Medical radiation protection patch

Abstract

The application relates to a medical ray protection patch. The patch comprises, from bottom to top, a non-stick film, a fiber film and a non-woven fabric which are sequentially stacked; the fiber film is made of any one of beta-glucan, lyocell fiber and cuprammonium fiber; fiber hairs are distributed on the surface of the fiber film; the density of the fiber hairs is 10 6 ~ 10 11 root / cm 2 ; the patch further comprises a solution; the non-woven fabric, the fiber film and the non-stick film are all soaked in the solution and are mutually adhered through the solution; the raw materials of the solution comprise superoxide dismutase, trehalose, curcumin, sorbitol, potassium sorbate and water. The technical problem to be solved is how to provide a medical ray protection patch, enable the superoxide dismutase to continuously and closely contact the skin in the form of patching, avoid the rapid evaporation of moisture, thereby prolong the action time of the effective components, and promote the penetration and continuous release of the effective components to the deep layer of the skin, so as to solve the problem of short action time of traditional sprays.

Description

Technical Field

[0001] This invention belongs to the field of medical device technology, and in particular relates to a medical radiation protection dressing. Background Technology

[0002] Medical radiation plays a vital role in medical diagnosis and treatment, but it also poses certain unavoidable health risks. Radiation-induced tissue damage is a common clinical complication. This is especially true during radiotherapy for patients with mid-to-late stage cancer, where high doses and frequent irradiation cause high-energy rays to penetrate human tissues and generate excessive exogenous free radicals. These excessive free radicals damage normal cells and tissues. Therefore, timely removal of excess free radicals and promotion of the body's self-healing ability are key methods to reduce or delay skin damage caused by radiotherapy.

[0003] Currently, one commonly used type of protective product in clinical practice is medical radiation protection spray. These products typically consist of a spray bottle, a spray pump, and a spray solution. The spray solution is often an aqueous preparation containing superoxide dismutase (SOD). For example, Chinese invention patent application (publication number CN105920589A) discloses a medical radiation protection spray whose formula mainly includes superoxide dismutase (SOD), curcumin, sodium alginate, potassium sorbate, sorbitol, and purified water.

[0004] However, these water-based sprays still have several limitations in practical use: the water evaporates quickly after spraying, resulting in a short residence time and limited penetration depth of the active ingredients on the skin surface; at the same time, the product is easily affected by the external environment after opening, and the solution system is not only prone to the growth of microorganisms, but the effective ingredients (such as SOD and curcumin) will also degrade more quickly, resulting in unstable protective effect and short duration. Summary of the Invention

[0005] The main objective of this invention is to provide a medical radiation protection patch. The technical problem to be solved is how to provide a medical radiation protection patch that allows superoxide dismutase (SOD) to maintain continuous and close contact with the skin through the application of the patch, preventing rapid evaporation of moisture, thereby prolonging the action time of the active ingredient and promoting its penetration and continuous release into the deeper layers of the skin, thus solving the problem of short action time of traditional sprays.

[0006] The objective of this invention and the technical problem it solves are achieved through the following technical solution. According to this invention, a medical radiation protection dressing comprises, from bottom to top, the following layers stacked together: an anti-adhesive membrane, a fiber membrane, and a nonwoven fabric. The fiber membrane is made of any one of β-glucan, lyocell fiber, and cuprammonium fiber. The surface of the fiber membrane is covered with fibers. The density of the fibers is 10. 6~10 11 root / cm 2 The dressing also includes a solution. The nonwoven fabric, fiber membrane, and anti-adhesive film are all impregnated in the solution and adhere to each other through the solution. The solution's ingredients include: superoxide dismutase, trehalose, curcumin, sorbitol, potassium sorbate, and water.

[0007] In one feasible approach, the thickness of the anti-stick film is 0.03–0.06 mm. The thickness of the fiber membrane is 0.3–0.6 mm. The thickness of the nonwoven fabric is 0.1–0.2 mm.

[0008] In one feasible way, the size of the patch is matched to the shape of the corresponding part of the human body.

[0009] In one feasible approach, the nonwoven fabric is the same size as the anti-adhesive layer and the fiber membrane.

[0010] In one feasible embodiment, the nonwoven fabric is made of viscose synthetic fiber. The anti-adhesive layer is made of polyethylene. The raw materials of the solution, by weight percentage, include: superoxide dismutase 0.03–0.05%, trehalose 1.5–2.5%, curcumin 0.2–0.4%, sorbitol 0.2–0.4%, potassium sorbate 0.1–0.3%, and the balance being purified water.

