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Degradable conductive biological medical polymer material

A polymer material, biomedical technology, used in catheters, medical science, non-metallic conductors, etc., can solve the problems of difficult and difficult processing and molding of conductive polymers

Inactive Publication Date: 2009-04-08
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are still some deficiencies in the application of conductive polymers in the field of biomedical engineering: (1) the processing and forming properties of conductive polymers
Since most conductive polymers are difficult to dissolve in common solvents, it is difficult to process and shape

Method used

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  • Degradable conductive biological medical polymer material
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  • Degradable conductive biological medical polymer material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 Preparation of poly(methylphenoxy / aniline hexamer) phosphazene

[0053] method 1:

[0054] (1) Preparation of polydichlorophosphazene

[0055] Nitrogen (N 2 Under the protection of ), the hexachlorotripolyphosphazene that has been purified by sublimation under reduced pressure for 3 times is put into the polymerization tube, and both ends of the polymerization tube mouth are melted and sealed under vacuum conditions. The unreacted hexachlorotripolyphosphazene was repeatedly washed with the petroleum ether; then the polymer was fully dissolved in tetrahydrofuran, and the tetrahydrofuran solution of the dissolved polymer 2 After filtering through a sand core funnel, slowly pour it into petroleum ether to obtain a white polydichlorophosphazene, which is dried under vacuum at 40°C to constant weight.

[0056] (2) Preparation of aniline hexamer

[0057] Dissolve 9.70 g of p-phenylenediamine in 250 mL of absolute ethanol, add 20 mL of acetaldehyde, and after com...

Embodiment 2

[0080] ②Conductivity: The conductivity of the material was measured by the standard four-point probe method: 7.8×10 -5 S / cm. Example 2 Preparation of poly(ethyl glycine ester / aniline hexamer) phosphazene

[0081] (1) Preparation of polydichlorophosphazene

[0082] After the hexachlorotripolyphosphazene purified by sublimation three times was melted and ring-opened at 250° C. for 24 hours, the unreacted hexachlorotripolyphosphazene was repeatedly washed with hot petroleum ether. Then use tetrahydrofuran to fully dissolve the polymer, and pass the tetrahydrofuran solution dissolving the polymer through G. 2 After filtering through a sand core funnel, slowly poured into n-heptane to precipitate to obtain white polydichlorophosphazene, which was vacuum dried at 40°C to constant weight.

[0083] (2) Preparation of aniline hexamer

[0084] Dissolve 14.5g of p-phenylenediamine in 300mL of anhydrous ethanol, add 30mL of acetaldehyde, after it is completely dissolved, slowly add 15...

Embodiment 3

[0094] Example 3 Preparation of poly(imidazolyl / aniline hexamer) phosphazene

[0095] (1) Preparation of polydichlorophosphazene

[0096] Nitrogen (N 2 Under the protection of ), the hexachlorotripolyphosphazene purified by sublimation under reduced pressure for 3 times was put into the polymerization tube, the two ends of the polymerization tube mouth were melted and sealed under vacuum conditions, and the ring-opening polymerization was melted at 250 ° C for 36 hours, and then tetrahydrofuran was used. Fully dissolve the polymer, pass the tetrahydrofuran solution of the dissolved polymer through G 2 After filtration through a sand core funnel, slowly poured into n-heptane to obtain white polydichlorophosphazene, which was dried under vacuum at 40°C to constant weight.

[0097] 2) Preparation of aniline hexamer

[0098] Dissolve 19.4 g of p-phenylenediamine in 500 mL of absolute ethanol, add 40 mL of acetaldehyde, and after it is completely dissolved, slowly add 20 mL of c...

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Abstract

The invention discloses a degradable electricity-conducting biomedical polymer material, which has a molecular constitution as shown in formula I: the polymer material takes the polymer in the formula, which comprises polyphosphazene, chitosan, polyvinyl alcohol, poly-beta-malic acid or modified polyester, as the main chain, a conductive group and a degradable group are grafted, and the modified polyester is lactic acid, polyglycolide, polycarbonate, polyanhydride, polycaprolactone or copolymers between each two thereof; the conductive group comprises oligo-pyrrole, oligo-thiophene, oligo-aniline or copolymers between each two thereof; the degradable group mainly comprises: (1) amino: glycine ethyl ester, phenylalanine ethyl ester, imidazole and the like; and (2) alkoxy: glycerol, glucose, lactic acid, p-methyl phenol, glycolic acid and polyester. The polymer material has degradability and conductivity and can be prepared into guide pipes, suture threads, membranes, sheet bodies, block bodies and materials for frames of tissue engineering.

Description

technical field [0001] The invention relates to grafting conductive groups and degradable groups on polymer chains to endow the polymers with degradability and conductivity. technical background [0002] There is a very close relationship between the physiological functions of the human body and bioelectricity. External stimuli, heart beating and muscle contraction, and brain thinking are all accompanied by the generation and change of bioelectricity. After a certain part of the human body is stimulated, the sensory organs will generate action potentials, which will be transmitted to the brain center through the corresponding nerve fibers. effector organ, thereby producing the functional activity of the organ or tissue. [0003] Research in the field of biomedical engineering has found that bioelectricity can reflect the physiological or pathological conditions of organs or tissues. At present, bioelectricity has been widely used in diagnosis, treatment and control. Some...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G79/02C08B37/08C08F116/06C08F8/00C08G63/91C08G64/42C08G67/04H01B1/12A61L17/04A61L27/18A61L29/06C08G79/025
Inventor 李世普闫玉华张青松陈晓明万涛王友法王欣宇冯涛
Owner WUHAN UNIV OF TECH
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