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Preparation method of biomedical polymer material of polyunsaturated acid gallic acid epoxy ester

A polymer material, acid epoxy ester technology, applied in the direction of non-polymer adhesive additives, grafted polymer adhesives, adhesive types, etc. The effect of high oxygen levels

Inactive Publication Date: 2014-04-02
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent application CN102276788B discloses a gallic acid epoxy resin and its technology for preparing composite materials, epoxy adhesives and coatings, but it takes several hours to prepare composite materials using gallic acid epoxy resin High temperature curing, which makes this technology unable to replace the bisphenol A epoxy ester currently used in dentistry, because it does not meet the conditions that can be cured by ultraviolet or visible light radiation as a dental restorative material

Method used

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  • Preparation method of biomedical polymer material of polyunsaturated acid gallic acid epoxy ester
  • Preparation method of biomedical polymer material of polyunsaturated acid gallic acid epoxy ester

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Preparation of Epoxy Ester of Unsaturated Acid Gallate:

[0036]Take 1 mole of gallic acid and put it into a reaction bottle, add 20 moles of epichlorohydrin and 1 mole of n-butanol as solvents and stir and mix, then gradually heat up and add 4 moles of 20% sodium hydroxide aqueous solution dropwise, at 90 degrees Celsius React for 6 hours, wash with deionized water to neutrality, and distill off water and unreacted epichlorohydrin under reduced pressure to obtain gallic acid epoxy resin; and its epoxy value is measured to be 0.8mol / 100g.

[0037] Take 50 grams of the above-mentioned gallic acid epoxy resin and add it to the reaction bottle, then add 1.5 times the molar amount of α-methacrylic acid according to the molar amount of epoxy groups, and then add 0.2 grams of N,N' dimethyl benzyl Amine and 0.01 gram of hydroquinone were slowly heated to 90 degrees centigrade and reacted for 8 hours under stirring, cooled to room temperature, washed with deionized water to rem...

Embodiment 2

[0039] Preparation of Epoxy Ester of Unsaturated Acid Gallate:

[0040] Get 1 mole of gallic acid and put it into a reaction bottle, add 40 moles of epichlorohydrin and 2 moles of isoamyl alcohol and stir and mix, then gradually heat up and add dropwise 4 moles of 20% sodium hydroxide aqueous solution, and react at 85 degrees Celsius for 6 hours, washed with deionized water to neutral, and evaporated water and unreacted epichlorohydrin under reduced pressure to obtain gallic acid epoxy resin; and its epoxy value was measured to be 0.9mol / 100g.

[0041] Add 50 grams of gallic acid epoxy resin to the reaction bottle, then add 1.5 times the molar amount of acrylic acid according to the molar amount of epoxy groups, then add 0.1 gram of N,N' dimethylaniline and 0.05 gram of hydroquinone, and slowly Raise the temperature to 100 degrees Celsius and react for 6 hours, cool to room temperature, wash off unreacted carboxylic acid with deionized water, and vacuum dehydrate to obtain uns...

Embodiment 3

[0043] Add 10 grams of polymethyl methacrylate powder in the 50 g α-gallic acid epoxy ester synthesized in Example 1, add 2 grams of ultraviolet photoinitiator TPO and 1.5 grams of silicon coupling agent-processed micron dioxide Silicon, 1 gram of 4-[β-3,5-di-tert-butyl-4-hydroxyphenyl) propionate] pentaerythritol ester, mixed evenly and put into the mold, irradiated with 800W UV light source for 30 minutes to cure. The glass transition temperature of the prepared material was determined to be 100 degrees Celsius, and the Rockwell hardness was 60.

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Abstract

The invention discloses a preparation method of a biomedical polymer material of a polyunsaturated acid gallic acid epoxy ester. The method comprises the following steps: evenly mixing the following components in parts by weight to carry out polymerization reaction: 60-90 parts of polyunsaturated acid gallic acid epoxy ester, 0-45 parts of unsaturated acid polyol ester, 2-4.5 parts of initiator, 0-5 parts of anti-ageing agent, 0-10 parts of micron grade silicon dioxide, 0-20 parts of polymethyl methacrylate powder, 0-0.5 parts of antioxidant and 0-5 parts of benzoic sulfimide. The method can be used for preparing the biomedical polymer material; preferably used as a dental or surgical high polymer material, the biomedical polymer material can be also applied to a sclerotin adhesive and the like. The biomedical polymer material is safe and nontoxic, and the decomposition product of the biomedical polymer material has an anti-cancer effect.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to a preparation method of polyunsaturated gallic acid epoxy ester medical polymer materials. Background technique [0002] Polymer materials are more and more widely used in medicine and medicine, and have gradually been applied to the inside of the human body from general medical devices, such as targeted drugs, sustained-release drug capsules, substitutes for bones, blood vessels and various organs. Tooth powder for tooth restoration has been used for many years. It is a polymethacrylate polymer material, but its texture is soft and its bonding strength is low, so other materials have been used instead; In recent years, the technology of repairing teeth with acrylic epoxy esters through ultraviolet or visible light curing has also been widely used. The currently used acrylic epoxy esters are mainly general-purpose bisphenol A epoxy resins. However, recent studi...

Claims

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Application Information

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IPC IPC(8): C08F299/00C08F290/06C08F220/20C08F2/44C08F2/48C08G59/17C08G59/06C08K13/06C08K9/06C08K9/04C08K3/36C08K5/134C08K5/526C08K5/13C09J151/08C09J11/06
Inventor 高俊刚韩宏哲侯桂香杜永刚
Owner HEBEI UNIVERSITY
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