Traditional Chinese medicine composition for treating exogenous headache and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating exogenous headache and a preparation method thereof, and belongs to the technical field of traditional Chinese medicinal materials. The traditional Chinese medicine raw material formula contains 6-20 parts by weight of radix puerariae, 1-5 parts by weight of fructus viticis, 1-5 parts by weight of rhizoma corydalis, 4-16 parts by weight of mint, 4-20 parts by weight of ligusticum wallichii, 4-20 parts by weight of schizonepeta, 1-5 parts by weight of asarum, 1-10 parts by weight of radix saposhnikoviae, 3-10 parts by weight of radix angelicae, 3-10 parts by weight of notopterygium root and 3-10 parts by weight of honey-fried licorice root. Traditional medicine believes that headache is mainly caused by internal organ dysfunction due to wind-cold damp evil invasion, emotion depression, improper diet and the like, exogenous evil invading brain collaterals, blood stasis and stagnation, and pain due to obstruction. The disease is treated according to the principle of dispelling wind, relieving pain and promoting blood circulation to remove blood stasis. The traditional Chinese medicine composition prepared by the method disclosed by the invention can dispel wind, dredge collaterals, dispel cold, eliminate dampness, clear head and eyes, promote qi circulation and relieve pain by matching the 11 traditional Chinese medicines.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for treating exogenous headache and a preparation method thereof. Background Art

[0002] Headache is one of the most common clinical symptoms. The incidence rate has been on the rise in recent years, especially migraine. Epidemiological surveys show that the incidence rate of migraine in my country is 9%, which is lower than that in European countries. However, based on the large population of my country, the disease burden it brings is becoming increasingly heavy. Although traditional Western medicines are effective quickly, long-term use of analgesics will increase the risk of medication overuse headaches, and there is an urgent need to find safer and more effective diagnosis and treatment methods. Headaches can have a serious impact on patients' daily lives. When the headache is splitting, it will make patients irritable, the body will feel severely uncomfortable, and the quality of life will be seriously reduced. Therefore, it is very important to find more reasonable and effective treatment measures.

[0003] Traditional Chinese medicine has long recognized headaches, which are characterized by headaches as the main symptom, manifested as pain in the forehead, frontotemporal region, vertex, occipital region, or even the entire head. The nature of the pain may be throbbing pain, stabbing pain, distending pain, fainting pain, dull pain, or empty pain. It may occur suddenly or repeatedly, and the duration of pain may range from minutes to hours or weeks. Headaches are mainly caused by two factors: exogenous and endogenous. Exogenous headaches are often acute and severe, manifested as throbbing pain, distending pain, distending pain, and endless pain. In modern medicine, migraines, headaches after colds, cyclical migraines, and tension headaches can refer to the syndrome differentiation and treatment of exogenous headaches, with the main means of dispelling wind, unblocking collaterals, relieving pain, and promoting qi, clearing depression, and clearing the orifices, which are often effective. For clinical headache treatment, modern medicine often seeks the cause after pain relief treatment to exclude organic lesions. Commonly used drugs for relieving headaches, such as ibuprofen, often have gastrointestinal and nervous system side effects and allergic reactions such as rashes and urticaria, and may even cause serious side effects such as nephrotic syndrome. Summary of the invention

[0004] The purpose of the present invention is to provide a Chinese medicine composition for treating exogenous headache in view of the above-mentioned problems existing in the prior art. The technical problem to be solved by the present invention is that the combination of Pueraria root, Vitex rotundifolia, Corydalis yanhusuo, Mentha, Chuanxiong, Nepeta tenuifolia, Asarum, Saposhnikovia divaricata, Angelica dahurica, Notopterygium wilfordii and Radix Glycyrrhizae can promote qi and blood circulation, dispel wind and dredge collaterals, clear the head, remove blood stasis and relieve pain, and has obvious effect on treating exogenous headache.

