159results about How to "Fat-lowering effect is good" patented technology

The invention relates to an osmotic pump controlled release pharmaceutical composition which contains two medicine active ingredients and is used for treating hyperlipoidemia and a preparation method thereof, the pharmaceutical composition has a nicotinic acids medicine such as acipimox and the other one estatina medicine such as atorvastatin; wherein, the nicotinic acids medicine such as acipimox is a controlled release part, and the estatina medicine such as atorvastatin is a quick release part; or both the acipimox and the atorvastatin are the controlled release part. The compound osmotic pump preparation of the invention has the advantages of comprehensive action, low toxicity and side effects and convenient use.

The invention relates to a preparation method of a eurotium cristatum mycelium extract, and mainly relates to a process for liquid fermentation of eurotium cristatum, collection of mycelium and extraction of active ingredients. A fermentation culture medium of the eurotium cristatum uses tea powder as a nutritional ingredient and a dispersion medium to promote the pelletizing property of the eurotium cristatum mycelium, so that the nutritional ingredients in the culture medium are used and converted to the maximum. Through fermentation culture in a 1L fermentation tank, the dry weight of the mycelium can be up to 15g / L. The fermentation liquor is centrifuged to collect the mycelium, then the mycelium is subjected to weight suspending by using water and then is twisted into fragments, a wall-breaking enzyme is added and uniformly mixed with the mycelium, and then the mixture is subjected to high-pressure homogenization and alcohol precipitation to extract the active ingredients in the mycelium. The preparation method improves the existing relative processes, so that the extraction rate of the active ingredients in the mycelium is improved, and large-scale production can be realized. The active ingredients in the mycelium mainly comprise polysaccharide, and have better effects on reducing fat and improving the stomach and intestines.

The blood pressure and blood lipid- lowering capsule is prepared with three kinds of Chinese medicinal materials, including cassia seed, haw and lotus leaf, in certain weight proportion. The medicine has the functions of clearing away heat, promoting blood circulation, falling turbid and relaxing the bowels, and possesses determined curative effect on hyperlipemia. It has high safety, short disintegrating period, small dosage, raised patient's compliance and high clinical curative effect.

The present invention relates to a kind of medicine for treating hyperlipermia and its preparation process. The medicine is prepared with prepared fleeceflower root, haw, lotus leaf, oriental water plantain, cattail pollen and fried cassia seed in certain proportion. The medicine is especially suitable for the clinical treatment of hyperlipermia and has excellent improving effect on dizziness, numbness of limbs and fullness sensation in chest.

Belonging to the field of medical technologies, the present invention discloses application of aloe-emodin in preparation of drugs reducing blood lipid and liver lipid. Specifically, blood lipid refers to total cholesterol and low density lipoprotein in serum, and liver lipid refers to total cholesterol in liver. Toxicity tests show that aloe-emodin has no obvious toxic and side effect. Pharmacodynamic tests of aloe-emodin show that aloe-emodin can significantly reduce the total cholesterol and low density lipoprotein in hyperlipidemia animal model serum, and has obvious blood lipid reducing effect. At the same time, aloe-emodin can also significantly reduce the total cholesterol content of a hyperlipidemia animal model liver, and has obvious liver lipid reducing effect. Therefore, the invention puts forward the application of aloe-emodin in reduction of blood lipid and liver lipid, aloe-emodin has the characteristics of significant lipid reducing effect, low toxicity, no irritation, low price, and convenient production, transportation, storage and taking, and can have broad application prospects as a blood lipid and liver lipid reducing drug.

The invention relates to a composite for lowering blood fat and regulating immunity, which comprises the following components of pseudo-ginseng and Liupu tea. An experiment proves that the composite disclosed by the invention has a better effect on lowering blood fat and regulating immunity if being compared with the prior art, and the composite also has a synergy.