[0011] In one feasible embodiment, the fiber membrane is provided with a first slit. The first slit extends a predetermined distance from the edge of the fiber membrane toward the center.

[0012] In one feasible embodiment, this application also proposes a medical radiation protection dressing according to the above, wherein the main body of the protective dressing is the above-mentioned medical radiation protection dressing, and the main body of the protective dressing includes a first main body portion and a second main body portion, the first main body portion being rectangular, the second main body portion being connected to the first main body portion on one side and arc-shaped on the other side.

[0013] In one feasible embodiment, this application also proposes a medical radiation protection dressing according to the above description, wherein the main body of the protective dressing is the aforementioned medical radiation protection dressing. The protective dressing is elliptical in shape, and the left and right edges of the protective dressing are straight lines.

[0014] In one feasible embodiment, this application also proposes a medical radiation protection dressing according to the above description, wherein the main body of the protective dressing is the aforementioned medical radiation protection dressing. The protective dressing is hexagonal in shape, and all six corners of the hexagon are rounded.

[0015] In one feasible embodiment, this application also proposes a medical radiation protection dressing according to the above-described medical radiation protection dressing, wherein the main body of the protective dressing is the aforementioned medical radiation protection dressing, and the main body of the protective dressing includes a first main body portion and a second main body portion. The first main body portion is trapezoidal, and one side of the second main body portion is connected to the upper bottom edge of the first main body portion, while the other side is arc-shaped. The length of the upper bottom edge of the first main body portion is greater than the length of the lower bottom edge of the first main body portion.

[0016] By employing the above technical solution, the medical radiation protection patch proposed in this invention has at least the following advantages: 1. Compared to traditional medical radiation protection sprays, this application uses a patch method to ensure that superoxide dismutase (SOD) remains in close and prolonged contact with the skin, preventing rapid moisture evaporation and thus extending the duration of action of the active ingredient and promoting its penetration and continuous release into the deeper layers of the skin. Simultaneously, encapsulating SOD in a patch form reduces contact with air and environmental microorganisms after the product is opened, lowering the degradation rate of SOD and the risk of microbial contamination, ensuring product performance stability within its shelf life.

[0017] 2. This application discloses the structure of an adhesive patch, comprising, from bottom to top: an anti-adhesive membrane, a fiber membrane, and a nonwoven fabric. The fiber membrane is the core functional layer, and its main components include any one or more of β-glucan, lyocell fiber, and cuprammonium fiber. The surface of the fiber membrane, made from these raw materials, is densely covered with microfibers. During use, an aqueous solution containing superoxide dismutase (SOD) as the main ingredient is saturated and adsorbed within the fiber membrane, covering the area of ​​skin receiving radiotherapy. At this time, the SOD-containing aqueous solution continuously and stably penetrates into the deep layers of the skin along the fiber fibers on the surface of the fiber membrane, prolonging the duration of action and enhancing the depth of penetration. Furthermore, the membrane material forms a protective layer on the skin surface, achieving physical isolation, moisturizing, and cooling, creating a favorable repair environment for damaged skin.

[0018] 3. This application discloses that the main components of the solution are: superoxide dismutase (SOD), trehalose, curcumin, sorbitol, potassium sorbate, and purified water. The main functional component is SOD enzyme, and the auxiliary components are trehalose, curcumin, sorbitol, potassium sorbate, and purified water. Regarding the SOD enzyme, this application discloses that the SOD enzyme activity value is ≥500 U / mL, ensuring a more efficient ability to scavenge free radicals, thereby improving the product's protective and repair capabilities. Regarding the auxiliary components, trehalose acts as a stabilizer for the SOD enzyme, improving the storage and use stability of SOD; curcumin and sorbitol have excipient, thickening, and lubricating functions; and potassium sorbate is a common preservative.