[0005] The object of the present invention can be achieved by the following technical scheme: a traditional Chinese medicine composition for treating exogenous headache, characterized in that the raw material formula of the traditional Chinese medicine composition includes 6-20 parts by weight of Pueraria root, 1-5 parts by weight of Vitex rotundifolia, 1-5 parts by weight of Corydalis yanhusuo, 4-16 parts by weight of peppermint, 4-20 parts by weight of Chuanxiong, 4-20 parts by weight of Nepeta tenuifolia, 1-5 parts by weight of Asarum, 1-10 parts by weight of Saposhnikovia divaricata, 3-10 parts by weight of Angelica dahurica, 3-10 parts by weight of Notopterygium wilfordii and 3-10 parts by weight of Radix Glycyrrhizae Preparata.

[0006] Preferably, the raw material formula of the traditional Chinese medicine composition includes 10-16 parts by weight of Pueraria root, 2-4 parts by weight of Vitex rotundifolia, 2-4 parts by weight of Corydalis yanhusuo, 8-12 parts by weight of peppermint, 8-16 parts by weight of Chuanxiong, 8-16 parts by weight of Schizonepeta tenuifolia, 2-4 parts by weight of Asarum, 3-6 parts by weight of Saposhnikovia divaricata, 5-8 parts by weight of Angelica dahurica, 5-8 parts by weight of Notopterygium wilfordii and 5-8 parts by weight of Glycyrrhiza uralensis.

[0007] Preferably, the dosage form of the traditional Chinese medicine composition is granules, capsules, tablets, pills, pastes or aqueous solutions.

[0008] The invention is based on the basic understanding of traditional Chinese medicine on the basic pathogenesis of exogenous headache disease, "exogenous evil invades, and pain occurs when the disease is blocked", and proposes the basic treatment principle of "dispelling evil and activating collaterals, promoting qi and relieving pain", and prepares a Chinese medicine composition. The composition uses Chuanxiong and Pueraria root as the main ingredients, Chuanxiong is pungent and warm, dispersing wind and activating blood circulation; Pueraria root relieves muscles and reduces fever, promotes blood circulation and activates collaterals; peppermint and schizonepeta are the ministers, dispersing wind and relieving pain, and clearing the head; Qianghuo, Baizhi and Xixin are respectively used to treat Taiyang, Yangming and Xixin headaches; Fangfeng disperses wind evil in the head, Vitex romantis clears the head, and Corydalis promotes blood circulation, promotes qi and relieves pain, which are all adjuvants, and help the main ingredient and minister to enhance the effect of dispersing wind and relieving pain. Roasted Licorice root invigorates qi and harmonizes the middle, and is the guiding drug. The whole formula cooperates to play the effect of dispersing wind, dispersing cold, dredging collaterals, and soothing the liver, promoting qi and relieving pain. The Chinese medicine composition of the present invention can improve the microcirculation of the back of the neck, increase the oxygen supply to the back of the brain, help sleep, and has a good therapeutic effect on exogenous headaches such as cervical spondylosis headache, rhinitis headache, occipital neuralgia, etc.

[0009] The beneficial effects are as follows: the present invention can dispel wind and dredge meridians, dispel cold and dampness, and relieve pain by combining the drugs of kudzu root, vitex rotundus, yanhusuo, mint, chuanxiong, schizonepeta, asarum, saposhnikovia, angelica dahurica, angelica dahurica and licorice, and can also dispel liver and remove blood stasis, and clear the head. It can promote microcirculation of the body, be beneficial to oxygen supply of blood vessels in the back of the neck and the brain, improve sleep, and has a good therapeutic effect on exogenous headaches such as cervical spondylosis headache, rhinitis headache, occipital neuralgia, etc., and the cure time is short, the toxic and side effects are small, and it is safe to take.

[0010] The second object of the present invention is to provide a method for preparing a Chinese medicine composition, characterized in that it comprises the following steps: (1) mixing Pueraria root, Vitex rotundus, Corydalis yanhusuo, Mentha, Chuanxiong, Nepeta tenuifolia, Asarum, Saposhnikovia divaricata, Angelica dahurica, Notopterygium wilfordii and Radix Glycyrrhizae with water according to the formula, decocting and filtering, and collecting a first filtrate;

[0011] (2) mixing the medicinal residue obtained in step (1) with water, boiling and filtering, and collecting a second filtrate;

[0012] (3) The first filtrate is mixed with the second filtrate and concentrated under reduced pressure to form a decoction.

