5 results about "Neurite" patented technology

This invention provides a pH-responsive immunomodulatory microneedle patch, its preparation method, and its application, belonging to the field of biomedical materials technology. This invention incorporates Zif-8 nanoparticles loaded with ChABC into GelMA hydrogel to prepare a pH-responsive immunomodulatory microneedle patch (Z@C-MN). As the patch gradually degrades, the system can continuously release Zn in a pH-responsive manner. 2+ Z@C-MN, along with ChABC, promotes in situ repair of cerebral fibrosis (SCI) after injury. Z@C-MN induces macrophage polarization towards a pro-regenerative phenotype, thereby downregulating the inflammatory response, increasing neurite length, and promoting the differentiation of neural stem cells into neurons. In vivo, Z@C-MN reduced the inflammatory microenvironment after injury and promoted angiogenesis in a rat SCI model. Furthermore, it activated axonal regeneration by inhibiting scar tissue formation and regulating CD4+. + T cell transformation supports neurogenesis.

This invention discloses a GPU-based neuronal skeleton extraction method based on topology-simplified trunk growth, relating to the fields of neuroinformatics and 3D biomedical image processing. The method includes: threshold filtering and denoising of the input volume data, and retaining the largest connected component based on 3D connected component labeling to remove isolated noise; given the cell body center coordinates, determining the cell body region through spherical expansion and removing it from the foreground to highlight neural protrusions such as dendrites and axons; after obtaining the coarse skeleton, using GPU to perform topology simplification, and constructing a path scoring function combining path length and average normalized brightness, iteratively selecting and retaining the trunk path with the best score, enhancing trunk continuity and suppressing pseudo-branches caused by noise and breaks. This invention can achieve robust skeleton extraction in 3D data with noise interference and uneven brightness, and is suitable for applications such as neuronal morphology reconstruction and quantitative analysis.

The present invention relates to a polypeptide that induces ribbon synapse formation in the inner ear or increases the number of ribbon synapses in the inner ear, or improves the function of ribbon synapses. The present invention also relates to a polypeptide having the ability to promote neurite outgrowth or increase branch points of spiral ganglion neurons. A pharmaceutical composition comprising a polypeptide, a nucleic acid molecule encoding the polypeptide, a vector comprising the nucleic acid molecule, recombinant viral particles comprising the vector and a capsid protein, a cell comprising the vector, a cell transformed with the vector, or a combination thereof, of the present invention, prevents or ameliorates damage to or abnormality of the auditory system or the equilibrium system (vestibular system), and thus can be effectively used as a therapeutic agent for inner ear diseases.

This application discloses a neuromorphic organoid chip for high-throughput drug screening, belonging to the fields of microfluidic chips and drug screening technology. The chip includes a chip substrate and packaging module, a neuron culture module, an organoid culture module, a unidirectional trend connection module, a high-throughput drug delivery and distribution module, and a detection and sampling module. By integrating the neuron culture module, organoid culture module, unidirectional trend connection module with directional bias characteristics, and high-throughput drug delivery and distribution module on the same chip substrate, this invention achieves partitioned culture and directed connection of iPSC-induced neurons and three-dimensional tissues such as tumor organoids, supporting the construction of neuromorphic tumor models and high-throughput drug screening. This invention can guide neurites to preferentially extend towards the organoid side and inhibit the reverse migration of cells on the organoid side, offering advantages such as clear model boundaries, high throughput, and suitability for parallel drug testing and mechanism research.

This invention relates to TAFA proteins, fragments thereof, or variants thereof that have the ability to increase the length of neurites or branching points. Furthermore, this invention relates to pharmaceutical compositions containing polypeptides comprising the amino acid sequence of said TAFA protein, its fragments, or variants thereof; nucleic acid molecules encoding said polypeptides; vectors carrying said nucleic acid molecules; recombinant viral particles comprising said vector and capsid protein; cells comprising said vector; cells transformed with said vector; or therapeutic uses thereof. The compositions of this invention promote repair from damaged retina (e.g., cone cells of photoreceptors, etc.) or increase the length of neurites in neurons, and are therefore advantageous for the prevention or treatment of retinal neurological disorders and / or neuropathic pain.