34 results about "Cholesterol total" patented technology

Disclosed is a strain of Bifidobacterium longum subsp. longum named dipro-O. The Bifidobacterium longum subsp. longum dipro-O used in the present invention has the ability to overproduce BSH, the ability to reduce cholesterol, and the ability to metabolize tryptophan into indole-3-lactic acid, can effectively reduce body weight, significantly lower insulin resistance levels resulting from high-fat diets, reduce the expression of the inflammatory cytokine TNF-α, significantly lower the levels of total cholesterol (TC) and low-density lipoprotein (LDL) in the blood, and increase the level of high-density lipoprotein (HDL), and can ameliorate disorders of the gut microbiome structure. In addition, the strain can also have an ameliorating effect on other lipid metabolism-related diseases such as hyperlipidemia, thereby providing health interventions for the host's body weight, liver, intestinal health, and blood lipid levels. Moreover, pasteurized dipro-O can also have the effect of regulating lipid metabolism, further extending the range of applications of the strain.

The invention provides an application of streptococcus salivarius in fatty liver, in particular to an application of streptococcus salivarius in preparation of a product, and the product is used for at least one of the following applications: (a) losing weight or reducing body fat; (b) improving the glucose tolerance of the patient; (c) increasing the sensitivity of the patient to insulin; (d) treating, relieving and preventing liver injury; (e) treating, relieving and preventing non-alcoholic steatohepatitis; (f) fat deposition caused by high-fat and high-cholesterol diet is reduced; (g) reducing blood fat; and / or (h) improving the level of at least one of the following indexes in the liver of the mammal: total cholesterol, triglyceride, low density lipoprotein-cholesterol and free fatty acid.

The invention discloses an application of an intestinal strain in preparation of a cholesterol-lowering product, and belongs to the technical field of microbial medicines. The intestinal bacterial strain is Oscillibacter ruminant, the viable bacteria concentration of the intestinal bacterial strain is controlled to be (4.8-5.2) * 10 < 9 > CFU / mL, the intestinal bacterial strain can be prepared into bacterial liquid, freeze-dried powder, capsules or tablets and other dosage forms, and pharmaceutically acceptable auxiliary materials such as lactose and microcrystalline cellulose can be added. According to the cholesterol-lowering product, the total cholesterol, triglyceride and low-density lipoprotein cholesterol level of an object can be remarkably reduced under the action of peste des petits ruminants, and meanwhile, the high-density lipoprotein cholesterol level is increased; in addition, abnormal blood glucose induced by high-fat diet can be improved, arterial lipid accumulation is reduced, and the plaque area proportion of atherosclerotic lesions is improved.

The present invention relates to use of a GLP-1R / GLP-2R dual agonist, namely dapiglutide, for reducing cholesterol, in particular total cholesterol (TC) and low-density lipoprotein cholesterol (LDL cholesterol). The invention also relates to dapiglutide for treatment of hyperlipidaemia, in particular hypercholesterolaemia.

The invention belongs to the technical field of functional compositions, and discloses a composition for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and the composition comprises the following raw materials in percentage by mass: 13-28% of ginseng, 18-28% of globe artichoke, 10-27% of pueraria peptide, 7-12% of houttuynia cordata, 7-9% of mulberry, 6-9% of gardenia and 10-29% of collagen composite peptide. The composition can reduce alcohol irritation, relieve alcohol absorption and increase the alcohol content; meanwhile, the liver and stomach are protected; meanwhile, alcohol metabolism is rapid, hangover is prevented, headache, dizziness, nausea and other uncomfortable symptoms caused by alcohol are relieved, and the drunkenness degree is relieved. After the medicine is taken for 2-6 months, mild fatty liver and moderate fatty liver can be obviously improved, and severe fatty liver and alcoholic liver can be obviously improved; indexes related to endocrine metabolism, such as blood sugar, blood fat, uric acid, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glutamic oxalacetic transaminase and glutamic-pyruvic transaminase, are obviously improved.

The invention discloses a preparation method of torreya grandis gel candies with an effect of reducing total cholesterol. The invention belongs to the technical field of functional food, the Chinese torreya oil and the flaxseed oil have a synergistic effect, and after the Chinese torreya oil and the flaxseed oil are compounded, the blood fat metabolism can be effectively regulated, the total cholesterol level can be reduced, and the content of high-density lipoprotein cholesterol can be increased; the Chinese torreya oil is extracted through a low-temperature pressing process, the linseed oil is prepared through a cold pressing process, active components in the raw materials are reserved to the maximum extent, and meanwhile, the stability and uniformity of functional components in the product are ensured by combining a feeding pump filtering process and a rolling die shaping process; by optimizing the formula and the preparation process of the gel matrix, the product has good elasticity and chewing feeling, is convenient to carry and take and is suitable for daily use. The health-care food does not contain artificially synthesized additives, all the raw materials are natural sources, and the health-care food is suitable for patients with hypercholesterolemia and crowds needing to regulate blood fat, and has relatively high safety and market promotion value.

