82 results about "Bacterial Adhesions" patented technology

Peptides that bind with high affinity to oral cavity surfaces, such as tooth enamel, have been discovered. The peptides exhibit antibacterial and mineralizing abilities, and are useful in many aspects of oral care. The peptides include the amino acid sequence AKRHHGYKRKFH-SpSp. The peptides can be included in oral care compositions such as toothpastes and mouthwashes. The oral care compositions can be used in methods to treat or prevent diseases or conditions induced by acidophilic oral bacteria. Exemplary methods include reducing or preventing tooth decay or demineralization, biofilm or dental plaque formation, and / or bacterial adhesion to a tooth surface; and promoting mineralization of teeth surfaces.

The invention provides a layer-by-layer self-assembled gallium-lysozyme composite antibacterial stainless steel coating and application thereof, and relates to the technical field of medical equipment. According to the composite antibacterial stainless steel coating, medical 316L stainless steel is used as a substrate material, a dopamine solution is used as a raw material, Tris salt is added to initiate a polymerization reaction of dopamine, and a polydopamine film is formed on the surface of the stainless steel; the preparation method comprises the following steps: carrying out Michael addition reaction on an easily oxidized catechol group and lysozyme containing amino and sulfydryl in an aerobic environment to form stable covalent linkage, thereby preparing the lysozyme-loaded polydopamine composite membrane. In the invention, the antibacterial composite coating aims to effectively kill biofilm embedding bacteria and prevent bacterial adhesion and biofilm formation on the surface of an implant under the condition of not hurting an organism, so that the antibacterial property of the implantable stent is improved, and the problem of clinical postoperative explosive infection of the implant is solved; and more thoughts and means and beneficial exploration are provided for treatment of chronic refractory inflammation caused by biological membranes.

The invention provides an antibacterial antifouling material and a preparation method thereof, and belongs to the technical field of antibacterial hydrophobic materials. The preparation method comprises the following steps: reacting choline chloride serving as an antibacterial modification raw material with isocyanate to obtain acrylic acid esterified choline chloride, and carrying out ultraviolet curing in an ethanol solution by taking an acrylate compound and trimethoxyvinyl silane as hydrophobic raw materials to obtain the antibacterial antifouling material. The prepared material has good long-term antibacterial performance and antifouling performance, firstly, the material retains the antibacterial performance of a quaternary ammonium salt structure and has good hydrophobicity, so that the material not only has the antibacterial performance, but also has the good hydrophobicity, effectively prevents bacterial adhesion, increases the antibacterial effect and has the antifouling effect at the same time.

The invention relates to the technical field of oral biological materials, in particular to a self-adaptive anti-caries coating as well as a preparation method and application thereof. The coating is prepared from random and block polymers, and is specifically prepared by polymerizing acid radical-containing functional monomers, phenylboronic acid and derivatives thereof. Construction of the coating depends on specific coordination of a functional group and Ca < 2 + > in enamel, and stable anchoring on the tooth surface is achieved. The core action mechanism is to introduce phenylboronic acid groups to endow the coating with pH sensitive characteristics: in a cariogenic acid environment, biofilm formation is synergistically inhibited through a plurality of mechanisms such as physical barrier, electrostatic repulsion and inhibition of mucoprotein-mediated adhesion. According to the application, the Ca < 2 + > anchoring monomer, phenylboronic acid and the derivative thereof are copolymerized, design is carried out aiming at two key links of protein adsorption and bacterial adhesion, multi-mechanism synergy and environment dynamic response are integrated, and an integrated anti-caries effect from early intervention to long-term protection is realized.

