56 results about "Cholesterol total" patented technology

The invention provides a method for preparing quintuple diglyceride oil for improving blood vessel health through enzymolysis, application and a product, and belongs to the technical field of enzyme engineering. The preparation method comprises the following steps: mixing low-erucic acid rapeseed oil, glycerol, water, fatty acid and lipase, and carrying out enzymolysis reaction, molecular distillation, decoloration and deodorization to obtain diglyceride oil; the lipase is a mixture of Candida antarctica Aspergillus niger lipase, Candida column lipase and bovine pancreas lipase, and the weight ratio of the low-erucic acid rapeseed oil to the glycerin to the water to the fatty acid to the lipase is 500: (80-100): (1-2): (30-60): (10-20). The diglyceride oil prepared by the method can be used for preparing a diglyceride oil composition, and has five functions of reducing blood uric acid, reducing blood total cholesterol, reducing blood triglyceride, reducing blood sugar and increasing blood flow velocity to improve blood vessel health.

Disclosed is a strain of Bifidobacterium longum subsp. longum named dipro-O. The Bifidobacterium longum subsp. longum dipro-O used in the present invention has the ability to overproduce BSH, the ability to reduce cholesterol, and the ability to metabolize tryptophan into indole-3-lactic acid, can effectively reduce body weight, significantly lower insulin resistance levels resulting from high-fat diets, reduce the expression of the inflammatory cytokine TNF-α, significantly lower the levels of total cholesterol (TC) and low-density lipoprotein (LDL) in the blood, and increase the level of high-density lipoprotein (HDL), and can ameliorate disorders of the gut microbiome structure. In addition, the strain can also have an ameliorating effect on other lipid metabolism-related diseases such as hyperlipidemia, thereby providing health interventions for the host's body weight, liver, intestinal health, and blood lipid levels. Moreover, pasteurized dipro-O can also have the effect of regulating lipid metabolism, further extending the range of applications of the strain.

The invention provides an application of streptococcus salivarius in fatty liver, in particular to an application of streptococcus salivarius in preparation of a product, and the product is used for at least one of the following applications: (a) losing weight or reducing body fat; (b) improving the glucose tolerance of the patient; (c) increasing the sensitivity of the patient to insulin; (d) treating, relieving and preventing liver injury; (e) treating, relieving and preventing non-alcoholic steatohepatitis; (f) fat deposition caused by high-fat and high-cholesterol diet is reduced; (g) reducing blood fat; and / or (h) improving the level of at least one of the following indexes in the liver of the mammal: total cholesterol, triglyceride, low density lipoprotein-cholesterol and free fatty acid.

The invention relates to N-fluorenylmethoxycarbonyl-L-2-amino-5-phenylpentanoic acid or a pharmaceutical composition and application thereof, and relates to the technical field of biological medicines. According to the application disclosed by the invention, the N-fluorenylmethoxycarbonyl-L-2-amino-5-phenylpentanoic acid is found to have the effects of reducing total cholesterol, triglyceride and low-density lipoprotein cholesterol in serum and increasing high-density lipoprotein cholesterol in serum for the first time; the compound can be used for preparing a medicine for reducing total cholesterol in serum, a medicine for reducing triglyceride in serum, a medicine for reducing low-density lipoprotein cholesterol in serum and a medicine for increasing high-density lipoprotein cholesterol in serum, and can be used for preparing medicines for reducing total cholesterol in serum, triglyceride in serum, low-density lipoprotein cholesterol in serum and high-density lipoprotein cholesterol in serum. And an effective new means and a new way are provided for preparing the medicine for preventing or treating the hyperlipemia.