The application belongs to the technical field of traditional Chinese medicine exosomes, and particularly relates to mulberry-derived extracellular vesicle particles, a preparation method thereof and application thereof in the preparation of medicines for preventing and treating hyperlipidemia and related symptoms. The mulberry-derived extracellular vesicle particles provided by the application are prepared by using mulberries as raw materials, centrifuging the mulberries at different centrifugal speeds after juice extraction, and then performing density gradient centrifugation with a sucrose solution with a specific density. Experimental research shows that the mulberry-derived extracellular vesicle particles can significantly reduce total cholesterol, triglyceride and low-density lipoprotein in blood, inhibit the formation of aortic plaques caused by hyperlipidemia and lipid deposition in the liver, and are safe and non-toxic, and therefore can be used for the preparation of medicines for preventing and treating hyperlipidemia and related symptoms.

The application discloses a composition for improving blood lipid metabolism, which comprises the following raw materials: sweet cinnamon powder, rhodiola powder, roxburgh rose powder and curcuma zedoaria powder. The preparation method of the composition for improving blood lipid metabolism comprises the following steps: screening the sweet cinnamon powder, the rhodiola powder, the roxburgh rose powder and the curcuma zedoaria powder respectively, mixing them uniformly to obtain mixed powder; adding sterile deionized water into the mixed powder to obtain a mixed solution; adding a complex enzyme into the mixed solution for enzymolysis; after the enzymolysis is completed, the enzyme is inactivated, filtration is conducted, and the filtrate is freeze-dried to obtain the composition for improving blood lipid metabolism. The plant powder is subjected to mixed enzymolysis through multiple enzymes, the natural active substances in the plant powder are enriched, and the types of the enzymolysis products are enriched, so that the total cholesterol, the triglyceride and the low-density lipoprotein content in blood can be reduced, and the high-density lipoprotein content in blood can be increased.

1. The name of the design product: tester. 2. The use of the design product: the product is used with the matching test paper for the detection of blood sugar, uric acid, blood ketone, total cholesterol and triglyceride. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention provides pediococcus acidilactici XZFMCC101.23156, a microbial preparation, an antibacterial composition and application of the pediococcus acidilactici XZFMCC101.23156, and belongs to the technical field of functional microorganisms. The preservation number of the pediococcus acidilactici XZFMCC101.23156 is GDMCC No: 66860, and the pediococcus acidilactici XZFMCC101.23156 can be used as a functional microbial agent to be applied in vivo to improve diseases such as hyperlipidemia and the like, and can also achieve the effect of reducing body weight. The result of the embodiment shows that the culture supernatant of the pediococcus acidilactici XZFMCC101.23156 can effectively reduce the total cholesterol, the triglyceride, the low-density lipoprotein and the high-density lipoprotein in a rat body. The pediococcus acidilactici XZFMCC101.23156 provides a new way for the development of oral probiotic preparations and the preparation of foods, drinks, health care products and medicines with the function of degrading cholesterol.

The invention discloses a polysaccharide composition for treating chronic alcoholic liver injury and application thereof, and belongs to the field of biological medicine. The polysaccharide composition is prepared by crushing phellinus linteus linteus, bolete, morchella and cordyceps militaris, mixing the crushed materials according to a mass ratio of 4: 2: 2: 2, performing water ultrasonic extraction, and performing hot water extraction. The polysaccharide composition can reduce fat vacuolation and hepatocyte swelling in the liver, inhibit expression of liver function related enzymes such as ALT and AST, improve secretion of blood fat such as total cholesterol, triglyceride and high-density lipoprotein cholesterol and reduce expression of inflammatory factors such as IL-1beta and TNF-alpha in the liver, and the effect of the polysaccharide composition is better than that of single polysaccharide. The polysaccharide composition can relieve liver injury caused by long-term drinking and achieve the effects of dispelling the effects of alcohol and protecting the liver.

