38 results about "Super oxide dismutase" patented technology

The present invention relates to compositions for the protection, treatment and repair of connective tissues in humans and animals comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothionine, one or more avocado / soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

The invention relates to Chinese traditional medicine biology crimple dispelling and skin delicating cosmetic and manufacturing method. It extracts natural amino acid, plant female incretion in angelica, notoginseng, kudzu root and raspberry and so on ten kinds of Chinese herbal medicines with current supercritical and supersonic extraction technology, adds in super oxide dismutase, collagen, transparent acid, natural vitamin E, transmits the effective component such as plant essence into corium with fat skin penetrating absorption technology, it can eliminates dissociated oxygen free radical, at the same time, it can supplement the collagen, plant female incretion and other nutriment for skin, reaches the balance between discharge and supplementation.

The present invention relates to compositions for the modulation of inflammation in connective tissues in humans and animals and the modulation of markers of such inflammation, including COX-2, TNF-α, IL-1β, iNOS, p38, and chemokines, comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothioneine, methylsulfanylmethane, one or more avocado / soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

Strains of Mycobacterium that have decreased immunosuppressive properties are provided. The Mycobacterium strains are genetically engineered to express but not secrete super-oxide dismutase (Sod). The presence of cytosol bound Sod allows replication and growth of the Mycobacterium, but does not result in attenuation of the host immune response. The Mycobacterium strains provide improved properties for use as vaccines.

The invention discloses a method for measuring superoxide anion radicals in tape grass leaves, belonging to the measuring field of the measuring of superoxide anion radicals. The method comprises the following steps of: firstly, collecting and cleaning the tip parts of fully exposed small and tender tape grass leaves; carrying out Tiron captureing on the Tiron of radicals in a closed operation box in a closed nitrogen environment; and finally measuring by using an EPR (Electron Paramagnetic Resonance) technology. The invention has the advantages of simpler operation and easy grasping, and can measure the superoxide anion radicals of the tape grass leaves in a very short time;, find that and the measured radicals are found to be the superoxide anion radicals according to the superfine structure constant and, the spectrogram shape analysis of an EPR spectrogram and the combination of the remarkable decreases of the radical strength of the leaves pretreated by SOD (Super Oxide Dismutase), and therefore the invention is the most direct, accurate and effective method for measuring the superoxide anion radicals. Superoxide anions are sensitive to pollutants and have a favorable dosage effect relation. The invention is also suitable for other aquatic plant and terrestrial plant species and can be suitable for measuring the radicals of the plant root tissue.

The invention provides a metal-organic framework-superoxide dismutase assembly, a preparation method and an application thereof in preparation of drugs for treating Parkinson, and belongs to the technical field of biology. The framework makes use of biomimetic mineralization assembly strategy to immobilize SOD enzyme molecules into a metal-organic framework ZIF-8, coordination bonds are formed between SOD amino and zinc ions of ZIF-8, so that metal organic framework-SOD enzyme assembly (SOD@ZIF-8) are constructed based on enzymes. The temperature stability of SOD enzyme molecules and pH tolerance are improved through the frame work, by treating the SOD@ZIF-8 assembly as a therapeutic drug, at the cellular level, active oxygen produced by stimulation of MPP+ can be removed effectively, so as to relieve apoptosis caused by active oxygen; at the animal level, after intravenous chemotherapy by the assembly, the barrier in sports ability of Parkinson model mouse constructed by MPTP can be relieved, the expression level of tyrosine hydroxylase in substantia nigra is improved, the therapeutic effect is good.

The invention discloses a whitening anti-aging cosmetic and a preparation method of the whitening anti-aging cosmetic. The whitening anti-aging cosmetic has the formula comprising an oil phase, a water phase, a functional component and a preservative, wherein the oil phase comprises 15-25% of oil, 0.5-10% of emulsifying agent and 1-5% of co-emulsifier; the water phase comprises 30-75% of ionized water, 0.5-8% of emulsifying agent, 3-8% of humectant, 0-3% of alkaline agent, 0-1.5% of thickening agent and 0-0.5% of emulsion stabilizer; the functional component comprises 0.5-1.5% of pomegranate bark extract, 0.5-3% of spirulina extract, 0.5-3% of corn super oxide dismutase extract and 1-5% of fruit acid mixture; the whitening anti-aging cosmetic comprises 0.3-2% of preservative. The whitening anti-aging cosmetic is prepared by reasonably compounding the active ingredients, and has the effects of whitening skin and resisting senility. The active ingredients are embedded, so that the problems of dispersity and stability of the active ingredients can be effectively solved; furthermore, the release speed of the active ingredients is effectively delayed, so that the aims of being effective for a long time and safe to use can be achieved.

