, system and apparatus for manufacturing anatomically and functionally accurate soft tissue phantoms with multimodality characteristics for imaging studies is disclosed. The organ/tissue phantom is constructed by filling a container containing an organ having inner vasculature therein with a molten elastomeric material; inserting a plurality of rods with bumps thereupon through the container and the organ; allowing the molten elastomeric material to harden and cure; removing the organ; replacing the organ with a plurality of elastomeric segments; and removing an elastomeric segment and replacing the void created thereupon with molten PVA to create a PVA segment; allowing the molten PVA segment to harden and cure; and repeating the creation of PVA segments until all the elastomeric segments have been removed, such that each successive molten PVA segment adheres to and fuses with the previous hardened PVA segment so as to form an approximately complete organ phantom cast. The organ/tissue phantom is completed by inserting the approximately complete organ phantom cast inserting upside-down into a fixture made from the bottom-most elastomeric segment, which contains molten PVA; and allowing the molten PVA to harden and cure.

The instant invention is a modular radiation beam analyzer for measuring the distribution and intensity of radiation produced by a radiation source. More specifically, the instant invention is a modular radiation scanning device that includes up to three modules. By selecting and assembling a predetermined number of modules a radiation detector may be manipulated through up to three axes for radiation beam scans as well as direct Tissue Maximum Ratio (TMR) and/or Tissue Phantom Ratio (TPR) scans.

The invention relates to a noninvasive analyzer and a method of using information determined at least in part from in-vitro spectra of tissue phantoms or analyte solutions to aid in the development of a noninvasive glucose concentration analyzer and/or in the analysis of noninvasive spectra resulting in glucose concentration estimations in the body. The preferred apparatus is a spectrometer that includes a base module and a sample module that is semi-continuously in contact with a human subject and that collects spectral measurements which are used to determine a biological parameter in the sampled tissue, such as glucose concentration. Collection of in-vitro samples is, optionally, performed on a separate instrument from the production model allowing the measurement technology to be developed on a research grade instrument and used or transferred to a target product platform or production analyzer for noninvasive glucose concentration estimation.

An apparatus and method are provided for performing Quality Assurance of complex beams of penetrating radiation inside a patient. A detector with a transverse scintillating screen images the radiation inside a tissue phantom with high spatial resolution. The scintillator is comprised of a mixture of two or more scintillators emitting different spectra of light and having different characteristic responses as a function of the beam LET value. The optics relaying the scintillation output have variable transmission with wavelength, further shaping the spectrum of light transmitted to the imaging sensor which also has spectrally varying sensitivity. Parameters of the scintillator construction, the optics, and the imaging sensor are chosen so the output of the composite detector is proportional to a characteristic of the input beam, for example the dose deposited as a function of depth inside the tissue phantom.

Speckle, a factor reducing image quality in optical coherence tomography (“OCT”), can limit the ability to identify cellular structures that are important for the diagnosis of a variety of diseases. The present invention allows for an implementation of an angular compounding, angular compounding by path length encoding (“ACPE”) for reducing speckle in OCT images. By averaging images obtained at different incident angles, with each image encoded by path length, ACPE maintains high-speed image acquisition and implements minimal modifications to OCT probe optics. ACPE images obtained from tissue phantoms and human skin in vivo demonstrate a qualitative improvement over traditional OCT and an increased signal-to-noise ratio (“SNR”). Accordingly, apparatus probe catheter, and method are provided for irradiating a sample. In particular, an interferometer may forward forwarding an electromagnetic radiation. In addition, a sample arm may receive the electromagnetic radiation, and can include an arrangement which facilitates a production of at least two radiations from the electromagnetic radiation so as to irradiate the sample. Such arrangement can be configured to delay a first radiation of the at least two radiations with respect to a second radiation of the at least two radiations.

A method for producing a multilayer tissue phantom involves successively forming at least two layers, each layer formed by depositing a viscous flowable material over a supporting element or over a previously formed layer of the phantom supported by the supporting element, selectively redistributing the material while material is solidifying to control a thickness distribution of the layer, and allowing the material to solidify sufficiently to apply a next layer. The supporting element supports the material in 2 or 3 directions and effectively molds a lumen of the tissue. The neighbouring layers are of different composition and of chosen thickness to provide desired optical properties and mechanical properties of the phantom. The phantom may have selected attenuation and backscattering properties to mimic tissues for optical coherence tomography imaging.

A polyacrylamide tissue phantom embedded with multi-formulated thermochromic liquid crystals for use in the evaluation of RF ablation therapies is provided. The tissue phantom approximates the properties of biological tissue, and therefore provides a suitable substitute for use in testing the effects of RF and other energy-emitting devices on biological tissue. Also provided is a system for using the tissue phantom in the evaluation of RF therapies.

