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Preparation method of novel hydrogel with low bacterial adhesion and sterilization and regenerable functions

A technology of bacterial adhesion and hydrogel, which is applied in the field of preparation of new hydrogels, can solve the problems of high cost and poor antibacterial effect, achieve effective controllable length, improve antibacterial efficiency, and achieve renewable effects

Active Publication Date: 2018-04-03
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing functional hydrogels are mainly researched on intelligent characteristics such as antibacterial and multi-responsiveness, and there is no anti-killing and renewable hydrogel available.
In practical applications, there are also some bottlenecks: for example, choosing polypeptides and proteins as gel-forming elements is expensive; selecting traditional antibacterial materials, such as antibiotics and quaternary ammonium salts, will lead to poor antibacterial effects

Method used

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  • Preparation method of novel hydrogel with low bacterial adhesion and sterilization and regenerable functions
  • Preparation method of novel hydrogel with low bacterial adhesion and sterilization and regenerable functions
  • Preparation method of novel hydrogel with low bacterial adhesion and sterilization and regenerable functions

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Example 1: Take a 50 mL beaker, add 1 g HEAA, 0.040 g AIBA, and 0.75 g deionized water in sequence, and after stirring until fully dissolved, transfer the solution to a spare mold, and use a wavelength of 365 nm UV irradiation for 60min to obtain the hydrogel matrix. Take 2 g of the above UV-synthesized hydrogel, add 1.50 g of EDCI, 1.10 g of DMAP, 10 mL of water, and 1.30 g of 3-bromopropionic acid, and stir at room temperature for 24 h to obtain an esterification-treated hydrogel matrix. Take 2 g of the esterified hydrogel (ATRP initiator) after the above treatment, add 0.50 g DVBAPS, 1.25 mL TFE, 2 mL ultrapure water, 6.5 μL Me 6 TREN, 10 mg CuBr, after multiple vacuum pumping-N 2 After cycling, the system was reacted at 25 °C for 24 h. Finally, the above-mentioned grafted hydrogel was placed in AgNO at a concentration of 0.01 mol / L 3 solution, soaked for 24 h, and irradiated with UV light for 30 min to obtain the functional hydrogel, as figure 2 shown.

Embodiment 2

[0028] Example 2: Take a 50 mL beaker, add 1.1 g HEMA, 0.11 g 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, and 0.78 g ultrapure water to it successively, and wait After stirring until fully dissolved, the solution was transferred to a spare mold and irradiated with UV light with a wavelength of 365 nm for 30 min to obtain a hydrogel matrix. Take 2 g of the above UV-synthesized hydrogel, add 1 g of 3-chloropropionic acid, 1.32 g of DCC, 0.68 g of HOBT, and 8 mL of water, and stir at room temperature for 24 h to obtain an esterification-treated hydrogel matrix. Take 2 g of the above esterified hydrogel (ATRP initiator), add 0.50 g of SVBP, 1.8 mL of LTFE, 1 mL of ultrapure water, 6.2 μL of Me 6 TREN, 8 mg CuCl, after multiple vacuum pumping-N 2 After cycling, the system was reacted at 25 °C for 24 h. Finally, the above-mentioned grafted hydrogel was placed in AgNO with a concentration of 0.001 mol / L 3 solution, soaked for 18 h, and irradiated with UV light for 30 min...

Embodiment 3

[0029]Example 3: Take a 50 mL beaker, add 1.3 g HEMA, 0.032 g 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone, and 0.73 g deionized water to it successively, and wait After stirring until fully dissolved, the solution was transferred to a spare mold, and irradiated with UV light with a wavelength of 365 nm for 120 min to obtain a hydrogel matrix. Take 2 g of the above-mentioned UV-synthesized hydrogel, add 1.21 g of 3-bromopropionic acid, 1.32 g of EDCI, 1.04 g of DMAP, and 9 mL of water, and stir at room temperature for 12 h to obtain an esterification-treated hydrogel matrix. Take 2 g of the above esterified hydrogel (ATRP initiator), add 0.50 g VBIPS, 1.34 mL TFE, 2.5 mL ultrapure water, 9 mg CuBr, 5.8 μL Me 6 TREN, after multiple vacuum pumping - through N 2 After cycling, the system was reacted at 25 °C for 36 h. Finally, the above-mentioned grafted hydrogel was placed in AgNO at a concentration of 0.05 mol / L 3 solution, soaked for 6 h, and irradiated with UV ligh...

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Abstract

The invention discloses a preparation method of novel renewable hydrogel with low bacterial adhesion and sterilization and regenerable functions and belongs to the technical field of hydrogel preparation. The preparation method specifically comprises steps as follows: 1) a UV polymerization reaction; 2) an esterification reaction; 3) an ATRP reaction; 4) a sliver-supporting reaction. The preparation method is simple and feasible, a polymerization method guarantees the effectiveness and controllability of the length of a functional polymer brush, and the long-time antibacterial effect is realized through slow release of silver ions. The product has a remarkable inhibition effect on escherichia coli and staphylococcus aureus; compared with an antibacterial product containing single components in the prior art, the product has greatly improved antibacterial efficiency. Besides, through the environmental responsibility of the functional polymer brush, shrinkage and extension of the polymerbrush due to the outside environment are changed, desorption of dead bacteria is further driven, and the regenerable antibacterial property of the hydrogel is realized.

Description

technical field [0001] The invention relates to the technical field of hydrogel preparation, in particular to a preparation method of a novel hydrogel with low bacterial adhesion, sterilization and regeneration. Background technique [0002] Bacteria are potential killers that endanger public health. How to effectively control and prevent their growth and spread is an important challenge facing society today. The premise of bacterial infection is that bacteria adhere to the material surface, so the most critical step in antibacterial is to prevent bacteria from adhering to the material surface, but anti-adhesion materials cannot completely and permanently prevent bacteria from adhering, that is, over time , a certain amount of bacteria will still be adsorbed on the surface of the material. Therefore, it is of vital importance to simultaneously introduce components with bactericidal or bacteriostatic properties to form dual antibacterial materials. [0003] As a polymer "so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08F293/00C08F212/14C08F120/58C08F120/20C08F120/38C08K3/08C08L53/00
CPCC08F120/20C08F120/38C08F120/58C08F212/14C08F293/005C08J3/075C08J2353/00C08K3/08C08K2003/0806C08L53/00
Inventor 杨晋涛张冬孙莉吴家慧陈枫范萍钟明强
Owner ZHEJIANG UNIV OF TECH
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