Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- PTC THERAPEUTICS INC
- Publication Date
- 2007-01-25
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
1. INTRODUCTION
[0001] The present invention relates to a method for screening and identifying compounds that modulate the activity of an animialia tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit or reduce the activity of an animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for preventing, treating, managing or ameliorating cancer or one or more symptoms thereof. 2. BACKGROUND OF THE INVENTION
[0002] 2.1 Cancer and Neoplastic Disease
[0003] Cancer is the second leading cause of death in the United States. The American Cancer Society estimated that in 2001, there would be 1.3 million new cases of cancer and that cancer will cause 550,000 deaths. Overall rates have declined by 1% per year during the 1990s. There are 9 million Americans alive who have ever had c...