Antibacterial hydrogel with sterilization, low bacterial adhesion and bacterial release, and preparation method and application thereof

A bacterial adhesion and hydrogel technology, applied in medical science, bandages, etc., can solve the problems of unsuitable for large-scale industrial production and application, poor biocompatibility of hydrogel, poor biocompatibility, etc., and achieve excellent biophase Compatibility, high biocompatibility, low cost effect
CN110330658AActive Publication Date: 2019-10-15ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2019-10-15

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Abstract

The invention belongs to the field of hydrogels, and particularly discloses a preparation method of an antibacterial hydrogel with sterilization, low bacterial adhesion and bacterial release, the method comprises the following steps: 1) mixing a response monomer and an epoxy monomer, and carrying out a free radical copolymerization reaction to obtain an epoxy group-containing response polymer; 2)mixing and dissolving the epoxy group-containing responsive polymer and an epoxy group-containing hydrophilic polymer in a solvent, and adding an amino group-containing bactericide to carry out epoxyring opening reaction to obtain the antibacterial hydrogel. The invention also discloses the antibacterial hydrogel with sterilization, low bacterial adhesion and bacterial release prepared by the preparation method and application thereof in wound dressing. The preparation process of the method is simple and efficient, the obtained hydrogel has comprehensive functions and good biocompatibility, has wide research prospects in the fields of biomedicine and tissue engineering, and provides a new idea for the preparation of functional materials.
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Description

technical field

[0001] The invention belongs to the field of hydrogels, and in particular relates to an antibacterial hydrogel with sterilization, low bacterial adhesion and bacterial release, a preparation method and application thereof. Background technique

[0002] Bacteria widely exist in nature, and the attachment and reproduction of some bacteria seriously threaten human health and normal life. According to statistics, about 60-70% of nosocomial infections are related to biological material-related infections. It is of great significance to human health to resist the attachment and proliferation of bacteria by constructing antibacterial surfaces. At present, antibacterial methods are mainly divided into three categories, namely, sterilization, anti-bacterial adhesion and bacterial release, and are gradually developing into multi-functional antibacterial methods.

[0003] Hydrogels have broad application prospects in the field of wound dressings due to their inherent ...

Claims

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