148 results about "Nicotinic Acids" patented technology

The invention provides a method for sterile sowing and efficient propagation of cymbidium faberi. The method comprises the following steps: pretreatment of cymbidium faberi seeds, sterile germination of the cymbidium faberi seeds, protocorm proliferation, differentiation, seedling strengthening and acclimatization and transplantation. The pretreatment comprises the steps of refrigerating hybrid seeds of cymbidium orchid at 4 DEG C, performing secondary disinfection with sodium hypochlorite, performing dark culture for 10-30 days after sowing, and then performing light culture, and the germination culture medium is prepared by taking 1 / 4 MS as a basic culture medium and adding 100-200ml / L of coconut water, 0.5-1.0 mg / L of 6-benayl aminopurine, 0.1-0.5 mg / L of naphthylacetic acid, 0.5-2.0 g / L of peptone and 0.5-1.0 g / L of activated carbon. According to the method, the seed germination rate can be effectively increased, the 60d seed germination rate reaches up to 85%, the pollution rate is reduced to 5% or below, 50.0 g / L inositol, 2.0 mg / L glycine and 2.0 mg / L nicotinic acid are added into a differentiation culture formula, the differentiation rate can be effectively increased, the leaf bud differentiation rate reaches up to 90%, meanwhile, rooting can be induced, the growth time of cymbidium faberi from seeds to seedlings is greatly shortened, a large number of high-quality seedlings can be obtained within a short time, and the method is suitable for large-scale popularization and application. Technical data are accumulated for cymbidium resource protection and new variety cultivation.

The invention discloses a fermentation medium for regulating and controlling a clostridium aerovorans target product and a fermentation method of the clostridium aerovorans target product. The medium comprises a basic component and a regulating component, the basic components comprise ammonium chloride, potassium chloride, magnesium sulfate heptahydrate, sodium chloride, monopotassium phosphate, yeast powder, calcium chloride dihydrate, sodium selenite, nickel chloride hexahydrate, biotin, folic acid, pyridoxine hydrochloride, thiamine, riboflavin, nicotinic acid, D-calcium pantothenate, cobalamin, para aminobenzoic acid and lipoic acid; the adjusting component comprises sodium tungstate, ferrous sulfate and sodium molybdate, sodium tungstate and ferrous sulfate have a forward adjusting effect on increasing the yield of acetic acid, ethanol and butanol in the target product, and sodium molybdate has a reverse adjusting effect on the target product. By optimizing the proportion of trace elements in the culture medium, the clostridium metabolism efficiency is improved, synthesis of a target product is regulated and controlled, and the method is particularly suitable for industrial production of acetic acid, ethanol, butanol and the like.

The invention discloses a glabridin-nicotinamide eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystals, the eutectic crystal comprises nicotinamide and glabridin molecules, the molecular formula of nicotinamide-glabridin is C26H26N2O5, and the molar ratio of nicotinamide to glabridin is 1: 1. According to the invention, the cocrystal is used as a raw material, complete characterization is carried out on the cocrystal to prove that the cocrystal has certain physical and chemical stability, the stability of nicotinamide is improved after the cocrystal is prepared, and no irritant substance nicotinic acid is generated in cosmetics in a cocrystal stability experiment. And the eutectic crystal is generally neutral, mild, non-irritant, natural and suitable for cosmetics or health care products.

The invention relates to the field of organic chemical synthesis, in particular to a preparation method of chiral 6-methyl nicotine. The invention provides a synthesis method of single chiral 6-methyl nicotine, which comprises the following steps: taking methyl 6-methyl nicotinate (compound I) and N-vinyl pyrrolidone (compound II) as initial raw materials, and sequentially carrying out condensation reaction, hydrolysis reaction, cyclization reaction, chiral reduction reaction and aminomethylation reaction to finally obtain the target product chiral 6-methyl nicotine (R or S compound VI). According to the synthetic route, the 6-methyl nicotine with two configurations of R and S can be prepared respectively, and the purity of the product can reach 99.5% or above. The synthesis method is simple in process, high in yield and suitable for industrial large-scale production.

