Hubei dwarf lilyturf tuber hetetopolysaccharide for curing type II diabete and preparation method thereof

A technology of Ophiopogon japonicus and polysaccharides, which is applied in the field of traditional Chinese medicine for the treatment of type II diabetes, and can solve problems such as dosage addition, adverse reactions, and secondary failure

Inactive Publication Date: 2010-09-22
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions, and long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled

Method used

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  • Hubei dwarf lilyturf tuber hetetopolysaccharide for curing type II diabete and preparation method thereof
  • Hubei dwarf lilyturf tuber hetetopolysaccharide for curing type II diabete and preparation method thereof
  • Hubei dwarf lilyturf tuber hetetopolysaccharide for curing type II diabete and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] Take Hubei Ophiopogon japonicus tuber 5kg, crush it into raw medicinal material powder, add water to decoct 3 times, add 20 liters of water for the first time, add 20 liters of water for the second time, add 10 liters of water for the third time, boil for 30 minutes each time, and combine the decoction The water decoction was adjusted to pH 6 with phosphate buffer solution, 25g of papain with an activity of 12u / mg was added, enzymolyzed in a water bath at 45°C for 2 hours, then immediately boiled for 5 minutes, left to stand at 4°C for more than 12 hours, and pumped Filter out the precipitate; put the filtrate into a dialysis bag with a molecular weight of 1000, dialyze with tap water for 1 day, then dialyze with distilled water for 1 day, concentrate the polysaccharide solution in the bag to 1.5g / mL, add absolute ethanol until the volume fraction of ethanol is 80%, 4 Stand still at ℃ for more than 12 hours, pour off the supernatant, and collect the precipitate; dissolve...

Embodiment 2

[0124] Preparation of Hubei Ophiopogon japonicus homogeneous polysaccharide capsules: Add 35 g of microcrystalline cellulose to 965 g of Hubei Ophiopogon japonicus homogeneous polysaccharide powder, mix well, sieve, and dry to obtain the medicinal material of the drug capsule. The medicinal raw materials were filled into 2924 capsules, and each capsule containing 0.33g of Hubei Ophiopogon japonicus homogeneous polysaccharide was prepared, which was equivalent to each capsule containing 2.68g of Hubei Ophiopogon japonicus medicinal material. It is recommended that adults take Hubei Ophiopogon japonicus capsules once a day before meals, 1 capsule each time, for more than 4 weeks.

Embodiment 3

[0126] Preparation of Hubei Ophiopogon japonicus homogeneous polysaccharide tablet: Add 35 g of microcrystalline cellulose to 965 g of Hubei Ophiopogon japonicus homogeneous polysaccharide powder, mix, sieve, and dry to obtain the medicinal raw material of the drug tablet. The medicinal raw material was dry-processed into granules, and 5,848 tablets of Hubei Ophiopogon japonicus homogeneous polysaccharide were obtained. Each tablet contained 0.165 g of Hubei Ophiopogon japonicus homogeneous polysaccharide, which was equivalent to 1.34 g of Hubei Ophiopogon japonicus raw medicinal material per capsule. It is recommended that adults take Hubei Ophiopogon japonicus polysaccharide tablets twice a day, once in the morning and before dinner, 2 tablets each time, for more than 4 weeks.

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Abstract

The invention provides a traditional Chinese medicine for curing type II diabete, which is Hubei dwarf lilyturf tuber hetetopolysaccharide extracted by taking Hubei dwarf lilyturf tuber as a raw material. The traditional Chinese medicine has obvious effects of reducing blood sugar of mice with the type II diabete, obvious effects of reducing insulin resistance and the effect strength of the traditional Chinese medicine has no statistical difference from that of rosiglitazone. Compared with the rosiglitazone, the hetetopolysaccharide can better reduce blood total cholesterol and triglycercide, improve ratio of high-density lipoprotein to low-density lipoprotein, and effectively prevent and curing arteriosclerosis and thrombosis.

Description

technical field [0001] The invention relates to traditional Chinese medicine technology, in particular to a traditional Chinese medicine for treating type II diabetes. Background technique [0002] Diabetes mellitus (DM) is a chronic systemic frequently-occurring disease related to genetic factors and various environmental factors. It is a syndrome of sugar, fat and protein metabolism disorders caused by insufficient insulin secretion or utilization. Diabetes disease" category. The prevalence of diabetes in my country is increasing year by year, especially in type 2 diabetes (non-insulin-dependent diabetes mellitus, NIDDM), but there is no ideal drug for treatment at home and abroad. Most of the chemical drugs currently used clinically to treat diabetes have serious adverse reactions. Long-term use needs to be increased and there is a possibility of secondary failure, especially the chronic complications cannot be effectively controlled. Traditional Chinese medicine has th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P31/10
Inventor 陈家春陈祥洪白雪文莉方进波
Owner HUAZHONG UNIV OF SCI & TECH
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