Disclosed are compositions and methods for quantitation and calibration of images in fluorescence microscopy. Also provided are tissue phantoms that contain known amount(s) of fluorophore standard(s), as well as components and diagnostic kits containing the same for use in various histological analyses. In certain embodiments, three distinct nucleic-acid based assays provide improvements over conventional TUNEL methods to facilitate precise quantitation of a variety of nucleic acids obtained from a biological sample.

A dosimeter based on a gas electron multiplier and method of use thereof for measurement of doses of therapeutic radiation to which a tissue-phantom is exposed. Subsequent to the in-phantom measurement and verification of radiation beam delivery, radiation can be effectively delivered to a human target organ, based on the verification of radiation quantities to which the phantom was exposed. Use of a gas electron multiplier-based dosimeter facilitates precise and accurate verification of the radiation dose within a phantom by taking measurements in real time, with no need for subsequent film processing.

The invention discloses an HIFU damage shear wave elastic characteristic estimation method based on LK optical flow. A damage formation and vibration continuous image is obtained with a high-speed camera when HIFU acts on tissue phantom, a vibration displacement curve of damage is obtained with the Lucas-Kanade optical flow method of an image pyramid, the propagation speed of acoustic radiation force shear wave generated on damage under the action of HIFU is calculated with the time-to-peak (TTP) method, quantitative estimation of shear elasticity modulus of damage can be conducted according to the relation among medium density, shear wave velocity in medium and medium shear elasticity modulus, and then the elastic characteristic of target tissue during treatment is monitored in real time and treatment effect is evaluated.

The invention discloses a tissue mimicking body model for detecting imaging distinguishability of ultrasound echotomography scanning equipment. The tissue mimicking body model is in the shape of a truncated cone, and comprises a body model housing, an acoustic window (3), a supporting and protecting plate (6), a plurality of target lines (4), a plurality of simulated niduses (6) and background tissue-mimicking materials (12), wherein the body model housing is manufactured by fixed connecting of an upper panel (2), a lower panel (11) and a supporting plate (14); a sealing space is formed by thebody model housing and the acoustic window (3) which is adhered and fixed to the side surface of the truncated cone; the background tissue-mimicking materials (12) are stuffed in the sealing space; the target lines (4) and the simulated niduses (6) are embedded in the background tissue-mimicking materials (12); each target line and each simulated niduse vertically penetrate from the upper panel (2) to the lower panel (11); an inlet for stuffing the background tissue-mimicking materials (12) is formed in the supporting plate (14); a blocking rubber is adhered to the inlet; and the supporting and protecting plate (6) is fixed outside the supporting plate (14).

The invention provides a method for constructing in-vitro model of 3D metastatic hepatoma-like tissues, characterized in that the method comprises the steps of continuously culturing highly metastatic human hepatoma cell line MHCC97H in a 3D rotary culture system combining an RWM bioreactor and a biologic scaffold PLGA (poly(lactic-co-glycolic acid)) for 15 days to form a metastatic hepatoma-like tissue model which has the characteristics closer to the in-vivo metastatic hepatoma tissues in terms of tissue morphological structure, specific gene expression and protein secretion, thereby better simulating and representing the growth characteristics and pathological changes of the in-vivo metastatic hepatoma solid tumor, therefore, the metastatic hepatoma-like tissue model is superior to the highly metastatic human hepatoma cell line model cultured by the tablet.

A multilayered optical tissue phantom fabrication approach and inherently produced test target structure which address the issues of optical conformity known in the art by controlling the formation of micrometer scale monolayers embedded with light-scattering microspheres.

The invention discloses a tissue mimicking phantom for detecting a transmission imaging pattern of ultrasound tomography equipment. The tissue mimicking phantom is cylindrical and comprises an upper panel (2), a lower panel (6), an acoustic window (3), a plurality of targets (4) and background tissue-mimicking materials (9), wherein a sealed space is formed by the upper panel (2), the lower panel(6) and the acoustic window (3) which is adhered and fixed to the side surface of the cylinder; the background tissue-mimicking materials (9) is stuffed in the sealed space; the targets (4) penetratethrough the upper panel (2) and the lower panel (6), and are embedded in the background tissue-mimicking materials (9); an inlet for stuffing the background tissue-mimicking materials (9) is formed inthe lower panel (6); and a block rubber is adhered to the inlet. The tissue mimicking phantom disclosed by the invention can be used for detecting and evaluating the transmission imaging pattern of the ultrasound tomography equipment.