The invention discloses a functional recombined leisure dried meat slice and a preparation method thereof. The preparation method is characterized by comprising the following steps of: selecting fresh lean meat and removing bones, fat and connective tissues to be used as raw material meat; extracting and preparing a scaphium scaphigerum, polygonum multiflorum and red date mixed extracting solution by adopting microwaves; extracting and preparing a grass jelly and rose mixed extracting solution by adopting hot water; injecting a pickling solution prepared by composite phosphate and refined salt into meat blocks and tumbling; chopping and sequentially adding the scaphium scaphigerum, polygonum multiflorum and red date mixed extracting solution, eggs, white pepper powder, white sugar, white spirit, monosodium glutamate and the grass jelly and rose mixed extracting solution; pickling for 1-4 hours; and filling into a mould, baking, chopping, packaging and sterilizing to obtain a finished product. The functional recombined leisure dried meat slice has the advantages of being enriched with dietary fibers, flavone and iron, and having high protein, high dietary fibers, low fat, low heat, dryness and crispiness, and obvious lipid reduction effect.

The invention relates to an onion fermentation milk and the production method thereof; the onion fermentation milk consists of fresh milk, non-antibiotic milk powder, onion juice and lactic bacteria leaven; the production method is that the pungency of onion is removed and the onion is squeezed to get onion juice, then the required fresh milk, non-antibiotic milk powder and onion juice are fully mixed into a mixture, and the mixture is added by the required quantity of lactic bacteria leaven to be fermented in constant temperature and slaked before acquiring an onion bio-fermentation milk. The onion bio-fermentation milk of the invention not only keeps the nutrition components of onion and milk, but also be endowed with onion aroma and fermented milk flavor with good taste, and the pungency of onion is removed and the tasted of fermented milk is improved, furthermore, no abdominal distension and disgusting and vomiting will occurs after continuous intaking, and the appetite of user will be improved; the blood lipid value of those with hyperlipemia may be decreased with obvious effect to normal value after a period of taking the onion bio-fermentation milk.

The invention pertains a kind of healthy pill for decreasing fat, belonging to the field of healthy food. Its composition: sanqi35-40%, danshen25-28%, haw25-28%, others are accessories. It use the traditional process, accessories are traditional also. Through more than 2000 people's usage, it has been proved it costs little, has good effect, use safely, and is a kind of natural green healthy food.

The invention relates to a drinking liquid with uric acid decreasing and lipid lowering effects and a preparation method of the drinking liquid. The drinking liquid contains a sunflower disc water extract which is diluted to 500 ml with a proper amount of water, wherein the sunflower disc water extract is prepared through the following steps: (1) crushing 200 g of the sunflower disc water extract into blocky particles with the size being 1.5 cm, adding 5 times the amount of water for soaking the blocky particles for 2-3 hours, performing extraction by ultra-high pressure equipment in 500-700 Pa of pressure for 5-15 minutes at the room temperature, performing pressure filtration, and concentrating a filtrate to the crude drug dose; (2) adding ethanol with the concentration of 50% and in a volume 2 times that of the filtrate to the concentrated filtrate for alcohol precipitation for 12 hours, taking a supernatant, and heating the supernatant to recover ethanol to obtain the sunflower disc water extract. The drinking liquid has remarkable uric acid decreasing and lipid lowering effects, has small toxic and side effects and can be taken for a long time.

The invention provides a peptide with a pancreatic lipase inhibitor effect. The sequence of the peptide is selected from SEQ ID NO.1-5; the invention also provides application of the peptide in preparation of medicines, foods and health-care products for treating hyperlipemia. The peptide is a plant-derived, non-toxic and harmless natural substance, and experiments prove that the peptide has remarkable pancreatic lipase inhibitory activity and lipid-lowering effect; the compound is clear in action mechanism and definite in target spot, is expected to become a substitute medicine for preventing and treating hyperlipemia, and has a good market prospect in the industries of medicine and functional food.

The invention relates to a making method of high-fiber bean crisp pastries. The making method comprises the following steps of (1) preparing 60-80-mesh mung bean powder; (2) mixing the mung bean powder with wheat flour and sweet potato dietary fibers, adding high temperature resistant alpha-amylase and high temperature resistant cellulase, performing activation, adjusting the moisture content of materials to be 15-20%, pouring the treated materials into a twin-screw extrusion bulking machine to obtain bar-shaped semi-finished products, performing drying, and performing crushing to 100-120 meshto obtain puffed powder; (3) preparing an additive capable of reducing blood lipid from raw materials of dry products of lotus leaves, haws and shiitake mushrooms; (4) mixing robinia honey with sucralose and maltitol, performing dissolving, performing granulation, performing drying, and performing granule separation to obtain a sweet mixture; (5) mixing the puffed powder with the additive capableof reducing blood lipid and the sweet mixture, adding glutinous rice flour, eggs and olive oil, and performing uniform stirring to obtain dough; (6) performing baking to obtain pastries; and (7) encapsulating products. The invention provides the making method of high-fiber bean crisp pastries having the function of reducing blood lipid, the mouth feel of coarse cereals is significantly improved,and the digestibility is improved.