The invention discloses a traditional Chinese medicine formula for preventing and treating body artery and blood vessel diseases, and relates to the technical field of pharmacy, in particular to a traditional Chinese medicine formula for preventing and treating body artery and blood vessel diseases, the traditional Chinese medicine composition is prepared from the following raw material medicines: 100g of radix puerariae, 100g of herba epimedii, 100g of herba leonuri, 50g of dioscorea panthaica, 50g of raw endothelium corneum gigeriae galli, 50g of fructus aurantii immaturus, 50g of rhizoma dioscoreae nipponicae, 50g of lumbricus and 50g of kapok leaves. Pharmacodynamic tests prove that compared with related traditional Chinese medicine prescriptions in the prior art, the traditional Chinese medicine composition can significantly reduce the intima-media thickness of blood vessels, reduce the area proportion of plaques, improve the blood vessel stenosis rate, and improve the curative effect. 0.05 in terms of prolonging thrombosis time, increasing microcirculation blood flow velocity, regulating blood lipid level (reducing total cholesterol, triglyceride and low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol), protecting vascular endothelial function (increasing the content of vascular endothelial relaxation factor NO and reducing endothelin ET level) and the like, and the pharmaceutical composition is superior to the prior art group (Plt: 0.05) in terms of prolonging thrombosis time, increasing microcirculation blood flow velocity, regulating blood lipid level (reducing total cholesterol, triglyceride, low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol).

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof.The traditional Chinese medicine composition comprises astragalus membranaceus, salvia miltiorrhiza, ligusticum wallichii, hawthorn, the root of kudzu vine, angelica sinensis, polygala tenuifolia, allium macrostemon, rhodiola rosea and euonymus alatus, and the preparation method comprises the steps that S1, medicinal materials are pretreated; s2, performing grouping extraction; s3, combining the extracting solutions; s4, purifying; and S5, drying. According to the scheme, winged euonymus twig is introduced, and the unique active ingredient dulcitrin contained in the winged euonymus twig can form a multi-dimensional synergistic system of tonifying qi, activating blood, activating yang and resisting oxidation with the medicinal materials such as astragalus membranaceus and salvia miltiorrhiza; experimental data show that the total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) of the traditional Chinese medicine composition containing the ramulus euonymi are obviously reduced, it is proved that the ramulus euonymi can enhance the synergistic effect of lowering lipid and improving hematorheology, and the problem that a traditional prescription is insufficient in regulating blood lipid strength is solved.

The application discloses a method for constructing a hyperlipidemia-resistant rat model, and belongs to the technical field of experimental animal model construction. S1, basic population screening: abnormal lipid metabolism rats are selected, and the rats are fed with high-fat feed at the age of 4 weeks, and the feeding is continuously performed for 4 weeks; S2, blood lipid detection and preliminary screening: the animals are fasted for 12h, blood is taken from the submandibular vein, serum is separated by centrifugation at 3000r / min for 10min, and the total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol contents are detected by using an automatic biochemical analyzer; S3, paired reproduction and subculture: 30 male rats and 30 female rats are selected, and the rats are paired for reproduction at a ratio of 1:1 to obtain F1 generation; S4, inbreeding and stabilization: the F2-F4 generation rats are repeatedly fed, detected, screened and paired for reproduction according to steps S1-S3, and the F4 generation hyperlipidemia-resistant rat model is obtained through inbreeding, and the technical effect of obtaining the hyperlipidemia-resistant rat model which is stable in phenotype and can be inherited and subcultured is achieved through the combination of hybridization screening and inbreeding.

1. The name of the design product: tester. 2. The use of the design product: the product is used with the matching test paper for the detection of blood sugar, uric acid, blood ketone, total cholesterol and triglyceride. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses a composition for improving blood lipid metabolism. The composition comprises the following raw materials: rhizoma nardostachyos powder, rhodiola rosea powder, roxburgh rose powder and curcuma zedoary powder. The preparation method of the composition capable of improving blood lipid metabolism comprises the following steps: respectively sieving the rhizoma nardostachyos powder, the rhodiola rosea powder, the roxburgh rose powder and the curcuma zedoary powder, and uniformly mixing to obtain mixed powder; adding sterile deionized water into the mixed powder to obtain a mixed solution; adding a compound enzyme into the mixed solution for enzymolysis; after enzymolysis is finished, enzyme deactivation and filtration are performed, filtrate is freeze-dried, and the composition with the effect of improving blood fat metabolism is obtained. The plant powder is subjected to mixed enzymolysis through various enzymes, natural active substances in the plant powder are enriched, and the types of enzymolysis products are enriched, so that the effects of reducing the content of total cholesterol, triglyceride and low-density lipoprotein in blood and increasing the content of high-density lipoprotein in the blood are achieved.

