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Modified keratin material as well as preparation method and application thereof

A keratin material and keratin technology, which are applied in the field of biomedical materials, can solve the problems of irreversible cross-linking reaction, large structural damage, lack of selectivity, etc., and achieve enhanced chemical stability, increased degree of cross-linking, and simple preparation method. Effect

Inactive Publication Date: 2013-09-04
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve problems such as large structural damage, irreversible cross-linking reaction, lack of selectivity and easy degradation in the existing keratin molecular modification effect , to provide a modified keratin material that is difficult to degrade and whose degree of degradation can be adjusted within a certain range

Method used

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  • Modified keratin material as well as preparation method and application thereof
  • Modified keratin material as well as preparation method and application thereof
  • Modified keratin material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Take human hair, wash it with surfactant, rinse it repeatedly with deionized water, and dry it in an oven at 80°C.

[0045] (2) Put it into a Soxhlet extractor, degrease with a 1:1 mixed solvent of ethanol and ether for 6 hours, rinse and dry repeatedly with deionized water for later use.

[0046] (3) Soak the human hair after washing and degreasing in a mixed solution of 30% hydrogen peroxide and concentrated ammonia water (volume ratio 3:1), and keep it at room temperature for 1 hour to completely depigment the human hair. Then wash and dry.

[0047] (4) Prepare a solution of 0.2 mol / L thioglycolic acid and 6 mol / L guanidine hydrochloride. Human hair samples after degreasing treatment were soaked in the extraction solution according to the mass ratio of 1:100, soaked at room temperature for 2 hours, and reacted at 50°C for 12 hours.

[0048] (5) The extract is filtered and centrifuged, and the filtrate is dialyzed against water for about 36 hours through a dialy...

Embodiment 2

[0055] (1) Take human hair, soak it in washing powder, rinse it repeatedly with deionized water, and dry it in an oven at 80°C.

[0056] (2) Put it into a distillation flask, add chloroform 10 times the mass of human hair, reflux extraction, degrease for 4 hours, separate the chloroform, add 10 times the mass of acetone, stir at room temperature for 1 hour, filter out the acetone, and use deionized water to send the sample Rinse and dry repeatedly.

[0057] (3) Human hair after degreasing and washing is soaked in 30% hydrogen peroxide, and kept at room temperature for 3 hours to completely depigment human hair. Then wash and dry.

[0058] (4) Prepare a solution of 0.5 mol / L mercaptoethanol and 8 mol / l guanidine hydrochloride.

[0059] (5) Human hair samples after degreasing treatment were soaked in the extraction solution according to the mass ratio of 1:100, soaked at room temperature for 2 hours, and reacted at 60°C for 12 hours.

[0060] (6) After the extract is filtered...

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Abstract

The invention discloses a modified keratin material as well as a preparation method and application thereof. The modified keratin material provided by the invention has a structural formula shown in a formula (I) in the specification. The invention further provides the preparation method of the modified keratin material. The modified keratin material provided by the invention is degradable or degraded slowly after being implanted inside a human body, and the degradation degree of the modified keratin material can be regulated by controlling preparation process parameters. The prepared modified keratin material can be applied to hemostasis materials, hydrogel, wound dressing, and soft tissue fillers and the like, and can also be used as a support material for building a tissue engineered tissue.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a modified keratin material and its preparation method and application. Background technique [0002] At present, the research on keratin at home and abroad mainly focuses on the extraction technology and performance research, and seldom involves the modification of keratin materials. [0003] In general, the disulfide bonds in keratin molecules make the peptide chains and peptide chains cross-linked to form a three-dimensional network structure, which makes natural keratin difficult to dissolve and brings great benefits to the extraction, processing and application of keratin in hair. come difficult. To obtain keratin with higher molecular weight and better solubility, it can only be achieved by selectively opening disulfide bonds and destroying hydrogen bonds. At present, the methods for extracting keratin generally include mechanical methods, chemical methods ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K1/113
Inventor 谢德明
Owner JINAN UNIVERSITY
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