The invention discloses an application of an intestinal strain in preparation of a cholesterol-lowering product, and belongs to the technical field of microbial medicines. The intestinal bacterial strain is Oscillibacter ruminant, the viable bacteria concentration of the intestinal bacterial strain is controlled to be (4.8-5.2) * 10 < 9 > CFU / mL, the intestinal bacterial strain can be prepared into bacterial liquid, freeze-dried powder, capsules or tablets and other dosage forms, and pharmaceutically acceptable auxiliary materials such as lactose and microcrystalline cellulose can be added. According to the cholesterol-lowering product, the total cholesterol, triglyceride and low-density lipoprotein cholesterol level of an object can be remarkably reduced under the action of peste des petits ruminants, and meanwhile, the high-density lipoprotein cholesterol level is increased; in addition, abnormal blood glucose induced by high-fat diet can be improved, arterial lipid accumulation is reduced, and the plaque area proportion of atherosclerotic lesions is improved.

The present invention relates to use of a GLP-1R / GLP-2R dual agonist, namely dapiglutide, for reducing cholesterol, in particular total cholesterol (TC) and low-density lipoprotein cholesterol (LDL cholesterol). The invention also relates to dapiglutide for treatment of hyperlipidaemia, in particular hypercholesterolaemia.

The present invention relates to a Korean microbiome-derived Clostridium butyricum strain having anti-obesity efficacy and a use thereof. The strain has an excellent effect of reducing the body weight and adipose tissue weight of experimental animals compared to a control group (strain-untreated) under high-fat diet conditions, has an excellent effect of reducing the content of total cholesterol, triglycerides, low-density lipoprotein (LDL), leptin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in serum, and has an excellent effect of reducing blood glucose and increasing the content of glucagon-like peptide-1 (GLP-1) in an oral glucose load test, and is thus expected to be effectively used as an ingredient in a composition for preventing, alleviating, or treating obesity and metabolic diseases caused by obesity.

The invention belongs to the technical field of functional compositions, and discloses a composition for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and the composition comprises the following raw materials in percentage by mass: 13-28% of ginseng, 18-28% of globe artichoke, 10-27% of pueraria peptide, 7-12% of houttuynia cordata, 7-9% of mulberry, 6-9% of gardenia and 10-29% of collagen composite peptide. The composition can reduce alcohol irritation, relieve alcohol absorption and increase the alcohol content; meanwhile, the liver and stomach are protected; meanwhile, alcohol metabolism is rapid, hangover is prevented, headache, dizziness, nausea and other uncomfortable symptoms caused by alcohol are relieved, and the drunkenness degree is relieved. After the medicine is taken for 2-6 months, mild fatty liver and moderate fatty liver can be obviously improved, and severe fatty liver and alcoholic liver can be obviously improved; indexes related to endocrine metabolism, such as blood sugar, blood fat, uric acid, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glutamic oxalacetic transaminase and glutamic-pyruvic transaminase, are obviously improved.

The invention discloses a preparation method of torreya grandis gel candies with an effect of reducing total cholesterol. The invention belongs to the technical field of functional food, the Chinese torreya oil and the flaxseed oil have a synergistic effect, and after the Chinese torreya oil and the flaxseed oil are compounded, the blood fat metabolism can be effectively regulated, the total cholesterol level can be reduced, and the content of high-density lipoprotein cholesterol can be increased; the Chinese torreya oil is extracted through a low-temperature pressing process, the linseed oil is prepared through a cold pressing process, active components in the raw materials are reserved to the maximum extent, and meanwhile, the stability and uniformity of functional components in the product are ensured by combining a feeding pump filtering process and a rolling die shaping process; by optimizing the formula and the preparation process of the gel matrix, the product has good elasticity and chewing feeling, is convenient to carry and take and is suitable for daily use. The health-care food does not contain artificially synthesized additives, all the raw materials are natural sources, and the health-care food is suitable for patients with hypercholesterolemia and crowds needing to regulate blood fat, and has relatively high safety and market promotion value.

The application belongs to the technical field of traditional Chinese medicine exosomes, and particularly relates to mulberry-derived extracellular vesicle particles, a preparation method thereof and application thereof in the preparation of medicines for preventing and treating hyperlipidemia and related symptoms. The mulberry-derived extracellular vesicle particles provided by the application are prepared by using mulberries as raw materials, centrifuging the mulberries at different centrifugal speeds after juice extraction, and then performing density gradient centrifugation with a sucrose solution with a specific density. Experimental research shows that the mulberry-derived extracellular vesicle particles can significantly reduce total cholesterol, triglyceride and low-density lipoprotein in blood, inhibit the formation of aortic plaques caused by hyperlipidemia and lipid deposition in the liver, and are safe and non-toxic, and therefore can be used for the preparation of medicines for preventing and treating hyperlipidemia and related symptoms.