[0013] The Chinese medicine composition prepared according to the Chinese medicine raw material formula and the method described in the present invention can effectively prevent and treat exogenous headaches, promote oxygen supply to the blood vessels in the neck, increase cerebral blood flow, improve sleep, and relieve pain and discomfort symptoms in the state of exogenous headaches.

[0014] In the method described in the present invention, in step (1), the ratio of the total mass of the kudzu root, vitex rotundus, yanhusuo, mint, chuanxiong, schizonepeta, asarum, siler, angelica dahurica, notopterygium and licorice to the mass of water is 1:(10-15).

[0015] In the method of the present invention, in step (1) and step (2), the boiling temperature is 90-100° C. and the boiling time is 20-40 minutes.

[0016] In step (2), the mass ratio of the medicinal residue to water can be 1:(5-10).

[0017] In step (3), the temperature for concentration under reduced pressure is 40 to 60°C.

[0018] In step (3), the concentration of the water decoction is 1-2 g / mL.

[0019] In the method of the present invention, the dosage of the Chinese medicine composition can be 0.2-1g crude drug / kg body weight. In a specific embodiment, the dosage of the Chinese medicine composition can be 0.2g crude drug / kg body weight, 0.4g crude drug / kg body weight, 0.6g crude drug / kg body weight, 0.8g crude drug / kg body weight, 1.0g crude drug / kg body weight. In the most preferred embodiment, the dosage of the Chinese medicine composition is 0.4g crude drug / kg body weight.

[0020] According to the method of the present invention, a Chinese medicine composition is prepared, and the 11 Chinese medicines are used in combination, which can relieve wind and dredge meridians, dispel cold and dampness, promote qi and relieve pain; it can also relieve liver and remove blood stasis, and clear the head. In addition, the Chinese medicine composition of the present invention can promote microcirculation of the body, promote oxygen supply to the back of the neck and the brain, improve sleep, and has a good therapeutic effect on exogenous headaches such as cervical spondylosis headache, rhinitis headache, occipital neuralgia, etc., with a short healing time, small toxic and side effects, safe to take, and has great value for promotion and application.

[0021] For exogenous headaches, modern medicine summarizes the pathogenesis of the pain into neurogenic and vascular theories. The neurogenic theory believes that when an exogenous headache occurs, it will cause platelet aggregation, and the body will release many active substances such as adrenaline, thromboxane A2, arachidonic acid, etc., which will further aggravate platelet aggregation and lead to reduced cerebral blood flow; the vascular theory believes that the disease is caused by dysfunction of intracranial vasomotor function.

