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Medicine composition and application thereof, and medicament containing medicine composition

A composition and drug technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, pharmaceutical formulations, etc., can solve problems such as poor blood sugar-lowering function, and achieve good lipid-lowering effect

Active Publication Date: 2014-03-12
HILL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the technical problem of poor hypoglycemic function of drugs in the prior art, the present invention provides a pharmaceutical composition with a synergistic hypoglycemic function and a good hypoglycemic effect, its application, and a medicament containing it

Method used

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  • Medicine composition and application thereof, and medicament containing medicine composition

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preparation example Construction

[0048] Preparation of reference substance solution Take an appropriate amount of 1-deoxynojirimycin (DNJ) reference substance, weigh it accurately, add 80% methanol to make 1ml containing 0.2024mg, which is the stock solution. Precisely measure 1mL of the stock solution and place it in a 25mL measuring bottle, add 0.2mol / L boric acid-potassium chloride buffer (PH=8.5) and 4mL of 20mmol / L fluorenylmethoxycarbonyl chloride in acetonitrile, shake well, and sonicate Treat (power 100W, temperature 42°C) for 20 minutes, immediately add 2 mL of 0.05 mol / L glycine, and shake well. Dilute to the mark with 0.1% acetic acid solution, shake well, and get ready.

[0049]Preparation of the test solution Accurately weigh about 0.1g of the sample in a 25mL measuring bottle, add 80% methanol to fully dissolve, ultrasonicate at room temperature for 10min, and set the volume to the mark. Accurately measure 1mL of the solution, put it in a 25mL measuring bottle, add 0.2mol / L boric acid-potassium...

Embodiment 1

[0067] Crush 1000g mulberry leaves, add 10 times the weight of water, soak for 30 minutes, boil for 1 hour, take out and keep the filtrate; add 8 times the weight of water to the filter residue, soak for 20 minutes, boil for 30 minutes, keep the filtrate; combine the extracts Concentrate, add water to dissolve, adjust pH to 4, add chitosan, stand still, centrifuge, take supernatant; supernatant adjust pH to 3.0, remove precipitation and then adsorb through macroporous cation exchange resin, wash with water to remove impurities , with a mass concentration of 2.5% ammonia water to elute the resin, collect the ammonia water eluate, concentrate and dry to obtain 9.5g of mulberry leaf extract, the total alkaloid mass content in the mulberry leaf extract is 52.4%, and 1- The content of deoxynojirimycin (DNJ) is 9.2%.

[0068] After crushing 1000g dry slices of bitter gourd, add 65% ethanol and carry out reflux extraction at 90°C for 2 times, each extraction for 60 minutes, filter, c...

Embodiment 2

[0071] Crush 4kg of mulberry leaves, add 0.02N hydrochloric acid to decoct twice, 1 hour each time, filter the liquid medicine, combine and concentrate the extracts, add water to dissolve, adjust the pH to 5, add sodium alginate, let stand, centrifuge, and take supernatant; adjust the pH to 3.0 in the supernatant, absorb by macroporous cation exchange resin after removing precipitation, and wash to remove impurities, then elute the resin with a mass concentration of 3% ammonia water, collect the ammonia water eluate, concentrate and dry to obtain mulberry The leaf extract is 42.4g, the total alkaloid content of mulberry leaves in the mulberry leaf extract is 75.2%, and the 1-deoxynojirimycin (DNJ) content in the mulberry leaf extract is 11.4%.

[0072] After crushing 1000g dry slices of bitter gourd, add water and carry out reflux extraction at 90°C for 2 times, each extraction for 60 minutes, filter, combine the filtrate, concentrate, adjust pH=8, then use AB-8 macroporous res...

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Abstract

The invention discloses a medicine composition and application thereof, and a medicament containing the medicine composition. The medicine composition comprises moraceae morus plant total alkaloids and balsam pear total saponins, wherein the mass content ratioof the moraceae morus plant total alkaloids and the balsam pear total saponins is 1:2-7:1; the moraceae morus plant total alkaloids are used in the form of moraceae morus plant extracts in the medicine composition, and the balsam pear total saponins are used in the form of balsam pear extracts in the medicine composition; the moraceae morus plant total alkaloids comprise 1-deoxynojirimycin, and the mass content of the 1-deoxynojirimycin in the moraceae morus plant extracts is 2-50%. Target components are extracted from natural plants; the medicine composition has excellent effects of decreasing blood-glucose, losing weight, and reducing lipid in a synergetic manner, and is particularly suitable for the treating and preventing type 2 diabetes.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, its application, and a medicament containing the pharmaceutical composition. Background technique [0002] In modern society, the number of diabetic patients is increasing, and hyperglycemia is becoming a serious problem. In the prior art, drugs with hypoglycemic effect and drugs for treating diabetes have poor hypoglycemic effect, and the development of drugs with good hypoglycemic effect has become a research hotspot. Contents of the invention [0003] In order to solve the technical problem of poor hypoglycemic function of drugs in the prior art, the present invention provides a pharmaceutical composition with synergistic hypoglycemic function and good hypoglycemic effect, its application, and the medicament containing it. [0004] The invention provides a pharmaceutical composition, which contains total alkaloids of Moraceae Morus plants and total saponins of Momordica balsam pear; t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61K36/42A61P3/10A61P3/04A61P3/06A61K31/445
Inventor 邓义德易跃能刘湘荣陈锋肖满意
Owner HILL PHARMA
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