The invention relates to a method for preparing a nerofloxacin chiral piperidylamine intermediate, which comprises the following steps of: carrying out condensation reaction on 5-hydroxy nicotinic acid which is simple and easy to obtain and is used as a raw material and different alcohols, screening through a series of asymmetric catalytic hydrogenation conditions to obtain optimal reaction conditions, and under the conditions, carrying out reaction on various 3, 3 '-dihydroxy nicotinic acid and 3, 3'-dihydroxy nicotinic acid to obtain the nerofloxacin chiral piperidylamine intermediate. The 2, 5-disubstituted pyridine quaternary ammonium salt is reduced into a tetrahydropyridine product, and the C5 site enantioselectivity of the product is excellent. The preparation method comprises the following steps: selecting methyl (R)-1-benzyl-5-hydroxy-1, 4, 5, 6-tetrahydropyridine-3-carboxylic acid methyl ester as a substrate, completely hydrogenating by using platinum dioxide hydrogen, and then carrying out methyl ester reduction, dehydroxylation, Mitsunobu reaction and protecting group removal to obtain a key chiral intermediate for industrial synthesis of a quinolone antibacterial drug nemonofloxacin with high enantioselectivity and high yield.

The mixture as the micronutrient composition is a combination of alpha-ketoglutaric acid, nicotinamide or nicotinic acid, L-proline, L-glutamine, L-citrulline, sodium pyruvate, pantothenic acid, L-cysteine or N-acetylcysteine, magnesium malate, magnesium citrate, and methionine. The mixture is effective for the treatment of diseases due to oxidative stress. More specifically, the mixtures and cores as micronutrient compositions are effective in reversing saccharification in diabetes mellitus.

The invention relates to the technical field of medicine preparation, and particularly discloses a preparation method and application of a xantinol nicotinate pharmaceutical composition, and the preparation method comprises the following steps: step S1, preparing the following raw materials in parts by weight: 6.2-7.6 parts of xantinol nicotinate, 86-98 parts of purified water, 16-22 parts of a filler, 64-76 parts of a coating solution, 14-20 parts of a flavoring agent, 42-54 parts of a modified disintegrating solution and 2-4 parts of a lubricant; step S2, preparing the xantinol nicotinate pharmaceutical composition; the coating liquid and the modified disintegrating liquid are added, active functional groups contained in the coating liquid can form hydrogen-bond interaction with the active ingredients of the medicine, flexible long-chain alkane on the coating liquid can be entangled with alkyl chains on the modified disintegrating agent, the modified disintegrating agent not only contains a cellulose nanocrystal structure, but also contains a carboxymethyl structure, so that the cellulose nanocrystal-modified disintegrating agent has the advantages that the cellulose nanocrystal-modified disintegrating agent can be applied to the preparation of the medicine; through the combined action of the structures, the coating property, the disintegration property and the slow release property of the xantinol nicotinate pharmaceutical composition are improved.

The present invention describes a composition comprising an effective amount of a combination of two or more components selected from acacetin, ACT1 peptide, α-lipoic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-β-methylbutyrate, bacopa monnieri, catechins, catechols, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (-)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercetin (EMIQ), shan Phosphate, black bean anthocyanins, leucine, lithium, luteolin, luteolin, luteolin, melatonin, menadione, 1‑methylnicotinamide (MNA), methyl salicylate, myricetin, nicotinamide adenine dinucleotide, nicotinic acid (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley, phenylephrine, pokeweed mitogen, 15‑Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxerutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin, and zinc (including its salts).

The invention discloses a freeze-dried human rabies vaccine and a preparation method thereof, and belongs to the technical field of viral vaccines. The method comprises the following steps: (1) cell culture; (2) virus inoculation; (3) harvesting viruses; (4) concentration and purification: clarifying the harvested virus liquid through a filter, carrying out ultrafiltration concentration through an ultrafiltration membrane to obtain a concentrated solution, and purifying by adopting a column chromatography to obtain a chromatographic solution; (5) preparing a stock solution: inactivating and hydrolyzing the chromatographic solution to obtain a virus inactivation solution, and adding human serum albumin into the virus inactivation solution to obtain the stock solution; (6) preparing a semi-finished product: diluting with a stabilizer to prepare the semi-finished product, wherein the stabilizer comprises the following raw materials: human serum albumin, araboxylan, L-arginine hydrochloride, casein phosphopeptides, alpha-tocopherol nicotinate, a solvent and the like; and (7) preparing a finished product. The rabies vaccine disclosed by the invention is excellent in quality and stable in immune efficacy, and liquid is clear after redissolution.

The invention relates to a preparation method of (S, S)-2, 8-diazabicyclo [4, 3, 0] nonane and an intermediate of the (S, S)-2, 8-diazabicyclo [4, 3, 0] nonane. Specifically, the invention discloses a method for preparing (S, S)-2, 8-diazabicyclo [4, 3, 0] nonane from a cheap raw material 2-chloronicotinic acid through an esterification reaction, a substitution reaction, a reduction reaction and an asymmetric hydrogenation reaction, and the method is novel in route, simple to operate, high in product yield, good in purity, safe, environment-friendly and very suitable for industrial production.

