Thermally induced hydrogel containing selenium or tellurium, and preparation method and applications thereof

Abstract

The invention belongs to the field of biomedical polymer materials, and specifically relates to a thermally induced hydrogel containing selenium or tellurium, and a preparation method and applications thereof. The thermally induced hydrogel is composed of an amphiphilic block copolymer containing selenium or tellurium and a solvent; thermally induced gelatinization phase transformation of a water system of the amphiphilic block copolymer and the solvent can be realized with temperature increasing so as to realize spontaneous formation of a physical hydrogel, wherein the amphiphilic block copolymer containing selenium or tellurium is obtained via covalent bonding of small molecules containing selenium or tellurium with an amphiphilic block copolymer. Long-acting platinum drug gel sustained-release preparations can be obtained via coordination of the thermally induced hydrogel with platinum drugs. The long-acting platinum drug gel sustained-release preparations are capable of prolonging and adjusting release behavior of the loaded platinum antitumor drugs. Drug administration of the long-acting platinum drug gel sustained-release preparations in tumor, around tumor, or in tumor cavity can be realized via injection; in situ formation of gel is realized at body temperature, and the platinum drugs loaded via coordination bonds can be released from the gel slowly, so that administration frequency is reduced, and drug whole body toxicity is reduced. The long-acting platinum drug gel sustained-release preparations can be applied to tumor treatment at different periods.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to a thermogenic hydrogel containing selenium or tellurium and a preparation method and application thereof. Background technique [0002] Biomedical polymer materials have many advantages such as good biocompatibility and easy-to-adjust biodegradability, and are an important research direction of biomedical materials, especially in the fields of drug sustained release and tissue engineering, which have broad application prospects. Among them, injectable hydrogels based on amphiphilic block copolymers have attracted extensive attention due to their advantages of easy synthesis, easy sterilization, and minimally invasive injection. [0003] The relationship between human health and trace elements is a research hotspot today. As one of the essential trace elements for the human body, selenium has unique redox properties, especially anti-oxidation propert...

AI Technical Summary

Problems solved by technology

[0006] However, cisplatin drugs are easily combined with plasma proteins in the human body, especially vulnerable to the attack of sulfhydryl-containing proteins (such as human serum albumin), thus losing their anticancer activity

This not only reduces the utilization rate of the drug in the body and reduces the efficacy of the drug, but also leads to some serious side effects, including nausea and vomiting and other gastrointestinal reactions, nephrotoxicity, ototoxicity, neurotoxicity, and occasionally bone marrow suppression, etc.

Although people have developed a variety of new platinum-containing anti-cancer drugs in recent years to improve the anti-tumor efficiency, these drugs are small molecules with short half-life, and they still need to be administered repeatedly and have obvious adverse reactions.

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