The invention discloses phytosterol nano-emulsion capable of losing weight and lowering lipid and a preparation method of the phytosterol nano-emulsion. The phytosterol nano-emulsion is prepared fromthe following raw materials in percentage by mass: 0.5 to 4 percent of phytosterol, 5 to 25 percent of nutritional oil, 5 to 15 percent of an emulsifier, 0.1 to 0.6 percent of an antioxidant, 0.1 to 0.5 percent of an inorganic additive and the balance of water which is aaded until the content is 100 percent. According to the phytosterol nano-emulsion disclosed by the invention, the ratio of threetypes of phytosterols are reasonably adjusted, and 4-demethlyate sterol and 4,4'-dimethyl sterol have a sufficient synergetic effect to alleviate the obesity; meanwhile, a cholesterol lowering effectand a mechanism of adjusting an endogenous cannabinoids system are used simultaneously to realize the effect of cooperatively lowering the lipid. The phytosterol nano-emulsion prepared by the invention can be directly applied to functional foods, medicines and the like; the dosage of lipid-lowering Western medicines is reduced and the lipid-lowering effect is remarkable; other complications can beobviously alleviated or eliminated.

The invention relates to a food additive used to reduce fat and relative application, wherein said additive comprises that: dry lotus leaf, haw thorn, and Dioscorea japonica at 1:1. 2:1. 2 breaking materials into dry powder. The invention can be added into food at 10-13%. The inventive additive can reduce fat and protect stomach, with wide application.

The invention is a kind of compound plant ethanol which can decrease serum cholesterin and the manufacturing technique, the plant ethanol or plant sterol are heated and dispersed into other medium, there medium can be ovenproof edible emulsifier such as lactic acid stearate, sucrose fatty acid ester, they also can be nutrient oil such as evening primrose oil. Korean pine seed oil, flex seed oil, colored glaze lettuce seed oil, deepwater fish oil, bark soil, vitamin E, they may be the compound of the emulsifier and nutrient oil. The invention is scientific, convenient, no peculiar smell and no toxic side effect.

The invention discloses an earthworm protein for reducing blood sugar and blood pressure and eliminating diabetic complications. The earthworm protein is prepared by adopting the following steps of: 1) cleaning earthworms, namely, selecting live earthworms, removing impurities and dead earthworms, putting the live earthworms into water of which the PH value is 4 to 5.8 for 10 to 15 minutes, meanwhile, adding 50 g of salt, leaching the cleaned live earthworms, and flushing the live earthworms by using warm water of 28 DEG C to remove redundant moisture and impurities on the outer surfaces; 2) pulping; 3) filtering or centrifuging the homogenate obtained in the step 2) to remove rough residue therein, and filtering the residue removed homogenate to obtain clear liquor, wherein each milliliter of the clear liquor contains more than 180 enzyme activity units; putting the clear liquor into a disinfected container, injecting high-pressure CO2 gas, mechanically and fully stirring the clear liquor to be treated for 3 to 8 minutes, and releasing pressure through a conduit, wherein the solubility of CO2 is quickly reduced after the pressure is reduced; then filtering to remove impurities, and settling for 12 hours to obtain supernate; and 4) freeze-drying, namely drying the supernate in a freeze drier of 28 DEG C below zero to obtain a powdery product, wherein each milligram of the product contains 2,000 to 3,000 enzyme activity units.

The invention discloses a petroleum ether extract of traditional Chinese medicine for preventing and treating glucose and lipid metabolic disturbance, comprising the following active components: isoceryl alcohol, beta-sitosterol, n-hexacosane acid, butenolide III, oleanolic acid, berberine, jateorhizine, salvianolic acid B, lignocerane, 9,12-octadecadienoic acid, 5,7-dimethoxy coumarin and ginsenoside Rb1. The preparation method comprises the following steps: after extracting crude medicines of root of red rooted salvia, glossy privet fruit, coptis, thistle, eucommia, white atractylodes rhizome, pseudo-ginseng and finger citron by C1-3 alcohols and / or water, combining all the extracts, and extracting the total extract by petroleum ether to obtain the petroleum ether extract of traditional Chinese medicine for preventing and treating glucose and lipid metabolic disturbance. A big amount of inactive components in the original compound traditional Chinese medicine are removed from the extract provided by the invention, so that much more efficient extraction parts of the traditional Chinese medicines are obtained, and the extract has a stable preparation process, controllable quality and notable curative effect, and is convenient to use and be produced into various dosage forms.