[0022] As one of the main drugs of this Chinese medicine composition, modern pharmacological studies have shown that the extracts of Chuanxiong, such as ligustrazine, ferulic acid, and ligustilide, can reduce peripheral vascular resistance and blood viscosity, increase cerebral blood flow, resist platelet aggregation, and enhance prostaglandin activity, play analgesic and relieve vasospasm effects, thereby achieving the purpose of treating headaches. Among the active ingredients of Pueraria root, isoflavones, as one of the active ingredients of Pueraria root, have good antioxidant and lipid-lowering effects. Another active ingredient, puerarin, has a good effect on lowering blood pressure and improving the body's microcirculation. It can synergize with other active ingredients such as total flavonoids and soybean aglycone to dilate cerebral blood vessels, promote microvascular movement, improve cardiovascular and cerebrovascular circulation, and control blood pressure levels to be normal and stable. Peppermint, Angelica dahurica and Schizonepeta tenuifolia are traditional Chinese medicines for treating headaches. They are aromatic traditional Chinese medicines with volatile oil as the main component. They have strong biological activity and play anti-inflammatory and improve vascular microcirculation. Mint is a traditional Chinese medicine for relieving the symptoms of cold and phlegm. Pharmacological experiments show that mint has an anti-mental fatigue effect. The piperonene and menthol components in mint have obvious antipyretic and analgesic effects. The latter can also selectively activate the body's menthol receptors, participate in pain, inflammatory response, vasoconstriction and other physiological functions, and play a role in the treatment of headaches. Angelica dahurica is warm in nature and pungent in taste. It is a medicine for relieving the symptoms of cold and phlegm. Its ingredients are rich in furanocoumarins, which can regulate the arachidonic acid metabolic pathway by inhibiting cyclooxygenase-2 to achieve anti-inflammatory purposes. Coumarin compounds represented by imperatorin have biological activities such as anti-inflammatory analgesia, antioxidant, anticoagulation, and relaxation of vascular smooth muscle. These compounds are found in Angelica dahurica and Notopterygium wilfordii, and are the main components for the analgesic effect, which can have a good effect on the treatment of headaches. Nepeta tenuifolia is warm in nature and flat in taste. It is a "moisturizing agent for wind medicine" and is good at expelling wind evil. Research on the pharmacological effects of Nepeta has found that its main chemical component is volatile oil, which can play an anti-inflammatory, analgesic, antiviral and immune-regulating role through multiple signal transduction pathways and metabolic pathways. In the composition, Notopterygium root is pungent, warm, bitter and dry, which can reach the head and clear the joints, and is good at treating headaches of the Taiyang meridian. Its active ingredients, chlorogenic acid, ferulic acid, isoimperatorin and other phenolic acid components and coumarin components have antipyretic, anti-inflammatory, sedative and analgesic effects, and can increase cerebral blood flow, improve cerebral circulation, and relieve migraine. Asarum is often used to treat headaches in the meridians of Shaoyin. The volatile oil components such as racemic higenamine and peppermint oil contained in it can dilate cerebral vascular smooth muscle, relieve cerebral vasospasm, increase blood flow, play a central analgesic effect, and effectively relieve headaches. Vitex roxburghii volatile oil has obvious antipyretic, sedative and analgesic effects. The main active ingredients of Corydalis yanhusuo are berberine alkaloids such as yanhusuo and yanhusuo, which can play a role in sedation, analgesia, hypnosis, anti-anxiety, and anti-cerebral ischemia. As the main analgesic substance, yanhusuo may have an analgesic effect of 40% of analgesics such as morphine, and is particularly suitable for persistent chronic dull pain in clinical practice.At the same time, tetrahydropalmatine is also the main sedative, hypnotic and anti-anxiety component, which can reduce the excitability of the central nervous system to pain signal processing to a certain extent, thereby effectively relieving the sleep disorder and anxiety associated with headache symptoms in patients. Contemporary pharmacological studies have confirmed that Saposhnikovia contains a variety of pharmacological components, including volatile oils, coumarins and polysaccharides, which can relieve fever and swelling, and relieve inflammation and analgesia. For example, cimicifuga glycosides can exert anti-inflammatory effects by inhibiting the expression of COX-2. In addition, coumarins and acidic polysaccharides in Saposhnikovia can regulate the expression of inflammatory factors and the release of related pain factors in the body, achieving the purpose of antipyretic and analgesic. Chinese medicine clinically calls it the ability to dispel wind and cold evil. Licorice, with its sweet and flat nature, has the effect of nourishing the spleen and harmonizing various medicines. Modern pharmacological research and analysis show that its main pharmacologically active ingredient, glycyrrhizin, can inhibit the degranulation of mast cells and prevent the secretion and release of allergic substances such as histamine, and regulate the body's immune function. At the same time, compound extracts of various licorice, such as glycyrrhizic acid and ribose polysaccharides, also have certain anti-allergic effects. DETAILED DESCRIPTION

[0023] The following are specific embodiments of the present invention, which further describe the technical solutions of the present invention, but the present invention is not limited to these embodiments.