The application discloses a composition for improving blood lipid metabolism, which comprises the following raw materials: sweet cinnamon powder, rhodiola powder, roxburgh rose powder and curcuma zedoaria powder. The preparation method of the composition for improving blood lipid metabolism comprises the following steps: screening the sweet cinnamon powder, the rhodiola powder, the roxburgh rose powder and the curcuma zedoaria powder respectively, mixing them uniformly to obtain mixed powder; adding sterile deionized water into the mixed powder to obtain a mixed solution; adding a complex enzyme into the mixed solution for enzymolysis; after the enzymolysis is completed, the enzyme is inactivated, filtration is conducted, and the filtrate is freeze-dried to obtain the composition for improving blood lipid metabolism. The plant powder is subjected to mixed enzymolysis through multiple enzymes, the natural active substances in the plant powder are enriched, and the types of the enzymolysis products are enriched, so that the total cholesterol, the triglyceride and the low-density lipoprotein content in blood can be reduced, and the high-density lipoprotein content in blood can be increased.

A method that enables quantification of cholesterol in high-density lipoprotein 3 (HDL3) in a test sample without requiring a laborious operation is disclosed. The method for quantifying cholesterol in HDL3 comprises: Step 1 wherein phospholipase and / or sphingomyelinase is / are allowed to act on a test sample to transfer cholesterol to the outside of the reaction system; and Step 2 wherein cholesterol remaining in the reaction system is quantified. The method enables specific quantification of HDL3 cholesterol in a test sample using an automatic analyzer without requirement of a laborious operation such as ultracentrifugation or pretreatment. Further, quantification of the HDL2 cholesterol level can also be carried out by subtracting the HDL3 cholesterol level from the total HDL cholesterol level obtained by a conventional method for quantifying the total HDL cholesterol in a test sample.

The invention discloses a preparation method and application of cannabis sativa peptide with effects of reducing blood fat and adjusting lipid metabolism, belongs to the technical field of biology, and has a wide application prospect. The fructus cannabis peptide obtained by the technical scheme and the preparation method disclosed by the invention has the following effects: 1, the fructus cannabis peptide prepared by the preparation method disclosed by the invention can be used for remarkably improving pancreatic lipase activity (the highest inhibition rate can reach 65.0%), so that digestion and absorption of a human body on lipid substances such as animal and vegetable oil and cholesterol are blocked; 2, the cannabis sativa peptide prepared by the preparation method disclosed by the invention can be used for remarkably improving the abnormality of four items of blood fat, reducing the level of total cholesterol, triglyceride and low-density lipoprotein and remarkably improving the level of high-density lipoprotein; 3, the prepared cannabis sativa peptide can obviously relieve non-alcoholic fatty liver disease caused by obesity and reduce liver fat accumulation; 4, the cannabis sativa peptide prepared by the invention can effectively relieve the occurrence and progress of obesity, reduce the weight change rate and reduce the obesity index, and has good lipid-lowering and weight-losing effects.

1. The name of the design product: tester. 2. The use of the design product: the product is used with the matching test paper for the detection of blood sugar, uric acid, blood ketone, total cholesterol and triglyceride. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

A phloretin derivative and its use in the medicine for treating diabetes-associated non-alcoholic fatty liver, which relates to the technical field of medicine, in particular to the compound shown in formula (1) and its activity of alleviating diabetes metabolic syndrome-related non-alcoholic fatty liver; the pharmacological experimental results show that the compound shown in formula (1) can significantly alleviate hepatomegaly, reduce the presence of lipid droplets in liver tissues, restore the morphology of liver cells, and reduce the contents of total cholesterol, triglyceride and low-density lipoprotein in the blood, reduce related inflammatory indexes, and enhance antioxidant activity.

