Non-steroidal anti-inflammatory drug orally disintegrating tablet and producing method thereof

Abstract

The invention discloses a non-steroidal anti-inflammatory drug orally disintegrating tablet and a producing method thereof, and relates to the non-steroidal anti-inflammatory drug orally disintegrating tablet and a prescription and a process utilizing the freeze-drying method to produce the non-steroidal anti-inflammatory drug orally disintegrating tablet. The non-steroidal anti-inflammatory drug orally disintegrating tablet is produced by main drug and pharmaceutic adjuvant, no water is needed while users take the tablet, and the tablet disintegrates rapidly after being delivered to the mouth, thereby the tablet is suitable for dysphagia patients such as the old, children and the like; the tablet is suitable for traveling under the condition that water is not easy to get; the non-steroidal anti-inflammatory drug orally disintegrating tablet has the advantages of convenience in taking, rapid absorption, small first pass effect, small irritation to digestive tract mucosa and the like, the tablet has a broad application prospect in the market, and the non-steroidal anti-inflammatory drug orally disintegrating tablet is capable of effectively reducing side effects of non-steroidal anti-inflammatory drugs. In addition, the invention further relates to the non-steroidal anti-inflammatory drug orally disintegrating tablet producing method.

Description

Technical field: [0001] The invention relates to a non-steroidal anti-inflammatory drug orally disintegrating tablet and a preparation method thereof, in particular to a non-steroidal anti-inflammatory drug orally disintegrating tablet prepared by a freeze-drying method. Background technique: [0002] Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of anti-inflammatory drugs that do not contain a steroidal structure. At present, there are more than 100 kinds of thousands of brands on the market, such drugs include meloxicam, indomethacin, diclofenac sodium, lornoxicam, ketoprofen, etc. These drugs have anti-inflammatory, anti-rheumatic and pain-relieving properties. , antipyretic and anticoagulant effects, it is widely used clinically to relieve osteoarthritis, rheumatoid arthritis, various fevers and various pain symptoms. At present, NSAIDs are one of the most used drugs in the world, and about 30 million people in the world use them every day. [0003] Non-st...

AI Technical Summary

Problems solved by technology

[0005] In China, the preparation technology of orally disintegrating tablets started relatively late. At present, the direct compression method is mostly used to prepare orally disintegrating tablets. Most disintegrants are insoluble in water, so the orally disintegrating tablets prepared by this method often have a gritty feeling after tasting, which affects the taste and compliance of patients when taking it; and the disintegration of the preparation will be very slow

Some domestic scholars also use the freeze-drying method to prepare this dosage form, but most of them follow the shortcomings of the direct compression method, adding a large amount of disintegrants and other excipients, which makes the performance of the orally disintegrating tablets prepared poor.

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