The invention relates to an omega-3 fish oil soft capsule. The omega-3 fish oil soft capsule comprises a core material and a capsule material, wherein the core material is prepared from the following components in part by weight: 40-70 parts of EPA (eicosapntemacnioc acid), 78-192 parts of DHA (docosahexaenoic acid), 15-32 parts of ginkgo leaf, 14-28 parts of acanthopanax root, 16-35 parts of pseudoginseng, 15-21 parts of salvia extract, 20-45 parts of anthocyanin, 35-68 parts of natural vitamin E, 24-49 parts of soybean oil, 21-56 parts of lecithin and 15-34 parts of arachidonic acid. The capsule material is prepared from the following components in part by weight: 10-15 parts of gelatin, 8-16 parts of glycerine, 4-8 parts of purified water, 3-9 parts of edible emulsifier and 4-9 parts of edible pigment. The Chinese herbs pseudoginseng, acanthopanax root, ginkgo leaf, salvia and the like have the functions of promoting blood circulation, eliminating blood stasis, inhibiting platelet aggregation, regulating blood lipid and the like, the EPA and the DHA extracted from deep-sea fish oil also have significant blood lipid-lowering effect, the vitamin E and the anthocyanin have a significant antioxidant effect, and the components are combined in certain part by weight, so that the omega-3 fish oil soft capsule has a significant blood lipid-lowering effect and can protect heart and brain blood vessels well to avoid cardiovascular events caused by long-term lipid disorder.

The invention provides a hypolipidemic compound 9-demethylberberine. The 9-demethylberberine is derived from a main in-vivo metabolite of natural medicine berberine, and is also named as berberrubine. The researches on model animals with hyperlipidemia find that the 9-demethylberberine has good drug effects of reducing cholesterol, triglyceride, low density lipoprotein (LDL) and the like, and has no obvious side effects for 6 weeks of continuous medication. The discovery can lead to discovery of a new hypolipidemic drug, and provides another alternative medicine for clinic treatment of hyperlipidemia, lipid metabolism disorder and high fat and obese patients and related people wanting to lose weight.

The invention discloses a medicine composition and application thereof, and a medicament containing the medicine composition. The medicine composition comprises moraceae morus plant total alkaloids and balsam pear total saponins, wherein the mass content ratioof the moraceae morus plant total alkaloids and the balsam pear total saponins is 1:2-7:1; the moraceae morus plant total alkaloids are used in the form of moraceae morus plant extracts in the medicine composition, and the balsam pear total saponins are used in the form of balsam pear extracts in the medicine composition; the moraceae morus plant total alkaloids comprise 1-deoxynojirimycin, and the mass content of the 1-deoxynojirimycin in the moraceae morus plant extracts is 2-50%. Target components are extracted from natural plants; the medicine composition has excellent effects of decreasing blood-glucose, losing weight, and reducing lipid in a synergetic manner, and is particularly suitable for the treating and preventing type 2 diabetes.

The invention provides a new osmotic pump controlled release pharmaceutical composition used for treating hyperlipoidemia and a preparation method thereof, the pharmaceutical composition has a nicotinic acids medicine such as acipimox and the other one estatina medicine such as simvastatin; wherein, the nicotinic acids medicine such as acipimox is a controlled release part, and the estatina medicine such as simvastatin is a quick release part; or both the acipimox and the simvastatin are the controlled release part. The compound osmotic pump preparation of the invention has the advantages of comprehensive action, low toxicity and side effects and convenient use.

The invention discloses applications of an emodin succinyl ester compound in preparing lipid-lowering medicines, belonging to the technical field of medicines. The emodin succinyl ester compound has the structure (R is C1-5 alkyls) as shown in the formula I. The pharmacological experiment is carried out on the experiment mixed type rats with hyperlipemia, and the result proves that the emodin succinyl ester compound provided by the invention is superior to emodin, and has the advantages that the lipid-lowering effect is obvious, the safety is good, the medication is simple and convenient, theraw materials are cheap and easily available, and the transportation and storage are convenient. The emodin succinyl ester compound provided by the invention has the wide application prospect in the field of preparation of the lipid-lowering medicines.

