An antibacterial heat conducting material

A heat-conducting material and antimicrobial peptide technology, applied in peptides, surgery, coatings, etc., can solve the problems of poor antibiotic treatment effect, strong drug resistance of infected bacteria, and prone to postoperative infection, etc., and achieve good market prospects and social Public benefit value, prevention of postoperative infection, good thermal conductivity effect

Active Publication Date: 2021-06-15
嘉兴莱普晟医疗科技有限公司
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Problems solved by technology

[0007] In order to solve the problems existing in the prior art that organ transplantation surgery is prone to postoperative infection, and the infection bacteria are highly resistant to antibiotics, the effect of antibiotic treatment is not good, and the internal temperature stability is not high during the working process of the mechanical perfusion system. Problem, the inventor of the present invention uses the coating prepared by graphene oxide and antibacterial peptide to prepare mechanical perfusion system, which can solve the above problems well. In view of this, the present invention provides an antibacterial and thermally conductive coating, which is characterized in that , the antibacterial thermal conductive coating contains graphene oxide and antimicrobial peptides, the mass ratio of graphene oxide and antimicrobial peptides is 1:25-1:75

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 composite antimicrobial peptide

[0029] The mutated compound antimicrobial peptide was synthesized by peptide synthesis method, and the synthesized peptide was named CT-1. The peptide synthesis adopts the F-moc automatic solid-phase synthesis method, and the specific method is as follows:

[0030] 1.1 Synthesis of peptides

[0031] Protected polypeptides were assembled on resin using a model of the 433A automated synthesizer (ABI, Foster City, CA). The peptide resin was incubated in suspension for 2.5 hours at room temperature to deprotect the group. The suspension system is composed of 10 ml of TFA, 0.75 g of phenol, 0.25 ml of 1,2-ethanedithiol, 0.5 ml of sulfide anisole and 0.5 ml of water. The resin was separated from the peptide deprotected mixture by filtration. The crude polypeptide was precipitated in 150ml pre-cooled ether solution, and purified by chromatography on a Sephadex G-25 column with 10% glacial acetic acid as elue...

Embodiment 2

[0037] Example 2 Preparation of thermally conductive material covered with graphene oxide-loaded antimicrobial peptide coating

[0038] In this implementation, the reduced graphene oxide-loaded antimicrobial peptide coating is prepared first, and then the coating is applied to the surface of the heat-conducting material by self-assembly. The heat-conducting material is aluminum alloy, and the graphene oxide-loaded antimicrobial peptide coating is obtained. The aluminum alloy material, concrete preparation method is as follows:

[0039] 2.1 Surface modification of thermally conductive materials

[0040] First immerse the cleaned and dried aluminum alloy in 2mg / ml dopamine hydrochloride solution, adjust the pH value to 8.5 with NaOH, and use it after reacting overnight at room temperature. After fully washing with distilled water, dry at room temperature, and repeat the above steps Three times, the surface of the aluminum alloy is modified with polydopamine, and then the alumin...

Embodiment 3

[0049] Comparison of the antibacterial effect of the coating prepared by the composite antimicrobial peptide and graphene oxide in different proportions of embodiment 3

[0050] In this example, in order to explore the antibacterial effect of coatings prepared by different proportions of composite antibacterial peptides and graphene oxide, the optimal concentration ratio of composite antibacterial peptides and graphene oxide was found out, and the composite antibacterial peptides and reduced Graphene oxide volume ratio is 1:1, 1:2, 1:2.5, the concentration of 1:3, the method for embodiment 2 prepares the aluminum alloy material GO-CT-1-A of corresponding coating, GO- CT-1-B, GO-CT-1-C, GO-CT-1-D, the experimental setting control group is aluminum alloy material without coating, as shown in Table 2 Table 2: Different antimicrobial peptides and Coating Preparation of Graphene Proportion

[0051]

[0052] 3.1 Determination of antibacterial properties

[0053] The antibacteri...

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Abstract

The invention provides an antibacterial and heat-conducting coating, which is characterized in that the antibacterial and heat-conducting coating contains graphene oxide and antibacterial peptide, and the mass ratio of graphene oxide and antibacterial peptide is 1:25-1:75. The antibacterial and heat-conducting coating of the invention can reduce postoperative infection of organ transplantation, and can provide a stable internal environment for organs, and has good market prospect and social public welfare value.

Description

technical field [0001] The invention belongs to the technical field of antibacterial material manufacture, and in particular relates to an antibacterial heat-conducting coating. Background technique [0002] During organ transplantation, mechanical perfusion instruments are usually used to preserve them. The working principle of mechanical perfusion preservation instruments is to use a controllable continuous preservation solution to eliminate metabolites and provide nutrients and oxygen to organs. In other words, The simulation of the environment inside the perfusion apparatus is the key to the successful preservation of isolated organs. Therefore, the temperature stability inside the perfusion device, as well as the biocompatibility and antibacterial properties of the materials inside the perfusion device play a crucial role in the survival and function of the organ. Traditional perfusion instruments usually use resin as the box design material. Although the resin has a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K19/00A61L31/16A61L31/10A61L31/08
Inventor 李建辉杨子江郑俊辛立明
Owner 嘉兴莱普晟医疗科技有限公司
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