The invention relates to the field of oral cleaning products, in particular to oral antibacterial paste capable of deeply resisting bacteria and a preparation method of the oral antibacterial paste. According to the technical scheme, the incision smearing healing medicine capable of achieving rapid treatment is prepared from 15-25 parts of hydrated silica, 53-67 parts of sorbitol, 5.1-9.1 parts of water, 1.5-2.5 parts of cocamidopropyl betaine and 4-6 parts of glycerin, pathogenic bacteria are rapidly killed through triclosan, the micro-ecology is continuously adjusted through probiotics and plant extracts, the risk of drug resistance is reduced, and the healing effect is good. The plant anti-inflammatory components in the traditional Chinese medicine mixed extract are combined with the glycerol, so that red and swollen gums are relieved, wound healing is accelerated, then cocamidopropyl betaine is used for mildly cleaning oral mucosa, assisting in removing food residues and reducing bacterial attachment, and the anti-inflammatory effect is achieved. The toothpaste can deeply clean dead corners such as gingival gaps and deep mucous membranes, and can deeply play a role in the interior by virtue of an anti-bacteria and decomposition technology, so that the problem that a common oral product is limited in cleaning effect and only can clean the surface is solved.

The invention relates to the technical field of computer vision, in particular to a dynamic scale adaptive bacterium detection method and device and a storage medium, and the method comprises the steps: inputting a bacterium AST image into a backbone network of a bacterium detection model, and extracting features through a plurality of convolution blocks and a boundary feature enhancement module to obtain a plurality of hierarchical features of different scales; inputting the plurality of hierarchy feature maps into a neck network to obtain corresponding enhanced features, wherein the feature of the last hierarchy passes through a deformable attention encoder module to obtain the corresponding enhanced feature; inputting the plurality of enhanced features into a fine-grained feature enhancement module to obtain a target feature; and inputting the target features into the prediction head to obtain a bacteria detection result. According to the invention, the problem of leak detection caused by bacterial adhesion, various forms and small bacterial sizes can be effectively reduced, and the bacterial detection precision is improved.

The invention discloses a phosphoric acid compound capable of resisting intestinal bacterial adhesion as well as a preparation method and application of the phosphoric acid compound, and belongs to the technical field of foods and medicines. The phosphoric acid compound is prepared from an amino-rich compound, a solution containing a phosphate compound with the mass concentration being 3% or above, a solution containing a zinc compound with the mass concentration being 3% or above, glucomannan, an alkaline solution and water. The phosphoric acid compound can effectively inhibit the adhesion of bacteria to intestinal mucosa, can control the probability of intestinal bacteria invasion, reduce the occurrence probability of intestinal leakage, control chronic inflammation in the body, can solve the intestinal health problem caused by the adhesion of intestinal bacteria, and plays an important role. In order to ensure the safety of the product and not introduce reagents and substances harmful to health, the used preparation process and production process are simple and easy to industrially amplify, harmful substances are prevented from being generated in the production process, the operation is easy, and large-scale production can be realized.

The application discloses a kind of processing methods for improving the sterilization performance and anti-adhesion performance of medical titanium metal surface, and the specific steps are as follows: 1) pretreatment is carried out on titanium metal sample and cleaned and dried for standby;2) nanosecond laser is used to process the titanium metal sample after pretreatment, to form micron grid structure on its surface;3) configure zinc oxide seed solution, and spin coating solution on the titanium metal sample after laser processing, so that micron grid structure surface is evenly fixed on zinc oxide seed layer;4) using hydrothermal synthesis method, prepare rod-shaped zinc oxide nanostructure on the titanium metal surface with zinc oxide seed layer spin coated;5) configure ethanol solution containing fluorosilane, modify the surface of micro-nano composite structure, and after standing, dry.The titanium metal surface constructed by the application has the dual functions of sterilization and inhibition of bacterial adhesion, the preparation method is simple, and bacterial resistance is not easy to produce, and has potential application prospect.

