Hemostasis needle and preparing method and application thereof
A technology of needles and electrostatic action, applied in the field of hemostatic needles, can solve problems such as bleeding and lack of hemostasis methods, and achieve the effects of good biocompatibility, strong design, and easy large-scale production.
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[0033] The present invention proposes a method for preparing the hemostatic needle. The cross-linked polymer solution prepared by mixing the polymer matrix, the cross-linking agent and the solvent is coated on the peripheral surface of the needle, and the hemostatic coating with the hemostatic coating is obtained after removing the solvent. needle; wherein, the polymer matrix and the cross-linking agent are cross-linked through metal coordination, covalent bonds or non-covalent bonds to obtain the cross-linked polymer hemostatic coating, and non-covalent bond cross-linking such as Van der Waals forces, electrostatic interactions, and hydrogen bonds. In the preparation process of the hemostatic needle of the present invention, it is necessary to strictly control the concentration and ratio of the polymer matrix and the cross-linking agent, so that the two can be cross-linked with an appropriate degree of cross-linking, and then the polymer hemostatic coating will swell with wate...
Embodiment 1
[0045] A hemostatic needle is prepared according to the following method: first, according to the molar ratio of sodium alginate and calcium chloride of 1:1, a cross-linked polymer aqueous solution with a mass fraction of 5% is prepared, and then 40 μL of cross-linked polymer is coated on the syringe needle The solution was dried at room temperature to remove the solvent water to obtain a hemostatic needle with a cross-linked polymer coating thickness of 30 μm.
[0046] figure 1 Schematic diagram of the hemostatic needle prepared for this example, which includes a syringe needle, the peripheral surface of the needle is coated with a layer of hemostatic coating, the thickness of the hemostatic coating is 30 μm, the length of the hemostatic coating is 2 cm, and the hemostatic coating is close to the needle tip The distance from one end of the needle to the tip is 0, and the diameter of the needle is 710 μm.
[0047] figure 2 It is a schematic diagram of the preparation proces...
Embodiment 2
[0060] A kind of hemostatic needle is prepared according to the following method: first, according to chitosan and sodium glycerophosphate molar ratio 1:3 configuration mass fraction is the cross-linked polymer aqueous solution of 15%, and then the cross-linked polymer of 80 μ L is coated on syringe needle solution, drying to remove the solvent water to obtain a hemostatic needle with a cross-linked polymer coating thickness of 178 μm, the length of the hemostatic coating is 5.5 cm, and the distance between the end of the hemostatic coating and the needle tip is 2 cm, and the The diameter is 1.26mm.
[0061] Effect verification:
[0062] 1 Simulated hemostatic effect in vitro
[0063] The hemostatic needle was prepared by using the method in Example 2, and the hemostatic effect was simulated in vitro by puncturing the skin of nude mice. Take the skin of the nude mouse and fix it to the lower end of the syringe, add a certain volume of normal saline to the syringe, use a blan...
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