[0024] In order to achieve the above object, the present invention provides a traditional Chinese medicine composition for treating exogenous headache. The traditional Chinese medicine composition is prepared from a traditional Chinese medicine raw material formula, and the traditional Chinese medicine raw material formula contains 6-20 parts by weight of Pueraria root, 1-5 parts by weight of Vitex rotundifolia, 1-5 parts by weight of Corydalis yanhusuo, 4-16 parts by weight of Menthus, 4-20 parts by weight of Chuanxiong, 4-20 parts by weight of Nepeta tenuifolia, 1-5 parts by weight of Asarum, 1-10 parts by weight of Saposhnikovia divaricata, 3-10 parts by weight of Angelica dahurica, 3-10 parts by weight of Notopterygium wilfordii and 3-10 parts by weight of Radix Glycyrrhizae Preparata.

[0025] The exogenous headache disease of the present invention has clinical symptoms of aversion to cold, fever, nasal congestion, migraine and neck pain. It is a cold. After being affected by wind evil and cold evil, local blood vessels in the head and neck are constricted, resulting in ischemia and hypoxia. Frequent attacks affect work and rest and sleep. In severe cases, dangerous consequences such as cerebrovascular accidents such as hypertension and cerebral hemorrhage may occur.

[0026] In the traditional Chinese medicine composition of the present invention, preferably, the traditional Chinese medicine raw material formula contains 10-16 weight parts of Pueraria root, 2-4 weight parts of Vitex rotundifolia, 2-4 weight parts of Corydalis yanhusuo, 8-12 weight parts of peppermint, 8-16 weight parts of Chuanxiong, 8-16 weight parts of Schizonepeta tenuifolia, 2-4 weight parts of Asarum, 3-6 weight parts of Saposhnikovia divaricata, 5-8 weight parts of Angelica dahurica, 5-8 weight parts of Notopterygium wilfordii and 5-8 weight parts of Radix Glycyrrhizae Preparata. In a specific embodiment, Pueraria root can be 10 weight parts, 12 weight parts, 14 weight parts or 16 weight parts; Vitex rotundus can be 2 weight parts, 3 weight parts or 4 weight parts; Corydalis yanhusuo can be 2 weight parts, 3 weight parts or 4 weight parts; Menthus can be 8 weight parts, 10 weight parts or 12 weight parts; Ligusticum chuanxiong can be 8 weight parts, 12 weight parts or 16 weight parts; Schizonepeta can be 8 weight parts, 12 weight parts or 16 weight parts; Asarum can be 2 weight parts, 3 weight parts or 4 weight parts; Saposhnikovia divaricata can be 3 weight parts, 5 weight parts or 6 weight parts; Angelica dahurica can be 5 weight parts, 7 weight parts or 8 weight parts.

[0027] In the most preferred embodiment, the Chinese medicine raw material formula contains 12 parts by weight of Pueraria root, 3 parts by weight of Vitex rotundus, 3 parts by weight of Corydalis yanhusuo, 12 parts by weight of Menthus, 12 parts by weight of Chuanxiong, 12 parts by weight of Schizonepeta tenuifolia, 3 parts by weight of Asarum, 5 parts by weight of Saposhnikovia divaricata, 6 parts by weight of Angelica dahurica, 6 parts by weight of Notopterygium wilfordii and 6 parts by weight of Radix Glycyrrhizae preparata.

[0028] The Chinese medicine composition of the present invention can be prepared into a conventional dosage form that is clinically acceptable by adding conventional excipients (including fillers and flavoring agents) according to conventional methods when used. Specifically, the dosage form of the Chinese medicine composition can be, for example, granules, capsules, tablets, pills, pastes or aqueous solutions; preferably, the dosage form of the Chinese medicine composition is an oral aqueous solution.

[0029] The second aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine composition for treating exogenous headache, the method comprising the following steps:

[0030] (1) according to the formula, kudzu root, vitex rotundus, yanhusuo, mint, chuanxiong, schizonepeta, asarum, siler, angelica dahurica, notopterygium and licorice root are mixed with water, boiled and filtered, and the first filtrate is collected;

[0031] (2) mixing the medicinal residue obtained in step (1) with water, boiling and filtering, and collecting a second filtrate;

[0032] (3) The first filtrate and the second filtrate are mixed and concentrated under reduced pressure to form a decoction.

