New medical application of traditional Chinese medicine privet and preparation method of its extraction

Abstract

The invention provides a new medical application of a Chinese traditional medicine fructus ligustri lucidi and the producing method of the extract thereof, which is produced by following steps: ethanol circumfluence, extracting and concentrating from the plant fructus ligustri lucidi to get an ethanol extract, separation by crystallization with the hydrochloric acid function, NaOH treating, again acid out, washing, drying, obtaining other effective components. Pharmacological experiments prove that the medicine can be used for treating the II-type diabetes and induced complication, which has the effects such as reducing the blood sugar, triglyceride, total cholesterin, and low density lipoprotein, and increasing the high density lipoprotein and etc. Furthermore, it can avoid the weight decrease and has a long action and no side effects.

Description

technical field

[0001] The invention relates to a non-synthetic hypoglycemic drug for treating endocrine-metabolic system non-insulin-dependent diabetes mellitus (NIDDM, ie type II) and preventing its complications. It is prepared from Chinese herbal medicine Ligustrum lucidum. Background technique

[0002] Diabetes is a common disease that seriously endangers human health. It currently accounts for 5% of the world's population. The death rate caused by its complications ranks third, second only to cardiovascular and cerebrovascular diseases and cancer, and it is increasing year by year. Its occurrence is related to nutritional conditions, obesity, heredity, emotion and other factors, and more than 85% of them are non-insulin-dependent diabetes mellitus (type II). The basic pathological changes of diabetes are hyperglycemia caused by metabolic disorders of sugar, fat, protein, water and electrolytes due to absolute or relative insulin deficiency, often accompanied by hyperli...

Examples

experiment example

[0019] Drug efficacy experiment example: Experiments on blood sugar and blood lipids in mice

[0020] In the experiment, pharmacological research is carried out on the medicine of the present invention, and its influence on blood sugar and blood lipids in mice is observed.

[0021] 1. Materials

[0022] 1.1 Animals

[0023] Healthy, mature, body weight (18-22g), ICR clean-grade mice, half male and half male, were provided by the Experimental Animal Center of Beijing Medical University. The feeding conditions of the mice were room temperature 22±2°C, 12h light and dark cycle, free access to water and food for 7 days, and the experiment was started after adaptation.

[0024] 1.2 Reagents

[0025] Ligustrum lucidum, origin: Zhejiang, Hunan, Henan, Hebei and Shaanxi, and identified as Ligustrum lucidum by experts of traditional Chinese medicine and "Chinese herbal medicines commonly used in China", "Color Atlas of Chinese herbal medicines commonly used in China"; Alloxan (STZ),...

technical field

[0001] The invention relates to a non-synthetic hypoglycemic drug for treating endocrine-metabolic system non-insulin-dependent diabetes mellitus (NIDDM, ie type II) and preventing its complications. It is prepared from Chinese herbal medicine Ligustrum lucidum. Background technique

[0002] Diabetes is a common disease that seriously endangers human health. It currently accounts for 5% of the world's population. The death rate caused by its complications ranks third, second only to cardiovascular and cerebrovascular diseases and cancer, and it is increasing year by year. Its occurrence is related to nutritional conditions, obesity, heredity, emotion and other factors, and more than 85% of them are non-insulin-dependent diabetes mellitus (type II). The basic pathological changes of diabetes are hyperglycemia caused by metabolic disorders of sugar, fat, protein, water and electrolytes due to absolute or relative insulin deficiency, often accompanied by hyperli...

Examples

experiment example

[0019] Drug efficacy experiment example: Experiments on blood sugar and blood lipids in mice

[0020] In the experiment, pharmacological research is carried out on the medicine of the present invention, and its influence on blood sugar and blood lipids in mice is observed.

[0021] 1. Materials

[0022] 1.1 Animals

[0023] Healthy, mature, body weight (18-22g), ICR clean-grade mice, half male and half male, were provided by the Experimental Animal Center of Beijing Medical University. The feeding conditions of the mice were room temperature 22±2°C, 12h light and dark cycle, free access to water and food for 7 days, and the experiment was started after adaptation.

[0024] 1.2 Reagents

[0025] Ligustrum lucidum, origin: Zhejiang, Hunan, Henan, Hebei and Shaanxi, and identified as Ligustrum lucidum by experts of traditional Chinese medicine and "Chinese herbal medicines commonly used in China", "Color Atlas of Chinese herbal medicines commonly used in China"; Alloxan (STZ),...

Images