An object of the present invention is to provide an agent effective for the treatment and / or prevention of motor neuron disease such as amyotrophic lateral sclerosis (ALS). The present invention provides a therapeutic and / or preventive agent for motor neuron disease comprising the following oligopeptide shown in any of (a) to (c) or a pharmaceutically acceptable salt thereof as an active ingredient: (a) an oligopeptide consisting of the amino acid sequence represented by Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO: 1); (b) an oligopeptide consisting of an amino acid sequence having a deletion, substitution, insertion, or addition of one or several amino acids in Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala (SEQ ID NO: 1), and having an activity that inhibits neuronal cell death caused by a mutant superoxide dismutase-1 gene; and (c) a modified oligopeptide from the oligopeptide (a) or (b).

The invention relates to a powerful antifatigue super oxide dismutase (SOD) health wine and a preparation method thereof, belonging to the technical field of health food. The health wine is prepared by mixing the following main traditional Chinese medicine raw materials, such as ginseng, cordyceps sinensis, gynostemma pentaphylla, cortex lycii radicis, cartialgenous, astragalus mongholicus, angelica sinensis, safflower, penisotariae, Chinese yam, green plum, medlar, sea otter, sea horse and plant extract-SOD with a proper amount of distilled spirit. The health wine has the effects of powerful anti-fatigue, improving immunity, generating sperm and tonifying the kidney, stimulating the menstrual flow and invigorating the circulation of blood, keeping up spirits and tonifying qi, invigorating the circulation of blood and eliminating stasis, strengthening tendon and bone, activating physiological functions, promoting metabolism of human body and the like and has the functions of enhancing sexual passion, enlarging penis, lengthening sexual intercourse time, beautifying people and eliminating toxicant, promoting human health and the like and enjoys obvious opsonic action on impotence, premature ejaculation, sexual debility, sexlessness, soreness of waists and pain of legs, numbness of muscles and bones, abnormal menstruation and dysmenorrhea. In the preparation method of the invention, the traditionally medicinal material soaking production technology is replaced by the production technology in which a raw material extract liquor is used for preparing the wine, thus not only effects and nutritious ingredients of the medicine are improved, but also production time is reduced; meanwhile, the health wine prepared by the method is free from animal fishy taste, zoohormone, and strong foreign flavour of medicines and is a natural green health food.

The invention provides a composition prepared from pine pollen and curcuma, a preparation method thereof, and application of the composition in preparing a medicament for treating inflammatory bowel disease, relating to a composition prepared from plants and a preparation method and application thereof. The composition provided by the invention has a repairing effect on the mucous membrane of colon with lesion, and after a mouse with inflammatory bowel disease is treated by the composition, the MDA (malondialdehyde) content is reduced and the activity of SOD (super oxide dismutase) is improved, so that the composition can be used for preparing a medicament for treating inflammatory bowel disease. The composition comprises the following components in parts by weight: 1-10 parts of wall-broken pine pollen and 1 part of curcuma extract, wherein the curcuma extract is composed of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mass ratio of (6-8):(1.5-2.5):(0.7-1.3).

The invention relates to the technical field of natural product extraction and fermentation and the field of cosmetics, in particular to a maguey leavening for anti-aging cosmetics. A fermentation raw material for the maguey leavening for anti-aging cosmetics is prepared from the following components in percentage by weight: 50 to 98 percent of agave, 0.5 to 2 percent of urea, 0.5 to 2 percent of saccharomycetes, 0.5 to 1.5 percent of lactic acid bacteria and the balance of deionized water supplemented to 100 percent. A maguey plant is fermented by a fermentation process, so that the utilization rate of the maguey plant raw material is increased, and the absorption rate of the skin to active components is increased; furthermore, by the combination of an acetone extraction method and an enzyme separation process, waste of the raw material is avoided, the content of super oxide dismutase is increased, the anti-aging effect is better, and the repetitiveness is high; meanwhile, the leavening prepared by the preparation method has the corrosion resistance effect, so that no extra preservative is needed to be added, and the safety, the efficiency and the stability of a product are guaranteed.

