4 results about "High serum" patented technology

This invention belongs to the field of functional food core efficacy ingredient production technology, and discloses a food-grade nano-curcumin microcapsule powder, its production method, and applications. This production method utilizes the dual characteristics of pH-mediated dissociation and reconstruction of casein nanomicelles and the solubility of curcumin in a strongly alkaline environment, achieving efficient and high-loading encapsulation of curcumin with sodium caseinate, and the industrial production of high-quality microcapsule powder. The food-grade nano-curcumin microcapsule powder produced by this invention is not only simple and safe in its formulation, with its main components being only sodium caseinate, curcumin, and spray drying aids, but also features a simple production process that is easy to industrialize. Animal experiments have verified that the food-grade nano-curcumin microcapsule powder produced by this invention can significantly improve the symptoms of alcohol intoxication in mice, increase the activity of serum alcohol-metabolizing enzymes while alleviating oxidative stress damage, and reduce the release of inflammatory factors, thus exhibiting superior hangover relief and liver protection effects.

The present disclosure relates to therapeutic combinations comprising an anti- KMA antibody and a proteasome inhibitor for the treatment of multiple myeloma. The present disclosure also relates to methods of treating multiple myeloma in subjects with high serum cytokine levels.

The application discloses a composition with qi and blood tonifying effect, a preparation method, application and related products, and belongs to the technical field of traditional Chinese medicines. The technical problem to be solved is to provide a traditional Chinese medicine composition with better qi and blood tonifying effect. The technical solution is characterized in that the composition is prepared from 5-15 parts of angelica sinensis, 9-30 parts of astragalus root and 7.5-15 parts of reynoutria root. The angelica sinensis is a mixture of raw angelica sinensis and vinegar-fried angelica sinensis, the astragalus root is a mixture of raw astragalus root and honey-fried astragalus root, and the reynoutria root is a mixture of raw reynoutria root and prepared reynoutria root. Animal experiments show that the composition provided by the application can significantly improve the levels of RBC, HGB, HCT, WBC and PLT of blood deficiency mice, and improve the levels of EPO, G-CSF, M-CSF and sVCAM-1 in serum.

The application discloses an organic small molecule which can be activated by alkaline phosphatase and visible light, and a preparation method and application thereof. The structural formula of the organic small molecule is shown as formula I. The organic small molecule and cis-trans isomers thereof exist in a stable cis or trans configuration under dark conditions and have no cytotoxicity. Under visible light irradiation, the organic small molecule undergoes cis-trans isomerization, and the isomerization efficiency is regulated by the concentration of serum albumin in the environment. Based on this, the good biocompatibility of visible light and the wide existence of albumin in vivo can be used as a double regulation means, so that the organic small molecule has no toxic side effects under high serum albumin physiological conditions. In a tumor cell environment, through visible light irradiation and albumin concentration removal, the organic small molecule is in a trans configuration, and through alkaline phosphatase reaction, the organic small molecule has a high tumor cell killing ability, achieves time and space control of drug activity, and has application prospects in on-demand precise treatment of tumors.