Application of resveratrol in preparing medicines for preventing and curing vessel endothelial injuries caused by organophosphorus pesticides

Abstract

The invention provides application of resveratrol in preparing medicines for preventing and curing vessel endothelial injuries caused by organophosphorus pesticides and also provides an application of the resveratrol in preparing medicines for preventing and curing diseases induced by the vessel endothelial injuries caused by the organophosphorus pesticides. Proved by pharmacological tests, the resveratrol can suppress vessel endothelial dependency diastole reaction reduction caused by the organophosphorus pesticides and has better dose dependency. The resveratrol also has the effects of protecting the vessel endothelial cell activity and preventing vessel endothelial permeability increase caused by oxygen and phosphorus and morphologic changes and can also protect the function of endothelial cells for releasing NO and the activity of superoxide dismutase and reduce the content of malondialdehyde which is a lipid peroxided metabolic product.

Description

technical field The invention relates to the application of resveratrol, in particular to the application of resveratrol in the preparation of medicines for preventing and treating vascular endothelial damage caused by organophosphorus pesticides. Background technique my country is a large agricultural country, and it is also one of the countries in the world where organophosphorus pesticides are widely used and organophosphorus pollution is relatively serious. Organophosphorus (OPs) pesticides (such as paraoxon, triazophos, phoxim, profenofos, etc.) It is widely used in rural areas of our country. Although most farmers have paid attention to the prevention of acute organophosphate poisoning, they have not paid enough attention to the damage to the body caused by long-term low-dose exposure to organophosphate pesticides. At present, studies abroad have pointed out that the activity and concentration of paraoxonase-1 (PON1) in the body of flower workers who spray organophosph...

AI Technical Summary

Problems solved by technology

Although most farmers have paid attention to the prevention of acute organophosphate poisoning, they have not pa

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