A stabilized, colloidal free radical reduced aqueous suspension containing a complex of amorphous Hyaluronic acid (HA) with a mean molecular weight (mean MW) in the range of 80 to 400 kDa and amorphous protein drug, such as insulin, glucagon-like peptide 1 (GLP1), human growth hormone (hGH), erythropoietin (EPO) and super oxide dismutase (SOD), and an excess amount of HA, for example a HA with a mean MW of 6-15 kDa, to minimize the water-content, is described. The composition may additionally comprise HA with a mean MW in the range between 1 and 8 kDa when it is in lyophilized free-flowing powder form. Further, a pharmaceutical composition comprising the suspension and a method of producing the suspension including production of amorphous hyaluronic acid and amorphous protein, are disclosed. The pharmaceutical composition is intended for oral as well as parenteral administration.

The invention discloses a chitosan composite material modified by a tetraaza macrocyclic manganese complex with high SOD (Super Oxide Dismutase) enzyme activity and a preparation method thereof. A polyaza macrocyclic complex is a complex formed by a macrocyclic tetraaza compound containing four cantilevers and manganese ions; the complex is formed through combining a carboxyl group and an amino group of chitosan through an amide bond. According to the chitosan composite material disclosed by the invention, the tetraaza macrocyclic manganese complex with the high SOD is combined with chitosan through a covalent bond, so that active sites are uniformly dispersed on a chitosan carrier; the chitosan composite material has the characteristics of high stability, good activity and good biocompatibility and is hopefully applied to clinical medicine and medicines and an application field of related problems of eliminating superoxide anion free radicals.

The invention relates to a selenium milk SOD (Super Oxide Dismutase) apple product and a production method thereof. The production method of the selenium milk SOD apple product comprises the following steps of: spraying organic selenium biological product onto blades of a fruit tree in an apple growth process; spraying SOD active enzyme onto the blades of the fruit tree, irrigating milk to the root of an apple tree, each kilo of produced apple contains 0.05-0.30g of selenium and contains 0.05-0.35g of SOD. The apple is sweeter and more fragrant than common apples, is rich in organic selenium and SOD, can promote physical health and can prevent multiple diseases.

The invention discloses a facial cream composition containing lipidosome with an anti-aging effect and a preparation method of the facial cream composition. The facial cream composition is prepared from the following raw material components of 0.1 to 15 percent of lipidosome with an anti-aging effect, 1 to 30 percent of a humectant, 1 to 22.5 percent of an emollient, 1 to 21 percent of an emulsifying agent, 0.1 to 10 percent of a filling agent, 1 to 12.5 percent of a thickening agent, 0.1 to 3.5 percent of a preservative, 0.01 to 1 percent of a pH regulator, 0.01 to 1 percent of daily essence and the balance of de-ionized water. The main components of the lipidosome with the anti-aging effect comprise hexapeptide-11, a dunaliella salina extract, an epilobium fleischeri extract and a fiveleaf gynostemma herb extract. By compounding the components at the same time, synthesis of skin collagen can be increased, the activity of superoxide dismutase is enhanced, excessive free radicals in skin are removed, peroxidation damage of tissue or cells is relieved, skin barrier is enhanced, and skin structure is strengthened to resist skin aging and relaxation.

The invention provides a soybean protein composite polymer micro-gel-based antioxidant. Soybean protein isolate with poor hydrophilicity and relative stability is combined with water-soluble polymer polyvinyl alcohol, a hydrogen bonding effect on hydroxyl, carboxyl and amino contained in the soybean protein isolate and hydroxyl contained in polyvinyl alcohol is achieved through a heat dispersion and cold shrinkage method, so that soybean protein polymer micro-gel which can be uniformly dispersed in water is formed; then the micro-gel is combined with a salicylaldehyde-cysteine schiff base metal coordination compound to obtain the soybean protein composite polymer micro-gel-based antioxidant. A research on the anti-oxidization performance proves that the composite polymer micro-gel-based antioxidant has strong ability of removing oxygen free radicals; therefore, the composite polymer micro-gel-based antioxidant can be used as super oxide dismutase (SOD) analogue, and has good application prospect in the fields of medicines, food processing and packaging materials.

