204 results about "Bacterial Adhesions" patented technology

The present invention provides antimicrobial coatings for coating substrate surfaces, particularly medical devices, for preventing bacterial adhesion and biofilm formation by inhibiting microbial growth and proliferation on the coating surface. The antimicrobial coatings are composed of a hydrogel and a bioactive agent including a substantially water-insoluble antimicrobial metallic material that is solubilized within the coating. Antimicrobial coating formulations for obtaining such coatings, and coating methods are also described.

Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding protein compositions and methods of use. The DBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological Borrelia infections, and in particular, for use in the prevention of bacterial adhesion to decorin. DNA segments encoding these proteins and anti-(decorin binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of Borrelia colonization in an animal. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of Lyme disease.

The present invention encompasses an oral composition containing an anti-adhesion agent, preferably a cysteine protease and most preferably ficin. In another aspect, the cysteine protease is in combination with one or more ingredients, such as antibacterial agent and surfactant. The anti-adhesion agent mitigates interaction between a subject oral cavity and plaque-forming materials.

The invention discloses a biological antibacterial and antifouling low surface energy coating with a surface micro-structure and a preparation method of the biological antibacterial and antifouling low surface energy coating. The antibacterial and antifouling coating comprises a microemulsionprepolymerizationsolution prepared from raw materials as follows: a fluorine-containinglow surface energy monomer, an acrylate monomer, a hydantoinderivative, an emulsifying agent, a co-emulsifier, an ammonia solution and tetraethoxysilane. The antifouling coating not only has anti-adhesion low surface energy hydrophobic nature, has a sterilization functionsimultaneously, can simultaneously resist protein adsorption and bacterial adhesion and has a double-protection function to delay formation of a biological film on the surface of a coating, so that growth and breeding of large-scale living organisms such as microalgae and the like on the coating surface are slowed down; the antifouling coating is prepared with a one-step microemulsion polymerizationmethod, can effectively prevent volatilization pollution of organic solvents, doesn't release toxic substances simultaneouslyand has the characteristics of environment-friendliness and safety; and the preparation method is simple and convenient, and film forming is fast.

The invention belongs to the field of hydrogels, and particularly discloses a preparation method of an antibacterial hydrogel with sterilization, low bacterial adhesion and bacterial release, the method comprises the following steps: 1) mixing a response monomer and an epoxy monomer, and carrying out a free radical copolymerization reaction to obtain an epoxy group-containing response polymer; 2)mixing and dissolving the epoxy group-containing responsive polymer and an epoxy group-containing hydrophilic polymer in a solvent, and adding an amino group-containing bactericide to carry out epoxyring opening reaction to obtain the antibacterial hydrogel. The invention also discloses the antibacterial hydrogel with sterilization, low bacterial adhesion and bacterial release prepared by the preparation method and application thereof in wound dressing. The preparation process of the method is simple and efficient, the obtained hydrogel has comprehensive functions and good biocompatibility, has wide research prospects in the fields of biomedicine and tissue engineering, and provides a new idea for the preparation of functional materials.

The invention provides an enzyme-responsive intelligent bacterial adhesion resistant and bactericidal layer-by-layer self-assembled multi-layer film coating and a preparation method thereof. A surface-hydrophobic gel coating which is stable in a water environment is obtained through physical coating of chitosan, hyaluronic acid and a lysine solution, so that a material is endowed with bacterial adhesion resisting and contact sterilizing functions; polylysine improves the bacterial adhesion resistance of the material, so that the coating has the favorable gram-positive and gram-negative bacterial adhesion resisting and sterilizing capabilities. The preparation method is simple in process, quick, mild in condition, and easy for dip-coating, spin-coating, spray-coating and layer-by-layer self-assembly, can be implemented industrially, and has a wide application range, and the antibacterial performance, the bio-compatibility and the lubricity of the surface of medical devices can be effectively improved.

This invention relates generally to a method for treatment of lens surfaces by first coating the mold material with a reactive macromonomer and subsequently casting and curing the lens forming material along with the coating material present on the surface of the mold. The macromonomer reacts with the lens monomer mix and is covalently bound to the lens matrix. The modified lenses may ultimately show enhanced wettability, inhibition of bacterial adhesion and lower levels of protein and lipid deposition leading to increased comfort and longer wearing times.

Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding protein compositions and methods of use. The DBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological Borrelia infections, and in particular, for use in the prevention of bacterial adhesion to decorin. DNA segments encoding these proteins and anti-(decorin binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of Borrelia colonization in an animal. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of Lyme disease.

The present invention relates to biostatic compositions, as well as coatings and methods for preparing biostatic articles using the same. The compositions contain a hydrophilic polymer possessing a functional group which covalently bonds to an amine, thiol, carboxyl, or hydroxyl active group of an antimicrobial agent. The functional group is capable of reacting with and covalently bonding to an antimicrobial agent without effectively reducing antimicrobial property of the antimicrobial agent below its capability of acting as a biostatic agent and without releasing the antimicrobial agent into a solution.