[0019] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, the preferred embodiments of the present invention are described in detail below. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the medical radiation protection dressing described in this invention; Figure 2 This is a schematic diagram of the medical radiation protection patch described in Embodiment 1 of the present invention; Figure 3 This is a schematic diagram of the medical radiation protection dressing described in Embodiment 2 of the present invention; Figure 4 This is a schematic diagram of the medical radiation protection patch described in Embodiment 3 of the present invention; Figure 5 This is a schematic diagram of the medical radiation protection dressing described in Embodiment 4 of the present invention; Figure 6 This is a schematic diagram of the cut seam of the fiber membrane described in this invention. Detailed Implementation

[0021] To further illustrate the technical means and effects adopted by the present invention to achieve its intended purpose, the following, in conjunction with the accompanying drawings and preferred embodiments, details the specific implementation, structure, features, and effects of a medical radiation protection patch according to the present invention. In the following description, different "embodiments" or "embodiments" do not necessarily refer to the same embodiment. Furthermore, specific features, structures, or characteristics in one or more embodiments can be combined in any suitable form.

[0022] The present invention aims to address the technical problem by employing the following technical solution. A medical radiation protection dressing according to the present invention, such as... Figure 1 As shown, the dressing 100 comprises, from bottom to top, the following layers: an anti-adhesive membrane 400, a fiber membrane 300, and a nonwoven fabric 200. The fiber membrane is made of any one of β-glucan, lyocell fiber, and cuprammonium fiber. The surface of the fiber membrane is covered with fibers. The density of the fibers is 10. 6 ~10 11 root / cm 2 The dressing also includes a solution. The nonwoven fabric, fiber membrane, and anti-adhesive film are all impregnated in the solution and adhere to each other through the solution. The solution's ingredients include: superoxide dismutase, trehalose, curcumin, sorbitol, potassium sorbate, and water.

[0023] The purpose of this application is to disclose a comprehensive system with synergistic effects of "physical protection, chemical removal and moist repair", rather than a simple medical radiation protection patch that is simply a combination of a patch and a protective liquid.

[0024] Therefore, in terms of material selection, the fiber membrane disclosed in this application uses materials such as β-glucan, lyocell fiber, and cuprammonium fiber. β-glucan is not extracted from plants but is produced by the fermentation of specific bacteria, and is a type of bacterial cellulose. Lyocell fiber is derived from wood pulp and is a type of regenerated wood pulp cellulose; cuprammonium fiber is also a regenerated cellulose. Using these materials, it is possible to produce a surface with ultra-high density (10⁻⁶ ppm). 6 ~10 11 root / cm 2 The fibrous membrane structure of the fibers increases the specific surface area, enabling it to efficiently adsorb aqueous solutions containing superoxide dismutase (SOD) as the main raw material. The SOD-containing aqueous solution then continuously and stably penetrates deep into the skin along the fibers on the membrane surface, prolonging the action time and enhancing the depth of penetration. This achieves better adhesion between the patch and the skin, as well as physical isolation, moisturizing, and cooling, creating a favorable repair environment for damaged skin. Preferably, the fiber membrane is composed of β-glucan.

[0025] In terms of solution formulation, this application targets the mechanism of radiation damage: through the synergistic effect of superoxide dismutase and curcumin, it effectively removes excess free radicals generated by radiation, thereby reducing oxidative stress damage at the source; at the same time, curcumin exerts anti-inflammatory activity, while trehalose and sorbitol build a powerful moisturizing and repairing layer, stabilize cell membranes, and relieve dryness and burning sensation.

[0026] The medical radiation protection dressing disclosed in this application is composed of a solution and an anti-adhesive film, a fiber membrane, and a nonwoven fabric immersed in the solution. The anti-adhesive film, fiber membrane, and nonwoven fabric are always immersed in the solution, achieving individual, independent packaging. This design ensures the product remains stable during storage, is ready to use immediately, and can be discarded after use, thus maintaining controllable stability of ingredient activity and sterility throughout the entire process.

[0027] In the dressing described in this application, the anti-adhesive film, the fiber film, and the nonwoven fabric are bonded together only by the adhesiveness of the solution itself, rather than by an adhesive.

[0028] In one feasible approach, the thickness of the anti-stick film is 0.03–0.06 mm. The thickness of the fiber membrane is 0.3–0.6 mm. The thickness of the nonwoven fabric is 0.1–0.2 mm.

[0029] In one feasible way, the size of the patch is matched to the shape of the corresponding part of the human body.

[0030] In one feasible approach, the nonwoven fabric is the same size as the anti-adhesive layer and the fiber membrane.

[0031] The dimensions of the nonwoven fabric, anti-adhesive layer, and fiber membrane disclosed in this application can be the same or different. Specifically, the size of the anti-adhesive layer can be slightly larger or smaller than the size of the fiber membrane, and the nonwoven fabric can also be slightly larger or smaller relative to the fiber membrane, thereby facilitating the peeling operation of the anti-adhesive layer and the nonwoven fabric. The specific dimensions can be flexibly adjusted according to actual usage needs.