Disclosed is crisp fried fish. The crisp fried fish comprises main ingredients, minor ingredients and seasoning, wherein the main ingredients comprise, by weight, 750-1,250 g of Fructus Fici powder, 400-600 g of spare ribs and 600-1,000 g of Scomberomorus niphonius, the minor ingredients comprise, by weight, 600-1,000 g of lotus root, 10-15 g of dry kelp and 1,000-1,750 g of Chinese cabbage, and the seasoning comprises, by weight, 10-15 g of green onion, 40-60 g of ginger, 100-150 g of salt, 200-304 g of soybean sauce, 125-180 g of vinegar, 100-150 g of cooking wine, 20-100 g of pricklyash peel and 20-100 g of dried chilli. The crisp fried fish has the advantages that the crisp fried fish is crisp, spicy and unique in flavor, contains a great quantity of natural nutrient substances such as amino acids, vitamin D, calcium, phosphorus, iron, zinc, selenium, superoxide dismutase, anthocyanin, anti-aging substance diastase, esterase, lipase and protease, and can be used for supplementing 8 kinds of human essential amino acids, eliminating human 'free radials' and preventing constipation, skin aging, memory deterioration and cardiovascular and cerebrovascular diseases.

The present invention relates to compositions for the modulation of inflammation in connective tissues in humans and animals and the modulation of markers of such inflammation, including COX-2, TNF-a, IL-1 (3, iNOS, p38, and chemokines, comprising any or all of anabolic, anti-catabolic, anti-oxidant and analgesic agents, including aminosugars, S-adenosylmethionine, arachadonic acid, GAGs, including pentosan, collagen type II, tetracyclines or tetracycline-like compounds, diacerin, super oxide dismutase, L-ergothioneine, methyl sulfanylmethane, one or more avocado / soybean unsaponifiables, and an analgesic, e.g., acetaminophen, and to methods of treating humans and animals by administration of these novel compositions to humans and animals in need thereof.

The invention relates to a powerful antifatigue super oxide dismutase (SOD) health wine and a preparation method thereof, belonging to the technical field of health food. The health wine is prepared by mixing the following main traditional Chinese medicine raw materials, such as ginseng, cordyceps sinensis, gynostemma pentaphylla, cortex lycii radicis, cartialgenous, astragalus mongholicus, angelica sinensis, safflower, penisotariae, Chinese yam, green plum, medlar, sea otter, sea horse and plant extract-SOD with a proper amount of distilled spirit. The health wine has the effects of powerfulanti-fatigue, improving immunity, generating sperm and tonifying the kidney, stimulating the menstrual flow and invigorating the circulation of blood, keeping up spirits and tonifying qi, invigorating the circulation of blood and eliminating stasis, strengthening tendon and bone, activating physiological functions, promoting metabolism of human body and the like and has the functions of enhancingsexual passion, enlarging penis, lengthening sexual intercourse time, beautifying people and eliminating toxicant, promoting human health and the like and enjoys obvious opsonic action on impotence, premature ejaculation, sexual debility, sexlessness, soreness of waists and pain of legs, numbness of muscles and bones, abnormal menstruation and dysmenorrhea. In the preparation method of the invention, the traditionally medicinal material soaking production technology is replaced by the production technology in which a raw material extract liquor is used for preparing the wine, thus not only effects and nutritious ingredients of the medicine are improved, but also production time is reduced; meanwhile, the health wine prepared by the method is free from animal fishy taste, zoohormone, and strong foreign flavour of medicines and is a natural green health food.

The invention relates to Chinese traditional medicine biology crimple dispelling and skin delicating cosmetic and manufacturing method. It extracts natural amino acid, plant female incretion in angelica, notoginseng, kudzu root and raspberry and so on ten kinds of Chinese herbal medicines with current supercritical and supersonic extraction technology, adds in super oxide dismutase, collagen, transparent acid, natural vitamin E, transmits the effective component such as plant essence into corium with fat skin penetrating absorption technology, it can eliminates dissociated oxygen free radical, at the same time, it can supplement the collagen, plant female incretion and other nutriment for skin, reaches the balance between discharge and supplementation.

Provided are compositions comprising super-oxide dismutase and a soluble fiber. The compositions may additionally comprise other antioxidants, vitamins and nutrients. The compositions can be used as dietary supplements and for improving health and well-being.