The invention relates to a magnesium- aluminium layered double hydroxide (Mg-Al LDH) based filler product comprising boron and functionalised with phosphocholine chloride calcium salt tetrahydrate (PC), the synthesis method of this filler product, and obtaining a new material by preparing a composite material of this filler product, which has antibacterial activity, with a thermoplastic polymer or thermosetting polymer. In the production of the composite material that is the subject of the invention, as the polymer, preferably unsaturated polyester resin (DPes) is used. The composite material comprising the filler product of the invention has the feature of preventing bacterial adhesion / biofilm formation. Said material has the potential to be used for various applications, including medical devices, industrial processes, food production, storage and sales areas, food contact surfaces, areas requiring cleaning and hygiene, and different surface materials.

The utility model discloses a cavitation microbubble enhanced ultraviolet sterilization lamp tube, and aims to solve the problems that a traditional ultraviolet sterilization technology is difficult to effectively treat bacterial clusters and is influenced by water quality. According to the lamp tube, the hydrodynamic cavitation technology and ultraviolet sterilization are combined, a bacterial cluster structure is destroyed through microbubble blasting, bacteria are comprehensively killed, and meanwhile the bacteria are prevented from being attached to the surface of the lamp tube. The utility model is characterized in that a special tank body structure and an abrupt change structure are designed, so that higher energy utilization rate and sterilization effect are realized, the equipment structure is simplified, the space is saved, and the efficiency and reliability of sterilization operation are improved. Due to the uniqueness and practicability of the device, the device has important innovation and application prospects in the technical field of sterilization equipment.

The application belongs to the field of medical treatment and health, and particularly relates to a urinary catheter. The urinary catheter of the embodiment of the application is entirely covered with a nano coating prepared from an aqueous solution of aminated multi-walled carbon nanotubes. The nano coating can prevent bacterial adhesion, thereby effectively reducing the occurrence of complications such as infection and thrombus during use of the urinary catheter, can reduce the friction coefficient of the surface of the urinary catheter, improve the smoothness and wear resistance of the surface, reduce damage to the urethra, and has long-term performance stability and biocompatibility, thereby avoiding potential toxicity and side effects.

The invention relates to a pet composition for preventing urinary tract calculi and improving urinary tract health and application thereof. The composition for pets comprises a mucosal barrier repairing agent, an antibacterial adhesive, an inflammation regulator, a diuretic and an antioxidant, the antibacterial adhesive comprises a combination of D-mannose and a cranberry extract. The composition for pets provided by the invention can be used for repairing bladder mucosa from multiple dimensions, inhibiting bacteria from adhering to the bladder wall, reducing urinary stones, regulating inflammation and improving urinary tract health.

The invention belongs to the technical field of material surface performance detection, and particularly relates to a method for detecting biological pollution resistance and durability of a silicone rubber surface, and the method comprises the following steps: S1, sequentially carrying out biological membrane inhibition rate quantitative detection, antibacterial adhesion detection, protein adsorption resistance test and surface wettability test on a silicone rubber sample to be detected; s2, carrying out durability treatment on the parallel sample; s3, repeating partial or all tests in the step S1 on the sample treated in the step S2; s4, comparing the performance data obtained in the step S1 and the performance data obtained in the step S3, and evaluating the biological pollution resistance and durability of the silicone rubber sample. According to the invention, biological membrane inhibition rate quantitative detection, anti-bacterial adhesion detection, anti-protein adsorption performance test, surface wettability analysis and durability test are organically combined to form a complete evaluation closed loop from molecular adsorption to microbial community and from immediate efficiency to long-acting stability, and all key links of biological pollution are comprehensively covered.

The invention discloses a directional cultivation method for a sulfur autotrophic nitrogen removal filter material with a multi-gradient pore structure. The directional cultivation method specifically comprises the following steps: step 1, preparing raw materials; step 2, gradient mixing; thirdly, layered pressure forming is conducted; 4, controllable ablation hole forming is carried out; step 5, surface modification treatment; step 6, performance detection and optimization; 7, filter material application and effect evaluation; the nitrate nitrogen diffusion coefficient is increased by 35% and the reaction kinetic constant (k) reaches 0.23 h <-1 > through a three-stage pore system; the Zeta potential (-25mV) on the surface of the micropore promotes the adhesion of bacteria, and the forming time of a biological membrane is shortened by 30%; the solid deposition rate is reduced through the large-hole channel spacing design, and the operation cycle is prolonged to two times of that of a traditional filter material.

