112results about How to "Improve resistance to degradation" patented technology

The invention relates to an injectable crosslinked hyaluronic acid gel and a preparation method thereof. The injectable crosslinked hyaluronic acid gel is prepared by blending hyaluronic acid gel granules and chlorinated sodium phosphate physiological buffer solution; the hyaluronic acid gel granules are prepared by comprising the steps of crosslinking treatment, emulsion crosslinking granulation, purification and drying and swelling, filling and sterilization technologies. The hyaluronic acid gel granules are uniform in granule size, the residual of the crosslinking agent is less than 0.2ppm, the injection pushing is proper, and the in-vivo degradation time can last more than 8-12 months. The implant has an excellent esthetical restoration effect, is applicable to being injected to and subcutaneous dermis deep layer to subcutaneous superficial layer, restoration of moderate to severe wrinkles or folds, and can satisfy the restoration demand of wrinkles or folds caused due to skin aging.

The invention relates to the spike protein from the virus (SARS-CoV) that is etiologically linked to severe acute respiratory syndrome (SARS); polypeptides and peptide fragments of the spike protein; nucleic acid segments and constructs that encode the spike protein, polypeptides and peptide fragments of the spike protein, and coupled proteins that include the spike protein or a portion thereof; peptidomimetics; vaccines; methods for vaccination and treatment of severe acute respiratory syndrome; antibodies; aptamers; and kits containing immunological compositions, or antibodies (or aptamers) that bind to the spike protein.

Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I:where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group covalently bound to a reactive group of at least one of the amino acid residues or surrogates, pharmaceutical compositions including such linear constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.

The invention discloses an organic amine compound absorbent for removal of carbon dioxide in fire coal flue gas; the organic amine compound absorbent comprises the following components: by mass, 10%-45% of a main absorbent component, 0-10% of an assistant absorbent component, 0.01%-6% of a corrosion inhibitor, 0.01-3% of an antioxidant, 0-5% of a defoaming agent and the balance of water; wherein the main absorbent component comprises the following components: account for the total mass percentage of the organic amine composite absorbent, 3%-20% of monoethanolamine MEA, 0-12% of 2-amino-2-methyl-1-propanol AMP, 1%-15% of sun of piperazine PZ and N-aminoethyl piperazine AEP and 1%-12% of sum of aminoethyl ethanolamine AEEA and N-methyl monoethanolamine MMEA; and the assistant absorbent comprises one or a plurality of component selected from the group comprising diethanol amine DEA, diethylenetriamine DETA, triethylene tetramine TETA, N-methyldiethanolamine MDEA, sulfolane and tertbutylaminoethoxyethanol TBEE. The organic amine compound absorbent has the advantages of good stability, large absorption capacity, high purification degree, low regeneration energy consumption, good desorption effect, great reduction of degradation loss of the compound absorbent in the process of using, and the like.

The invention discloses a method for simultaneously treating multiple kinds of biological tissue. The method includes the steps of pretreating, degreasing, cell extraction, crosslinking and sterilization. The method for simultaneously treating the multiple kinds of biological tissue can simultaneously treat the multiple kinds of biological tissue, the batch-treated biological tissue amount is large, the treatment degree is uniform, the process is simple, industrialization is easy, and efficient production is achieved. According to the method for simultaneously treating the multiple kinds of biological tissue, use of strong acid, strong base and protease is completely avoided, natural three-dimensional collagen support fiber structures of extracellular matrixes of the multiple kinds of biological tissue can be reserved, and cell components, causing immunogenicity, in the tissue are removed. The biological tissue prepared through the method has good bio-compatibility and mechanical performance, compared with natural biological tissue, high degradation resistance is achieved, and the biological tissue can be used for repairing various kinds of soft tissue injuries.

A method for modifying wood includes steps of impregnating the wood followed by curing the wood at temperatures between 70 and 200° C. The impregnation composition includes di-, tri-, and / or polysubstituted furan compounds.