The invention provides pediococcus acidilactici XZFMCC101.23156, a microbial preparation, an antibacterial composition and application of the pediococcus acidilactici XZFMCC101.23156, and belongs to the technical field of functional microorganisms. The preservation number of the pediococcus acidilactici XZFMCC101.23156 is GDMCC No: 66860, and the pediococcus acidilactici XZFMCC101.23156 can be used as a functional microbial agent to be applied in vivo to improve diseases such as hyperlipidemia and the like, and can also achieve the effect of reducing body weight. The result of the embodiment shows that the culture supernatant of the pediococcus acidilactici XZFMCC101.23156 can effectively reduce the total cholesterol, the triglyceride, the low-density lipoprotein and the high-density lipoprotein in a rat body. The pediococcus acidilactici XZFMCC101.23156 provides a new way for the development of oral probiotic preparations and the preparation of foods, drinks, health care products and medicines with the function of degrading cholesterol.

1. Name of the design product: multifunctional measuring instrument (YTN21). 2. Use of the design product: for measuring blood pressure, blood sugar, uric acid and total cholesterol for users. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view.

The application discloses a kind of traditional Chinese medicine preparation for treating hyperlipidemia, which is prepared from the following raw medicinal materials: radix codonopsis 10-20 g, astragalus 25-35 g, gynostemma pentaphyllum 10-20 g, atractylodes 10-20 g, zanthoxylum 3-8 g, monascus 10-15 g, and galangal 10-20 g. When treating, it is orally taken, one dose per day, taken twice, taken half an hour after breakfast and dinner, and continuously taken for 4 weeks as a treatment course. The traditional Chinese medicine preparation for treating hyperlipidemia has the advantages that it is helpful to improve hyperlipidemia, and the serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol and other indicators of patients after treatment are obviously better than those of the control group (oral atorvastatin), with statistical significance (P<0.05). The traditional Chinese medicine preparation for treating hyperlipidemia has the advantages of remarkable curative effect, good safety, low price and simple prescription, and has high clinical popularization value.

The present disclosure is directed to the treatment of ischemic heart disease and clinical conditions associated with ischemic heart disease. A composition containing a monoclonal antibody directed against gastric inhibitory polypeptide is administered. This results in cardioprotective effects against acute myocardial infarction, such as a decrease in circulating triglycerides, total cholesterol, and low-density lipoproteins, and an increase in the ratio of high-density lipoprotein to total cholesterol.

The invention discloses a polysaccharide composition for treating chronic alcoholic liver injury and application thereof, and belongs to the field of biological medicine. The polysaccharide composition is prepared by crushing phellinus linteus linteus, bolete, morchella and cordyceps militaris, mixing the crushed materials according to a mass ratio of 4: 2: 2: 2, performing water ultrasonic extraction, and performing hot water extraction. The polysaccharide composition can reduce fat vacuolation and hepatocyte swelling in the liver, inhibit expression of liver function related enzymes such as ALT and AST, improve secretion of blood fat such as total cholesterol, triglyceride and high-density lipoprotein cholesterol and reduce expression of inflammatory factors such as IL-1beta and TNF-alpha in the liver, and the effect of the polysaccharide composition is better than that of single polysaccharide. The polysaccharide composition can relieve liver injury caused by long-term drinking and achieve the effects of dispelling the effects of alcohol and protecting the liver.

