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Pyridine androstane derivative and application thereof to preparing medicine for preventing and/or treating prostatic cancer

A technology of use and medicinal salt, applied in the field of pyridine androster derivatives and their use in the preparation of medicaments for preventing and/or treating prostate cancer, can solve problems such as inability to block androgens, and achieve high effective bioavailability , Less side effects, less dosage effect

Inactive Publication Date: 2012-05-30
苏州波锐生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods do not block androgen production elsewhere in the body

Method used

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  • Pyridine androstane derivative and application thereof to preparing medicine for preventing and/or treating prostatic cancer
  • Pyridine androstane derivative and application thereof to preparing medicine for preventing and/or treating prostatic cancer
  • Pyridine androstane derivative and application thereof to preparing medicine for preventing and/or treating prostatic cancer

Examples

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Embodiment 1

[0050] The present embodiment provides a compound represented by formula (II):

[0051]

Embodiment 2

[0053] The present embodiment provides a compound represented by formula (III):

[0054]

Embodiment 3

[0056] The present embodiment provides a compound represented by formula (IV):

[0057]

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PUM

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Abstract

The invention relates to a novel pyridine androstane derivative and application thereof to preparing a medicine for preventing and / or treating prostatic cancer. The pyridine androstane derivative disclosed by the invention is an ideal selective cytochrome oxidase CYP450c17 inhibitor and can be used for treating or preventing various indications relative to male hormonal functions, in particular prostatic cancer. The pyridine androstane derivative has lower oxidative metabolism and higher effective bioavailability, therefore having the advantages of less application dosage, better tolerance and little side effect.

Description

technical field [0001] The present invention relates to pyridine androster derivatives and their use in the preparation of drugs for preventing and / or treating prostate cancer. Background technique [0002] Important male hormones are testosterone, androsterone, androdione, and dehydroepiandrosterone. Testosterone is secreted by the Leydig cells of the testes and is the most important male hormone in the body. Androsterone, androdione, and dehydroepiandrosterone are metabolites of testosterone (testosterone → androsterone → androdione → dehydroepiandrosterone). The adrenal cortex also secretes a male hormone, adrenal androsterone. These hormones can stimulate the growth of prostate cancer. Therefore, the first choice for the treatment of prostate cancer is to suppress the production of androgen in the testes through drugs or surgery. However, these methods do not block androgen production in other parts of the body. [0003] Steroid hormone synthesis starts from cholest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J43/00A61K31/58A61K31/675A61P35/00A61P5/28
Inventor 殷建明朱惠霖
Owner 苏州波锐生物医药科技有限公司
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