The invention discloses a chitosan composite material modified by a tetraaza macrocyclic manganese complex with high SOD (Super Oxide Dismutase) enzyme activity and a preparation method thereof. A polyaza macrocyclic complex is a complex formed by a macrocyclic tetraaza compound containing four cantilevers and manganese ions; the complex is formed through combining a carboxyl group and an amino group of chitosan through an amide bond. According to the chitosan composite material disclosed by the invention, the tetraaza macrocyclic manganese complex with the high SOD is combined with chitosan through a covalent bond, so that active sites are uniformly dispersed on a chitosan carrier; the chitosan composite material has the characteristics of high stability, good activity and good biocompatibility and is hopefully applied to clinical medicine and medicines and an application field of related problems of eliminating superoxide anion free radicals.

The invention provides a medicine composition for preventing and / or treating alcoholic stomach injury. The medicine composition comprises berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin. The invention provides an application of a drug combination of berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin in a drug for preventing and / or treating alcoholic stomach injury. Research finds that the pharmaceutical composition can significantly improve pathological changes of stomach tissues in an acute alcohol stomach injury rat model, can significantly improve functional indexes (improving superoxide dismutase (SOD) activity and reducing malondialdehyde (MDA) and gastrin (GAS) content) in serum of acute alcohol injury modeling rats, can reduce indexes of inflammatory factors (IL-1, iNOS and TNF-alpha), and can significantly reduce inflammatory factors (IL-1, iNOS and TNF-alpha) in serum of the acute alcohol injury modeling rats. The gene expression and the protein expression of inflammatory factors (IL-1, IL-6 and TNF-alpha) in stomach tissues are reduced, and a good effect of relieving the alcoholic stomach injury is achieved.

The invention belongs to the technical field of natural medicine extraction and particularly relates to a method for extracting SOD (super oxide dismutase) from bovine blood. The SOD of the bovine blood is extracted through six steps including pretreatment, cleaning, blood dissolution, primary centrifugation, secondary centrifugation and freeze drying. The process is simple, the extraction effect is significant and the product purity is high.

The invention discloses a preparation process of holboellia latifolia and chaenomeles speciosa compound enzyme. The preparation process comprises the following steps: (1), washing holboellia latifoliacleanly; taking fruit flesh; grinding the fruit flesh to be pulp; filtrating the pulp to obtain holboellia latifolia juice; washing chaenomeles speciosa cleanly; peeling and deseeding the chaenomelesspeciosa; grinding the chaenomeles speciosa without seeds into pulp; filtering the pulp to obtain chaenomeles speciosa juice; mixing the holboellia latifolia juice with the chaenomeles speciosa juiceto obtain a product A; (2), putting the product A into a fermentation tank, firstly adding white sugars into the fermentation tank, then adding saccharomycetes into the fermentation tank, and sealinga mouth of the fermentation tank and carrying out primary fermentation at a constant temperature to obtain a product B; and (3), adding lactobacillus into the product B, sealing the mouth of the fermentation tank and carrying out secondary fermentation at the constant temperature, and carrying out filtration to take a clear solution after fermentation is carried out completely so as to obtain holboellia latifolia enzyme. The holboellia latifolia enzyme prepared by adopting the process disclosed by the invention has the characteristics of higher content of ursolic acid, total phenols, total flavonoids and SOD (Super Oxide Dismutase), and higher DPPH (1,1-dipheny-2-picryhydrazyl) free radical scavenging ability, hydroxyl free radical scavenging ability and ABTS (2, 2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) free radical scavenging ability.

The invention provides a composition prepared from pine pollen and curcuma, a preparation method thereof, and application of the composition in preparing a medicament for treating inflammatory bowel disease, relating to a composition prepared from plants and a preparation method and application thereof. The composition provided by the invention has a repairing effect on the mucous membrane of colon with lesion, and after a mouse with inflammatory bowel disease is treated by the composition, the MDA (malondialdehyde) content is reduced and the activity of SOD (super oxide dismutase) is improved, so that the composition can be used for preparing a medicament for treating inflammatory bowel disease. The composition comprises the following components in parts by weight: 1-10 parts of wall-broken pine pollen and 1 part of curcuma extract, wherein the curcuma extract is composed of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mass ratio of (6-8):(1.5-2.5):(0.7-1.3).