The invention discloses a traditional Chinese medicine formula for preventing and treating body artery and blood vessel diseases, and relates to the technical field of pharmacy, in particular to a traditional Chinese medicine formula for preventing and treating body artery and blood vessel diseases, the traditional Chinese medicine composition is prepared from the following raw material medicines: 100g of radix puerariae, 100g of herba epimedii, 100g of herba leonuri, 50g of dioscorea panthaica, 50g of raw endothelium corneum gigeriae galli, 50g of fructus aurantii immaturus, 50g of rhizoma dioscoreae nipponicae, 50g of lumbricus and 50g of kapok leaves. Pharmacodynamic tests prove that compared with related traditional Chinese medicine prescriptions in the prior art, the traditional Chinese medicine composition can significantly reduce the intima-media thickness of blood vessels, reduce the area proportion of plaques, improve the blood vessel stenosis rate, and improve the curative effect. 0.05 in terms of prolonging thrombosis time, increasing microcirculation blood flow velocity, regulating blood lipid level (reducing total cholesterol, triglyceride and low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol), protecting vascular endothelial function (increasing the content of vascular endothelial relaxation factor NO and reducing endothelin ET level) and the like, and the pharmaceutical composition is superior to the prior art group (Plt: 0.05) in terms of prolonging thrombosis time, increasing microcirculation blood flow velocity, regulating blood lipid level (reducing total cholesterol, triglyceride, low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol).

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof.The traditional Chinese medicine composition comprises astragalus membranaceus, salvia miltiorrhiza, ligusticum wallichii, hawthorn, the root of kudzu vine, angelica sinensis, polygala tenuifolia, allium macrostemon, rhodiola rosea and euonymus alatus, and the preparation method comprises the steps that S1, medicinal materials are pretreated; s2, performing grouping extraction; s3, combining the extracting solutions; s4, purifying; and S5, drying. According to the scheme, winged euonymus twig is introduced, and the unique active ingredient dulcitrin contained in the winged euonymus twig can form a multi-dimensional synergistic system of tonifying qi, activating blood, activating yang and resisting oxidation with the medicinal materials such as astragalus membranaceus and salvia miltiorrhiza; experimental data show that the total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) of the traditional Chinese medicine composition containing the ramulus euonymi are obviously reduced, it is proved that the ramulus euonymi can enhance the synergistic effect of lowering lipid and improving hematorheology, and the problem that a traditional prescription is insufficient in regulating blood lipid strength is solved.

The application discloses a method for constructing a hyperlipidemia-resistant rat model, and belongs to the technical field of experimental animal model construction. S1, basic population screening: abnormal lipid metabolism rats are selected, and the rats are fed with high-fat feed at the age of 4 weeks, and the feeding is continuously performed for 4 weeks; S2, blood lipid detection and preliminary screening: the animals are fasted for 12h, blood is taken from the submandibular vein, serum is separated by centrifugation at 3000r / min for 10min, and the total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol contents are detected by using an automatic biochemical analyzer; S3, paired reproduction and subculture: 30 male rats and 30 female rats are selected, and the rats are paired for reproduction at a ratio of 1:1 to obtain F1 generation; S4, inbreeding and stabilization: the F2-F4 generation rats are repeatedly fed, detected, screened and paired for reproduction according to steps S1-S3, and the F4 generation hyperlipidemia-resistant rat model is obtained through inbreeding, and the technical effect of obtaining the hyperlipidemia-resistant rat model which is stable in phenotype and can be inherited and subcultured is achieved through the combination of hybridization screening and inbreeding.

The invention relates to FGF19 mutant protein and application thereof. Compared with the FGF19, the mutant protein disclosed by the invention has the advantages that on the premise of keeping the functions of up-regulating high-density lipoprotein content and down-regulating blood sugar, triglyceride, bile acid and total cholesterol of the FGF19, the side effects of liver function damage, liver cell proliferation promotion and the like caused by up-regulating low-density lipoprotein, up-regulating total bilirubin and direct bilirubin by the FGF19 are relieved. In addition, consistent with FGF19, the mutant protein provided by the invention can improve liver cell lesion.

The invention relates to the technical field of traditional Chinese medicine, and discloses a traditional Chinese medicine composite granule and a production method thereof.The traditional Chinese medicine composite granule is prepared from poria cocos, hawthorn, dextrin, semen cassiae, salvia miltiorrhiza and a cordycepin slow-release component, cordycepin is coated with the cordycepin slow-release component to form a micro-capsule structure, the slow-release effect is achieved, the residence time in the body is prolonged, and the cordycepin slow-release effect is achieved. According to the traditional Chinese medicine composition granules, cordycepin is added, the stability and bioavailability of the cordycepin are improved, the treatment effect is further improved, the cordycepin can effectively reduce the content of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL-C) in serum, and then the cordycepin is mixed with other traditional Chinese medicine components with the effects of dispersing blood stasis, clearing heat, eliminating dampness, promoting bowel relaxing and metabolism and enhancing viscera to prepare the traditional Chinese medicine composition granules. The pharmaceutical composition has an excellent lipid-lowering effect, and can reduce the administration frequency and improve the administration convenience.