An aromatic carbonate polymer composition having improved thermal stability consisting of an aromatic carbonate polymer such as a polycarbonate or polycarbonate / polyester blend and an impact modifier which is free of alkali materials which catalytically degrade a polycarbonate. Also an impact modifier which is preferably of a shell-core structure prepared by the emulsion polymerization process and has a pH of about 3 to about 8. A preferred emulsifier is an alkyl sulfonate having an alkyl group of C6-C18 carbons.

The invention discloses a preparation method of an epoxy non-isocyanate polyurethane heavy anti-corrosion coating comprising a component A and a component B. The component A is a mixture of a cyclic-carbonate-terminated compound and an epoxy-terminated compound; the component B is amine-terminated polyether which is one or a mixture of amine-terminated polyether D-230, D-400 and T-403; and the mass ratio of the component A to the component B is (2.1-1):1. The components A and B of the epoxy non-isocyanate polyurethane heavy anti-corrosion coating are stored independently, and the shelf life of the components A and B is longer than half a year at a room temperature; the usage period of the mixture of the components A and B is longer than 1 hour; and after the coating is solidified for half a hour at 100 DEG C, the peeling strength of the coating can reach a maximum value of 40%, or after the coating is solidified for 7 days at a room temperature, the peeling strength of the coating can reach the maximum value.

The invention discloses a macromolecule cross-linking agent based on oxidized cellulose, a gelatin film thereof and a preparation method. The preparation method of the gelatin film comprises the following steps: 1, oxidizing a primary amino group on the C6 position of cellulose into carboxyl through a TEMPO / NaBr / NaClO system, and obtaining oxidized cellulose TOMCC; 2, treating N-hydroxy succinimide and TOMCC obtained in step 1 as raw materials, and manufacturing a macromolecule cross-linking agent TMN; 3, making the macromolecule cross-linking agent TMN be subjected to chemical cross-linking with a gelatin film, and obtaining the food package gelatin film based on oxidized cellulose chemical cross-linking. Light-blocking performance, thermal stability, anti-biodegradation capability, the mechanical property (elasticity) and hydrophobicity of the gelatin film are all improved to a large extent, and a favorable condition is provided for application of the gelatin film to the food package field. In addition, biodegradation mechanisms of a modified gelatin film and a pure gelatin film in a phosphate buffered solution (PBS) and lysozyme are explored and analyzed as well.

The invention relates to the proton exchange membrane which is used for the fuel cell; put concretely it is an multi layered anti-alcohol compound membrane for anti- degenerating the fuel cell; is compound a layer Nafion proton exchange membrane which includes H2O2 decomposition catalyst on the altogether amixing hydrocarbon compound proton exchange membrane side or two sides. Its preparation method is, Nafion alcohol solution with the same volume high boiling point solvent, sets in the flask to reduce pressure distillation, removes alcohol, prepares the Nafion-high boiling point solvent solution, joins the H2O2 decomposition catalyst, the super-sonic surges 30 minutes, match the solution with H2O2 decomposition catalyst / (H2O2 decomposition catalyst +Nafion) load ratio is 1-10%, the solution compound altogether mixing hydrocarbon compound proton exchange membrane side or two sides, after treats solvent volatility, puts in the vacuum drying oven, under 120-160 degree centigrade, handing 2-8 hours, namely obtains the multilayered anti- mellow compound membrane which is used for anti- degeneration fuel cell. The multi layered anti-alcohol compound membrane for anti- degenerating the fuel cell in the invention has good anti-alcohol performance, high conductivity, the high anti-degeneration ability, good mechanics machine capability,the low cost and so on characteristic.

The invention relates to the spike protein from the virus (SARS-CoV) that is etiologically linked to severe acute respiratory syndrome (SARS); polypeptides and peptide fragments of the spike protein; nucleic acid segments and constructs that encode the spike protein, polypeptides and peptide fragments of the spike protein, and coupled proteins that include the spike protein or a portion thereof; peptidomimetics; vaccines; methods for vaccination and treatment of severe acute respiratory syndrome; antibodies; aptamers; and kits containing immunological compositions, or antibodies (or aptamers) that bind to the spike protein.

