High molecular material surface modification method and its product and application

A polymer material and surface modification technology, applied in the field of biomimetic modification, can solve the problems of cumbersome grafting process, complicated and cumbersome operation process, and difficult to achieve, and achieve the effect of improving the physical and chemical properties of the surface and eliminating the limitation of sight.

Active Publication Date: 2017-09-22
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the use of wet chemical cross-linking technology is not only relatively complicated and cumbersome to operate, but also introduces toxic organic cross-linking reagents
More importantly, this chemical method is difficult to graft multiple bioactive molecules on the surface at the same time, and the sequential grafting of multiple biomolecules will make the grafting process extremely cumbersome or even difficult to achieve.

Method used

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  • High molecular material surface modification method and its product and application
  • High molecular material surface modification method and its product and application
  • High molecular material surface modification method and its product and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A polytetrafluoroethylene sheet with a diameter of 15 mm and a thickness of 0.1 mm was ultrasonically cleaned with acetone, alcohol, and deionized water in sequence. This pretreated sample is called PTFE control.

[0056] The pretreated PTFE was treated by gas plasma immersion ion implantation technology. Use nitrogen injection, ammonia injection, or nitrogen injection followed by ammonia injection for treatment. The specific treatment process is: the background vacuum is 5×10 -3 Pa, the flow rate of the gas introduced is 30 sccm, the negative bias applied to the sample disk is 15 kV, the injection pulse width is 20 microseconds, the injection pulse frequency is 500 Hz, and the radio frequency power is 1000 W. Wherein, the injection time of nitrogen is 180 minutes, and the sample after this treatment is called N2PIII; The injection time of ammonia is 60 minutes, and the sample after this treatment is called NH3PIII; After injecting nitrogen 180 minutes, inject ammonia...

Embodiment 2

[0059] Using an atomic force microscope to characterize the surface roughness of the polytetrafluoroethylene sample processed in Example 1, the surface three-dimensional picture, section profile and corresponding mean square roughness (RMS) results shown in Figure 2 were obtained. From the three-dimensional image of the surface in Figure 2, it can be seen that the results obtained by the atomic force microscope are basically consistent with the surface morphology obtained by the scanning electron microscope in Example 1. Figure 2a The surface mean square roughness of the PTFE control shown is 17.9nm. Nitrogen plasma injection significantly increased the surface roughness of the sample to 134nm ( Figure 2b ). Ammonia plasma injection has basically no effect on the surface roughness, and the mean square roughness after treatment is 18.2nm ( Figure 2c ). The mean square roughness of the surface after nitrogen plasma injection and ammonia gas injection is basically the same ...

Embodiment 3

[0061] Carry out X-ray photoelectron energy spectrum (XPS) wide-field scanning to the polytetrafluoroethylene sample surface that processing obtains in embodiment 1, obtain image 3 The XPS full-spectrum spectrum is shown. The abscissa represents the binding energy, and the ordinate represents the peak intensity. By observing image 3 The peak heights of the C 1s peak, O 1s peak, N 1s peak and F 1s peak of each sample in the sample show that the nitrogen plasma immersion ion implantation treatment reduces the fluorine element content on the surface of PTFE to a certain extent, and in the material Oxygen was introduced into the surface; and ammonia plasma immersion ion implantation treatment significantly reduced the content of surface fluorine, and significantly increased the proportion of surface nitrogen and oxygen.

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Abstract

The invention discloses a high molecular material surface modification method and its product and application. The surface modification method particularly relates to a biomedical polymer material surface treated on the basis of plasma immersion ion injection and a surface covalent grafting bioactive molecule after treatment so as to realize its bionic modification; the method particularly includes steps of 1), treating the high molecular material through gas plasma immersed ion injection; 2), incubating the treated high molecular material in the solution containing biological molecules. The high molecular material with modified gas plasma immersion ion injection surface has good stability; the grafting ability still cannot be significantly declined even though the high molecular material is stored in the air for a long time, and the high molecular material does not use chemical crosslinking agent; the whole surface modification technique is simple in process, low in cost, and suitable for batch and industrial production. The method and its product have wide application prospects in medical implant materials, functional materials, bioactive materials and other domain.

Description

technical field [0001] The present invention relates to a method for surface modification of polymer materials and its products and applications. The surface modification method especially relates to the treatment of the surface of medical polymer materials based on plasma immersion ion implantation and the covalent grafting of biological substances on the surface after treatment. Active molecules to achieve their biomimetic modification. Background technique [0002] Polymer materials, also known as polymer materials, are widely used in the biomedical field for the repair, replacement and regeneration of biological tissues, as well as for nursing and medical appliances. Because of its special application environment (requires direct contact with body fluids, blood, organs, tissues, etc.), biomedical polymer materials must have good physical and mechanical properties, chemical stability, non-toxicity, and easy processability. It must also have biocompatibility, medical func...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08L27/18C08L61/16
CPCC08J7/12C08J2327/18C08J2361/16
Inventor 王怀雨高昂朱剑豪
Owner SHENZHEN INST OF ADVANCED TECH
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