The present invention relates to a composition for body fat reduction containing extracts of Taraxacum platycarpum and Lonicerae japonica as active ingredients. It has been confirmed that a mixed extract of Taraxacum platycarpum and Lonicerae japonica according to the present invention reduces body weight and body fat when administered to mice with obesity induced by a high-fat diet. Also, it has been confirmed that the mixed extract reduces the size of fat tissue, reduces fat vacuoles (pore) in liver tissue, reduces total cholesterol, triglycerides, and LDL-cholesterol in the blood, and increases HDL-cholesterol. Furthermore, it has been confirmed that the mixed extract suppresses the expression of PPAR-γ which is related to fat synthesis. In addition, it has been confirmed that the mixed extract has a synergistic effect on the regulation of intracellular fat accumulation and fat metabolism factors in cells in which fat accumulation is induced.

The invention belongs to the technical field of microorganisms, and provides enterococcus faecalis FC-1 helpful for reducing blood fat and application of the enterococcus faecalis FC-1, the enterococcus faecalis FC-1 is preserved in the China General Microbiological Culture Collection Center, and the preservation number is CGMCC No.33967. The enterococcus faecalis FC-1 can be used for reducing blood fat. In a model experiment of a golden hamster fed with a high-fat and high-cholesterol feed, the strain shows the capabilities of retarding weight gain and fat deposition, and reducing blood fat and liver lipid level; after intervention, the liver index of the hamster is reduced by 24.74%, the triglyceride level in serum is reduced by 3.93 times, the total cholesterol level is reduced by 2.05 times, the low-density lipoprotein cholesterol level is reduced by 3.02 times, and the triglyceride level, the total cholesterol level and the low-density lipoprotein cholesterol level in the liver are respectively reduced by 34.44%, 58.85% and 40.76%. The strain can be used for preparing medicines and health-care products for losing weight, treating fatty liver and reducing blood fat.

1. The name of the design product: tester. 2. The use of the design product: the product is used with the matching test paper for the detection of blood sugar, uric acid, blood ketone, total cholesterol and triglyceride. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

The invention discloses a composition for improving blood lipid metabolism. The composition comprises the following raw materials: rhizoma nardostachyos powder, rhodiola rosea powder, roxburgh rose powder and curcuma zedoary powder. The preparation method of the composition capable of improving blood lipid metabolism comprises the following steps: respectively sieving the rhizoma nardostachyos powder, the rhodiola rosea powder, the roxburgh rose powder and the curcuma zedoary powder, and uniformly mixing to obtain mixed powder; adding sterile deionized water into the mixed powder to obtain a mixed solution; adding a compound enzyme into the mixed solution for enzymolysis; after enzymolysis is finished, enzyme deactivation and filtration are performed, filtrate is freeze-dried, and the composition with the effect of improving blood fat metabolism is obtained. The plant powder is subjected to mixed enzymolysis through various enzymes, natural active substances in the plant powder are enriched, and the types of enzymolysis products are enriched, so that the effects of reducing the content of total cholesterol, triglyceride and low-density lipoprotein in blood and increasing the content of high-density lipoprotein in the blood are achieved.

This invention relates to FGF19 mutant protein and its applications. Compared with FGF19, the mutant protein of this invention retains the functions of FGF19 in upregulating high-density lipoprotein levels and downregulating blood glucose, triglycerides, bile acids, and total cholesterol, while alleviating the side effects of FGF19 such as liver damage and hepatocyte proliferation caused by upregulating low-density lipoprotein, total bilirubin, and direct bilirubin. Furthermore, consistent with FGF19, the mutant protein of this invention can improve hepatocellular lesions.