The invention relates to novel nitrilase and application thereof in nicotinic acid biosynthesis. The nucleotide sequence of the novel nitrilase disclosed by the invention is as shown in SEQ ID NO: 1, and the amino acid sequence of the novel nitrilase is as shown in SEQ ID NO: 2. The novel nitrilase can efficiently catalyze 3-cyanopyridine to generate nicotinic acid, especially the nitrilase activity of the nitrilase after promoter optimization is improved, the substrate conversion rate reaches 100%, the accumulated concentration of the product nicotinic acid can reach 123.11 g / L, and the novel nitrilase has important industrial application value for green and efficient preparation of nicotinic acid and derivatives thereof.

The present application relates to a kind of meloxicam benzene sulfonic acid tablets and its preparation method and application, the meloxicam benzene sulfonic acid tablets include stabilizer, the stabilizer is selected from one or more of anhydrous citric acid, polyethylene glycol, sorbitol, crosslinked povidone, sodium acetate trihydrate, anhydrous sodium acetate, nicotinic acid, nicotinamide, polyacrylic acid resin, ascorbic acid palmitate.The stability of meloxicam benzene sulfonic acid tablets prepared according to the prescription of the present application is significantly improved, while the preparation process is simple, and has good application prospect.

The application discloses a glabridin-nicotinamide co-crystal as well as a preparation method and application thereof, belongs to the technical field of co-crystals, and comprises nicotinamide and glabridin molecules. 26 H 26 N2O5, and the molar ratio of the nicotinamide and the glabridin is 1:1.The application prepares a glabridin-nicotinamide co-crystal, and the co-crystal is completely characterized, and it is proved that the co-crystal has certain physical and chemical stability, the stability of the nicotinamide is improved after being made into the co-crystal, and no stimulating substance nicotinic acid is found in the co-crystal stability experiment. The co-crystal is generally neutral, mild and non-irritating, and is naturally suitable for cosmetics or health products.

The application provides a preparation method of a PARP1 inhibitor intermediate, which comprises the following steps: after 6-hydroxy nicotinic acid is reacted with nitric acid, an intermediate shown in formula I is prepared through halogenation reaction, esterification reaction, hydrolysis reaction and the like. The method has low synthesis cost and high product yield, provides a new advantageous process route for synthesis of the PARP1 inhibitor, and has industrialized popularization and application prospects.

The invention relates to the technical field of biological medicines, and discloses an application of N2L in preparation of medicines for preventing and treating obesity and fatty liver, and the N2L is a dimer compound of alpha-lipoic acid and nicotinic acid. According to the embodiment of the invention, the application value of the GPR109A and GLP-1R double-target collaborative strategy in obesity and fatty liver treatment is proposed and verified for the first time, and the small molecule compound N2L with the GPR109A and GLP-1R double-target collaborative strategy can improve muscle endurance while reducing the weight of obese patients and can improve liver fatty degeneration at the same time. The defect that an existing GLP-1R agonist needs to be injected is overcome, meanwhile, the flushing side effect of an existing GPR109A agonist nicotinic acid medicine is avoided, a larger range is provided for medicine selection in the fields of obesity and fatty liver, and meanwhile, the application range of N2L is widened.

The present invention relates to amino acid salts of nicotinic acid ribosides and compositions thereof of Formula I, useful in the treatment of disorders and diseases associated with deficiencies in NAD+:wherein M1, R1, R2, and R3 are as described herein.

The invention discloses a pharmaceutical composition for improving biphasic depression and a pharmaceutical preparation and application thereof, and belongs to the technical field of research and development of biphasic depression drugs, the pharmaceutical composition is composed of nicotine and a second-generation antipsychotic drug, and the second-generation antipsychotic drug is quetiapine or risperidone. Experiments prove that the combined use of the nicotine and the second-generation antipsychotic has a synergistic effect in the aspect of improving the manic behavior of biphasic depression and has a better effect of improving the biphasic depression compared with the independent use of the nicotine and the second-generation antipsychotic.