The invention discloses an antibacterial fabric for underwear and a preparation method of the antibacterial fabric, and relates to the technical field of textile fabrics. According to the invention, 2-(chloromethyl) 1, 3-butadiene and dodecyl dimethyl tertiary amine are used as reaction raw materials to prepare quaternary ammonium salt, and then the quaternary ammonium salt and vinyl-terminated silicone oil are subjected to a polymerization reaction to generate an organosilicon quaternary ammonium salt antibacterial agent, so that bacterial adhesion can be effectively prevented, and the antibacterial performance of the fabric is enhanced; ethylene glycol and 2, 5-dimercapto terephthalic acid are condensed to obtain sulfydryl-containing polyester fibers, ethylene glycol disodium salt is added to obtain modified polyester fibers, the antibacterial performance of the fabric is improved, meanwhile, the moisture absorption performance of the fabric is improved, and the fabric is easy to dye; soaking the modified polyester fiber into the organosilicon quaternary ammonium salt antibacterial agent mixed solution, performing water treatment, drying, and weaving to obtain the antibacterial fabric for underwear. The prepared antibacterial fabric for underwear has excellent antibacterial, moisture-absorbing and easy-to-dye effects.

The present invention provides a class of compounds that can be used for textile antibacterial treatment, as well as their preparation methods and uses, and belongs to the field of medical material technology. The present invention develops a compound with high photosensitivity, the structure of which is shown in Formula I. The compound has advantages such as good modifiability, good biocompatibility, strong bioadhesion and adsorption capacity, and easy binding to cell membranes. It can effectively adsorb nucleic acids or proteins of bacteria or viruses, and can effectively fight bacteria without light treatment. After light treatment, it has a better antibacterial effect and shows excellent antibacterial effect against both Gram-positive and Gram-negative bacteria. Textiles treated with the compound of the present invention have a certain hydrophobicity, can inhibit bacterial adhesion, exert excellent antibacterial effects, are simple to operate, low cost, and are suitable for antibacterial treatment of various textiles, with broad application prospects.

The invention provides a preparation method and application of a high-flux blood-compatible polyimide separation membrane, polyimide polymer powder is added into a solvent B, a quaternization reagent is added to obtain quaternization polyimide polymer powder, the quaternization polyimide polymer powder is added into a solvent C, and the high-flux blood-compatible polyimide separation membrane is obtained. And scraping the membrane casting solution by using a scraper to prepare an asymmetric separation membrane, and washing to obtain the high-flux blood-compatible polyimide separation membrane. The separation membrane applied to the field of biological water treatment is prepared through chemical imidization condensation reaction and quaternization reaction. The high-flux blood-compatible polyimide separation membrane obtained by the invention has excellent thermal stability, good mechanical properties, protein adsorption resistance, bacterial adhesion resistance, blood compatibility and anticoagulation capability. The method has wide application prospects in the fields of ultrafiltration, hemodialysis, purification, biological sewage treatment and the like.

The present disclosure relates to a method (100) of producing a part (300) for use in a bioprocessing system, the method (100) comprising: manufacturing (110) the part (300) using an additive manufacturing process; and postprocessing (120) a surface of the part (300), wherein the surface is intended to be wetted in use; wherein the postprocessed surface has one or more of the following areal roughness parameter values (e.g. measured in accordance with ISO 25178-2:2022), wherein the one or more areal roughness parameter values are measured for the surface after filtering the surface to remove surface features having long wavelengths (e.g. above about 54 µm): a reduced dale height, Svk, of less than about 5 µm; an arithmetical mean height, Sa, of less than about 2.5 µm; a dale void volume, Vvv, of less than about 0.5 µm3 µm-2; and / or a five-point pit height, S5v, of less than about 15 µm.