[0033] The Chinese medicine composition prepared according to the Chinese medicine raw material formula and the method of the present invention can effectively prevent and treat exogenous headaches, promote oxygen supply to the blood vessels in the neck, increase cerebral blood flow, improve sleep, and relieve pain and discomfort symptoms in the state of exogenous headaches.

[0034] In the method of the present invention, in step (1), the total mass ratio of Pueraria root, Vitex rotundus, Corydalis yanhusuo, Mentha, Ligusticum chuanxiong, Nepeta tenuifolia, Asarum, Saposhnikovia divaricata, Angelica dahurica, Notopterygium wilfordii and Radix Glycyrrhizae Preparata to the mass ratio of water is 1:(10-15).

[0035] In a specific embodiment, the ratio of the total mass of 12 Chinese medicinal materials including Pueraria lobata, Vitex rotundus, Corydalis yanhusuo, Mentha, Ligusticum chuanxiong, Nepeta tenuifolia, Asarum, Saposhnikovia divaricata, Angelica dahurica, Notopterygium wilfordii and Radix Glycyrrhizae preparata to the mass of water can be 1:10, 1:11, 1:12, 1:13, 1:14 or 1:15.

[0036] In the most preferred embodiment, the ratio of the total mass of the 12 Chinese medicinal materials including Pueraria lobata, Vitex rotundus, Corydalis yanhusuo, Mentha, Ligusticum chuanxiong, Nepeta tenuifolia, Asarum, Saposhnikovia divaricata, Angelica dahurica, Notopterygium wilfordii and Radix Glycyrrhizae preparata to the mass of water is 1:12.

[0037] In the method of the present invention, in step (1), the decoction temperature may be 90-100°C; and the decoction time may be 20-40 minutes. In a specific embodiment, in step (1), the decoction temperature may be 90°C, 92°C, 94°C, 96°C, 98°C or 100°C; and the decoction time may be 20 minutes, 25 minutes, 30 minutes, 35 minutes or 40 minutes.

[0038] In the most preferred embodiment, in step (1), the decoction temperature is 95°C and the decoction time is 30 minutes.

[0039] In the method of the present invention, in step (2), the mass ratio of the medicinal residue to water can be 1:(5-10). In a specific embodiment, in step (2), the mass ratio of the medicinal residue to water can be 1:5, 1:6, 1:7, 1:8, 1:9 or 1:10.

[0040] In the most preferred embodiment, in step (2), the mass ratio of the medicinal residue to water is 1:8.

[0041] In the method of the present invention, in step (2), the decoction temperature may be 90-100°C; and the decoction time may be 20-40 minutes. In a specific embodiment, in step (2), the decoction temperature may be 90°C, 92°C, 94°C, 96°C, 98°C or 100°C; and the decoction time may be 20 minutes, 25 minutes, 30 minutes, 35 minutes or 40 minutes.

[0042] In the most preferred embodiment, in step (2), the decoction temperature is 95° C. and the decoction time is 30 minutes.

[0043] In the method of the present invention, in step (3), the temperature of reduced pressure concentration can be 40 to 60° C. In a specific embodiment, in step (3), the temperature of reduced pressure concentration can be 40° C., 45° C., 50° C., 55° C. or 60° C.

[0044] In the most preferred embodiment, in step (3), the temperature of the reduced pressure concentration is 50°C.

[0045] In the method of the present invention, in step (3), the concentration of the decoction can be 1-2 g / mL. In a specific embodiment, in step (3), the concentration of the decoction can be 1 g / mL, 1.2 g / mL, 1.4 g / mL, 1.6 g / mL, 1.8 g / mL or 2 g / mL.

[0046] In the most preferred embodiment, in step (3), the concentration of the water decoction is 1.5 g / mL.

[0047] The third aspect of the present invention provides a use of the above-mentioned traditional Chinese medicine composition or the traditional Chinese medicine composition prepared according to the above-mentioned method in treating exogenous headache.

[0048] In the method of the present invention, the dosage of the Chinese medicine composition can be 0.2-1g crude drug / kg body weight. In a specific embodiment, the dosage of the Chinese medicine composition can be 0.2g crude drug / kg body weight, 0.4g crude drug / kg body weight, 0.6g crude drug / kg body weight, 0.8g crude drug / kg body weight, 1.0g crude drug / kg body weight. In the most preferred embodiment, the dosage of the Chinese medicine composition is 0.4g crude drug / kg body weight.