The present invention belongs to the technical field of biological medicine, and discloses a ceramide compound shown in Chemical Formula I: #imgabs0# wherein, R 1 is selected from the residues after condensation of sialic acid, chelidamic acid monohydrate, 2,5-furandicarboxylic acid, quinic acid, chlorogenic acid, ectoine, nicotinic acid, shikimic acid, glucuronic acid, salicylic acid, carnosic acid, dihydrooat acylanthranilic acid, abietic acid, ursolic acid, tranexamic acid, syringic acid, gentisic acid, vanillic acid, 5-hydroxyisovanillic acid, orotic acid, 5-aminoorotic acid, 3,5-dihydroxy-4-methylbenzoic acid, glycyrrhizic acid or gallic acid, R 2 is selected from one of the following structures: -C 15 H 29 、-C 15 H 31 、-C 15 H 27 、-CHOHC 14 H 27 、-CHOHC 14 H 29 . The present invention also discloses a preparation method and application of the ceramide compound. The present invention introduces a molecular fragment with physiological activity of a functional carboxylic acid into ceramide, which will enhance the original efficacy of this type of molecule and also improve the physicochemical properties of the ceramide compound.

This invention provides a chemical mechanical polishing (CMP) slurry and its application. The CMP slurry comprises: a catalyst, a stabilizer, an oxidant, a pH adjuster, abrasive particles, a corrosion inhibitor, and water. The corrosion inhibitor is a nitrogen-containing heterocyclic carboxylic acid compound, wherein the nitrogen-containing heterocyclic carboxylic acid compound includes at least one selected from nicotinic acid, isonicotinic acid, pyridinecarboxylic acid, imidazocarboxylic acid, pyrazolecarboxylic acid, 3-pyridineacetic acid, 3-pyridinepropionic acid, 3-methyl-2-pyridinecarboxylic acid, and L-piperidine acid. The CMP slurry provided by this invention can simultaneously polish tungsten and silicon oxide, and can also control the polishing rate of silicon oxide while inhibiting tungsten corrosion, thus making it suitable for different application scenarios. In addition, the CMP slurry has good stability and can maintain its performance even after long-term standing.

The invention relates to the technical field of medicines, in particular to a preparation process of xantinol nicotinate injection and an impurity control method of the xantinol nicotinate injection. According to the process, water for injection is subjected to nitrogen deoxidation treatment, a whole-process nitrogen-sealed environment is maintained, xantinol nicotinate is gradually added in three times, and a multi-component synergistic stable system including hydroxypropyl-beta-cyclodextrin, N-acetyl-L-cysteine, L-methionine, diethylenetriamine pentaacetic acid, sodium metasulfite, sodium thiosulfate and the like is matched, so that the xantinol nicotinate injection is prepared. Double-molecular-weight dextran is introduced to regulate and control a microenvironment, an acetic acid-sodium acetate buffer system is introduced to optimize pH, and finally, high stability and low impurity generation of the finished injection at high temperature are realized through nitrogen replacement subpackaging and precise sterilization conditions. According to the method, the content and the purity of the xantinol nicotinate injection are remarkably improved, the impurity content during sterilization and storage is remarkably reduced, the safety and the effectiveness of drugs are guaranteed, and the method has important significance on optimization of a heat-sensitive injection process.

The invention relates to combination or composition comprising: (i) nicotinic acid or a derivative thereof, and (ii) a fatty acid or a derivative thereof selected from tetradecylthioacetic acid 5 (TTA) or a derivative thereof. The invention further relates to a pharmaceutical or nutritional combination or composition for use in a method of preventing or treating mitochondrial diseases, inflammatory diseases, metabolic disorders, neurodegenerative diseases and / or aging of an animal, and / or a method of increasing brain metabolism of an animal, wherein said pharmaceutical or nutritional 10 combination or composition is administered to said animal, and wherein said pharmaceutical or nutritional combination or composition comprises: (i) nicotinic acid or a derivative thereof, and (ii) a fatty acid or a derivative thereof selected from tetradecylthioacetic acid (TTA) or a derivative thereof.

Disclosed herein are compounds related to triphenylphosphonio and triphenylphosphonium derivatives of nicotinate and nicotinamide riboside, and methods of making and using the compounds to treat skin ailments or conditions associated with or caused by inflammation, sun damage, or natural aging. Also disclosed herein is a method for making nicotinic acid mononucleoside (NAMN).