[0032] It is worth noting that the sizes of the nonwoven fabric, fiber membrane, and anti-stick membrane disclosed in this application refer to the length and width of the nonwoven fabric, fiber membrane, and anti-stick membrane.

[0033] In one feasible embodiment, the nonwoven fabric is made of viscose synthetic fiber. The anti-adhesive layer is made of polyethylene. The raw materials of the solution, by weight percentage, include: superoxide dismutase 0.03–0.05%, trehalose 1.5–2.5%, curcumin 0.2–0.4%, sorbitol 0.2–0.4%, potassium sorbate 0.1–0.3%, and the balance being purified water.

[0034] This application discloses the specific components and dosage of the solution. The added potassium sorbate is a preservative of sorbic acid and its salts, and its dosage fully complies with the limits for this type of preservative (maximum usage is 0.6%) in the "Cosmetic Safety Technical Specifications (2015 Edition)" (Announcement No. 268 of 2015 issued by the State Food and Drug Administration). Therefore, its use in this formulation is safe and compliant.

[0035] In one feasible manner, the activity of the superoxide dismutase is ≥500 U / mL.

[0036] In one feasible manner, the activity of the superoxide dismutase is ≥1000 U / mL.

[0037] In one feasible manner, the pH value of the fiber membrane is 5.5 to 7.5.

[0038] Maintaining the pH of the fiber membrane environment within a near-neutral to slightly acidic range corresponds to the pH range for injectable water specified in the National Pharmacopoeia and is close to the normal pH range of human skin (approximately 5.5). This setting reduces skin irritation, maintains the skin's microecological balance, and also helps maintain stable SOD enzyme activity.

[0039] It is worth noting that the pH value of the fiber membrane mentioned herein refers to the pH value when the fiber membrane is immersed in the solution.

[0040] In one possible implementation, the fiber membrane 300 is provided with a first cut slit 310. The first cut slit extends a predetermined distance from the edge of the fiber membrane 300 toward the center.

[0041] like Figure 6 As shown, the first cut slit 310 on the fiber membrane disclosed in this application has the main function of facilitating the application process and enabling the fiber membrane to adhere more closely to human skin.

[0042] The fiber membrane disclosed in this application can extend from any position on the edge of the fiber membrane toward the center.

[0043] In one possible implementation, the other end of the first cut slit 310 is provided with a first cut opening 320.

[0044] The first cut is set at the end of the first cut seam (the end closest to the middle of the fiber membrane). This can effectively prevent the cut seam from continuing to extend and tear into the fiber membrane during use due to stretching or bending. This ensures the structural integrity of the fiber membrane, extends the service life of the dressing, and avoids local failure or skin irritation caused by accidental tearing.

[0045] In one feasible embodiment, a second cut slit is provided on the nonwoven fabric. The second cut slit extends a predetermined distance from the edge of the nonwoven fabric toward the center. The second cut slit coincides with the first cut slit.

[0046] In one feasible embodiment, a second cut is provided at the other end of the second cut seam. The second cut coincides with the first cut.

[0047] This application provides a second cutting seam and a second cutting opening on the nonwoven fabric that coincide with the positions of the first cutting seam and the first cutting opening. This allows the fiber membrane and the nonwoven fabric to unfold or deform synchronously during application, avoiding relative slippage, delamination, or edge curling between multi-layer structures due to misalignment of the cutting seams. At the same time, it maintains the overall flexibility and consistency of the application, making it easier for medical staff to complete the application in one go, improving ease of use and application effect.

[0048] The second cutting seam and the first cutting seam described in this application coincide, and the second cutting opening coincides with the first cutting opening. The term "coincidentally" means that the two are in the same position. The sizes of the two can be equal or unequal, and can be flexibly set according to the needs of use, as long as the functional requirements are met.

[0049] In one feasible embodiment, a third cut seam is provided on the release layer. The third cut seam extends a predetermined distance from the edge of the nonwoven fabric toward the center. The third cut seam coincides with the first and second cut seams.

[0050] In one feasible embodiment, a third cut is provided at the other end of the third cut seam. The second and third cuts coincide with the first and second cuts.

