6 results about "Antiproliferative Agents" patented technology

The present invention is related with the use of 1,3,5-triaza-7-phosphaadamantane (PTA) and derivatives thereof of formula (I) as active antiproliferative agents for photodynamic therapy (PDT) and Photoactivated Chemotherapy (PACT). The invention is further related with new compounds of formula (I').

Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including a direct factor Xa inhibitor, and a direct factor IIa inhibitor disposed in or on the structure. The structure is configured to be positioned adjacent an injury site in the patient's body. The one or more active substances optionally include an anti-proliferative agent. The therapeutic composition is formulated to release the one or more active substances to the injury site to provide one or more of inhibit clot formation, promote clot dissolution, inhibit or dissolute inflammation, inhibit vessel injury, increase time before clotting, and / or inhibit cell proliferation.

A unitary product is disclosed to prevent and / or treat stenosis in a blood vessel. It is tube or wrap of appropriate dimensions to be slid over or wrap a blood vessel. The devices described herein comprise a tube or wrap comprising an effective amount of antiproliferative agent to mitigate and / or treat stenosis. They are constructed of a biocompatible, preferably biodegradable material carrying an amount of an antiproliferative drug which may be rapamycin or a rapamycin analogue with similar antiproliferative activity to effectively address the stenosis.

The invention relates to compounds according to formula (I)and pharmaceutically acceptable derivatives thereof for use as novel inhibitors of Mouse Double Minute 2 (MDM2) activity by inhibiting interactions between MDM2 and its natural negative regulator, p53. Pharmaceutical compositions containing a compound of Formula (I), or a derivative thereof, including compositions that also contain one or more additional antiproliferative agents, can be used in methods of treating proliferative diseases, including various cancers.

A unitary product is disclosed to prevent and / or treat stenosis in a blood vessel. It is tube or wrap of appropriate dimensions to be slid over or wrap a blood vessel. The devices described herein comprise a tube or wrap comprising an effective amount of antiproliferative agent to mitigate and / or treat stenosis. They are constructed of a biocompatible, preferably biodegradable material carrying an amount of an antiproliferative drug which may be rapamycin or a rapamycin analogue with similar antiproliferative activity to effectively address the stenosis.