8 results about "Bacterial Adhesions" patented technology

The application relates to the technical field of tracheal catheters, and discloses a medical tracheal catheter with double coatings of local anesthetic and antibacterial drugs, which comprises a catheter main body and a cuff main body connected to the outer wall of the catheter main body, the catheter main body comprises a catheter base material layer, a first transition bonding layer, a first nano local anesthetic coating and a first antibacterial coating; the cuff main body comprises a cuff base material layer, a second transition bonding layer, a second nano local anesthetic coating and a second antibacterial coating; a tracheal tube is mounted on the catheter main body; and a head tube is connected to the bottom end of the catheter main body. The first nano local anesthetic coating, the first antibacterial coating, the second nano local anesthetic coating and the second antibacterial coating are arranged, so that the catheter main body and the cuff main body can realize a synergistic protection mechanism of analgesia and antibiosis; during the process of leaving the catheter, the local anesthetic drug acts on the mucosa of the tracheal wall through slow release, and the antibacterial component effectively reduces bacterial adhesion and biofilm formation.

The embodiment of the application discloses an acid-responsive oxygen-releasing chitosan / polycaprolactone core-shell microsphere and a preparation method and application thereof. The microsphere comprises an oxygen-releasing inner core taking polycaprolactone and calcium peroxide as base materials, and a pH-responsive outer shell modified by chitosan through N-acetyl-d-glucosamine and loaded with a natural medicine 6-Gin; the microsphere is disintegrated in the outer shell under the gastric acid environment and rapidly releases 6-Gin, and the inner core continuously releases oxygen by reacting with water. The microsphere provided by the application can effectively inhibit bacterial adhesion, destroy a biofilm and directly kill H. pylori, and solves the problem of poor curative effect caused by a microenvironment in traditional therapy, and provides a new effective strategy for anti-H. pylori therapy.

The application discloses a medical material for promoting tissue regeneration and a preparation method and application thereof. The medical material can realize reversible regulation of interface surface potential. Under light stimulation, photo-generated carriers are generated in the inorganic nano functional component, the holes are enriched on the surface of the material, the surface potential is significantly positively deviated, and a transient high positive potential state is formed, so that the inhibition of bacterial adhesion and biofilm formation is enhanced. After the light stimulation is removed, the surface potential of the material returns to a negative potential state close to a physiological microenvironment, so that the immune microenvironment is regulated and tissue regeneration is promoted. Therefore, the medical material can realize time sequence reversible regulation of surface potential polarity and intensity based on external light stimulation, so that the material can respectively play antibacterial and tissue regeneration promoting functions in different repair stages.

This utility model relates to the field of stent technology and discloses a special stent for anesthesia machine tubing, including a base, a support rod fixedly connected to the upper side of the base, and an adjustment component provided on the upper side of the base. The adjustment component includes an insertion rod fixedly connected to the inner side of the lower end of the support rod, and a sleeve rod sleeved on the upper end of the insertion rod. A retaining ring is fixedly connected to the upper end of the sleeve rod. A movable plate is inserted inside the end of the support rod away from the sleeve rod, and a first spring is fixedly connected to the lower end of the movable plate. The lower end of the first spring is fixedly connected to the support rod. An insertion plate is inserted into the inner side of the lower end of the movable plate, and the lower end of the insertion plate is fixedly connected to the support rod. A second spring is fixedly connected to the upper end of the insertion plate, and the upper end of the second spring is fixedly connected to the movable plate. The adjustment component allows medical staff to adjust the height by stepping on it, eliminating the need for manual adjustment during surgery, thereby avoiding bacterial adhesion and reducing the workload of medical staff's hands.

This application provides a surface-functionalized polyolefin dressing and its preparation method, relating to the field of dressing technology. A method for preparing a surface-functionalized polyolefin dressing includes the following steps: S1, surface-treating the polyolefin dressing using a plasma treatment machine; S2, preparing a modification solution and purging with nitrogen to remove oxygen; the modification solution contains 5-50% by volume of a modifying monomer and a solvent; the modifying monomer contains amino groups and carbon-carbon double bonds that can be photoinitiated for polymerization; S3, placing the polyolefin dressing treated in S1 into the modification solution, adding a photoinitiator, irradiating with ultraviolet light, and washing with anhydrous ethanol to obtain the modified surface-functionalized polyolefin dressing. This application, by grafting cationic groups onto its surface, aims to significantly improve the adhesion performance and adhesion strength to bacteria while avoiding strong bactericidal activity in the material itself, thus improving biocompatibility and bacterial adhesion rate.

The present application provides the use of methylcatester for treating periodontitis. The present application also provides a method for preparing a sustained-release drug film containing methylcatester. The sustained-release drug film provided by the present application can inhibit the release of inflammatory factors, inhibit bacterial adhesion, and has a sustained-release time of up to the seventh day, has obvious effect on anti-periodontitis, and can effectively reduce the pathological changes of periodontal tissue.

To provide a bacteria adhesion inhibitor capable of obtaining good bacteria adhesion inhibiting effect against various bacterial strains and on surfaces of solid bodies made of various materials.SOLUTION: (1) A bacteria adhesion inhibitor contains a polymer that has a hydrophobic group having three or more carbon atoms at a side chain terminal, at least either of a main chain or a side chain has hydrophilicity, and in which the polymer satisfies the following conditions 1 and 2; and (2) a bacteria adhesion inhibiting method includes a treatment step in which the polymer is physically adsorbed onto a surface of a solid body with an aqueous solution containing the polymer that has a hydrophobic group having three or more carbon atoms at a side chain terminal, and at least either of a main chain or a side chain has hydrophilicity, and the polymer satisfies the conditions 1 and 2. The condition 1 is: in a crystal oscillator microbalance method, a frequency variation ΔF and an energy dissipation change ΔD of a 0.1 mass% solution of the polymer in water with a hardness of 4° dH to a polyester-coated crystal oscillator are measured, and a ratio (ΔD / ΔF) obtained by such measurement should be 0.15 or more; and the condition 2 is: in a captive bubble method, an underwater contact angle of a bubble to the polymer to be measured should be 120° or more.SELECTED DRAWING: None