The invention provides a culture method of human umbilical cord mesenchymal stem cells, and belongs to the technical field of cell culture. The method comprises the following steps: firstly, constructing an activation culture medium aiming at an initial culture stage and an amplification culture medium aiming at an amplification culture stage; wherein the activation culture medium takes alpha-MEM containing 10% of fetal calf serum as a basic culture medium, and alpha-tocopherol, nicotinic acid and gypenoside are added as additives, so that the cell amplification efficiency in the initial stage can be fully improved; a serum-free scheme is adopted for an amplification culture medium, RPMI-1640 is taken as a basic culture medium, and glutamine, rhG-CSF, bFGF, VEGF, transferrin, vitamin C, 2-mercaptoethanol, zoledronic acid, lenalidomide, ethanolamine and sodium selenite with specific amounts are added, so that the cell amplification speed in an amplification culture stage is remarkably increased. On the basis, a three-stage amplification process is adopted, and large-scale culture of the umbilical cord mesenchymal stem cells is realized. The method is short in culture time and high in cell quantity accumulation speed, and the culture efficiency is remarkably improved.

The invention provides a strain of lactobacillus plantarum ZENIYOUTH-01 and application thereof, and belongs to the technical field of probiotics and application thereof. The fermented whole grain prepared by adopting the lactobacillus plantarum disclosed by the invention effectively retains nutritional ingredients such as vitamin B, vitamin E, nicotinic acid, mineral substances and the like in the whole grain; abundant enzyme systems secreted by lactobacillus plantarum are utilized to degrade macromolecular proteins, dietary fibers and the like in the raw materials to generate bioactive peptides, short-chain fatty acids, exopolysaccharides and flavor compounds, release of functional components such as polyphenols, flavonoid compounds and the like is promoted, the contents of protein peptides, lactic acid, acetic acid, citric acid and beta-glucan are increased, and the nutritional value of the beverage is improved. The traditional Chinese medicine composition can effectively proliferate intestinal effective microbial communities and promote intestinal peristalsis, and has a remarkable effect in the aspect of improving constipation.

[Problem] To provide a cosmetic in which discoloration and generation of an unpleasant odor that are caused by heat or aging can be suppressed, according to the present invention.[Solution] A cosmetic including (A) nicotinic acid or derivative thereof, (B) a compound having a carbonyl group or a compound capable of forming a carbonyl group, (C) chlorphenesin, and (D) water.

The present invention relates to amino acid salts of nicotinic acid mononucleotide and nicotinamide mononucleotide of formula I and compositions thereof, which can be used to treat diseases related to NAD + Deficiency-related conditions and diseases: (I), where A, M 1 、M 2 、R 1 、R 2 and R 3 As described in this article. #imgabs0#

The invention provides a method for detecting B vitamins and application thereof. The vitamin B is one or more of vitamin B1, vitamin B2, nicotinic acid, nicotinamide and vitamin B6; the method comprises the following steps: S1, pretreatment: heating a mixture to prepare a liquid sample to be detected; the mixture comprises a sample to be detected, an EDTA saturated solution, formic acid and water; s2, detection: respectively analyzing different standard samples and liquid samples to be detected by adopting a liquid chromatography ultraviolet detector to obtain analysis results of the standard samples and analysis results of the liquid samples to be detected; s3, analysis: comparing the analysis result of the to-be-detected liquid sample with the analysis result of each standard sample, and carrying out qualitative and quantitative analysis on the B vitamins in the to-be-detected sample. According to the method, the use of toxic reagents is reduced, the operation is simple, different B vitamins can be qualitatively and quantitatively detected at the same time, and the detection is rapid, simple, convenient and accurate.

The invention discloses a camellia antler SCR0319T2 strain and an application of the camellia antler SCR0319T2 strain. According to the invention, a strain of camellia antler SCR0319T2 is collected and screened from the field, molecular biology identification shows that the strain belongs to Flammulina filiformes, subculture shows that the strain has excellent stability, can still grow stably after more than 30 times of passage, is low in elimination rate, can be used as an industrial large-scale production strain, and is high in strain running speed and short in production period. Through detection, the content of vitamin B1 and nicotinic acid in sporocarps is higher than that of common varieties, and mushroom bodies are durable in storage and good in taste.

The invention relates to a crystal form of a free state or a pharmaceutically acceptable salt of (R)-3-(3-((S)-2-(4-(2-chlorophenoxy)-2-oxo-2, 5-dihydro-1H-pyrrole-1-yl)-4-methyl valeryl amino)-1H-pyrazole-1-yl)-2-hydroxy propyl nicotinate (compound A), a pharmaceutical composition of the crystal form and a preparation method of the crystal form. The invention also discloses application of the crystal form in preparation of medicines for treating diabetes and related symptoms.

Disclosed in the present invention are an amorphous form and polymorph of a nicotinate compound, a preparation method therefor and the use of same. The amorphous form has an XRPD pattern substantially as shown in figure 20. Unexpectedly, the amorphous form of the present invention has more excellent stability and hygroscopicity and lower solvent residue than the polymorph, and thus has good developability.