The present invention provides a compound of formula I:wherein:X is —OR1 or —N(R5)2,Y is halo, trifluorophenoxy, or tetrafluorophenoxy;R1 is:C1-6 straight chained or branched
alkyl, alkenyl, or alkynyl, wherein the
alkyl, alkenyl, or alkynyl is optionally substituted with optionally substituted
aryl, CF3, CI, F, OMe, OEt, OCF3, CN, or NMe2;C1-6 cycloalkyl, wherein 1-2 carbon atoms in the cycloalkyl is optionally replaced with —O— or —NR5—;R2 is C1-6 straight chained or branched
alkyl;Art Unit 1625R3 is
hydrogen, halo, OCF3, CN, or CF3;R4 is
hydrogen, halo, OCF3, CN, or CF3; andeach R5 is independently H, C1-6 straight chained or branched alkyl,
aryl, —O—C1-6 straight chained or branched alkyl, or —O-
aryl. The present invention also provides pharmaceutical compositions and methods using such compositions for treating a
caspase-mediated
disease, particularly in the
central nervous system.