65 results about "Oxidative metabolism" patented technology

The invention relates to a novel pyridine androstane derivative and application thereof to preparing a medicine for preventing and / or treating prostatic cancer. The pyridine androstane derivative disclosed by the invention is an ideal selective cytochrome oxidase CYP450c17 inhibitor and can be used for treating or preventing various indications relative to male hormonal functions, in particular prostatic cancer. The pyridine androstane derivative has lower oxidative metabolism and higher effective bioavailability, therefore having the advantages of less application dosage, better tolerance and little side effect.

The invention relates to a novel 2-arylthiazole derivative and medicinal salts thereof, and an application in the preparation of medicaments for preventing and / or treating gout. The compound of the invention is an ideal selective xanthine oxidoreductase inhibitor, is applicable to the treatment and prevention of various indications associated with uric acid synthesis in the body, and is especially applicable to the treatment of gout. The compound has reduced oxidative metabolism and acyl glucuronidation metabolism, reduced first-pass effect, higher effective bioavailability, and less side effect due to its low using amount.

The present invention is generally related to the discovery of the therapeutic benefit of administering gamma-tocopherol and gamma-tocopherol derivatives. More specifically, the use of gamma-tocopherol and racemic LLU-alpha, (S)-LLU-alpha, or gamma-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.

The present invention relates to a method for producing a heavy chain aminocarboxylic acid and, more particularly, to a recombinant microorganism in which a fatty aldehyde dehydrogenase gene in [omega]-oxidative metabolic pathway and a [beta]-oxidative metabolic pathway-related gene are deleted and a [omega]-transaminase gene is introduced, and a method for producing a heavy chain aminocarboxylicacid by culturing the recombinant microorganism. The recombinant microorganism of the present invention can prevent additional oxidation of fatty aldehyde and [beta]-oxidative metabolism and also produce a heavy chain aminocarboxylic acid, such as 12-aminodecane, as a raw material of nylon 12 from a substrate such as fatty acid with a high yield by introducing an amine group into a terminal thereof.

The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo imaging with PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well.

The invention relates to an application of Chinese yarn glycoprotein in improvement of the activities of an oxidative metabolism enzymes of mitochondria of a brain cell. Selection and verification are carried out by an animal test so as to prove that the Chinese yarn glycoprotein can obviously improve the activities of key enzymes namely pyruvate dehydrogenase and alpha-oxoglutarate dehydrogenase used for oxidative metabolism in the mitochondria of the brain cell, so that brain cell deterioration and damage diseases, such as senile dementia, vascular dementia, cerebral infarction and cerebral palsy, accompanying with oxidative metabolism efficiency reduction caused by reduction of the activities of the enzymes can be effectively treated.

A warm perfusion system that has the ability to support a tissue or organ at a near normal metabolic rate provides the mechanism not only for restored oxidative metabolism of the organ but for the delivery of cells, cell-based therapeutics, and growth and differentiation factors to a damaged tissue or organ. Subsequent to delivery of therapeutic cells, such as stem cells or progenitor cells, to the damaged organ, the cells can be prompted to grow, multiply and differentiate, thereby restoring damaged tissue.

The invention relates to an ultrasonic dredging robot device capable of freely moving in a blood vessel front and back. The ultrasonic dredging robot device comprises a strip-shaped shell, an electricpropelling mechanism, a storage battery and a high-frequency ultrasonic vibration element, wherein the electric propelling mechanism is composed of paddles, an ultra-micro motor and a gear assembly;the high-frequency ultrasonic vibration element and the storage battery are mounted in the strip-shaped shell; the high-frequency ultrasonic vibration element, the ultra-micro motor and the storage battery are electrically connected; and the electric propelling mechanism is mounted at the end part of the strip-shaped shell. The ultrasonic dredging robot device can move in the blood vessel and canbe used for carrying out ultrasonic cavitation on blood, so that fat in the blood can be broken into relatively fine particles by cavitation; under the ultrasonic cavitation effect, blood molecules move in an accelerated manner and the body temperature is raised; and the fine particle fat is subjected to peroxidation metabolism by a main component, namely triglyceride, in the fat under the effectof body hormones, and the triglyceride is decomposed and converted into energy, water and carbon dioxide to be discharged out of a body, so that the treatment effect of treating both principal and secondary aspects of diseases is realized.

The invention belongs to the technical field of judicial expertise and analytic chemistry, and relates to a method for detecting ethyl alcohol non-oxide metabolins in human whole blood, in particularto a method for simultaneously detecting 4 species of ethyl alcohol non-oxide metabolins (10 kinds in total) in the human whole blood. The method for simultaneously, qualitatively and quantitatively analyzing 4 species of ethyl alcohol non-oxide metabolins with big nature differences is built, has high sensitivity, high specificity and a wide linearity range, can be used for determining the natures and the quantity of the 4 species of ethyl alcohol non-oxide metabolins (10 kinds in total) in 50mu L of human whole blood few examined material, is simple and fast to operate and less in extractionsolvent dosage, can meet the requirements on judicial expertise task urgency and high detection time demand, and can be popularized and applied on a large scale.