[0051] The protective dressing disclosed in this application allows for the creation of cut seams and slits at the same locations on the nonwoven fabric, release layer, and fiber membrane. In one feasible manner, this application also proposes a medical radiation protection dressing according to the above-described method, such as... Figure 2 As shown, the protective dressing body 110 is the aforementioned medical radiation protective dressing, and the protective dressing body includes a first main body 1101 and a second main body 1102. The first main body is rectangular, and one side of the second main body is connected to the first main body, while the other side is arc-shaped.

[0052] In one feasible manner, on the side where the second main body is connected to the first main body, the side length 11021 of the connecting side is equal to the corresponding side length of the first main body.

[0053] In one possible implementation, the two corners 11011 on the side of the first main body that is not connected to the second main body are rounded.

[0054] The side of the second main body portion disclosed in this application that connects to the first main body portion has a side length equal to the corresponding side length of the first main body portion. The two corners of the side of the first main body portion that does not connect to the second main body portion are rounded. This shape of protective dressing is suitable for the chest and abdomen of the human body.

[0055] The protective dressing body described herein includes a first body portion and a second body portion, which refers to the overall division of the protective dressing (including the nonwoven fabric, the release layer, and the fiber membrane). In the protective dressing disclosed in this application, the nonwoven fabric, the release layer, and the fiber membrane have the same shape.

[0056] In one feasible manner, this application also proposes a medical radiation protection dressing according to the above-described method, such as... Figure 3 As shown, the main body 120 of the protective dressing is the aforementioned medical radiation protective dressing. The protective dressing is elliptical in shape, and the left and right edges 1201 of the protective dressing are straight lines.

[0057] This application discloses a protective dressing that can be oval-shaped, but the sides of the oval are straight lines instead of curved lines. This shape is suitable for the chest and abdomen of the human body.

[0058] In one feasible manner, this application also proposes a medical radiation protection dressing according to the above-described method, such as... Figure 4 As shown, the protective dressing body 130 is the aforementioned medical radiation protective dressing. The protective dressing is hexagonal in shape, and all six corners 1301 of the hexagon are rounded.

[0059] The protective dressing disclosed in this application can also be hexagonal, but all six corners of the hexagon are rounded. This shape of protective dressing can be used on the limbs of the human body.

[0060] In one feasible manner, this application also proposes a medical radiation protection dressing according to the above-described method, such as... Figure 5 As shown, the protective dressing body is the aforementioned medical radiation protective dressing, and the protective dressing body 140 includes a first main body portion 1401 and a second main body portion 1402. The first main body portion is trapezoidal, and one side of the second main body portion is connected to the upper bottom edge 14012 of the first main body portion, while the other side is arc-shaped. The length of the upper bottom edge of the first main body portion is greater than the length of the lower bottom edge 14013 of the first main body portion.

[0061] In one feasible manner, on the side where the second main body is connected to the first main body, the length of the connecting edge is equal to the length of the upper bottom edge of the first main body.

[0062] In one possible implementation, the two corners 14014 on the side of the first main body that is not connected to the second main body are rounded.

[0063] like Figure 5 As shown, the protective dressing disclosed in this application can have an upper part that is arc-shaped and a lower part that is trapezoidal, similar to a fan shape. The arc-shaped upper part connects to the upper base of the trapezoid, and the side length of the connecting side is the same. In addition, the two corners on the other side of the trapezoid are rounded. This shape of protective dressing can be used on the neck of the human body.

[0064] This application provides a method for using a medical radiation protection dressing, as detailed below: 1. Preparation before use: Cleanse the skin in the treatment area and ensure it is dry.

[0065] 2. Remove the dressing: Tear open the medical aluminum foil packaging and remove the three-layer composite dressing (in order: anti-adhesive film, fiber film and non-woven fabric).

[0066] 3. Fully unfold the dressing, first peel off the bottom protective film to expose the fiber membrane, then cover the exposed fiber membrane with the skin area to be protected, gently smooth it and push out any air bubbles under the membrane to ensure it adheres closely to the skin, and finally peel off the non-woven fabric on the surface of the fiber membrane.

[0067] 4. After applying the patch, leave it on for about 30 minutes, then remove the fiber membrane. There is no need to wash the skin. You can gently press the area for a few minutes to promote absorption. The application is now complete.

[0068] 5. Frequency and duration of use: It is recommended to use it 1 to 2 times a day during radiotherapy and continue to use it for 7 to 10 days after the end of radiotherapy. Please follow your doctor's advice for specific instructions.