A composite comprising a silicone compound sorbed onto a porous cross-linked polymer. This composition can be included in an oral care composition and inhibit bacterial adhesion on an oral surface.

The invention discloses a method for preparing a broad-spectrum long-acting antibacterial anti-adhesive chitosan nano silver composite gel coating layer, and is characterized in that with use of solutions of chitosan, silver nitrate and polyvinylpyrrolidone, the nano composite gel coating layer having hydrophilic surface and being stable in an aqueous environment is obtained by base material pretreatment, physical coating and in-situ reduction; the coating layer has excellent broad-spectrum bacterial adhesion resistance and sterilization abilities, and has excellent cellular biocompatibility. The method is simple and rapid in process, mild in conditions, easy to achieve by spin coating, dip coating, spray coating and other methods which can be implemented industrially, is wide in applicable scope, and can effectively improve antibacterial property, biocompatibility and lubricating property of surfaces of medical devices.

The invention provides a preparation method of a stability-enhanced compound antibacterial coating. The method comprises the following steps that (1) a chitosan water solution is used for soaking a collagen substrate; then, water washing is performed to remove uncombined chitosan, wherein the molecular weight of the chitosan is 50 thousand to 500 thousand; (2) a nano-silver water solution is usedfor soaking the matter obtained in the step (1); then, water washing is performed to remove uncombined nano-silver; (3) an EDC and NHS mixed solution is used for soaking the matter obtained in the step (2); then, water washing is performed; next, drying is performed to obtain the stability-enhanced compound antibacterial coating. The obtained compound antibacterial coating has three kinds of antibacterial functions of resisting the bacterial adhesion, releasing bactericides for sterilization and realizing contact sterilization; the antibacterial performance is excellent; meanwhile, the compound antibacterial coating also has excellent stability, is applicable to various kinds of complicated environment and is particularly applicable to medical instrument surface anti-bacterium.

Disclosed are surfaces for resisting and reducing biofilm formation, particularly on medical articles (100). The surfaces include a plurality of microstructures (120) including a plurality of nanofeatures (140) arranged according to at least one unit cell. Also disclosed are methods for creating anti - adherent surfaces.

A transcutaneous prosthesis includes a first component shaped for implantation into a bone, the first component including flutes or grooves on a surface thereof for deterring rotation of the prosthesis within a bone; a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachment of epithelial cells; and a third component adapted for location to extend from the skin surface and is adapted to extend directly from the skin surface in use, the third component having a coating of a non-stick material on an outer surface thereof, the coating having a surface energy that is lower than a surface energy of the first and second components and which is low enough to deter bacterial adhesion.

The invention provides a medical macromolecular three-dimensional structural composite material and a preparation method thereof. The method comprises the following steps that a degradable medical macromolecular polymer with the weight ratio of 1-10% is placed in an organic solvent and stirred for 2-12 hours; a mixed solution is prepared into a thin film with a three-dimensional structure; the three-dimensional structural material is placed in a dopamine solution for surface functionalization treatment; the three-dimensional structural material is taken out and placed in a zwitterionic polymerand collagen blended solution for a reaction of 12-48 hours; the three-dimensional structural material is taken out, washed with distilled water twice, dried under vacuum overnight and stored for use. The method is simple, feasible and high in controllability; the prepared composite material can resist bacterial adhesion, has good adhesion to cells and good biocompatibility, stability and mechanical properties, and is suitable for surface modification of three-dimensional stent materials.

The instant invention provides a live labeling microorganism assay for screening a one-bead one-compound library to identify synthetic anti-adherent compounds for blocking biofilm formation. The compounds of libraries may be peptides, small molecules, nucleic acids, other types of molecules or a combination of the foregoing. The live labeling microorganisms are incubated with a one-bead one-compound library for a long period with fresh-labeled bacteria and nutrition replacement in regular intervals. Those beads without bacterial adhesion are transferred into nutritional agar for the culture. The true anti-adherent beads are isolated and the sequences of each isolated compound-bead are determined with sequencer. The anti-adherent compounds identified in this invention are proved to possess long-term effect of blocking bacterial adhesion and biofilm formation. Thus the instant invention provides a unique and powerful method to identify anti-adherent compounds from library more quickly and reliably than current state-of-the-art technology allows.

The invention discloses a method for constructing an antifouling-sterilizing-releasing type surface coating by using dopamine, which comprises the following steps: adding an epoxy group-containing stimuli-responsive polymer, a sterilization polymer and an anti-pollution polymer into a dopamine solution, and standing and co-depositing on a substrate to obtain the anti-pollution-sterilization-release surface coating. The method is simpler and more efficient and can be applied to any substrate, and the application range of antibacterial surfaces is greatly expanded. The invention further discloses the antifouling-sterilizing-releasing type surface coating prepared by the method, the coating can resist bacterial adhesion for a long time and kill bacteria, and when the adhesion amount of dead bacteria reaches a certain degree, the bacteria adhered to the surface can be released by changing external conditions, and functional regeneration is realized.