5 results about "Neuron cell death" patented technology

A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and / or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and / or treating a disease, disorder, and / or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

The present invention provides novel irisin peptides (e.g, irisin glycosylation mutants and biologically active fragments thereof). Also provided are methods for preventing or reducing degeneration of dopaminergic neurons and / or preventing or ameliorating at least one motor deficit in a subject in need thereof, such as in a subject with α-synucleinopathy, using the novel irisin peptides to modulate irisin-induced integrin signaling. The novel irisin peptides can also be used in methods for increasing expression of brain-derived neurotrophic factor (BDNF), and / or treating or preventing neurological diseases or disorders that would benefit from decreased neuronal cell death and / or increased neuronal survival in a subject. In addition, the novel irisin peptides may be used in methods for preventing or treating muscular atrophy or muscular dystrophy.

Compounds of Formula (I) or (X) are provided including for treatment of disorders such as a disorder or symptom associated with neuronal cell death. In one aspect, compounds which are selective inhibitors of calpain-2 are provided. Preferred compounds can be useful to treat acute neurodegeneration.

Methods and dosing regimens using alpha 7 acetylcholine nicotine receptor binding agents are provided to prevent or inhibit intracellular accumulation of amyloid in cells leading to inhibition or prevention of neuronal cell death. In addition, these methods and dosing regimens are coupled with methods and dosing regimens to reduce and / or prevent blood-brain barrier leakage of vascular-derived amyloid into the brain and / or methods and dosing regimens to reduce and / or prevent neuroinflammation to prevent and / or inhibit the progression of Alzheimer's disease and other forms of dementia and mild cognitive impairment. Also provided are methods for identifying individuals for this treatment.

The invention discloses application of PDA (Personal Digital Assistant)-mediated photothermal therapy in regeneration and repair of injured optic nerves. The invention provides application of PDA nanoparticles or substances thereof in combination with an NIR-I photo-thermal treatment system in preparation of a treatment product for regenerating and repairing optic nerve injury or optic nerve injury related diseases. The NIR is utilized to excite the PDA photothermal effect, heat is generated to activate the regeneration potential of RGCs while the PDA mediates the anti-oxidation effect, microglial cell phenotypic transformation is promoted in the early stage of nerve injury, and inflammatory factor storm around injured nerves is relieved; the invention provides a new therapeutic product and means for optimizing the treatment of optic nerve injury related diseases, preventing neuron cell death and promoting the regeneration of injured neuron axons, and the new therapeutic product and means are provided for improving the treatment of optic nerve injury related diseases, preventing neuron cell death and promoting the regeneration of injured neuron axons.