[0069] It is worth noting that the medical radiation protection dressing disclosed in this application has the following precautions: 1. Do not use on broken, ulcerated, or incomplete skin.

[0070] 2. If allergic reactions such as skin redness or itching occur during use, please stop using the product immediately and wash it thoroughly. If necessary, seek medical attention promptly.

[0071] 3. Not for use by those allergic to the raw materials.

[0072] 5. Before use, check that the packaging is intact. If it is damaged, do not use.

[0073] 6. Avoid placing this product in direct sunlight.

[0074] 7. Please use as directed by your doctor.

[0075] 8. For external use only. Do not ingest.

[0076] The present invention will be further described below with reference to specific embodiments, but this should not be construed as a limitation on the scope of protection of the present invention. Some non-essential improvements and adjustments made by those skilled in the art based on the above description of the present invention still fall within the scope of protection of the present invention.

[0077] Unless otherwise specified, all materials and reagents mentioned below are commercially available products well known to those skilled in the art; unless otherwise specified, all methods described are methods known in the art. Unless otherwise defined, the technical or scientific terms used should have the ordinary meaning understood by those skilled in the art to which this invention pertains.

[0078] Example 1 A medical radiation protection dressing, such as Figure 1 and Figure 2 As shown, it includes an anti-adhesive film, a fiber membrane, a nonwoven fabric, and a solution. The anti-adhesive film, fiber membrane, nonwoven fabric, and solution are all packaged together inside a medical aluminum foil package; the shape of the dressing is roughly square; the length of the dressing is 200 mm and the width is 200 mm.

[0079] The raw materials of the solution, by weight percentage, include: 0.04% superoxide dismutase, 2.0% trehalose, 0.3% curcumin, 0.3% sorbitol, 0.2% potassium sorbate, and the balance purified water; the activity of superoxide dismutase is ≥500 U / mL.

[0080] The structure of the dressing, from bottom to top, includes: an anti-adhesive membrane, a fiber membrane, and a nonwoven fabric; the fiber membrane is made of any one of the following raw materials: β-glucan, lyocell fiber, and cuprammonium fiber; the surface of the fiber membrane is covered with fibers; the density of the fibers is 10. 6 ~10 11The thickness of the fiber membrane is 6.5; the thickness of the anti-stick membrane is 0.05 mm; the thickness of the fiber membrane is 0.45 mm; and the thickness of the nonwoven fabric is 0.15 mm.

[0081] Example 2 A medical radiation protection dressing, such as Figure 1 and Figure 3 As shown, it includes an anti-adhesive film, a fiber membrane, a nonwoven fabric, and a solution. The anti-adhesive film, fiber membrane, nonwoven fabric, and solution are all packaged together inside a medical aluminum foil package; the shape of the dressing is roughly circular; the length of the dressing is 200 mm and the width is 200 mm.

[0082] The raw materials of the solution, by weight percentage, include: 0.04% superoxide dismutase, 2.0% trehalose, 0.3% curcumin, 0.3% sorbitol, 0.2% potassium sorbate, and the balance purified water; the activity of superoxide dismutase is ≥500 U / mL.

[0083] The structure of the dressing, from bottom to top, includes: an anti-adhesive membrane, a fiber membrane, and a nonwoven fabric; the fiber membrane is made of any one of the following raw materials: β-glucan, lyocell fiber, and cuprammonium fiber; the surface of the fiber membrane is covered with fibers; the density of the fibers is 10. 6 ~10 11 The thickness of the fiber membrane is 6.5; the thickness of the anti-stick membrane is 0.05 mm; the thickness of the fiber membrane is 0.45 mm; and the thickness of the nonwoven fabric is 0.15 mm.

[0084] Example 3 A medical radiation protection dressing, such as Figure 1 and Figure 4 As shown, it includes an anti-adhesive film, a fiber membrane, a nonwoven fabric, and a solution. The anti-adhesive film, fiber membrane, nonwoven fabric, and solution are all packaged together inside a medical aluminum foil package; the shape of the dressing is polygonal; the length of the dressing is 300 mm and the width is 300 mm.

[0085] The raw materials of the solution, by weight percentage, include: 0.04% superoxide dismutase, 2.0% trehalose, 0.3% curcumin, 0.3% sorbitol, 0.2% potassium sorbate, and the balance purified water; the activity of superoxide dismutase is ≥500 U / mL.

