4 results about "Oxidative metabolism" patented technology

This invention proposes a bioecological process for utilizing waste from sugary drinks by producing highly nutritious proteins from single-celled organisms, as well as other molecules of various interest, while significantly reducing the pollutant load of this waste. The process involves the upstream separation of the returned products, which are highly concentrated in sugars. The first step involves preparing the musts for fermentation by degassing and adjusting the sugars to 20 g / L and the pH to 5. An enrichment matrix is ​​used for musts made from carbonated beverage waste. The culture is carried out in batch or semi-continuous mode at a temperature of 30 ± 2°C with an agitation speed of approximately 150 rpm and oxygenation to promote oxidative metabolism. The incorporation of nectars and juices into the fermentation musts of carbonated beverages at a rate of ≥ 50% ensures a significant improvement in biomass yields. The process guarantees almost complete depletion of the sugars initially present in the musts (≥ 95%), producing biomass with a protein content exceeding 50% on a dry matter basis, which can be used in animal feed, aquaculture, or cosmetics.

This method and composition involves oral administration of a low dose of D-ribose to enhance adenosine monophosphate-activated protein kinase (AMPK) activity in both exercising and sedentary mammals, improve mitochondrial-related oxidative metabolic parameters, and thereby promote overall metabolic health in mammals.

This invention relates to the field of cell biology, and discloses a culture medium and method for inducing physiological myocardial hypertrophy based on carnosine. The culture medium for inducing physiological myocardial hypertrophy contains carnosine. By introducing an appropriate concentration of carnosine into a cardiomyocyte system, this invention can induce a series of phenotypic changes in cardiomyocytes related to physiological myocardial hypertrophy, including increased cardiomyocyte area, increased mitochondrial number, enhanced oxidative metabolic capacity, and increased ATP production capacity. These changes can improve the energy metabolism level of cardiomyocytes, thus providing a new technical solution for studying myocardial adaptive remodeling.

This invention relates to a selenopeptide that activates TNFR2 and its applications. The TNFR2-activating selenopeptide comprises a tmTNF-targeting peptide, an oligoethylene glycol hydrophilic chain, a selenoamino acid linker, and an alkyl hydrophobic chain connected in sequence. This invention develops a self-assembled selenopeptide with TNFR2-activating activity, which possesses functions of inflammation-targeted delivery, oxidative response phase transition, and reactive oxygen species (ROS) scavenging. In use, it can be pre-assembled into nanomicelles and delivered intravenously to rheumatoid arthritis (RA) tissues for enrichment. In the microenvironment of highly reactive oxygen species in inflamed tissues, the selenoamino acid linker specifically cleaves in response to the overexpression of ROS in damaged cells. This eliminates ROS and reduces oxidative stress. Furthermore, its oxidative metabolite, the tmTNF-targeting peptide, induces liquid-liquid phase separation of tmTNF on the surface of dendritic cell membranes, inducing oligomerization and efficient activation of TNFR2 on the surface of Treg cell membranes, thereby promoting Treg cell proliferation and improving RA inflammation.