The invention discloses a cellulose based macromolecular cross-linking agent, a preparation method thereof and an application of the cellulose based macromolecular cross-linking agent in preparation of modified gelatin, and belongs to the field of gelatin cross-linking agents. The preparation method of the cross-linking agent comprises steps as follows: 1), EDTA (ethylene diamine tetraacetic acid) dianhydride and microcrystalline cellulose are taken as raw materials to prepare EDTA dianhydride functionalized microcrystalline cellulose ME; 2), N- hydroxysuccinimide and ME obtained in the step 1) are taken as raw materials to prepare the macromolecular cross-linking agent. The ester group in the cross-linking agent can have a cross-linking reaction with primary amino in gelatin, a gelatin film is modified in a chemical reaction manner, and the limitation of gelatin modification through cellulose macromolecule blending in the prior art is broken. The heat stability, the degradation resistance, the mechanical property (elasticity), the light blocking performance and the hydrophobicity of the gelatin film are improved to a greater degree.

The invention discloses a method for preparing high-strength alginate fiber. The method mainly includes the following steps that a sodium alginate solution with the mass concentration being 3-12% is prepared and divided into two parts according to the volume ratio of 1:3 to 1:5, and nano calcium carbonate is added into one part; then the other part of the sodium alginate solution is added and evenly stirred, and a spinning solution is prepared; the obtained spinning solution is filtered and quickly defoamed, wet spinning is conducted with calcium chloride as coagulating bath, and nano nascent fiber is obtained; then, the nascent fiber is soaked in deionized water for 24-72 h, and then aftertreatment is conducted to obtain the high-strength alginate fiber. By introducing nano calcium carbonate into the sodium alginate solution and using the principle that interaction adsorption and interface free volume of nanoparticles is increased, viscosity of the spinning solution of the alginate fiber is effectively reduced, spinnability of the fiber is improved, the process is simple and easy to control, and the spun fiber is high in strength and good in degradation resistance.

A fuel cell includes an anode, a cathode, and an ion conducting membrane interposed between the anode and cathode. The ion conducting membrane includes a base layer that has an ion conducting polymer and additive layer that has a metal supported on an oxide support, the oxide support scavenging hydroxyl radicals formed during fuel cell operation.

The invention discloses an epoxy non-isocyanate polyurethane heavy anti-corrosion coating comprising a component A and a component B. The component A is a mixture of a cyclic-carbonate-terminated compound and an epoxy-terminated compound; the component B is amine-terminated polyether which is one or a mixture of amine-terminated polyether D-230, D-400 and T-403; and the mass ratio of the component A to the component B is (2.1-1):1. The components A and B of the epoxy non-isocyanate polyurethane heavy anti-corrosion coating are stored independently, and the shelf life of the components A and B is longer than half a year at a room temperature; the usage period of the mixture of the components A and B is longer than 1 hour; and after the coating is solidified for half a hour at 100 DEG C, the peeling strength of the coating can reach a maximum value of 40%, or after the coating is solidified for 7 days at a room temperature, the peeling strength of the coating can reach the maximum value.

The invention discloses recombinant human-like elastin and a composition thereof. The recombinant human-like elastin is formed through series connection of short repeat amino acid sequences, wherein the short repeat amino acid sequences are target protein polypeptide sequences which are formed through 3-7 times of tandem repeat of (VAPGVG)3S, and the target protein polypeptide sequences are shownin SEQ No. 1. The recombinant human-like elastin which is obtained through in vitro expression of a prokaryotic expression system has high activity for removal of superoxide radicals. Good resistanceto degradation is still maintained through a small number of tandem repeat of the active peptide fragments, and the catalytic activity can be kept longer than the catalytic activity of a single original fragment; and the service cycle of the recombinant human-like elastin can be improved significantly through assistance of a selected protective agent.

