Bone repair material and preparation method thereof

A bone repair and material composition technology, applied in the field of medical biomaterials, can solve problems such as poor long-term anti-infection ability, non-degradable bone prosthetic materials, and unfavorable bone growth in patients

Active Publication Date: 2020-10-30
上海禾麦医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fixed shape of the bone prosthesis, it is not suitable for bone defects with complex shapes, and the bone prosthesis material made by it is not degradable,

Method used

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  • Bone repair material and preparation method thereof
  • Bone repair material and preparation method thereof
  • Bone repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] The preparation method of nano silicon nitride-magnesium phosphate bone cement composite bone repair material comprises the following steps:

[0093] (1) Dissolve nano-silicon nitride particles into 200 μmol / L puerarin solution, stir for 2 hours, and then centrifuge and dry to obtain the desired drug-loaded nano-silicon nitride particles;

[0094] (2) The bone cement powder is uniformly mixed with magnesium oxide and sodium dihydrogen phosphate at a molar ratio of 1:1;

[0095] (3) Mix 0.75g of drug-loaded nano-silicon nitride particles with 4.25g of magnesium phosphate bone cement powder evenly, take 4g of gallic acid aqueous solution and mix with the powder, put it into the mold and solidify (the solidification time is 6~10min) and place it at 37 ℃, 100% humidity environment to cure 72h.

[0096] In the nano-silicon nitride-magnesium phosphate bone cement composite bone repair material, the proportion of nano-silicon nitride is 15wt%, and the proportion of magnesium ...

Embodiment 2

[0098] The preparation method of nano silicon nitride-magnesium phosphate bone cement composite bone repair material comprises the following steps:

[0099] (1) Dissolve nano-silicon nitride particles into 200 μmol / L puerarin solution, stir for 2 hours, and then centrifuge and dry to obtain the desired drug-loaded nano-silicon nitride particles;

[0100] (2) The bone cement powder is uniformly mixed with magnesium oxide and sodium dihydrogen phosphate at a molar ratio of 1:1;

[0101] (3) Mix 1.5g of drug-loaded nano-silicon nitride particles with 3.5g of magnesium phosphate bone cement powder evenly, take 4g of gallic acid aqueous solution and mix with the powder, put it into the mold for solidification (setting time is 6~10min), and place it in 37 ℃, 100% humidity environment to cure 72h.

[0102] In the nano-silicon nitride-magnesium phosphate bone cement composite bone repair material, the proportion of nano-silicon nitride is 30wt%, the proportion of magnesium phosphate ...

Embodiment 3

[0104] The preparation method of nano silicon nitride-magnesium phosphate bone cement composite bone repair material comprises the following steps:

[0105] (1) Dissolve nano-silicon nitride particles into 100 μmol / L puerarin solution, stir for 2 hours, then centrifuge and dry to obtain the desired drug-loaded nano-silicon nitride particles;

[0106] (2) The bone cement powder is uniformly mixed with magnesium oxide and sodium dihydrogen phosphate at a molar ratio of 1:1;

[0107] (3) Mix 1.5g of drug-loaded nano-silicon nitride particles with 3.5g of magnesium phosphate bone cement powder evenly, take 4g of gallic acid aqueous solution and mix with the powder, put it into the mold and solidify (the solidification time is 6~10min) and place it in 37 ℃, 100% humidity environment to cure 72h.

[0108] In the nano-silicon nitride-magnesium phosphate bone cement composite bone repair material, the proportion of nano-silicon nitride is 30wt%, the proportion of magnesium phosphate ...

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Abstract

The present invention relates to a bone repair material composition comprising a bone cement component and nano silicon nitride, wherein the bone cement component comprises magnesium oxide and sodiumdihydrogen phosphate, and the weight ratio of the nano silicon nitride to the bone cement component is 1: (1.5-9). The bone repair material prepared according to the invention has dual effects of resisting infection and promoting bone growth, not only inhibits bacterial adhesion, but also promotes adhesion and proliferation of osteoblasts, and can play a role in resisting infection and improving bony combination between an implant and a host bone after being implanted into a body.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a bone repair material and its preparation method and application. Background technique [0002] Bone is a natural inorganic / organic composite material, more than 90% of the organic phase is collagen, and the inorganic phase mainly includes calcium phosphate, hydroxyapatite (HA), sodium phosphate, calcium citrate, magnesium phosphate etc., among which hydroxyapatite is the main one. When the natural bone is traumatized, due to the joint action of bone morphogenic protein and growth factors, it has a certain self-repair ability. After the bone repair material is implanted, it can ensure that the patient's bone defect remains fixed and the patient can carry out normal work. Daily activities, and often bone repair materials can also help damaged bone tissue repair itself, speeding up the healing process. [0003] The development of bone repair materials has experienced numerous...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/12A61L27/02A61L27/54A61L27/58
CPCA61L27/50A61L27/12A61L27/025A61L27/54A61L27/58A61L2300/216A61L2300/602A61L2400/06A61L2430/02
Inventor 苏佳灿胡衍魏杰黄标通
Owner 上海禾麦医学科技有限公司
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