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Compound nanoemulsion oral liquid for reducing blood fat and preparation method thereof

An emulsion oral liquid and blood lipid-lowering technology, which is applied in the directions of emulsion delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., can solve the problems of reducing the effective content, serious fishy smell of deep-sea fish oil, easy to be oxidized, etc. Low-density lipoprotein, improved sensory quality, and anti-bacterial effect

Inactive Publication Date: 2012-04-18
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fishy smell of deep-sea fish oil is serious, and it is unacceptable to eat directly
EPA contains 5 unsaturated double bonds, so it is extremely sensitive to oxygen, light and heat, and is easily oxidized, reducing its effective content

Method used

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  • Compound nanoemulsion oral liquid for reducing blood fat and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Preparation:

[0056] 1) Weigh the surfactant, co-surfactant, oil phase, EPA deep-sea fish oil, carboxymethyl chitosan, taurine, almond oil, perilla seed oil, natural vitamin E and deionized water according to the proportion of the formula. ;

[0057] 2) Fully stir and mix the surfactant and co-surfactant;

[0058] 3) Add the oil phase, EPA deep-sea fish oil, almond oil, perilla seed oil, natural vitamin E in the proportion of the formula, and mix well;

[0059] 4) adding carboxymethyl chitosan and taurine in the required ratio of the formula to deionized water to make the water phase;

[0060] 5) Slowly add the aqueous phase prepared in step 4) to the solution prepared in step 3) at 20°C, and stir well until a yellow or colorless transparent nanoemulsion that is clear, transparent, low in viscosity and fluid is formed .

[0061] Consists of EPA deep sea fish oil 0.20g, carboxymethyl chitosan 0.15g, taurine 0.10g, almond oil 0.01g, perilla seed oil 0.03g, natural vi...

Embodiment 2

[0063] Consists of EPA deep sea fish oil 0.45g, carboxymethyl chitosan 0.20g, taurine 0.10g, almond oil 0.10g, perilla seed oil 0.10g, natural vitamin E 0.05g, EL-40 4.00g, 1,2- Composed of propylene glycol 0.30g, ethyl acetate 0.15g, deionized water 4.55g.

Embodiment 3

[0065] Composed of EPA deep sea fish oil 1.00g, carboxymethyl chitosan 0.01g, taurine 0.30g, almond oil 0.01g, perilla seed oil 0.01g, natural vitamin E 0.10g, RH-40 3.25g, EL-40 2.62g,

[0066] Composition of glycerol 0.10g, wheat germ oil 0.10g, deionized water 2.50g.

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Abstract

The invention discloses compound nanoemulsion oral liquid for reducing the blood fat. The particle size of the oral liquid is 1nm-100nm. The compound nanoemulsion oral liquid comprises the following components in percentage by weight: 2%-10% of EPA deep-sea fish oil, 0.1%-4% of carboxymethyl chitosan, 1%-3% of taurine, 0.1%-3% of apricot kernel oil, 0.1%-3% of perilla oil, 0.1%-1% of natural vitamin E, 30%-60% of surfactant, 1%-10% of cosurfactant, 1-6% of oil phase and the balance of deionized water, and the sum of the mass percents of all the components is 100%. The compound nanoemulsion oral liquid can reduce the total cholesterol of the blood, the low-density lipoprotein, the triglyceride and the absorption of lipid simultaneously, has an obvious effect for reducing the blood fat and plays a positive role in preventing the cardiovascular diseases such as cerebral thrombosis, cerebral hemorrhage and high blood pressure and the like.

Description

technical field [0001] The invention relates to a compound preparation for effectively lowering blood fat, which is rich in active ingredients such as EPA, carboxymethyl chitosan and perilla seed oil, and is prepared into a clear, transparent and stable nano-scale microemulsion oral liquid. The invention belongs to the field of health medicine preparation. [0002] Background technique [0003] With the improvement of people's quality of life, opportunities for high-protein and high-fat diets have increased, and the amount of exercise has decreased. The number of patients with hyperlipidemia in my country has reached 160 million. Modern medical certification: Hyperlipidemia is a systemic lipid metabolism abnormality caused by high serum cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) or low serum high-density lipoprotein (HDL) . The incidence of fatty liver in severely obese people caused by hyperlipidemia is as high as 61-94%. The death toll from c...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K47/44A61K47/26A61K9/107A61P3/06A61K31/355A61K31/185A61K31/557
Inventor 欧阳五庆周莹欧阳伸雨
Owner NORTHWEST A & F UNIV
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