[0049] According to the method of the present invention, a Chinese medicine composition is prepared, and the 11 Chinese medicines are used in combination, which can dispel wind and dredge meridians, dispel cold and dampness, promote qi and relieve pain; it can also soothe the liver and remove blood stasis, and clear the head. In addition, the Chinese medicine composition of the present invention can promote the body's microcirculation, promote oxygen supply to the back of the neck and the brain, improve sleep, and has a good therapeutic effect on exogenous headaches such as cervical spondylosis headache, rhinitis headache, occipital neuralgia, etc., with a short healing time, small toxic and side effects, safe to take, and has great value for promotion and application.

[0050] The specific embodiments described herein are merely examples of the spirit of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in similar ways, but they will not deviate from the spirit of the present invention or exceed the scope defined by the appended claims.

Claims

1. A Chinese medicine composition for treating exogenous headache, characterized in that: The raw material formula of the traditional Chinese medicine composition comprises 6-20 parts by weight of Pueraria root, 1-5 parts by weight of Vitex rotundifolia, 1-5 parts by weight of Corydalis yanhusuo, 4-16 parts by weight of peppermint, 4-20 parts by weight of Chuanxiong, 4-20 parts by weight of Schizonepeta tenuifolia, 1-5 parts by weight of Asarum, 1-10 parts by weight of Saposhnikovia divaricata, 3-10 parts by weight of Angelica dahurica, 3-10 parts by weight of Notopterygium wilfordii and 3-10 parts by weight of Radix Glycyrrhizae Preparata.

2. A Chinese medicine composition for treating exogenous headache according to claim 1, characterized in that: The raw material formula of the traditional Chinese medicine composition comprises 10-16 parts by weight of Pueraria root, 2-4 parts by weight of Vitex rotundifolia, 2-4 parts by weight of Corydalis yanhusuo, 8-12 parts by weight of peppermint, 8-16 parts by weight of Chuanxiong, 8-16 parts by weight of Schizonepeta tenuifolia, 2-4 parts by weight of Asarum, 3-6 parts by weight of Saposhnikovia divaricata, 5-8 parts by weight of Angelica dahurica, 5-8 parts by weight of Notopterygium wilfordii and 5-8 parts by weight of Radix Glycyrrhizae Preparata.

3. A Chinese medicine composition for treating exogenous headache according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is granules, capsules, tablets, pills, pastes or aqueous solutions.

4. A method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: (1) mixing kudzu root, vitex rotundus, yanhusuo, mint, chuanxiong, schizonepeta, asarum, siler, angelica dahurica, notopterygium wilfordii and licorice root with water according to the formula, boiling and filtering, and collecting the first filtrate; (2) mixing the medicinal residue obtained in step (1) with water, boiling and filtering, and collecting a second filtrate; (3) The first filtrate is mixed with the second filtrate and concentrated under reduced pressure to form a decoction.

5. The method for preparing a Chinese medicine composition according to claim 4, characterized in that: In step (1), the total mass ratio of the kudzu root, vitex rotundus, yanhusuo, mint, chuanxiong, schizonepeta, asarum, siler, angelica dahurica, notopterygium and glycyrrhiza uralensis to the mass ratio of water is 1:(10-15).

6. The method for preparing a Chinese medicine composition according to claim 4, characterized in that: In step (1) and step (2), the decoction temperature is 90-100° C. and the decoction time is 20-40 minutes.

7. The method for preparing a Chinese medicine composition according to claim 4, characterized in that: In step (2), the mass ratio of the medicinal residue to water can be 1:(5-10).

8. The method for preparing a Chinese medicine composition according to claim 4, characterized in that: In step (3), the temperature for concentration under reduced pressure is 40 to 60°C.

9. The method for preparing a Chinese medicine composition according to claim 4, characterized in that: In step (3), the concentration of the water decoction is 1-2 g / mL.