[0086] The structure of the dressing, from bottom to top, includes: an anti-adhesive membrane, a fiber membrane, and a nonwoven fabric; the fiber membrane is made of any one of the following raw materials: β-glucan, lyocell fiber, and cuprammonium fiber; the surface of the fiber membrane is covered with fibers; the density of the fibers is 10. 6 ~10 11 root / cm 2The pH value of the fiber membrane is 6.5; the thickness of the anti-stick membrane is 0.05 mm; the thickness of the fiber membrane is 0.45 mm; and the thickness of the nonwoven fabric is 0.15 mm.

[0087] Example 4 A medical radiation protection dressing, such as Figure 1 and Figure 5 As shown, it includes an anti-adhesive film, a fiber membrane, a nonwoven fabric, and a solution. The anti-adhesive film, fiber membrane, nonwoven fabric, and solution are all packaged together inside a medical aluminum foil package; the shape of the dressing is fan-shaped; the length of the dressing is 50 mm and the width is 50 mm.

[0088] The raw materials of the solution, by weight percentage, include: 0.04% superoxide dismutase, 2.0% trehalose, 0.3% curcumin, 0.3% sorbitol, 0.2% potassium sorbate, and the balance purified water; the activity of superoxide dismutase is ≥500 U / mL.

[0089] The structure of the dressing, from bottom to top, includes: an anti-adhesive membrane, a fiber membrane, and a nonwoven fabric; the fiber membrane is made of any one of the following raw materials: β-glucan, lyocell fiber, and cuprammonium fiber; the surface of the fiber membrane is covered with fibers; the density of the fibers is 10. 6 ~10 11 root / cm 2 The pH value of the fiber membrane is 6.5; the thickness of the anti-stick membrane is 0.05 mm; the thickness of the fiber membrane is 0.45 mm; and the thickness of the nonwoven fabric is 0.15 mm.

[0090] Comparative Example 1 A medical radiation protection spray, the main ingredients of which are superoxide dismutase (SOD), curcumin, sodium alginate, potassium sorbate, sorbitol and purified water.

[0091] The cooling performance of the medical radiation protection patch prepared in Example 1 was tested, and the method is as follows: 1. Turn on the power of the constant temperature and humidity chamber, set the temperature to 40℃ and the relative humidity to 50%, place the thermometer inside the chamber, and insulate it from the chamber body with heat insulation material. Preheat for more than 30 minutes.

[0092] 2. Quickly read the thermometer value and record the temperature T0.

[0093] 3. Open the medical radiation protection dressing, remove the fiber membrane layer and tightly wrap it around the thermometer probe, place it in the constant temperature and humidity chamber, and start timing.

[0094] 4. Take thermometer readings at 10 min, 20 min, 30 min, 40 min, 50 min, and 60 min respectively, and record the temperatures T1, T2, T3, T4, T5, and T6.

[0095] 5. Following the steps above, a total of 5 parallel tests were conducted on the medical radiation protection patch products prepared in Example 1, and the average value T was calculated for each product. P , and cooling ΔT.

[0096] The test results are shown in Table 1: Table 1: Results of Cooling Performance Tests on the Medical Radiation Protection Patch Prepared in Example 1 The experimental results in Table 1 show that the fiber membrane in the medical radiation protection patch disclosed in this application has high adsorption capacity, enabling it to saturate and adsorb the solution. When the fiber membrane comes into contact with the skin, the fibers can stably and continuously apply the solution to the skin, thereby exerting good cooling performance.

[0097] The medical radiation protection patch prepared in Example 1 and the medical radiation protection spray prepared in Comparative Example 1 were tested for their superoxide anion (i.e., the main active free radical in the human body) scavenging ability, and the method is as follows: Prepare the sample into test solutions of the corresponding concentrations. According to the instructions of the superoxide anion reagent kit, prepare the reaction system according to the amount of each reagent added in Table 2, mix well, set up 3 replicates for each concentration, and use 0.3 mg / mL vitamin C as a positive control.

[0098] Table 2: Experimental Design for Superoxide Anion Scavenging Test Mix well and let stand at room temperature for 10 minutes. Then, take 200 μL from each tube and transfer it to a 96-well plate. Measure the absorbance of each tube at a wavelength of 550 nm. Calculate the scavenging rate of superoxide anions by the sample according to formula (I).

[0099] Superoxide anion scavenging rate = [(Control OD - Measured OD) / Control OD] × 100%... Equation (I) The test results are shown in Table 3: Among them, the significant difference between the sample group and the control group was... This means that a p-value < 0.05 indicates that... A p-value < 0.01 indicates that... .

