The invention relates to a preparation method of
ropivacaine mesylate injection packed by a soda-
lime glass
bottle, which comprises the following
processing steps of ingredient preparation, liquor preparation, soda-
lime glass
bottle and rubber plug cleaning, filling, capping, sterilization, lamp test, labeling, packing and finished
product inspection. The injection is subject to a
filtration sterilization
processing step once and a flowing
steam sterilization processing step once, wherein microorganisms larger than 0.22 microns in liquid
medicine are removed by a filter method, microorganismssmaller than 0.22 microns are killed by flowing
steam sterilization, and insoluble particles in the liquid
medicine are removed during
filtration sterilization simultaneously, thereby greatly reducingthe occurrence of phlebitis; and the invention is packed by the soda-
lime glass
bottle which has the advantages of
heat resistance, acid and alkali resistance, large strength, and the like, thereby ensuring the stability of the
medicine. Clinic comparison tests show that the
ropivacaine mesylate injection packed by a soda-lime glass bottle has the advantages of quicker effect, long action time, reliable
anesthetic effect, small
toxicity to heart, separate blocking pf sensory and motor nerves, and the like, thereby being suitable for
anesthesia in surgeries and postoperative analgesia.