The application discloses a straw fiber and lithium residue reinforced bio-solidified feldspar powder roadbed material and a use method thereof, and belongs to the technical field of road materials. The application takes straw fiber, lithium residue, microbial bacteria liquid, mineralizing liquid and feldspar powder as raw materials, combines a microbial induced carbonate precipitation technology, generates a calcium carbonate-calcium sulfate-aluminosilicate ternary system, and cooperatively improves the strength and toughness of the material. CaCO3 fills macroscopic pores, CaSO4 provides an early skeleton, C-S-H gel strengthens a microscopic interface to form a multi-level enhancement, and cracks are caused to be tortuous between heterogeneous interfaces to consume more fracture energy. The added straw fiber plays a synergistic enhancement role in the bio-solidified system, significantly improves the stability of the lithium residue-feldspar powder matrix through a skeleton connecting effect, bacterial adhesion nucleation regulation and multi-scale synergistic enhancement, and thus the strength and toughness of the material are comprehensively improved.

The invention relates to a PPR pipeline with anti-sticking performance and a preparation method of the PPR pipeline, the PPR pipeline comprises an inner-layer anti-sticking antibacterial material and an outer-layer base material, the inner-layer anti-sticking antibacterial material comprises polypropylene random copolymer, anti-sticking antibacterial master batch, PP-g-MAH and an antioxidant 1010; the preparation method of the PPR pipeline comprises the following steps: preparing the composite antibacterial agent, the anti-sticking antibacterial master batch and the inner-layer anti-sticking antibacterial material, and carrying out co-extrusion molding. In order to solve the problems that an existing antibacterial pipeline containing silver ions has dissolution risks, may poison human bodies and cannot guarantee long-term antibacterial effects, and existing other antibacterial pipelines are poor in anti-detail adhesion, polyethylene glycol PEG is adopted to modify zinc oxide ZnO, meanwhile, sulfobetaine methacrylate SBMA is grafted, the polyethylene glycol PEG, the sulfobetaine methacrylate SBMA and the polyethylene glycol PEG and the sulfobetaine methacrylate SBMA are synergistically matched, and the antibacterial effect of the antibacterial pipeline is improved. The antibacterial agent has a safe and long-acting antibacterial effect, has a function of preventing bacterial adhesion, is non-toxic and harmless to human health, can effectively guarantee sanitation and safety of a water supply system for a long time, and meets the high-quality requirements of modern families on healthy water.

The application discloses an antibacterial and anti-adhesion coating, an antibacterial and anti-adhesion coating layer and a preparation method and application thereof, and belongs to the technical field of coatings. The antibacterial and anti-adhesion coating provided by the application has good antibacterial and anti-bacterial adhesion properties by selecting appropriate proportions of raw materials, and the raw materials cooperate with each other, especially the good synergistic effect between the zwitterionic copolymer and the polypyrrole / barium titanate composite particles. The antibacterial and anti-adhesion coating layer prepared by applying the antibacterial and anti-adhesion coating has a long-lasting antifouling effect, can be widely applied to marine structures, and prolongs the service life of the marine structures.

The invention discloses a water purification rare earth antibacterial filter material and a preparation method thereof, and belongs to the technical field of water treatment filter materials. According to the filter material, a lanthanum-based compound is loaded on the surface of a porous carrier framework and the inner wall of a pore channel to form an adsorption layer, and a continuous interface immobilization layer is constructed on the outer side and cerium oxide nanoparticles are immobilized to form an antibacterial layer; and the interface immobilization layer comprises at least one of a catechol-based adhesion polymer and a hydrolyzable organic silicon component, so that the washing resistance retention rate of the nano component is improved. The preparation method comprises the steps of carrier forming, lanthanum salt deposition alkalization, immobilization layer film forming curing and nano cerium oxide dip-coating curing. The filter material can stably remove phosphate and other anion pollutants, inhibit bacterial attachment and biofilm formation, delay blockage and reduce the component falling risk.