[0100] The scavenging ability against reactive free radicals was evaluated by testing the superoxide anion scavenging rates of Example 1 (medical radiation protection patch) and Comparative Example 1 (medical radiation protection spray). The results showed that the superoxide anion scavenging rate of the patch was 63.75%, significantly higher than the 54.09% of the spray, with a statistically significant difference between the two groups (p < 0.01), indicating that the patch has a greater advantage in antioxidant capacity. This superior performance is attributed to its unique design: a high-density (10T) fiber membrane surface. 6 ~10 11 root / cm 2 The fibrous structure of the patch effectively enhances the adsorption and release efficiency of superoxide dismutase (SOD) aqueous solution. Simultaneously, the dual antioxidant system constructed from SOD and curcumin works synergistically under the stable protection of trehalose, achieving highly efficient scavenging of superoxide anions. Furthermore, the patch has a high water content (≥60%), achieving a cooling effect of 2.3℃~3.2℃. Through excellent moisturizing and physical isolation effects, it provides a good humid environment and cooling relief for skin repair after radiotherapy, further promoting the healing of damaged tissues.

[0101] In the above embodiments, the descriptions of each embodiment have different focuses. For parts not described in detail in a certain embodiment, please refer to the relevant descriptions in other embodiments.

[0102] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A medical radiation protection dressing, characterized in that, The dressing comprises, from bottom to top, layers of: an anti-adhesive membrane, a fiber membrane, and a nonwoven fabric; the fiber membrane is made of any one of β-glucan, lyocell fiber, and cuprammonium fiber; the surface of the fiber membrane is covered with fibers; the density of the fibers is 10. 6 ~10 11 root / cm 2 The dressing further includes a solution; the nonwoven fabric, the fiber membrane, and the anti-adhesive membrane are all immersed in the solution and are bonded together by the solution; the raw materials of the solution include: superoxide dismutase, trehalose, curcumin, sorbitol, potassium sorbate, and water.

2. The medical radiation protection dressing according to claim 1, characterized in that, The thickness of the anti-sticking film is 0.03–0.06 mm; the thickness of the fiber film is 0.3–0.6 mm; and the thickness of the nonwoven fabric is 0.1–0.2 mm.

3. The medical radiation protection dressing according to claim 1, characterized in that, The size of the patch is matched to the shape of the corresponding part of the human body.

4. The medical radiation protection dressing according to claim 1, characterized in that, The nonwoven fabric is the same size as the anti-adhesive layer and the fiber membrane.

5. The medical radiation protection dressing according to claim 1, characterized in that, The nonwoven fabric is made of viscose synthetic fiber; the anti-adhesive layer is made of polyethylene; the raw materials of the solution, by weight percentage, include: superoxide dismutase 0.03-0.05%, trehalose 1.5-2.5%, curcumin 0.2-0.4%, sorbitol 0.2-0.4%, potassium sorbate 0.1-0.3%, and the balance being purified water.

6. The medical radiation protection dressing according to claim 1, characterized in that, The fiber membrane is provided with a first cut slit; the first cut slit extends a predetermined distance from the edge of the fiber membrane toward the center.

7. A protective dressing suitable for the chest and abdomen, characterized in that, The protective dressing body is the medical radiation protective dressing according to any one of claims 1-6, and the protective dressing body includes a first main body and a second main body, the first main body is rectangular, one side of the second main body is connected to the first main body, and the other side is arc-shaped.

8. A protective dressing suitable for the chest and abdomen, characterized in that, The protective dressing body is the medical radiation protective dressing according to any one of claims 1-6; the protective dressing is elliptical in shape, and the left and right edges of the protective dressing are straight.

9. A protective dressing for the head and neck, characterized in that, The protective dressing body is the medical radiation protective dressing according to any one of claims 1-6; the protective dressing is hexagonal in shape, and all six corners of the hexagon are rounded.

10. A protective dressing for the head and neck, characterized in that, The protective dressing body is a medical radiation protective dressing as claimed in any one of claims 1-6, and the protective dressing body includes a first main body and a second main body. The first main body is trapezoidal, one side of the second main body is connected to the upper bottom edge of the first main body, and the other side is arc-shaped. The side length of the upper bottom edge of the first main body is greater than the side length of the lower bottom edge of the first main body.

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