Compositions for transient but prolonged exogenous mRNA expression through the use of the transcription system of negative strand RNA viruses, and methods of use thereof are disclosed. In some embodiments, the system contains only RNAs and does not include any DNA molecules. The compositions typically include an RNA template unit (rTeUn) that includes a virus regulatory sequences operably linked to a coding sequence of interest. The rTeUn is typically transfected to a host cell's cytoplasm in the presence of virus expression system proteins that mediate replication of the rTeUn and transcription of the transgene. The rTeUn RNA bonded to viral proteins exhibits high resistance to degradation, prolonged duration of expression, and is free of viral genes. The compositions can be used to reprogram cell. For example, the compositions and methods can be used to redirected lymphocytes to target cancer cells, or to dedifferentiate somatic cells into induce pluripotent stem cells.

The invention discloses a biological magnesium alloy containing rich LPSO structures and a preparing method of the biological magnesium alloy. The biological magnesium alloy is obtained in the mannerthat manganese is alloyed to a magnesium alloy with the LPSO structures through an SLM technology, on one hand, the magnesium alloy stacking fault energy is reduced through the manganese element, andintermetallic compound precipitation is reduced while the number of the LPSO structures is increased; and on the other hand, the alloy supercooling degree is increased through the manganese element, grains and the LPSO structures are refined, and the magnesium alloy with the rich, fine and evenly-distributed LPSO structures is obtained. A base body is full of the formed LPSO structures in a parallel lamellar manner, a dense degraded product is formed through preferable degrading, the magnesium base body is protected, and accordingly the degrading resistance of the magnesium alloy is greatly improved.

The invention discloses a polyglycolic-acid-orientation nanometer fiber bundle and a preparing method thereof. The fiber bundle is formed by polyglycolic acid nanometer fibers wrapped with a polylactic acid-hydroxyacetic acid copolymer. According to the preparing method, the molecular weight, the optical isomer content and the mixing ratio of polylactic acid and polyglycolic acid are preferred, and polylactic acid / polyglycolic acid blend fibers are produced at the suitable spinning temperature and the spinning speed. Under the specific conditions such as the preferred raw material components and sufficiently-strong stretch flow fields, the polyglycolic acid nanometer fibers (the average diameter is 50 nanometers to 200 nanometers) are in-situ formed in the forming process of the polylacticacid / polyglycolic acid blend fibers. The directional-arrangement polyglycolic-acid-orientation nanometer fiber bundle has excellent heat resistance, can keep the stability of the size and the orientation structure at the temperature of being higher than 120 DEG C, and has good degradability resistance, and a performance bottleneck that a conventional polyglycolic-acid nanometer fiber bundle is easy to disorientate and easy to degrade is broken through.

The invention discloses sulfhydrylated hyaluronic acid polysaccharide hydrogel as well as a preparation method and application thereof. The sulfhydrylated hyaluronic acid polysaccharide hydrogel is polysaccharide hydrogel formed by one or two of sulfhydrylated hyaluronic acid derivatives and an aqueous solvent, wherein the mass percent concentration of the sulfhydrylated hyaluronic acid derivatives is 3-6%, and the sulfhydryl substitution degree of the sulfhydrylated hyaluronic acid derivatives is 3-20%. According to the prepared sulfhydrylated hyaluronic acid polysaccharide hydrogel, by means of grafting hydroxyl and carboxyl of hyaluronic acid with side chain groups, and controlling the moderate sulfydryl substitution degree, the intermolecular and intramolecular supporting performance of the sulfhydrylated hyaluronic acid polysaccharide hydrogel is improved, the flexibility of the hydrogel can be improved, good rebound resilience can be kept, the gel form is kept, and the performance requirements of the vitreous body substitute are met. As a vitreous body substitute, the hydrogel provided by the invention can improve the damping function, and the good self-healing function and rebound resilience can keep the eyeball shape and press the retina in place.