The invention discloses lactobacillus mucus fermentation HF04 with cholesterol lowering capacity and application of the lactobacillus mucus fermentation HF04. The lactobacillus mucus fermentation HF04 is lactobacillus mucus fermentation HF04 and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.25482. The invention further discloses a preparation method of the lactobacillus mucus fermentation HF04. Probiotic strains with cholesterol removing capacity are screened out according to in-vitro experiments, and strains with good tolerance are obtained through simulated gastric juice and simulated intestinal juice tolerance experiments of the strains. Experiments prove that the lactobacillus mucilaginosus HF04 disclosed by the invention has acid-resistant and cholate-resistant capabilities, and in-vitro and in-vivo experiments show that the lactobacillus mucilaginosus HF04 has cholesterol removal capability; animal experiments show that the strain has the function of remarkably reducing cholesterol, can reduce the level of total cholesterol, triglyceride and low-density lipoprotein cholesterol in serum, and meanwhile, can remarkably reduce the level of liver lipid and relieve liver injury caused by long-term high-fat diet of mice.

The invention discloses exosome vesicle nano-selenium as well as a preparation method and application thereof, the exosome vesicle nano-selenium is prepared by adopting a lactic acid bacteria strain YKX which is screened out from a selenium-rich area and has a high nano-selenium conversion rate, and the influence of the exosome vesicle nano-selenium on mouse glycolipid metabolism disorder based on intestinal flora is studied; results show that the nano-selenium slows down weight increase and obesity of mice to a certain extent; the content of total cholesterol, total triglyceride and low-density lipoprotein cholesterol in serum of obese mice is reduced, and the content of high-density lipoprotein cholesterol is obviously increased; secondly, the intervention of the nano-selenium slows down the increase of the abundance of the mouse intestinal tract thick-wall mycophylum induced by high diet to a certain extent at the phylum level, improves the abundance of bacteroides and the overall diversity of the intestinal flora of the mouse, and improves the disorder of the intestinal flora; and finally, the nano-selenium intervenes in a metabolite level of intestinal microorganisms, so that the content of short-chain fatty acid is increased.

The invention provides application of SPPARMs in treatment of atherosclerosis, and belongs to the technical field of biological medicine. An ApoE gene knockout mouse is subjected to high-fat feeding to construct an atherosclerotic mouse model, THP-1 macrophages are exposed to oxidized low-density lipoprotein to construct a macrophage foaming model, INT131 is used for drug administration to an animal model and a cell model, and results show that INT131 can effectively relieve formation of atherosclerotic plaques, and can be used for treating atherosclerotic plaques. The content of AS mouse serum total cholesterol and low-density lipoprotein cholesterol is obviously reduced, and the content of high-density lipoprotein cholesterol is increased. In addition, INT131 can reduce intake of lipid in macrophages, promote cholesterol excretion and cholesterol metabolism, and inhibit formation of foam cells by inhibiting inflammatory response.

1. Name of the product in this design: Blood Lipid Analyzer. 2. Purpose of this design: For self-testing of four lipid parameters (total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein) by patients with hyperlipidemia or for bedside testing in medical institutions. 3. The key design features of this product are: the main view. 4. The image or photograph that best illustrates the design's key features: the front view.

The invention discloses hippophae rhamnoides enzymolysis polysaccharide as well as a preparation method and application thereof. The enzymolysis process conditions of the method are as follows: in a buffer system with the pH value of 5.0, the hippophae rhamnoides crude polysaccharide is degraded under the conditions that the addition amount of polygalacturonic acid-pectinase is 810.6 U / g, the reaction temperature is 51.3 DEG C and the enzymolysis time is 90.1 min. Structural characterization results show that the hippophae rhamnoides polysaccharide after enzymolysis is in a loose and porous form, and the specific surface area is obviously increased; and the molecular weight is greatly reduced from 1.57 * 10 Da to 4.45 * 10 Da. In-vitro activity evaluation shows that the scavenging capacity of the enzymolysis polysaccharide on DPPH free radicals is obviously superior to that of a non-enzymolysis sample; in a non-alcoholic fatty liver model constructed by HepG2 cells, the enzymolysis polysaccharide can effectively reduce the content of triglyceride and total cholesterol in the cells.

