3 results about "Antiproliferative Agents" patented technology

A unitary product is disclosed to prevent and / or treat stenosis in a blood vessel. It is tube or wrap of appropriate dimensions to be slid over or wrap a blood vessel. The devices described herein comprise a tube or wrap comprising an effective amount of antiproliferative agent to mitigate and / or treat stenosis. They are constructed of a biocompatible, preferably biodegradable material carrying an amount of an antiproliferative drug which may be rapamycin or a rapamycin analogue with similar antiproliferative activity to effectively address the stenosis.

The invention relates to compounds according to formula (I)and pharmaceutically acceptable derivatives thereof for use as novel inhibitors of Mouse Double Minute 2 (MDM2) activity by inhibiting interactions between MDM2 and its natural negative regulator, p53. Pharmaceutical compositions containing a compound of Formula (I), or a derivative thereof, including compositions that also contain one or more additional antiproliferative agents, can be used in methods of treating proliferative diseases, including various cancers.