The invention discloses a method for preparing a comb-shaped polymer solid-solid phase change material. The method comprises the following processes of: dissolving 1-3 kinds of 1-n-alkanols into 2-4-times of the 1-n-alkanols of solvent uniformly, adding one of diisocyanates with the same mole number as the 1-n-alkanols at the speed of 1-50mL / min, and reacting for 2-4 hours in a solvent of 30-90 DEG C under stirring to form a prepolymer solution; dissolving dried polyvinyl alcohol into the solvent, adding a dibutyltin dilaurate catalyst -assisted 0.01-1 percent of the mass of the polyvinyl alcohol, and adding the prepolymer solution at the speed of 5-50mL / min, wherein the molar ratio of the prepolymer to the polyvinyl alcohol is 1,000:1-2,500:1; and controlling the reaction temperature at a temperature 30-90 DEG C, reacting for 6-12 hours under stirring, then washing the obtained product, and drying the product to obtain the comb-shaped polymer solid-solid phase change material.

An adhesion preventive membrane including a nonwoven fabric layer of collagen fibers, having on a surface thereof a coating layer containing a mixture of collagen and hyaluronic acid, or a method of producing a continuous collagen single strand, wherein a strand-like collagen is dehydrated / coagulated in a hydrophilic organic solvent having a water content of about 10% or less and then dried under conditions of a relative humidity of about 50% or less and a temperature of about 42° C. or less. A collagen nonwoven fabric of first and second layers composed of a plurality of collagen strand-like materials spun out of a solubilized collagen solution, and arranged in parallel, the first and second layers being laminated and bonded to each other so that directions of arrangements of the strand-like materials of the first and the second layers are at an angle therebetween.

The invention discloses a medical magnesium alloy with uniform controllable degradation performance and a preparation method thereof. The magnesium alloy is composed of a ZK30 matrix and long-period stacking ordered structures uniformly distributed in ZK30 grains. The method comprises the preparation steps that Gd powder and ZK30 powder are subjected to ball-milling under protective atmosphere, uniformly dispersed mixed powder is obtained, and then the magnesium alloy with the LPSO structures is prepared through laser selective melting. By adopting a laser selective melting process, rapid melting and rapid solidifying can be achieved, on the one hand, matrix grains and the LPSO structures are greatly refined, on the other hand, the solid solubility of solute elements is improved, and precipitation of intermetallic compounds is avoided; the formed LPSO structures are in the form of parallel layers and are evenly distributed in the matrix grains, the directions of the LPSO structures aredifferent in the different grains, and thus expansion of the degradation process to the adjacent grains can be effectively hindered; and meanwhile, the LPSO structures are used as an unstable secondphase and are preferentially degraded, compact degraded products are formed, and the magnesium matrix is further protected.

The invention discloses a super-hydrophilic and biodegradable oil-water separation membrane and a preparation method thereof. A nanofiber membrane is prepared from polyglycolic acid nanofiber with a surface wrapped by a polylactic acid-glycolic acid copolymer. According to the method, polylactic acid / polyglycolic acid blend fiber is produced at a proper spinning temperature and spinning speed through preferably choosing the molecular weights of the polylactic acid and the polyglycolic acid as well as the content and mixed proportion of optical isomers. In specific conditions such as above preferential raw material ingredients and strong enough elongation flow fields, polyglycolic acid nanofiber is in situ formed in the molding process of the polylactic acid / polyglycolic acid blend fiber. The nanofiber is in situ generated in the process of melt spinning at a relatively high speed, not only are the shapes and sizes uniform, but also the degree of orientation and the degree of crystallinity are relatively high, meanwhile, the surface of the nanofiber is coated with the polylactic acid-glycolic acid copolymer, which is in situ formed through ester exchange, and the super-hydrophilic performance and degradation resistance of the oil-water separation membrane are obviously superior to the super-hydrophilic performance and degradation resistance of common polyglycolic acid nanofiber.

The invention discloses a preparation method of a multi-copolymerized high salt tolerant acrylic resin. Specifically, 99.98% high purity acrylic acid, 2-acrylamido-2-methylpropanesulfonic acid, potassium carbonate, starch, and acrylamide are adopted as raw materials, ammonium peroxydisulfate and sodium bisulfate are taken as redox initiators, and N, N-methylene-bisacrylamide is employed as a crosslinking agent to synthesize the multi-copolymerized high salt tolerant acrylic resin. By adding multielement components, an advanced level of the product is achieved, and fast absorption of multi-salt components is realized. The structural strength of the product is reinforced. Manual labor is substantially reduced, automatic operation of the product is realized, and the product stability is ensured. The anti-degradation property of the product is prolonged, thus being more conducive to the health and environmental protection of consumers during use of the product.