The utility model discloses a combined test reagent card for comprehensive blood lipid indexes. The combined test reagent card comprises a shell, and a quantitative sample adding module and a test strip which are arranged in the shell, the test strip comprises a bottom plate, and a sample pad, a detection pad and a sample absorption pad which are sequentially overlapped on the bottom plate; the blood fat indexes comprise four indexes of total cholesterol, triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol; a detection line and a quality control line are arranged on the detection pad, the detection line is coated with specific capture antibodies aiming at the four indexes, and the quality control line is coated with haptens or antibodies capable of being combined with quality control detection antibodies aiming at the four indexes; the quantitative sample adding module is arranged corresponding to the sample pad and comprises a quantitative bin and a waste liquid bin which are communicated with each other, and flow guide fibers are arranged between the quantitative bin and the waste liquid bin. According to the utility model, the joint detection of four blood fat indexes can be realized, the cost consumption is reduced, and accurate sample adding can be realized under the condition that verified sample adding equipment and professional technicians are not needed.

The invention discloses a composition for diabetes. The composition comprises carbohydrate, dietary fiber, protein, grease and trace elements. The composition can reduce fasting blood glucose levels, reduce serum triglyceride and total cholesterol levels, increase high density lipoprotein levels and improve insulin tolerance in diabetic patients. Therefore, the composition is used for preparing medicines or health-care products for treating and / or preventing diabetes mellitus.

The invention belongs to the technical field of medicines, and particularly relates to a composition for preventing and treating children obesity and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 35-45 parts of active pharmaceutical ingredients and 8-15 parts of auxiliary materials, the active pharmaceutical ingredient is composed of sipunculus nudus polypeptide and catalpa glycoside in a mass ratio of 1: (1.5-3). The composition can inhibit the weight gain of mice with high fat diet, reduce the total cholesterol, triglyceride and low-density lipoprotein level in serum of the mice, and improve the high-density lipoprotein level in the serum. In addition, the composition can also improve liver fat accumulation and relieve fatty liver lesion caused by liver fat accumulation, and has no influence on renal functions.

1. The name of the design product: health all-in-one machine. 2. The use of the design product: for the measurement and data collection of physiological parameters such as height, weight, temperature, blood pressure, blood oxygen, blood lipids, blood sugar, total cholesterol, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The main purpose of the present invention is to provide a Monascus pilosus strain and a composition for preventing or treating nonalcoholic fatty liver disease. The composition comprises Monascus pilosus and / or its fermented product, or comprises an active ingredient of its fermented product. Another objective of the present invention is to provide a use of Monascus pilosus in the manufacture of a composition for the prevention or treatment of nonalcoholic fatty liver disease. The composition of the present invention not only has the efficacy of reducing the accumulation of TC (total cholesterol) and TG (triglycerides) caused by obesity-related nonalcoholic fatty liver disease (NAFLD) but also has the efficacy of reducing serum liver function markers Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT). Therefore, the composition of the present invention has the potential for preventing or treating nonalcoholic fatty liver and metabolic diseases such as hyperlipidemia.

1. The name of the design product: tester. 2. The use of the design product: the product is used with the matching test paper for the detection of blood sugar, uric acid, blood ketone, total cholesterol and triglyceride. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

1. Name of the product in this design: Blood Lipid Detection Card. 2. Purpose of this design: For the analysis and detection of total cholesterol, triglycerides and high-density lipoprotein cholesterol in whole blood or serum. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention discloses a blood fat four-item detection card and application thereof. The blood fat four-item detection card comprises an upper cover plate (1), blood fat detection test paper (2) and a bottom plate (3), wherein the blood fat detection test paper (2) sequentially comprises a supporting layer (4), a diffusion layer (5), a blood filtering layer (6), a filtering layer (7) and a reaction layer (8) from top to bottom. According to the blood fat four-item detection card, total cholesterol, high-density lipoprotein cholesterol, triglyceride and low-density lipoprotein cholesterol can be directly detected on the dry chemical test paper at the same time without being influenced by the concentration of the triglyceride in a sample, and the detection result of the low-density lipoprotein cholesterol is still accurate when the concentration of the triglyceride is larger than 4.5 mmol / L.

This invention relates to the field of functional product technology, and more particularly to a composition for assisting in lowering blood lipids and its application. The invention provides a composition comprising *Bifidobacterium animalis* subsp. *lactamase* MN-Gup, microalgae oil, and phytosterol esters. The composition of this invention can simultaneously and effectively reduce triglyceride and total cholesterol levels, particularly significantly reducing low-density lipoprotein cholesterol while increasing high-density lipoprotein cholesterol levels. Compared to each individual component, it exhibits significant advantages, demonstrating significant auxiliary lipid-lowering efficacy with good safety and industrial feasibility. This provides a basis for the development of auxiliary lipid-lowering products and offers a new intervention strategy for blood lipid health management.