Petroleum ether extract of traditional Chinese medicine for preventing and treating glucose and lipid metabolic disturbance and preparation method thereof

Abstract

The invention discloses a petroleum ether extract of traditional Chinese medicine for preventing and treating glucose and lipid metabolic disturbance, comprising the following active components: isoceryl alcohol, beta-sitosterol, n-hexacosane acid, butenolide III, oleanolic acid, berberine, jateorhizine, salvianolic acid B, lignocerane, 9,12-octadecadienoic acid, 5,7-dimethoxy coumarin and ginsenoside Rb1. The preparation method comprises the following steps: after extracting crude medicines of root of red rooted salvia, glossy privet fruit, coptis, thistle, eucommia, white atractylodes rhizome, pseudo-ginseng and finger citron by C1-3 alcohols and / or water, combining all the extracts, and extracting the total extract by petroleum ether to obtain the petroleum ether extract of traditional Chinese medicine for preventing and treating glucose and lipid metabolic disturbance. A big amount of inactive components in the original compound traditional Chinese medicine are removed from the extract provided by the invention, so that much more efficient extraction parts of the traditional Chinese medicines are obtained, and the extract has a stable preparation process, controllable quality and notable curative effect, and is convenient to use and be produced into various dosage forms.

Description

A kind of traditional Chinese medicine petroleum ether extract for preventing and treating glucose and lipid metabolism disorder and its preparation method technical field The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine petroleum ether extract for preventing and treating diseases related to glucose and lipid metabolism disorders (hyperlipidemia, diabetes, metabolic syndrome, animal atherosclerosis and other related diseases) and a preparation method thereof. Background technique Chinese patent 200410051250.4 discloses a drug for treating hyperlipidemia, named "Fufang Zhenzhu Tiaozhi Fang" (FTZ), which contains Ligustrum lucidum, Daji, Atractylodes macrocephala, Salvia miltiorrhiza, Eucommia, bergamot, and notoginseng and coptis. The preferred weight percentage of each component is Ligustrum lucidum 20-25%, Daji 12-15%, Atractylodes macrocephala 10-15%, Salvia miltiorrhiza 10-15%, Eucommia 10-15%, Bergamot...

AI Technical Summary

Problems solved by technology

Although Fufang Zhenzhu Tiaozhi Decoction has good blood lipid regulation and anti-arteriosclerosis functions and clinical curative effects, but because it is a compound preparation of traditional Chinese medicine, there are still many shortcomings: (1) Its ingredients are complicated, and its active ingredients are not clear enough, It is not easy to quantify, and the quality of its products is not easy to be effectively controlled in practical applications, which will eventually affect the stability of the clinical efficacy of the product; (2) The preparation process is relatively simple, the active ingredients in the prescription cannot be purified as they should be, and there are many impurities. Large (nearly more than 5 grams per day), the patient's compliance is not ideal; (3) due to the large amount of prescription extracts, it is inconvenient to make various controlled-release dosage forms, the preparation of pharmaceutical preparations cannot be diversified, and the scope of application is subject to various restrictions

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