The application relates to the technical field of tracheal catheters, and discloses a medical tracheal catheter with double coatings of local anesthetic and antibacterial drugs, which comprises a catheter main body and a cuff main body connected to the outer wall of the catheter main body, the catheter main body comprises a catheter base material layer, a first transition bonding layer, a first nano local anesthetic coating and a first antibacterial coating; the cuff main body comprises a cuff base material layer, a second transition bonding layer, a second nano local anesthetic coating and a second antibacterial coating; a tracheal tube is mounted on the catheter main body; and a head tube is connected to the bottom end of the catheter main body. The first nano local anesthetic coating, the first antibacterial coating, the second nano local anesthetic coating and the second antibacterial coating are arranged, so that the catheter main body and the cuff main body can realize a synergistic protection mechanism of analgesia and antibiosis; during the process of leaving the catheter, the local anesthetic drug acts on the mucosa of the tracheal wall through slow release, and the antibacterial component effectively reduces bacterial adhesion and biofilm formation.

The invention discloses an intelligent glove system based on stretchable bacteria pressure sensors, and relates to the technical field of wearable equipment, the system comprises a power supply, a plurality of bacteria pressure sensors, a PCB circuit board and a glove; wherein each bacteria pressure sensor is arranged in the glove; each bacterial pressure sensor comprises target bacteria and adhesion factors expressed by the target bacteria; the adhesion factor enables the target bacteria to be mutually connected and adhered so as to form an engineering bacteria adhesion material; the PCB comprises a signal acquisition module, a single chip microcomputer and a wireless communication module; the signal acquisition module is used for acquiring a pressure signal of each bacteria pressure sensor; and the single chip microcomputer is used for sending the pressure signal to external equipment through the wireless communication module. The engineering bacterium adhesion material provided by the invention can keep stable electric signal output in both bending and stretching states, and the measurement stability and accuracy of the bacterium pressure sensor in a complex dynamic environment are improved.

The embodiment of the application discloses an acid-responsive oxygen-releasing chitosan / polycaprolactone core-shell microsphere and a preparation method and application thereof. The microsphere comprises an oxygen-releasing inner core taking polycaprolactone and calcium peroxide as base materials, and a pH-responsive outer shell modified by chitosan through N-acetyl-d-glucosamine and loaded with a natural medicine 6-Gin; the microsphere is disintegrated in the outer shell under the gastric acid environment and rapidly releases 6-Gin, and the inner core continuously releases oxygen by reacting with water. The microsphere provided by the application can effectively inhibit bacterial adhesion, destroy a biofilm and directly kill H. pylori, and solves the problem of poor curative effect caused by a microenvironment in traditional therapy, and provides a new effective strategy for anti-H. pylori therapy.

The invention discloses a wound dressing with both strong bacterial adhesion and high liquid absorbency, and relates to the technical field of medical dressings, the wound dressing is prepared from composite yarn, the composite yarn is of a two-layer structure, the two-layer structure of the composite yarn comprises an inner hydrophilic layer and an outer hydrophobic layer, and the inner hydrophilic layer and the outer hydrophobic layer are arranged on the outer hydrophilic layer. The composite yarn is formed by wrapping inner-layer hydrophilic fibers with outer-layer hydrophobic fibers, and an outer-layer hydrophobic layer is made of hydrophobic fiber filaments. The invention has the advantages of higher safety, no addition of any antibacterial substance, no risk, easily available materials, batch production, direct purchase of the used materials, and simple process.

