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The positive strand of DNA is the one whose sequence contains the instructions for building a protein. The negative strand merely contains the complementary sequence, according to the base-pairing rules (A pairs with T, C pairs with G); the negative strand is not normally transcribed into RNA nor translated into protein.
Temperature-sensitive minus-strand RNA virus or virus vector and RNA genome thereof
The present invention provides a temperature-sensitive negative-strand RNA virus or virus vector and an RNA genome thereof. According to the invention, provided is a negative-strand RNA virus or virus vector having a negative-strand RNA genome wherein the phosphoprotein (P protein) on the RNA genome has an amino acid mutation(s) corresponding to a substitution(s) in an amino acid(s) of the P protein corresponding to one or more or all of D433, R434, and K437 and optionally further has an amino acid mutation corresponding to a further amino acid substitution in an amino acid of the P protein corresponding to L511.
Owner:REPLI-TECH CO LTD