The invention relates to the process for extracting protein of Chinese medicinal cassia seed having a molecular weight of 19680, which comprises, extracting cassia seed crude protein, purifying the cassia seed crude protein, separating and purifying cassia seed protein peak2. The invention relates to the use of the cassia seed protein in preparing grease-lowering medicament.

The present invention relates to a production process of clover and perilla concentrated extract. Firstly, said invention selects the clover variety richly containing polysaccharide, saponin and flavone health-care nutrient components as material for germination and making leaf powder and selects large-leaf perilla as material for making perilla leaf powder, then said invention adopts the following steps: preparing selenium-enriched clover germ powder, preparing fresh clover leaf powder and preparing fresh perilla leaf powder, then making preparation of clover and perilla plant concentrated extract, in aqueous solution extracting clover germ powder, clover leaf powder and perilla leaf powder, filtering extracts to oblain concentrated germ liquor and concentrated leaf liquor, combining them according to a certain ratio so as to obtain the invented clover and perilla concentrated extract with rich effective nutrient components and the functions of reducing blood fat and raising immunity.

The invention belongs to the technical field of vinegar production and brewing, and provides a method for brewing lipid-lowering vinegar in order to improve a healthcare effect of the vinegar and makedevelopment of the vinegar be no longer limited to seasoning. The method comprises the following steps: using naked oats, chenopodium quinoa willd and sorghums as main grains; using chaffs, rice husks and brans as auxiliary materials; mixing tartary buckwheat with Pu-er ripe tea as a red yeast rice fermentation substrate; using purple red yeast rice numbered as CICC: 41601 as a fermentation strain; fermenting monascus sp.; mixing the main grains with the monascus sp. at a weight ratio of 1: 0.625, fermenting with alcohol; adding the auxiliary materials into the obtained wine mash to be mixedas a vinegar culture, wherein the weight ratio of the main grains to the auxiliary materials is 1: 1; inoculating acetic acid bacteria being 12%-15% by weight of the vinegar culture for acetic fermentation; and then smoking and sprinkling the vinegar culture to obtain the lipid-lowering vinegar. The method provided by the invention obviously increases a content of lovastatin in the obtained vinegar up to 890 mg / L, improves a healthcare function of the vinegar, and particularly has a significant lipid-lowering effect.

The invention relates to an osmotic pump preparation containing acipimox, rosuvastatin and other pharmaceutical excipients, wherein, the acipimox is the controlled-release part, the rosuvastatin is the rapid-release part; or the acipimox and the rosuvastatin are both the controlled-release parts. In addition, the invention further discloses a preparation method of an osmotic pump tablet of the composition, and the osmotic pump table which is prepared by applying the method can better bring the synergy of the acipimox and the rosuvastatin into play.

The medicine composition for treating hyperlipemia is prepared with Chinese medicinal materials nutagrass flatsedge rhizome, rhubarb, trogopterus dung, etc and through conventional medicine preparing process. The present invention has the advantages of unique recipe, determined curative effect, high safety, low cost and no obvious toxic side effect. It has the functions of regulating vital energy, alleviating mental depression, promoting blood circulation, eliminating blood clots, promoting digestion, etc. and is suitable for treating Qi stagnation, blood stasis and phlegm stagnation type hyperlipemia.

The invention relates to an osmotic pump preparation containing acipimox, fluvastatin and other pharmaceutical excipients, wherein, the acipimox is the controlled-release part, the fluvastatin is the rapid-release part; or the acipimox and the fluvastatin are both the controlled-release parts. In addition, the invention further discloses a preparation method of osmotic pump tablets of the composition, and the osmotic pump table which is prepared by applying the method can better bring the synergy of the acipimox and the fluvastatin into play.

The invention discloses a medicinal composition for reducing blood fat and protecting liver. The medicinal composition is prepared from the following medicinal materials in parts by weight: 300-500 parts of astragalus root, 100-300 parts of piperis longi and 5-50 parts of kudzuvine root. Moreover, the invention also discloses a preparation method for the medicinal composition and application of the medicinal composition in blood fat reduction and liver protection.