Magnetic nano-carrier with targeted hydrophobic drug delivery to tumor and preparation method thereof

A magnetic nanocarrier, tumor targeting technology, applied in drug combinations, antitumor drugs, pharmaceutical formulations, etc., to reduce drug usage, reduce damage, and achieve the effect of magnetic targeting delivery
CN101632834AInactive Publication Date: 2010-01-27JILIN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JILIN UNIV
Publication Date
2010-01-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the technical field of biomedical polymer material and nanobiomaterial, particularly relates to a magnetic nano-carrier with targeted hydrophobic drug delivery to tumor and a preparation method thereof. The magnetic nano-carrier is formed by encapsulating superparamagnetic nano-particles with amphiphilic segmented copolymer methoxy polye thylene glycol-poly(lactide- glycolide) (MePEG-PLGA) micelles. First, a large amount of MePEG-PLGA with good dispersion is synthesized by the improved solution polymerization process, and then the MePEG-PLGA is used as raw materials to encapsulate Fe3O4 nano-particles by the solvent evaporation process to obtain a magnetic nano drug carrier. The carrier is expected to solve the solubility problem of insoluble drugs, achieves slow release of drugs, and achieves the passive-targeting of the drugs by the EPR effect of tumor; Fe3O4 nano-particles are used in the active-targeting of the drugs to reduce the dosage and the side effect and improve the treatment efficiency; besides, the carrier can be used in the magnetic resonance imaging (MRI) of tumor.
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Description

technical field

[0001] The invention belongs to the field of biomedical polymer materials and nano-biotechnology, and in particular relates to a magnetic nanocarrier for tumor-targeted delivery of hydrophobic drugs and a preparation method thereof. Background technique

[0002] Cancer remains one of the most terrifying diseases and a major threat to human life. Cancer is the leading cause of death in the United States for people under the age of 85, surpassing heart disease as the number one killer for the first time. This worrying statistic is not because cancer rates have risen, but because deaths from heart disease have fallen by nearly half while cancer-related deaths have remained virtually unchanged. Chemotherapy, the traditional standard therapy for most cancers, is not always successful even after more than 50 years of research, because traditional chemotherapy indiscriminately delivers toxic anticancer drugs to tumors and normal organs and tissues, thus damaging no...

Claims

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