The invention provides natural alcohol modified polyacrylate as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, dissolving acrylic anhydride and 4-dimethylaminopyridine in tetrahydrofuran; adding menthol into the solution to carry out esterification reaction; sequentially adding acrylic acid and ammonium persulfate to carry out polymerization reaction; after the reaction liquid is cooled, sequentially adding N, N-dicyclohexylcarbodiimide and 4-dimethylaminopyridine, and then adding geraniol to carry out esterification reaction; and finally, carrying out filtration, rotary evaporation, extraction and dialysis to obtain the natural alcohol modified polyacrylate. The natural alcohol modified polyacrylate disclosed by the invention has high antibacterial activity and excellent bacterial adhesion resistance; the preparation method is simple, convenient to operate, good in controllability, low in treatment equipment requirement and beneficial to industrial production; the natural fiber fabric can be endowed with good antibacterial property, bacterial adhesion resistance and durability, and has a wide application prospect.

The present invention relates to super-hydrophobic functional paper and food packaging technology field, and more particularly to a kind of preparation method and application of antibacterial adhesion super-double sparse antibacterial paper. The method includes: (1) nano-silicon dioxide particles are added in the mixed solution of absolute ethanol and ammonia, dispersed by ultrasonic dispersion instrument, and suspension is obtained; (2) the suspension obtained by step (1) is stirred at high speed, and 1H, 1H, 2H, 2H-perfluorodecyl triethoxysilane and tetraethyl silicate are added, and reacted at room temperature; (3) polyvinylidene fluoride is added to the suspension obtained by step (2) in proportion; (4) the suspension obtained by step (3) is added in spray gun spray pot, in 200KPa N2 atmosphere, sprayed on paper; (5) the paper obtained by step (4) is thoroughly dried, to obtain final product. The antibacterial adhesion super-double sparse antibacterial paper has excellent super-double sparse surface, compared with existing wrapping paper, has higher sterilization efficiency, acid and alkali corrosion resistance, is not easily contaminated and anti-ultraviolet radiation aging performance.

The present invention discloses a PET-biowax-SiO2 hydrophobic antibacterial electrospun food packaging film and a preparation method and application thereof. The preparation method comprises the following steps: preparing biowax@SiO2 super-hydrophobic powder, dissolving PET in a solvent b to obtain a PET spinning solution, adding the biowax@SiO2 super-hydrophobic powder and an antibacterial agent to the PET spinning solution, sealing and stirring at room temperature to form a uniform, stable, transparent solution, and utilizing electrostatic spinning technology to obtain the PET-biowax-SiO2 hydrophobic antibacterial electrospun food packaging film. The prepared electrospun film has high hydrophobicity, can prevent bacterial adhesion and growth, has anti-adhesion function and high antibacterial property; and has a porous structure and adjustable pore size characteristics, can be suitable for packaging various active foods such as fruits and vegetables that require breathability, and provides a valuable method and idea for the fresh-keeping storage of active foods such as fruits and vegetables that continue to respire after harvest.

The invention discloses an esterase response type nanogel modified bioprosthetic valve as well as a preparation method and application thereof, and belongs to the technical field of bioprosthetic valves. According to the invention, the problem of how to consider the infection resistance, biocompatibility and high surface modification rate of the bioprosthetic valve is solved. The preparation method comprises the following steps: synthesizing an esterase response monomer by taking methacrylate containing an ester bond and an antibiotic drug as raw materials, then synthesizing esterase response type nanogel, and then connecting the esterase response type nanogel to the surface of a bioprosthetic valve; under a pathological environment with relatively high esterase concentration, ester bond groups are decomposed, and antibiotic drugs are released in situ at fixed points, so that infection caused by bacteria is treated, inflammatory cell infiltration is reduced, and anti-infection and anti-inflammatory performance of the bioprosthetic valve is improved; in addition, the nanogel contains a large number of hydrophilic groups, a hydration layer is formed on the surface of the bioprosthetic valve, the risk of thrombus and blood coagulation can be effectively reduced, and bacterial adhesion is resisted. The prepared bioprosthetic valve has excellent anti-infection, anti-coagulation and anti-calcification capabilities and stability.