The invention discloses a preparation method of a comb-type polymer phase change energy storage material. The preparation method comprises the following steps: firstly, dissolving polymers such as dried poval and the like in a solvent the amount of which is 2-4 times that of the polymers, and then carrying out metallization reaction on the mixture and one of calcium hydride, sodium hydride, potassium hydride, sodium methoxide, sodium ethoxide, potassium methoxide or potassium ethoxide; stirring and reacting for 1-4 hours in the solvent at the temperature of 30-60 DEG C so as to obtain a polymer metalized product with an active group; adding at leas one of 1-halognated n-alkanes, wherein the molar ratio of the 1-halognated n-alkane to the polymers such as poval and the like is (0.1:1)-(6:1), and the adding speed is controlled at 1-10mL / min; adding a catalyst the weight of which is 0.01-1% of that of the polymers such as poval and the like; and stirring and carrying out grafting reaction for 4-12 hours in the solvent at the temperature of 30-90 DEG C; and washing the obtained product for impurity removal and drying, so as to obtain the comb-type polymer phase change energy storage material.

The invention discloses a preparation method of high-quality cross-linked sodium hyaluronate gel. The preparation method comprises the following steps: 1) dissolving sodium hyaluronate dry powder intoa sodium hydroxide solution; adding 1,4-butanediol diepoxy ether which accounts for 0.01 to 0.05 percent of the weight of the sodium hyaluronate dry powder; preserving heat at 35 to 50 DEG C for 5 to8h to obtain gel X; 2) pressing the gel X for 1 to 3min under the pressure of 500 to 1000MPa; 3) regulating the pH (Potential of Hydrogen) value of the pressed gel X to be neutral; adding a phosphatebuffering solution and swelling for 18 to 36h; 4) cooling the swollen gel X to -4 DEG C and carrying out heat-preservation treatment for 1 to 3h to obtain the sodium hyaluronate gel. The cross-linkedsodium hyaluronate gel has a relatively stable net-shaped structure, and can be used for effectively improving the degradation resistance of hyaluronic acid and prolonging the retention time of the hyaluronic acid in a body.

The invention discloses an anti-calcification biological patch preparation method. Epoxy chitosan quaternary ammonium salt is added into a raw material namely acellular dermal matrix or small intestinal submucosa to prepare an anti-calcification biological patch through reaction for a while under an alkaline condition. Due to adoption of epoxy chitosan quaternary ammonium salt as a cross-linking agent, a cross-linking effect between a molecular epoxy group and acellular dermal matrix or small intestinal submucosa can be realized, and the defect that a traditional formyl group cross-linking method is prone to causing patch calcification is overcome. Due to introduction of the chitosan quaternary ammonium salt structure into the biological patch, great antibacterial, bacteriostasis and hemostasis functions are achieved. The biological patch prepared according to the method is a new-generation multifunctional implant material and can be widely applied to the field of medicine.

The invention discloses a macromolecule cross-linking agent based on functional cellulose ester. The structural unit of the macromolecule cross-linking agent is shown in the formula I. The invention further discloses a preparation method of the macromolecule cross-linking agent. H-hydroxy succinimide and functional cellulose are used as raw materials, 1-(3-dimethyl aminopropy)-3-ethyl carbodiimide hydrochloride is used as an activating agent, a reaction is performed, and the macromolecule cross-linking agent is prepared. The active ester group in the prepared macromolecule cross-linking agent can have an amidation reaction with primary amine in gelatin, and the gelatin is modified in a chemical cross-linking mode; the heat stability, biodegradation resistance ability, mechanical property and surface hydrophobicity of the gelatin composition modified by the macromolecule cross-linking agent are improved to the great degree; particularly, the honeycomb small-cell type surface microscopic form of a freeze-dried gelatin composite network provides a dwelling plate for medicine loading and embedding, and advantages are provided for application of the gelatin as a medicine carrier.